A partir des données de trois études de cohortes prospectives incluant 167 765 femmes et 43 697 hommes, cette étude évalue l'association entre une consommation d'alcool et le risque de carcinome basocellulaire cutané

Alcohol consumption and risk of cutaneous basal cell carcinoma in women and men: 3 prospective cohort studies

Wu, Shaowei ; Li, Wen-Qing ; Qureshi, Abrar A ; Cho, Eunyoung

Background: Alcohol consumption has been associated with an increased prevalence of sunburn, which is an established skin cancer risk factor. Objective: We investigated whether alcohol consumption is associated with risk of cutaneous basal cell carcinoma (BCC). Design: We conducted a prospective analysis on alcohol consumption and risk of BCC on the basis of data from 167,765 women in the NHS (Nurses’ Health Study) (1984–2010) and NHS II (1991–2011) and 43,697 men in the Health Professionals [...]

A partir des données de la cohorte "Nurses' Health Study" incluant 105 972 participantes, cette étude prospective évalue l'association entre une consommation d'alcool et le risque de cancer du sein par sous-type moléculaire (période de suivi : 1980 à 2006)

Alcohol consumption and risk of breast cancer by molecular subtype: Prospective analysis of the nurses' health study after 26 years of follow-up

Hirko, Kelly A. ; Chen, Wendy Y. ; Willett, Walter C. ; Rosner, Bernard A. ; Hankinson, Susan E. ; Beck, Andrew H. ; Tamimi, Rulla M. ; Eliassen, A. Heather

Alcohol consumption is a consistent risk factor for breast cancer, although it is unclear whether the association varies by breast cancer molecular subtype. We investigated associations between cumulative average alcohol intake and risk of breast cancer by molecular subtype among 105,972 women in the prospective Nurses' Health Study cohort, followed from 1980 to 2006. Breast cancer molecular subtypes were defined according to estrogen receptor (ER), progesterone receptor, human epidermal growth [...]

Menée en Ukraine à partir de données portant sur 11 613 participants âgés de moins de 18 ans lors de l'accident de Tchernobyl, cette étude évalue l'association entre une exposition à l'iode 131 et le risque d'adénome folliculaire de la thyroïde chez les enfants et adolescents (38 cas)

Risk of Thyroid Follicular Adenoma Among Children and Adolescents in Belarus Exposed to Iodine-131 After the Chornobyl Accident

Zablotska, Lydia B. ; Nadyrov, Eldar A. ; Polyanskaya, Olga N. ; McConnell, Robert J. ; O'Kane, Patrick ; Lubin, Jay ; Hatch, Maureen ; Little, Mark P. ; Brenner, Alina V. ; Veyalkin, Ilya V. ; Yauseyenka, Vasilina V. ; Bouville, Andre ; Drozdovitch, Vladimir V. ; Minenko, Viktor F. ; Demidchik, Yuri E. ; Mabuchi, Kiyohiko ; Rozhko, Alexander V.

Several studies reported an increased risk of thyroid cancer in children and adolescents exposed to radioactive iodines, chiefly iodine-131 (131I), after the 1986 Chornobyl (Ukrainian spelling) nuclear power plant accident. The risk of benign thyroid tumors following such radiation exposure is much less well known. We have previously reported a novel finding of significantly increased risk of thyroid follicular adenoma in a screening study of children and adolescents exposed to the Chornobyl [...]

A partir de données de 14 études menées en Australie, en Europe et en Amérique du nord, cette étude évalue l'association entre des polymorphismes à simple nucléotide de 16 gènes liés au récepteur des androgènes, le risque d'endobrachyœsophage et d'adénocarcinome de l'œsophage

Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

Ek, Weronica E. ; Lagergren, Katarina ; Cook, Michael ; Wu, Anna H. ; Abnet, Christian C. ; Levine, David ; Chow, Wong-Ho ; Bernstein, Leslie ; Risch, Harvey A. ; Shaheen, Nicholas J. ; Bird, Nigel C. ; Corley, Douglas A. ; Hardie, Laura J. ; Fitzgerald, Rebecca C. ; Gammon, Marilie D. ; Romero, Yvonne ; Liu, Geoffrey ; Ye, Weimin ; Vaughan, Thomas L. ; MacGregor, Stuart ; Whiteman, David C. ; Westberg, Lars ; Lagergren, Jesper

The strong male predominance in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) remains inadequately explained, but sex hormones might be involved. We hypothesized that single nucleotide polymorphisms (SNPs) in the androgen pathway influence risk of developing BE and EAC. This genetic-epidemiological analysis included 14 studies from Australia, Europe and North America. Polymorphisms in 16 genes coding for the androgen pathway were analyzed using a gene-based approach: versatile [...]

A partir d'une revue systématique de la littérature publiée avant septembre 2014 (497 634 participants, 22 338 cas), cette méta-analyse évalue l'association entre une prise de poids à l'âge adulte et le risque de cancer de la prostate

Adult weight gain and risk of prostate cancer: A dose–response meta-analysis of observational studies

Chen, Qi ; Chen, Tao ; Shi, Wentao ; Zhang, Tianyi ; Zhang, Wei ; Jin, Zhichao ; Wei, Xin ; Liu, Yuzhou ; He, Jia

The association between adult weight gain and risk of prostate cancer has not been widely studied and the findings are inconsistent. Therefore, our study aimed to investigate the association between adult weight gain and risk of prostate cancer. PubMed, Embase and Web of Science databases were searched for relevant studies published before September 2014 using terms related to weight gain and prostate cancer. Summary estimates were obtained using the random-effects model. Dose–response [...]

A partir de données portant sur un total de 4 147 cas et 7 435 témoins, puis sur une cohorte complémentaire de 1 490 cas et 1 723 témoins, cette méta-analyse identifie de nouveaux loci de susceptibilité à différents types de gliome

Genome-wide association study identifies multiple susceptibility loci for glioma

Kinnersley, Ben ; Labussiere, Marianne ; Holroyd, Amy ; Di Stefano, Anna-Luisa ; Broderick, Peter ; Vijayakrishnan, Jayaram ; Mokhtari, Karima ; Delattre, Jean-Yves ; Gousias, Konstantinos ; Schramm, Johannes ; Schoemaker, Minouk J. ; Fleming, Sarah J. ; Herms, Stefan ; Heilmann, Stefanie ; Schreiber, Stefan ; Wichmann, Heinz-Erich ; Nothen, Markus M. ; Swerdlow, Anthony ; Lathrop, Mark ; Simon, Matthias ; Bondy, Melissa ; Sanson, Marc ; Houlston, Richard S.

Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 [times] [...]

Menée en Suède à partir de données portant sur 1 837 634 mères et sur 3 588 497 enfants (1973-2008), cette étude de cohorte évalue l'association entre la croissance fœtale de l'enfant et le risque ultérieur de cancer de la thyroïde chez la mère

Fetal growth and subsequent maternal risk of thyroid cancer

Crump, Casey ; Sundquist, Jan ; Sieh, Weiva ; Winkleby, Marilyn A. ; Sundquist, Kristina

Thyroid cancer has peak incidence among women of reproductive age, and growth factors, which have procarcinogenic properties, may play an important etiologic role. However, the association between fetal growth rate during a woman's pregnancy and her subsequent risk of thyroid cancer has not been previously examined. We conducted a national cohort study of 1,837,634 mothers who had a total of 3,588,497 live-births in Sweden in 1973–2008, followed up for thyroid cancer incidence through 2009. [...]