Menée en Australie, cette étude rétrospective analyse les pratiques de prise en charge de la fièvre et de la neutropénie chez les patients pédiatriques atteints de cancer et traités en milieu hospitalier

Management of fever and neutropenia in children with cancer

Vedi, A. ; Pennington, V. ; O’Meara, M. ; Stark, K. ; Senner, A. ; Hunstead, P. ; Adnum, K. ; Londall, W. ; Maurice, L. ; Wakefield, Claire ; Cohn, R. J.

Purpose : Febrile neutropenia remains a common, life-threatening complication of chemotherapy in paediatric oncology. Delays in institution of empiric antibiotics have been identified at tertiary and regional centres caring for these patients and associated with decreased survival. Our objective was to reduce the time to administration of empiric antibiotics to less than 60 min from the time of presentation to hospital. Methods : A retrospective study of the records of oncology patients [...]

Menée à Taïwan auprès de 109 patients atteints de cancer, cette étude analyse leurs croyances relatives à l'efficacité de médicaments opioïdes pour soulager leur douleur liée au cancer et améliorer leur qualité de vie

Opioid-taking self-efficacy affects the quality of life of Taiwanese patients with cancer pain

Liang, Shu-Yuan ; Ding, She-Anne ; Wu, Wei-Wen ; Liu, Chieh-Yu ; Lin, Chia-Chin

Goals : Quality of life is an important indicator for evaluating the outcome of treatment for patients with cancer pain. Perceived self-efficacy has been reported to play an important role in controlling quality of life (QOL). Limited studies have focused on opioid-taking self-efficacy effects on the patients’ QOL, which is caused by cancer pain. The purpose of this study was to evaluate how much of the variance in QOL among Taiwanese cancer patients with pain could be accounted for by [...]

Menée au Royaume-Uni à partir de données de deux enquêtes (l'une auprès de 68 patients, l'autre auprès de 148 patients), cette étude analyse les symptômes de fatigue liée au cancer chez des patients recevant une radiothérapie et/ou une thérapie systémique anticancéreuse

Cancer-related fatigue: results from patient experience surveys undertaken in a UK regional cancer centre

James, Sarah ; Wright, Pamela ; Scarlett, Clare ; Young, Teresa ; Jamal, Humaira ; Verma, Ranjena

Purpose : Cancer-related fatigue (CRF) is a common but under reported symptom significantly impacting on cancer patients’ quality of life. The purpose of these surveys was to drive improvements in the provision of support of patients with CRF. Method : Two surveys were conducted to determine the incidence and impact of cancer-related fatigue (CRF) amongst patients attending a Cancer Centre (CC) for radiotherapy and/or systemic anti-cancer therapy. Results : Survey 1: retrospective examination [...]

Menée au Canada par questionnaire auprès de 881 patients atteints de cancer avec métastases osseuses, cette étude rétrospective analyse l'évolution de leur fatigue et de leur qualité de vie à la suite d'une radiothérapie palliative

Fatigue scores in patients receiving palliative radiotherapy for painful bone metastases

Cheon, PaulM ; Pulenzas, Natalie ; Zhang, Liying ; Mauti, Emma ; Wong, Erin ; Thavarajah, Nemica ; Tsao, May ; Danjoux, Cyril ; Holden, Lori ; DeAngelis, Carlo ; Chow, Edward

Introduction : The purpose of this study was to examine changes in fatigue scores for patients receiving radiation therapy for bone metastases and its impact on quality of life (QOL). Methods : Fatigue and QOL scores were prospectively collected in patients for up to 3 months following radiation therapy for bone metastases using three questionnaires: group 1, Edmonton Symptom Assessment System (ESAS) (0–10); group 2, European Organization for Research and Treatment of Cancer Quality of Life [...]

Menée aux Etats-Unis, cette étude analyse la satisfaction et la qualité de vie de patients atteints d'un cancer de la prostate et suivis dans un hôpital spécialisé dans la prise en charge et les soins dédiés aux survivants d'un cancer

Quality of life and satisfaction among prostate cancer patients followed in a dedicated survivorship clinic

Gilbert, Scott M. ; Dunn, Rodney L. ; Wittmann, Daniela ; Montgomery, Jeffrey S. ; Hollingsworth, John M. ; Miller, David C. ; Hollenbeck, Brent K. ; Wei, John T. ; Montie, James E.

BACKGROUND : Integrating quality-of-life (QOL) outcomes into clinics may assist providers in identifying and responding to problems experienced by cancer survivors. To date, however, patient-reported outcomes (PROs) such as QOL are used infrequently to guide care. We integrated QOL assessments into a prostate cancer survivorship clinic and compared recovery and satisfaction among men managed in the survivorship clinic with those followed with more routine care. METHODS : We conducted a [...]

Menée en Angleterre par questionnaire auprès de patients atteints d'un cancer colorectal diagnostiqué en 2010 et 2011, cette étude analyse les facteurs associés à leur qualité de vie, 12 à 36 mois après le diagnostic

Health-Related Quality of Life After Colorectal Cancer in England: A Patient-Reported Outcomes Study of Individuals 12 to 36 Months After Diagnosis

Downing, Amy ; Morris, Eva J.A. ; Richards, Mike ; Corner, Jessica ; Wright, Penny ; Sebag-Montefiore, David ; Finan, Paul ; Kind, Paul ; Wood, Charlotte ; Lawton, Sarah ; Feltbower, Richard ; Wagland, Richard ; Vernon, Sally ; Thomas, James ; Glaser, Adam W.

Purpose : This population-level study was conducted to define the health-related quality of life (HRQL) of individuals living with and beyond colorectal cancer (CRC) and to identify factors associated with poor health outcomes. Patients and Methods : All individuals diagnosed with CRC in England in 2010 and 2011 who were alive 12 to 36 months after diagnosis were sent a questionnaire. This included questions related to treatment, disease status, other long-term conditions (LTCs), generic HRQL [...]

A partir des données des registres américains des cancers et de la base Medicare, cette étude analyse le taux de ré-admissions hospitalières et les coûts associés après un traitement chirurgical pour des patients atteints d'un cancer de la vessie, du poumon, du pancréas ou de l'œsophage diagnostiqué entre 2001 et 2007

Exploring the Burden of Inpatient Readmissions After Major Cancer Surgery

Stitzenberg, Karyn B. ; Chang, YunKyung ; Smith, Angela B. ; Nielsen, Matthew E.

Purpose : Travel distances to care have increased substantially with centralization of complex cancer procedures at high-volume centers. We hypothesize that longer travel distances are associated with higher rates of postoperative readmission and poorer outcomes. Methods : SEER-Medicare patients with bladder, lung, pancreas, or esophagus cancer who were diagnosed in 2001 to 2007 and underwent extirpative surgery were included. Readmission rates and survival were calculated using Kaplan-Meier [...]

A partir des données des registres américains des cancers, cette étude présente les estimations de l"'American Cancer Society" en matière d'incidence des cancers et de mortalité spécifique pour l'année 2015

Cancer statistics, 2015

Siegel, Rebecca L. ; Miller, Kimberly D. ; Jemal, Ahmedin

Each year the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer [...]

A partir des données des registres américains des cancers et de la cohorte "Childhood Cancer Survivor Study", cette étude analyse les facteurs associés à la survie chez des survivants à long terme d'un cancer pédiatrique

Conditional survival in pediatric malignancies: Analysis of data from the Childhood Cancer Survivor Study and the Surveillance, Epidemiology, and End Results Program

Mertens, Ann C. ; Yong, Jian ; Dietz, Andrew C. ; Kreiter, Erin ; Yasui, Yutaka ; Bleyer, Archie ; Armstrong, Gregory T. ; Robison, Leslie L. ; Wasilewski-Masker, Karen

BACKGROUND Long-term survivors of pediatric cancer are at risk of life-threatening late effects of their cancer. Previous studies have shown excesses in long-term mortality within high-risk groups defined by demographic and treatment characteristics. METHODS To investigate conditional survival in a pediatric cancer population, the authors performed an analysis of conditional survival in the original Childhood Cancer Survivor Study (CCSS) cohort and the Surveillance, Epidemiology, and End [...]

Menée à partir des données de la cohorte "Childhood Cancer Survivor Study", cette étude analyse l'évolution du statut de santé chez des survivants d'un cancer de l'enfance en fonction de leur âge

Age-Dependent Changes in Health Status in the Childhood Cancer Survivor Cohort

Hudson, Melissa M. ; Oeffinger, Kevin C. ; Jones, Kendra ; Brinkman, Tara M. ; Krull, Kevin R. ; Mulrooney, Daniel A. ; Mertens, Ann ; Castellino, Sharon M. ; Casillas, Jacqueline ; Gurney, James G. ; Nathan, Paul C. ; Leisenring, Wendy ; Robison, Leslie L. ; Ness, Kirsten K.

Purpose : To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort. Methods : Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys assessing health status. At each of three time points, participants were classified as having poor outcomes in general health, mental health, function, or daily activities if they indicated moderate to extreme impairment. Generalized linear [...]

A partir des données des registres suédois des cancers incluant 113 555 enfants ayant un parent atteint de cancer, cette étude analyse l'association entre un diagnostic de cancer chez un parent et le risque de mortalité chez leur enfant (durée de suivi : 561 198 personnes-années)

Parental cancer diagnosis and child mortality—A population-based cohort study in Sweden

Chen, Ruoqing ; Sjölander, Arvid ; Valdimarsdóttir, Unnur ; Varnum, Catherine ; Almqvist, Catarina ; Ye, Weimin ; Fall, Katja ; Czene, Kamila ; Fang, Fang

Objective Cancer diagnosis is known to induce severe psychological stress for the diagnosed patients; however, how it affects the next-of-kin is less well documented. This study aimed to assess the impact of parental cancer on the risk of childhood death. Methods A population-based cohort study was conducted using the Swedish national registries, including 2,871,242 children followed during the period of 1991–2009. Parental cancer diagnosis was defined as a time-varying exposure. We used Cox [...]

A partir des données des registres américains des cancers portant sur des patients atteints d'un cancer diagnostiqué entre 1992 et 2010, cette étude analyse les disparités ethniques dans l'incidence du lymphome diffus à grandes cellules B, du lymphome folliculaire, de la leucémie lymphocytaire chronique et du lymphome à petits lymphocytes, ainsi que dans la survie

Racial differences in three major NHL subtypes: Descriptive epidemiology

Li, Yang ; Wang, Yu ; Wang, Zhuoyue ; Yi, Danhui ; Ma, Shuangge

Background : NHL (non-Hodgkin lymphoma) consists of over 60 subtypes, ranging from slow-growing to very aggressive. The three largest subtypes are DLBCL (diffuse large B-cell lymphoma), FL (follicular lymphoma), and CLL/SLL (chronic lymphocytic leukemia/small lymphocytic lymphoma). For each subtype, different racial groups have different presentations, etiologies, and prognosis patterns. Methods : SEER (Surveillance, Epidemiology, and End Results) data on DLBCL, FL, and CLL/SLL patients [...]

Menée à partir des données des registres américains des cancers portant sur 3 587 participants fumeurs ou anciennement fumeurs et âgés de plus de 50 ans, cette étude évalue le risque de carcinome épidermoïde de la tête et du cou chez des individus à haut risque de cancer du poumon

Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study

Dixit, Ronak ; Weissfeld, Joel L. ; Wilson, David O. ; Balogh, Paula ; Sufka, Pamela ; Siegfried, Jill M. ; Grandis, Jennifer R. ; Diergaarde, Brenda

BACKGROUND Earlier detection and diagnosis of head and neck squamous cell carcinoma (HNSCC) should lead to improved outcomes. However, to the authors' knowledge, no effective screening strategy has been identified to date. In the current study, the authors evaluated whether it would be useful to screen subjects targeted for lung cancer screening for HNSCC as well. METHODS Medical records, death certificates, and cancer registry and questionnaire data were used to determine the number of [...]

Menée en Suède auprès de 4 623 patients atteints d'un cancer de la prostate diagnostiqué entre 1997 et 2002, cette étude de cohorte évalue l'association entre une activité physique après le diagnostic et la mortalité, totale et spécifique

Physical Activity and Survival among Men Diagnosed with Prostate Cancer

Bonn, Stephanie E. ; Sjölander, Arvid ; Lagerros, Ylva Trolle ; Wiklund, Fredrik ; Stattin, Pär ; Holmberg, Erik ; Gronberg, Henrik ; Bälter, Katarina

Background: Few studies have investigated the association between post-diagnosis physical activity and mortality among men diagnosed with prostate cancer. The aim of this study was to investigate the effect of physical activity after a prostate cancer diagnosis on both overall and prostate cancer–specific mortality in a large cohort. Methods: Data from 4,623 men diagnosed with localized prostate cancer 1997–2002 and followed-up until 2012 were analyzed. HRs with 95% confidence intervals (CI) [...]

Menée aux Pays-Bas auprès de 11 695 patientes atteintes d'un cancer du sein avant 75 ans, cette étude rétrospective analyse la survie globale après une ré-excision suivant une chirurgie conservatrice du sein

Overall survival in patients with a re-excision following breast conserving surgery compared to those without in a large population-based cohort

Vos, Elvira L. ; Jager, Agnes ; Verhoef, Cornelis ; Voogd, Adri C. ; Koppert, Linetta B.

Aim : To investigate the overall survival of invasive breast cancer patients with primary breast conserving surgery (BCS) followed by re-excision compared to those with primary BCS only. The Dutch re-excision indications are less stringent compared to other European and Northern American countries (Society of Surgical Oncology-American Society for Radiation Oncology (SSO/ASTRO) guideline). Methods : Retrospective analyses in women <75 years with breast cancer stage pT1–T3 treated by BCS and [...]

Menée aux Etats-Unis à partir de données portant sur 106 771 patientes, cette étude compare les caractéristiques associées à la patiente, à la tumeur, aux traitements et à la survie chez des patientes adolescentes ou jeunes adultes (âgées de 15 à 39 ans) atteintes d'un cancer du sein, qu'il soit primitif ou secondaire

Comparison of primary and secondary breast cancers in adolescents and young adults

Sadler, Claire ; Goldfarb, Melanie

BACKGROUND : Breast cancer is one of the most common cancers in adolescent and young adult (AYA) patients (ages 15-39) and may develop de novo or in patients previously treated for cancer. This study compares the demographic, tumor, treatment characteristics, and overall survival (OS) of primary versus secondary (SMN) breast cancer in female AYAs. METHODS : All cases of invasive female AYA breast cancer in the 1998-2010 American College of Surgeons National Cancer Database were divided into 2 [...]

A partir des données du registre néerlandais des cancers portant sur 14 310 patientes atteintes d'un cancer du sein métastatique diagnostiqué entre 1990 et 2012, cette étude analyse l'association entre des changements de stratégies thérapeutiques et la survie, totale et relative, en fonction de l'âge de la patiente (<65 ans, 65–75 ans et >75 ans)

Survival of older patients with metastasised breast cancer lags behind despite evolving treatment strategies – A population-based study

de Glas, N. A. ; Bastiaannet, E. ; de Craen, A. J. M. ; van de Velde, C. J. H. ; Siesling, S. ; Liefers, G. J. ; Portielje, J. E. A.

Background : Older women are more likely to be diagnosed with primary metastasised breast cancer than their younger counterparts. Evolving treatment strategies of metastasised breast cancer have resulted in improved survival in younger patients, but it remains unclear if this improvement has occurred in older patients as well. The aim of this study was to assess changes in treatment strategies over time in relation to overall and relative survival of older patients compared to younger patients [...]

A partir des données des registres américains des cancers portant sur 3 513 participants, cette étude de cohorte analyse l'incidence, les facteurs associés au risque d'une pneumopathie d'inhalation ainsi que la mortalité chez des patients atteints d'un cancer de la tête et du cou et recevant une chimioradiothérapie

Aspiration pneumonia after concurrent chemoradiotherapy for head and neck cancer

Xu, Beibei ; Boero, Isabel J. ; Hwang, Lindsay ; Le, Quynh-Thu ; Moiseenko, Vitali ; Sanghvi, Parag R. ; Cohen, Ezra E. W. ; Mell, Loren K. ; Murphy, James D.

BACKGROUND Aspiration pneumonia represents an under-reported complication of chemoradiotherapy in patient with head and neck cancer. The objective of the current study was to evaluate the incidence, risk factors, and mortality of aspiration pneumonia in a large cohort of patients with head and neck cancer who received concurrent chemoradiotherapy. METHODS Patients who had head and neck cancer diagnosed between 2000 and 2009 were identified from the Surveillance, Epidemiology, and End [...]

A partir d'une revue systématique de la littérature (20 études), cette étude fait le point sur les facteurs associés à la volonté d'avoir un enfant après un cancer

Motivations for having children after cancer – a systematic review of the literature

Schmidt, R. ; Richter, D. ; Sender, A. ; Geue, K.

Over the last decade, fertility-related issues have come to the fore of clinical oncology. The majority of research though has focused on a medical perspective without considering reproductive motivations that influence decisions on fertility-preserving options. In order to identify specific parenthood motivations in young survivors of various types of cancer, a systematic review of the literature was conducted. Relevant literature was searched manually and using databases (Medline/PubMed, [...]

Menée aux Etats-Unis auprès de parents de 127 survivants à long terme d'une leucémie lymphoblastique pédiatrique aiguë, cette étude analyse les facteurs associés à leurs symptômes de détresse émotionnelle

Emotional distress in parents of long-term survivors of childhood acute lymphoblastic leukemia

Malpert, Adele V. ; Kimberg, Cara ; Luxton, Joshua ; Mullins, Larry L. ; Pui, Ching-Hon ; Hudson, Melissa M. ; Krull, Kevin R. ; Brinkman, Tara M.

Objective : The current study investigated the occurrence of emotional distress in parents of long-term survivors of childhood acute lymphoblastic leukemia (ALL) and identified factors associated with parent emotional distress symptoms. Methods : Parents of 127 long-term survivors of childhood ALL treated on a chemotherapy-only protocol at St. Jude Children's Research Hospital participated in the study. Parents completed standard ratings of emotional distress, caregiver strain, and child [...]

Menée en Suède auprès de 1 615 patients atteints d'un cancer de l'œsophage et ayant reçu un traitement chirurgical, cette étude de cohorte analyse l'incidence de morbidités psychiatriques et leur impact sur la survie

Psychiatric Morbidity and Survival After Surgery for Esophageal Cancer: A Population-Based Cohort Study

Wikman, Anna ; Ljung, Rickard ; Johar, Asif ; Hellstadius, Ylva ; Lagergren, Jesper ; Lagergren, Pernilla

Purpose : To determine the cumulative incidence of and risk factors for psychiatric morbidity and establish the impact on survival among surgically treated patients with esophageal cancer. Patients and Methods : A nationwide Swedish cohort of 1,615 patients who underwent surgery for esophageal cancer between 1987 and 2010 with follow-up until 2012 was linked to national health registries for information on psychiatric morbidity (inferred from mental health care use). Multivariable logistic [...]

Menée aux Pays-Bas auprès de 3 410 cas et 6 645 témoins, cette étude analyse les taux de consultations chez le médecin généraliste associées à un cancer ou à une maladie chronique

The combined effect of cancer and chronic diseases on general practitioner consultation rates

Heins, M. J. ; Korevaar, J. C. ; Donker, G. A. ; Rijken, P. M. ; Schellevis, F. G.

Aim : More than two-thirds of cancer patients have one or more chronic diseases besides cancer. The purpose of this study was to get detailed insight into the combined effect of cancer and chronic diseases on general practitioner (GP) consultation rates. Methods : From the NIVEL Primary Care Database we identified cancer patients with diabetes mellitus (n = 629), osteoarthritis (n = 425), coronary artery disease (n = 466), COPD (n = 383) or without a chronic disease (n = 1507), diagnosed with [...]

A partir des données de 380 dossiers médicaux de patients atteints d'un cancer pédiatrique et âgés de moins de 22 ans lors de leur décès, cette étude analyse l'association entre leur participation à des essais de phase I et les caractéristiques des soins de fin de vie reçus

Does phase 1 trial enrollment preclude quality end-of-life care? Phase 1 trial enrollment and end-of-life care characteristics in children with cancer

Levine, Deena R. ; Johnson, Liza-Marie ; Mandrell, Belinda N. ; Yang, Jie ; West, Nancy K. ; Hinds, Pamela S. ; Baker, Justin N.

BACKGROUND : End-of-life care (EOLC) discussions and treatment-related decisions, including phase 1 trial enrollment, in patients with incurable disease are complex and can influence the quality of EOLC received. The current study was conducted in pediatric oncology patients to determine whether end-of-life characteristics differed between those who were and were not enrolled in a phase 1 trial. METHODS : The authors reviewed the medical records of 380 pediatric oncology patients (aged <22 [...]

Menée par enquête, cette étude analyse l'utilisation de médecines complémentaires et alternatives chez des enfants et adolescents atteints de cancer et traités au Mexique, en Uruguay ou au Nicaragua

Improving our understanding of the use of traditional complementary/alternative medicine in children with cancer

Ladas, Elena J. ; Lin, Meiko ; Antillion, Federico ; Rivas, Silvia ; Chantada, Guillermo ; Cacciavillano, Walter ; Ortiz, Roberta ; Stein, Katja ; Castillo, Luis ; Rocha, Valeria ; Fu, Ligia ; Rodriquez, Hilze ; Kelly, Kara M.

BACKGROUND Children with cancer in high-income and low-income countries often use traditional complementary/alternative medicine (TCAM). With efforts by the World Health Organization and international twinning programs improving access to conventional care for patients with childhood cancer, understanding the global use of TCAM is important because reliance on TCAM may affect time to presentation, adherence, and abandonment of care. In the current study, the authors describe the process and [...]