Menée par enquête dans cinq pays européens auprès de 947 participants (375 médecins, 186 infirmières en oncologie et 386 patients), cette étude transversale analyse l'incidence, les effets et la prise en charge des nausées et vomissements induits par la chimio ou radiothérapie, selon les perceptions des patients atteints de cancer ou celles des professionnels de santé

Impact and management of chemotherapy/radiotherapy-induced nausea and vomiting and the perceptual gap between oncologists/oncology nurses and patients: a cross-sectional multinational survey

Vidall, Cheryl ; Fernández-Ortega, Paz ; Cortinovis, Diego ; Jahn, Patrick ; Amlani, Bharat ; Scotté, Florian

Purpose : Chemotherapy/radiotherapy-induced nausea and vomiting (CINV/RINV) can affect half of oncology patients, significantly impacting daily life. Nausea without vomiting has only recently been thought of as a condition in its own right. As such, the incidence of nausea is often underestimated. This survey investigated the incidence and impact of CINV/RINV in patients compared with estimations of physicians/oncology nurses to determine if there is a perceptual gap between healthcare [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2012 (73 études), cette étude analyse l'implémentation et la mise en oeuvre d'interventions en soins de support dans les essais cliniques incluant des patients atteints de cancer

Implementation of Supportive Care and Best Supportive Care Interventions in Clinical Trials Enrolling Patients with Cancer

Lee, R. T. ; Ramchandran, K. ; Sanft, T. ; Von Roenn, J.

Background : With the growing and evolving role of palliative care in oncology, we examined how supportive care (SC) and best supportive care (BSC) are implemented in clinical trials when used as a comparison treatment arm. Methods : We conducted a systematic review of the literature for clinical trials published between 1980–2012 in which systemic anticancer therapy was compared with a SC only arm and compared SC implementation to World Health Organization (WHO) published guidelines. Results : [...]

Mené au Japon auprès de 82 patientes atteintes d'un cancer gynécologique, cet essai de phase II évalue l'efficacité d'un traitement à base de palonosétron et de dexaméthasone pour prévenir les nausées et vomissements induits par une chimiothérapie combinant paclitaxel et carboplatine

Palonosetron in combination with 1-day versus 3-day dexamethasone to prevent nausea and vomiting in patients receiving paclitaxel and carboplatin

Furukawa, Naoto ; Kanayama, Seiji ; Tanase, Yasuhito ; Ito, Fuminori

Purpose : The aim of the present study was to evaluate the efficacy and toxicity of palonosetron (PAL) and dexamethasone (DEX) on day 1 only in patients with gynecologic cancer receiving paclitaxel combined with carboplatin (TC). The primary endpoint was to evaluate the complete response (CR) rate in the delayed phase. Methods : This study was a randomized phase 2. Regardless of assignment to either study arm, all patients received an intravenous prophylactic regimen of DEX (20 mg) within 15 [...]

A partir d'une revue systématique de la littérature (5 essais), cette étude évalue l'efficacité d'interventions à base d'exercices physiques pour améliorer la qualité de vie de patients atteints d'une leucémie myéloïde

A systematic review on the use of exercise interventions for individuals with myeloid leukemia

Smith-Turchyn, Jenna ; Richardson, Julie

Purpose : The aim of this study is to explore the current literature examining the feasibility, safety, and efficacy of exercise interventions for individuals with myeloid leukemia. Methods : A literature search was conducted in Ovid MEDLINE, AMED, Embase, PsycINFO, CINAHL, CENTRAL, and Web of Science using the terms “exercise” OR “physical activity” AND “myeloid leukemia.” Two reviewers performed duplicate title/abstract and full text screening of clinical trials comparing outcomes for people [...]

Menée au Canada par enquête auprès de 60 patients atteints d'un cancer du poumon métastatique inopérable, cette étude analyse leurs motivations, leurs préférences et leurs capacités pour participer à un programme à base d'exercices physiques

Motivation and preferences of exercise programmes in patients with inoperable metastatic lung cancer: a need assessment

Kartolo, Adi ; Cheng, Susanna ; Petrella, Teresa

Objectives : The aim of this study is to investigate the motivation, ability, preferences, and perceived potential facilitating factors/barriers of patients with inoperable metastatic lung cancer towards exercise programmes. Methods : This is a cross-sectional study using survey adopting the Theory of Planned Behaviour (TPB) to obtain patients’ experience recruited through Odette Cancer Centre, Sunnybrook Health Sciences Complex. Results were expressed in percentages, P value, and Spearman’s [...]

Mené au Royaume-Uni auprès de 94 patients atteints d'un cancer de la prostate et recevant une hormonothérapie anti-androgénique, cet essai randomisé analyse l'efficacité d'une intervention à base d'activité physique et d'un régime alimentaire durant 6 mois pour réduire les effets indésirables du traitement

A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer

O’Neill, RoisinF ; Haseen, Farhana ; Murray, LiamJ ; O’Sullivan, JoeM ; Cantwell, MarieM

Purpose : Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with an increased fat mass, decreased lean mass, increased fatigue and a reduction in quality of life (QoL). The aim of this study was to evaluate the efficacy of a 6-month dietary and physical activity intervention for prostate cancer patients receiving ADT, to help minimise these side effects. Methods : Patients (n = 94) were recruited to this study if they were planned to receive ADT for prostate [...]

Mené aux Etats-Unis auprès de 58 patients et 172 témoins, cet essai analyse les effets d'une thérapie anti-androgénique sur l'évolution des déficiences cognitives de patients atteints d'un cancer de la prostate

Course and Predictors of Cognitive Function in Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Controlled Comparison

Gonzalez, Brian D. ; Jim, Heather S.L. ; Booth-Jones, Margaret ; Small, Brent J. ; Sutton, Steven K. ; Lin, Hui-Yi ; Park, Jong Y. ; Spiess, Philippe E. ; Fishman, Mayer N. ; Jacobsen, Paul B.

Purpose : Men receiving androgen-deprivation therapy (ADT) for prostate cancer may be at risk for cognitive impairment; however, evidence is mixed in the existing literature. Our study examined the impact of ADT on impaired cognitive performance and explored potential demographic and genetic predictors of impaired performance. Patients and Methods : Patients with prostate cancer were assessed before or within 21 days of starting ADT (n = 58) and 6 and 12 months later. Age- and education-matched [...]

Menée aux Pays-Bas par questionnaire auprès de 1 606 patients ayant survécu à un cancer du côlon, cette étude analyse leurs symptômes et leur qualité de vie en fonction des traitements reçus

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: Results from the population-based PROFILES registry

Verhaar, Simone ; Vissers, Pauline A. J. ; Maas, Huub ; van de Poll-Franse, Lonneke V. ; van Erning, Felice N. ; Mols, Floortje

Background : The goal of this study was to compare health related quality of life (HRQoL) and disease-specific symptoms between colon cancer patients treated with surgery only (SU) and surgery and adjuvant chemotherapy (SU + adjCT). Results were stratified for those aged <70 and ⩾70 years. HRQoL of patients was also compared with an age- and sex-matched normative population. Methods : Patients diagnosed with colon cancer between January 2000 and June 2009, as registered within the [...]

Mené pendant 5 ans auprès de 551 patientes atteintes d'un cancer du sein débutant un traitement par létrozole après le tamoxifène, cet essai randomisé analyse l'efficacité de l'acide zolédronique, administré immédiatement ou tardivement, pour la prévention de l'ostéoporose ou de fractures

5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial

Wagner-Johnston, Nina D. ; Sloan, Jeff A. ; Liu, Heshan ; Kearns, Ann E. ; Hines, Stephanie L. ; Puttabasavaiah, Suneetha ; Dakhil, Shaker R. ; Lafky, Jacqueline M. ; Perez, Edith A. ; Loprinzi, Charles L.

BACKGROUND Postmenopausal women with breast cancer receiving aromatase inhibitors are at an increased risk of bone loss. The current study was undertaken to determine whether upfront versus delayed treatment with zoledronic acid (ZA) impacted bone loss. This report described the 5-year follow-up results. METHODS A total of 551 postmenopausal women with breast cancer who completed tamoxifen treatment and were undergoing daily letrozole treatment were randomized to either upfront (274 patients) [...]

Menée aux Etats-Unis auprès de 2 086 patientes ayant survécu à un cancer du sein, cette étude analyse la prévalence et l'origine des symptômes chez des femmes recevant une hormonothérapie adjuvante

Symptoms and Symptom Attribution Among Women on Endocrine Therapy for Breast Cancer

Rosenberg, Shoshana M. ; Stanton, Annette L. ; Petrie, Keith J. ; Partridge, Ann H.

Background. Adherence to adjuvant endocrine therapy (ET) influences breast cancer survival. Because ET side effects are frequently cited as reasons for nonadherence, understanding how perceptions and motivations in relation to ET are associated with symptom attribution can help promote timely symptom management. Materials and Methods. Participants were 2,086 breast cancer survivors recruited through the Army of Women registry who were current tamoxifen or aromatase inhibitor (AI) users. [...]

Mené aux Etats-Unis auprès de 295 patientes ayant survécu à un cancer du sein non métastatique, cet essai randomisé analyse l'efficacité d'une pratique régulière et progressive d'haltérophilie pour réduire la détérioration des fonctions physiques

Weight Lifting and Physical Function Among Survivors of Breast Cancer: A Post Hoc Analysis of a Randomized Controlled Trial

Brown, Justin C. ; Schmitz, Kathryn H.

Purpose : Survivors of breast cancer may experience deterioration of physical function. This is important because poor physical function may be associated with premature mortality, injurious falls, bone fracture, and disability. We conducted a post hoc analysis to explore the potential efficacy of slowly progressive weight lifting to reduce the incidence of physical function deterioration among survivors of breast cancer. Methods : Between October 2005 and August 2008, we conducted a [...]

Menée aux Etats-Unis auprès de 596 patientes ayant survécu à un cancer du sein, cette étude évalue l'efficacité d'un outil permettant de mesurer, face à une arthralgie, la perception de leur vieillissement

Development and validation of the Penn Arthralgia Aging Scale among breast cancer survivors

Brier, Moriah J. ; Chambless, Dianne L. ; Lee, Laura ; Mao, Jun J.

BACKGROUND Breast cancer survivors on aromatase inhibitors often experience joint pain as a side effect of their treatment; qualitative investigations suggest that this arthralgia may cause women to feel that they are aging faster than they should be. To facilitate further study of this experience, the Penn Arthralgia Aging Scale (PAAS) was developed. This report describes the development and validation of the PAAS in a racially diverse sample of breast cancer survivors suffering from joint [...]

A partir des données des registres américains des cancers incluant 7 159 participants, cette étude en population analyse le risque d'un second cancer chez des patients atteints de tumeurs stromales gastro-intestinales

Increased risk of additional cancers among patients with gastrointestinal stromal tumors: A population-based study

Murphy, James D. ; Ma, Grace L. ; Baumgartner, Joel M. ; Madlensky, Lisa ; Burgoyne, Adam M. ; Tang, Chih-Min ; Martínez, María Elena ; Sicklick, Jason K.

BACKGROUND Most gastrointestinal stromal tumors (GISTs) are considered nonhereditary or sporadic. However, single-institution studies suggest that GIST patients develop additional malignancies at increased frequencies. It was hypothesized that greater insight could be gained into possible associations between GISTs and other malignancies with a national cancer database inquiry. METHODS Patients diagnosed with GISTs (2001-2011) in the Surveillance, Epidemiology, and End Results database were [...]

A patir des données de registres norvégiens portant sur des patients nés entre 1965 et 1985 et ayant survécu à un cancer diagnostiqué avant l'âge de 19 ans, cette étude de cohorte analyse les effets à long terme des traitements anticancéreux sur leurs capacités d'apprentissage, leur niveau d'éducation et de diplômes

Educational attainment among long-term survivors of cancer in childhood and adolescence: a Norwegian population-based cohort study

Ghaderi, Sara ; Engeland, Anders ; Gunnes, MariaWinther ; Moster, Dag ; Ruud, Ellen ; Syse, Astri ; Wesenberg, Finn ; Bjørge, Tone

Purpose : The number of young cancer survivors has increased over the past few decades due to improvement in treatment regimens, and understanding of long-term effects among the survivors has become even more important. Educational achievements and choice of educational fields were explored here. Methods : Five-year cancer survivors born in Norway during 1965–1985 (diagnosed <19 years) were included in our analysis by linking Norwegian population-based registries. Cox regression was applied to [...]

Menée en France par entretiens en 2011-2012 auprès de 80 patients ayant survécu à un cancer pédiatrique, cette étude longitudinale analyse les effets de la maladie et des traitements sur leurs parcours éducatifs, scolaires et professionnels

Educational trajectories after childhood cancer: When illness experience matters

Dumas, A. ; Cailbault, I. ; Perrey, C. ; Oberlin, O. ; de Vathaire, F. ; Amiel, P.

With the increase in survival from childhood cancer, research has increasingly focused on the educational and professional achievements of childhood cancer survivors. Yet, if large-scale studies provide an acute description of the current situation of childhood cancer survivors, little is known about their trajectories and the social processes shaping these trajectories. Using a qualitative methodology, drawing from a life course perspective, this study sought to describe the role of childhood [...]

Menée en Allemagne auprès de 590 patientes ayant survécu à un lymphome hodgkinien diagnostiqué avant l'âge de 18 ans, cette étude de cohorte prospective analyse les effets des différents traitements sur leurs capacités à avoir des enfants

Parenthood in adult female survivors treated for Hodgkin's lymphoma during childhood and adolescence: a prospective, longitudinal study

Brämswig, Jürgen H. ; Riepenhausen, Marianne ; Schellong, Günther

Little is known about parenthood in women who were treated for Hodgkin's lymphoma during childhood and adolescence. We aimed to assess the frequency of parenthood in female survivors of Hodgkin's lymphoma younger than 18 years at diagnosis, and to compare it with that in a female population control group. Methods : In this prospective, longitudinal study, our cohort consisted of 590 female patients younger than 18 years at diagnosis who participated in one of five Hodgkin's lymphoma treatment [...]

Menée aux Etats-Unis auprès de 2 510 patients atteints d'un cancer de la prostate traité entre 1997 et 2013, cette étude évalue l'association entre une hormonothérapie anti-androgénique et le risque de décès, chez les hommes à risque intermédiaire de récidive qualifié de favorable (1 902 cas) ou défavorable (608 cas)

Androgen deprivation therapy and the risk of death from prostate cancer among men with favorable or unfavorable intermediate-risk disease

Keane, Florence K. ; Chen, Ming-Hui ; Zhang, Danjie ; Moran, Brian J. ; Braccioforte, Michelle H. ; D'Amico, Anthony V.

BACKGROUND Radiotherapy (RT), short-course androgen deprivation therapy (ADT), and brachytherapy in various combinations are treatment options for patients with intermediate-risk prostate cancer (PC), but the question of which combination if any is necessary to minimize PC-specific mortality (PCSM) risk in patients with favorable or unfavorable intermediate-risk PC is unknown. The authors assessed PCSM risk after commonly used treatments. METHODS The cohort consisted of 2510 men with favorable [...]

A partir des données de deux registres français des cancers portant sur 3 622 patients atteints d'un cancer du côlon diagnostiqué entre 1985 et 2000 et ayant subi une résection curative du côlon, cette étude analyse les facteurs associés au risque de récidive à long terme (10 ans)

Incidence and patterns of late recurrences in colon cancer patients

Bouvier, Anne-Marie ; Launoy, Guy ; Bouvier, Veronique ; Rollot, Fabien ; Manfredi, Sylvain ; Faivre, Jean ; Cottet, Vanessa ; Jooste, Valérie

Long-term recurrences of colon cancer raised questions about the possible benefit of prolonging the recommended active 5-year surveillance. The aim of this study was to determine, for the first time, the incidence and patterns of late 10-year recurrence following curative resection of colon cancer. Data were obtained from two French digestive cancer registries. A total of 3,622 patients under 85 years resected for cure for colon cancer diagnosed between 1985 and 2000 were included. Information [...]

Menée aux Etats-Unis à partir de données portant sur 12 268 participantes, cette étude évalue les disparités ethniques dans la survie des patientes atteintes d'un cancer du sein, en fonction de facteurs socio-démographiques et médicaux (caractéristiques de la tumeur, traitements reçus)

Racial and Ethnic Differences in Breast Cancer Survival: Mediating Effect of Tumor Characteristics and Sociodemographic and Treatment Factors

Warner, Erica T. ; Tamimi, Rulla M. ; Hughes, Melissa E. ; Ottesen, Rebecca A. ; Wong, Yu-Ning ; Edge, Stephen B. ; Theriault, Richard L. ; Blayney, Douglas W. ; Niland, Joyce C. ; Winer, Eric P. ; Weeks, Jane C. ; Partridge, Ann H.

Purpose : To evaluate the relationship between race/ethnicity and breast cancer–specific survival according to subtype and explore mediating factors. Patients and Methods : Participants were women presenting with stage I to III breast cancer between January 2000 and December 2007 at National Comprehensive Cancer Network centers with survival follow-up through December 2009. Cox proportional hazards regression was used to compare breast cancer–specific survival among Asians (n = 533), Hispanics [...]

Menée aux Etats-Unis à partir de données portant sur 725 patients noirs et 5 247 patients blancs atteints d'un cancer du sein de stade précoce diagnostiqué entre 2004 et 2011, cette étude analyse les disparités ethniques dans l'accès aux traitements et dans la survie

Black/White Disparities in Receipt of Treatment and Survival Among Men With Early-Stage Breast Cancer

Sineshaw, Helmneh M. ; Freedman, Rachel A. ; Ward, Elizabeth M. ; Flanders, W. Dana ; Jemal, Ahmedin

Purpose : To examine the extent of black/white disparities in receipt of treatment and survival for early-stage breast cancer in men age 18 to 64 and ≥ 65 years. Patients and Methods : We identified 725 non-Hispanic black (black) and 5,247 non-Hispanic white (white) men diagnosed with early-stage breast cancer from 2004 to 2011 in the National Cancer Data Base. We used multivariable logistic regression and calculated standardized risk ratios to predict receipt of treatment and a proportional [...]

A partir des données de 3 études cas-témoins en population américaine incluant 4 608 patientes atteintes d'un cancer du sein, cette étude évalue l'association entre la pratique d'une activité physique de loisir avant le diagnostic et la survie des patientes, en fonction de leur appartenance ethnique

History of Recreational Physical Activity and Survival After Breast Cancer: The California Breast Cancer Survivorship Consortium

Lu, Yani ; John, Esther M. ; Sullivan-Halley, Jane ; Vigen, Cheryl ; Gomez, Scarlett Lin ; Kwan, Marilyn L. ; Caan, Bette J. ; Lee, Valerie S. ; Roh, Janise M. ; Shariff-Marco, Salma ; Keegan, Theresa H. M. ; Kurian, Allison W. ; Monroe, Kristine R. ; Cheng, Iona ; Sposto, Richard ; Wu, Anna H. ; Bernstein, Leslie

Recent epidemiologic evidence suggests that prediagnosis physical activity is associated with survival in women diagnosed with breast cancer. However, few data exist for racial/ethnic groups other than non-Latina whites. To examine the association between prediagnosis recreational physical activity and mortality by race/ethnicity, we pooled data from the California Breast Cancer Survivorship Consortium for 3 population-based case-control studies of breast cancer patients (n = 4,608) diagnosed [...]

Menée en Allemagne par questionnaire auprès de 188 dyades patients-soignants (patients atteints d'un cancer urologique, gastro-intestinal ou pulmonaire), cette étude analyse l'efficacité d'un outil permettant d'évaluer leurs besoins en soins de support pour soulager leurs symptômes de dépression et d'anxiété

Psychometric evaluation of the German Version of the Supportive Care Needs Survey for Partners and Caregivers (SCNS-P&C-G) of cancer patients

Sklenarova, H. ; Haun, M. W. ; Krümpelmann, A. ; Friederich, H. C. ; Huber, J. ; Thomas, M. ; Winkler, E. C. ; Girgis, A. ; Dinkel, A. ; Herzog, W. ; Hartmann, M.

This study aimed for psychometric validation of the German version of the Supportive Care Needs Survey for Partners and Caregivers (SCNS-P&C-G). In- and outpatients with lung, urological and gastrointestinal cancer at Heidelberg University Hospital in Germany and in each case one relevant caregiver were asked to complete a set of questionnaires assessing their unmet needs together with distress, depression, anxiety and caregiver strain. In addition, medical data of the patients were collected. [...]

Menée au Royaume-Uni par enquête auprès de 6 965 participants âgés de plus de 50 ans, cette étude met en évidence une association entre le tabagisme et des comportements d'évitement par rapport aux tests de diagnostic précoce d'un cancer

Smoking is associated with pessimistic and avoidant beliefs about cancer: results from the International Cancer Benchmarking Partnership

Quaife, S. L. ; McEwen, A. ; Janes, S. M. ; Wardle, J.

Background: Smoking cessation is the key cancer prevention behaviour for smokers; nonetheless, smokers can still benefit from earlier diagnosis of cancer. However, fewer smokers participate in screening despite their increased risk, which may reflect different beliefs about cancer. Methods: A UK population-representative sample of greater than or equal to 50 year-olds (n=6 965) was surveyed using the Awareness and Beliefs about Cancer measure. These analyses examine six items on cancer beliefs [...]

Menée au Canada auprès de 80 patients atteints d'un cancer de stade avancé, cette étude analyse l'efficacité d'une intervention pluridisciplinaire destinée à atténuer les symptômes de la dépression et améliorer la survie

An interdisciplinary palliative rehabilitation intervention bolstering general self-efficacy to attenuate symptoms of depression in patients living with advanced cancer

Feldstain, A. ; Lebel, S. ; Chasen, M. R.

Purpose : Patients with advanced cancer, post-anticancer treatment, are living longer than 10–20 years ago. This emerging population of survivors has unique palliative and rehabilitation needs. A particular concern is depression, which can impair functioning, quality of life, and survival. The interdisciplinary Palliative Rehabilitation Program offers holistic palliative rehabilitation for this population using a self-efficacy framework. The current study examined the unique impact of three [...]

Menée en Australie par enquête auprès de 151 patients atteints d'un cancer du poumon, cette étude transversale analyse leur détresse psychologique et leur qualité de vie en prenant en compte les effets des contraintes sociales et des marques apparentes de la maladie

Psychological distress and quality of life in lung cancer: the role of health-related stigma, illness appraisals and social constraints

Chambers, Suzanne K. ; Baade, Peter ; Youl, Philippa ; Aitken, Joanne ; Occhipinti, Stefano ; Vinod, Shalini ; Valery, Patricia C. ; Garvey, Gail ; Fong, Kwun M. ; Ball, David ; Zorbas, Helen ; Dunn, Jeff ; O'Connell, Dianne L.

Objective : Health-related stigma is associated with negative psychological and quality of life outcomes in lung cancer patients. This study describes the impact of stigma on lung cancer patients' psychological distress and quality of life and explores the role of social constraints and illness appraisal as mediators of effect. Methods : A self-administered cross-sectional survey examined psychological distress and quality of life in 151 people (59% response rate) diagnosed with lung cancer [...]

Menée au Royaume-Uni par questionnaire auprès de 311 participants atteints d'un cancer colorectal, cette étude analyse leur santé psychique suite à un diagnostic de cancer après le résultat négatif d'un test de recherche de sang occulte dans les selles, ainsi que leur qualité de vie et leur confiance dans le dépistage

The psychological impact of a colorectal cancer diagnosis following a negative fecal occult blood test result

Miles, Anne ; McClements, Paula L. ; Steele, Robert J.C. ; Redeker, Claudia ; Sevdalis, Nick ; Wardle, Jane

Background: Screening using fecal occult blood testing (FOBt) reduces colorectal cancer (CRC) mortality, but the test has low sensitivity. A 'missed' cancer may cause psychological harms in the screened population that partially counteract the benefits of early detection. Methods: 311 people diagnosed with CRC: i) after a negative FOBt result (interval cancer), ii) a positive result (screen-detected cancer), or iii) in regions where screening was not offered, completed questions on quality of [...]

Menée en Allemagne par entretiens auprès de 254 patientes atteintes d'un cancer du sein et suivies pendant 10 ans, cette étude observationnelle évalue l'association entre certains types de comportements pour faire face à la maladie et le risque de récidive à long terme

Coping with breast cancer and relapse: Stability of coping and long-term outcomes in an observational study over 10 years

Geyer, Siegfried ; Koch-Giesselmann, Heike ; Noeres, Dorothee

Many studies dealing with relationships between coping and breast cancer were based on a single measurement of coping behaviour. Assessments were taking place soon after surgery of primary breast cancer, and effects on long-term outcomes were considered. In our study it was examined whether coping behaviours are stable over time and whether they were associated with breast cancer recurrence. The analyses were based on a long-term study with initially 254 patients with three interviews and an [...]

Cette étude analyse le rapport coût-efficacité de tests à base de panels de gènes, réalisés par des technologies de séquençage à haut débit (NGS), pour le diagnostic des syndromes de polypose et du cancer colorectal

Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis Syndromes: A Cost-Effectiveness Analysis

Gallego, Carlos J. ; Shirts, Brian H. ; Bennette, Caroline S. ; Guzauskas, Greg ; Amendola, Laura M. ; Horike-Pyne, Martha ; Hisama, Fuki M. ; Pritchard, Colin C. ; Grady, William M. ; Burke, Wylie ; Jarvik, Gail P. ; Veenstra, David L.

Purpose : To evaluate the cost effectiveness of next-generation sequencing (NGS) panels for the diagnosis of colorectal cancer and polyposis (CRCP) syndromes in patients referred to cancer genetics clinics. Patients and Methods : We developed a decision model to evaluate NGS panel testing compared with current standard of care in patients referred to a cancer genetics clinic. We obtained data on the prevalence of genetic variants from a large academic laboratory and calculated the costs and [...]

A partir de données issues de 9 pays (Europe et Etats-Unis), cette étude analyse le coût des traitements chez des patients atteints d'un sarcome métastatique des tissus mous et répondant favorablement à la chimiothérapie

Cost of treatment in patients with metastatic soft tissue sarcoma who respond favourably to chemotherapy. The SArcoma treatment and Burden of Illness in North America and Europe (SABINE) study

Jönsson, L. ; Justo, N. ; Musayev, A. ; Krishna, A. ; Burke, T. ; Pellissier, J. ; Judson, I. ; Staddon, A. ; Blay, J. Y.

Treatment of metastatic soft tissue sarcoma (mSTS) commonly includes multiple lines of chemotherapy, until a decline in performance status precludes further treatment. The primary objective of this study was to describe the lifetime healthcare resource utilisation and cost among mSTS patients with favourable response to chemotherapy. SABINE was a multi-centre (n = 25), multi-country (n = 9) retrospective chart review study of mSTS patients with favourable response to chemotherapy following 4 [...]

Menée aux Etats-Unis auprès de 432 patients atteints d'un cancer de stade avancé, cette étude prospective analyse la fréquence d'utilisation des opioïdes et la prise en charge des effets secondaires par des spécialistes en médecine palliative

Frequency, Predictors, and Medical Record Documentation of Chemical Coping Among Advanced Cancer Patients

Kwon, Jung Hye ; Tanco, Kimberson ; Park, Ji Chan ; Wong, Angelique ; Seo, Lisa ; Liu, Diane ; Chisholm, Gary ; Williams, Janet ; Hui, David ; Bruera, Eduardo

Background : In this prospective study, we determined the frequency of opioid-related chemical coping among advanced cancer patients, as diagnosed by palliative medicine specialists. We also determined predictors for chemical coping and the concordance between the physician’s diagnosis and documentation in the medical records. Patients and Methods : Palliative medicine specialists evaluated and diagnosed consecutive patients seen for chemical coping. The proportion of patients identified as [...]

Menée aux Etats-Unis à partir de données portant sur 330 patients atteints d'une leucémie myéloïde aiguë et âgés de plus de 60 ans, cette étude analyse l'utilisation des soins et des ressources de santé en fin de vie (soins palliatifs, hospitalisations)

Health care utilization and end-of-life care for older patients with acute myeloid leukemia

El-Jawahri, Areej R. ; Abel, Gregory A. ; Steensma, David P. ; LeBlanc, Thomas W. ; Fathi, Amir T. ; Graubert, Timothy A. ; DeAngelo, Daniel J. ; Wadleigh, Martha ; Ballen, Karen K. ; Foster, Julia E. ; Attar, Eyal C. ; Amrein, Philip C. ; Brunner, Andrew M. ; Stone, Richard M. ; Temel, Jennifer S.

BACKGROUND Health care utilization in older adults (age ≥60 years) with acute myeloid leukemia (AML) has not been well studied. METHODS We conducted a retrospective analysis of 330 consecutive older patients who were diagnosed with AML between May 1, 2005 and December 23, 2011, at 2 hospitals in Boston to examine their health care utilization and end-of-life care. Using multivariable logistic and linear regression models adjusting for covariates, we also compared health care utilization between [...]