Menée en Chine auprès de 830 participants, cette étude évalue l'efficacité d'une aide nutritionnelle pour améliorer la survie de patients atteints d'un cancer de l'estomac et recevant une chimiothérapie

Nutrition support can bring survival benefit to high nutrition risk gastric cancer patients who received chemotherapy

Qiu, Miaozhen ; Zhou, Yi-xin ; Jin, Yin ; Wang, Zi-xian ; Wei, Xiao-li ; Han, Hong-yu ; Ye, Wen-feng ; Zhou, Zhi-wei ; Zhang, Dong-sheng ; Wang, Feng-Hua ; Li, Yu-hong ; Yang, Da-jun ; Xu, Rui-hua

Purpose : The aim of our study is firstly to evaluate the prevalence and prognostic value of nutrition risk in gastric cancer patients and secondly to explore whether the nutrition support can prolong the survival of advanced gastric cancer patients. Methods : It contained two study periods. In the first period, we prospectively evaluated the nutritional risk of gastric adenocarcinoma patients from 2009 to 2011 using the method of European Nutritional Risk Screening (NRS) 2002. The Kaplan-Meier [...]

A partir d'une revue systématique de la littérature, cette étude analyse les effets de troubles du sommeil sur la qualité de vie des patients atteints de cancer et plaide pour le développement de mesures permettant l'évaluation de la qualité du sommeil dans les études en oncologie

Incorporating measures of sleep quality into cancer studies

Redeker, NancyS ; Pigeon, WilfredR ; Boudreau, EilisA

Introduction/background : Sleep disturbance may influence the development of cancer and responses to treatment. It is also closely tied to recovery and quality of life in cancer patients, survivors, and caregivers, and recent studies have begun to show beneficial effects of sleep-promoting interventions. Despite the importance of sleep to cancer and its treatment and the availability of numerous tools for measuring sleep quality and quantity, sleep measurements are underutilized in cancer [...]

A partir d'une revue de la littérature, cette étude fait le point sur l'utilisation thérapeutique de la marijuana, et des médicaments dérivés du cannabis, en oncologie

Medical marijuana for cancer

Kramer, Joan L.

Marijuana has been used for centuries, and interest in its medicinal properties has been increasing in recent years. Investigations into these medicinal properties has led to the development of cannabinoid pharmaceuticals such as dronabinol, nabilone, and nabiximols. Dronabinol is best studied in the treatment of nausea secondary to cancer chemotherapy and anorexia associated with weight loss in patients with acquired immune deficiency syndrome, and is approved by the US Food and Drug [...]

Mené au Canada auprès de 122 patients atteints de lymphome, cet essai analyse l'efficacité d'un programme d'exercices physiques pour améliorer la survie sans progression

Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial

Courneya, KerryS ; Friedenreich, ChristineM ; Franco-Villalobos, Conrado ; Crawford, JenniferJ ; Chua, Neil ; Basi, Sanraj ; Norris, MaryK ; Reiman, Tony

Purpose : Few randomized controlled trials in exercise oncology have examined survival outcomes. Here, we report an exploratory follow-up of progression-free survival (PFS) from the Healthy Exercise for Lymphoma Patients (HELP) Trial. Methods : The HELP Trial randomized 122 lymphoma patients between 2005 and 2008 to either control (n = 62) or 12 weeks of supervised aerobic exercise (n = 60). PFS events were abstracted from medical records in 2013. In addition to the randomized comparison, we [...]

Mené en Allemagne auprès de 101 patientes atteintes d'un cancer du sein et recevant une chimiothérapie adjuvante, cet essai randomisé contrôlé évalue l'efficacité d'un programme d'exercices physiques pour réduire leur fatigue et améliorer leur qualité de vie

Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial

Schmidt, Martina E. ; Wiskemann, Joachim ; Armbrust, Petra ; Schneeweiss, Andreas ; Ulrich, Cornelia M. ; Steindorf, Karen

Multiple exercise interventions have shown beneficial effects on fatigue and quality of life (QoL) in cancer patients, but various psychosocial interventions as well. It is unclear to what extent the observed effects of exercise interventions are based on physical adaptations or rather on psychosocial factors associated with supervised, group-based programs. It needs to be determined which aspects of exercise programs are truly effective. Therefore, we aimed to investigate whether resistance [...]

Mené aux Etats-Unis auprès de 121 survivantes d'un cancer du sein, cet essai randomisé analyse l'efficacité d'exercices physiques pour diminuer la sévérité des douleurs articulaires induites par les inhibiteurs de l'aromatase

Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors

Irwin, Melinda L. ; Cartmel, Brenda ; Gross, Cary P. ; Ercolano, Elizabeth ; Li, Fangyong ; Yao, Xiaopan ; Fiellin, Martha ; Capozza, Scott ; Rothbard, Marianna ; Zhou, Yang ; Harrigan, Maura ; Sanft, Tara ; Schmitz, Kathryn ; Neogi, Tuhina ; Hershman, Dawn ; Ligibel, Jennifer

Purpose : Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity. Patients and Methods : Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain [...]

Menée à Taïwan par questionnaire auprès de 110 participants, cette étude transversale analyse les facteurs associés à un trismus (contraction constante et involontaire des muscles des mâchoires), à une xérostomie et au statut nutritionnel de survivants d'un carcinome du rhinopharynx traité par radiothérapie

Trismus, xerostomia and nutrition status in nasopharyngeal carcinoma survivors treated with radiation

Chen, Y. J. ; Chen, S. C. ; Wang, C. P. ; Fang, Y. Y. ; Lee, Y. H. ; Lou, P. J. ; Ko, J. Y. ; Chiang, C. C. ; Lai, Y. H.

The aims of the study were to: (1) examine levels of trismus, xerostomia and nutritional status; (2) compare levels of trismus, xerostomia and nutritional status in patients with nasopharyngeal carcinoma (NPC) receiving different types of radiation modalities; and (3) identify factors related to NPC survivors’ risk status for malnutrition and existing malnutrition. A cross-sectional study with consecutive sampling was conducted. NPC survivors were recruited from otolaryngology/oncology [...]

Menée en Corée auprès de 1 927 cas âgés de moins de 65 ans et de 1 924 témoins en population générale, cette étude analyse la situation professionnelle et les problématiques liées à l'emploi chez des survivants d'un cancer

Working situation of cancer survivors versus the general population

Lee, MyungKyung ; Yun, YoungHo

Purpose : The purposes of this study were to compare the working situation of cancer survivors and the general (cancer-free) population and investigate characteristics associated with the increased likelihood of unemployment between the two groups. Methods : We selected 1927 cancer survivors from the 2008 Korean Community Health Survey data less than 65 years of age and used propensity score matching to randomly select 1924 individuals from the general population who closely resembled the [...]

A partir des données de trois essais contrôlés (2 605 participants), cette étude américaine évalue les disparités ethniques dans le risque d'adénomes colorectaux métachrones et de polypes intestinaux, en fonction de l'âge du patient

The association of age and race and the risk of large bowel polyps

Wallace, Kristin ; Burke, Carol A. ; Ahnen, Dennis J. ; Barry, Elizabeth L. ; Bresalier, Robert S. ; Saibil, Fred ; Baron, John A.

Background: Blacks have a higher incidence of colorectal cancer (CRC) and a younger age at diagnosis compared to Whites. Few studies have investigated racial differences in risk of metachronous adenomas and serrated polyps whether this risk differs by polyp characteristics or age of patient. Methods: We analyzed data pooled from three placebo-controlled adenoma chemoprevention trials to explore racial differences in the risk of large bowel polyps in patients ≤50 and > 50 years of age. Using [...]

Menée aux Pays-Bas auprès de 2 926 patientes atteintes d'un cancer du sein diagnostiqué entre 1997 et 2004 et âgées de plus de 65 ans, cette étude analyse l'association entre l'âge de la patiente, la récidive de la maladie et la survie

Survival and relapse free period of 2926 unselected older breast cancer patients: A FOCUS cohort study

Kiderlen, Mandy ; van de Water, Willemien ; Bastiaannet, Esther ; de Craen, Anton J. M. ; Westendorp, Rudi G. J. ; van de Velde, Cornelis J. H. ; Liefers, Gerrit-Jan

Background : Previous studies have shown that breast cancer survival decreases with increasing age among older patients who participate in trials. However, trial participants differ from patients in the general population. Therefore, the aim of this study was to evaluate the association between age and breast cancer outcome in an unselected group of older breast cancer patients. Methods : We included all older (65 years and older) consecutive breast cancer patients, diagnosed between 1997 and [...]

Menée aux Etats-Unis auprès de 274 630 patients atteints d'un carcinome épidermoïde de la tête et du cou, cette étude analyse l'évolution des délais entre le diagnostic et le début des traitements, sur la période 1998-2011

Increasing time to treatment initiation for head and neck cancer: An analysis of the National Cancer Database

Murphy, Colin T. ; Galloway, Thomas J. ; Handorf, Elizabeth A. ; Wang, Lora ; Mehra, Ranee ; Flieder, Douglas B. ; Ridge, John A.

BACKGROUND : The objective of this study was to identify trends and predictors of the time to treatment initiation (TTI) for patients with head and neck squamous cell carcinoma (HNSCC). METHODS : The National Cancer Database (NCDB) was reviewed for the following head and neck cancer sites: oral tongue, oropharynx, larynx, and hypopharynx. TTI was defined as the number of days from diagnosis to the initiation of definitive treatment and was measured according to covariates. Significant [...]

Menée en Australie auprès de 311 patients atteints de cancer et traités à l'extérieur de l'hôpital, cette étude analyse leurs expériences de détresse psychologique et les facteurs associés à leur refus de prise en charge et de soins psychosociaux

Why do oncology outpatients who report emotional distress decline help?

Clover, Kerrie Ann ; Mitchell, Alex J. ; Britton, Ben ; Carter, Gregory

Objective : Many patients who experience distress do not seek help, and little is known about the reasons for this. We explored the reasons for declining help among patients who had significant emotional distress. Methods : Data were collected through QUICATOUCH screening at an Australian hospital. Oncology outpatients scoring 4 or more on the Distress Thermometer were asked if they would ‘like help’ with their distress. Those who declined help were asked their reasons. Demographic variables [...]

A partir des données du registre finlandais des cancers portant sur 13 860 cas et 43 392 témoins, cette étude analyse les morbidités psychiatriques chez des survivants à 5 ans d'un cancer survenu dans l'enfance ou au début de l'âge adulte

Late psychiatric morbidity in survivors of cancer at a young age: A nationwide registry-based study

Ahomäki, Ritva ; Gunn, Mirja E. ; Madanat-Harjuoja, Laura M. ; Matomäki, Jaakko ; Malila, Nea ; Lähteenmäki, Päivi M.

Childhood cancer survivors have been shown to be prone to psychosocial adverse outcomes. Data on young adults and their psychiatric late effects are still scarce. In a nationwide, registry-based study, we explored the risk (HR) of new psychiatric diagnoses in 5-year survivors of childhood and young adulthood (YA) cancer (n = 13,860) compared with a sibling cohort (n = 43,392). Hazard ratios (HRs) were calculated using Cox regression models. Patients and siblings were identified from the Finnish [...]

Mené à Taïwan auprès de 116 patients atteints d'un cancer du poumon, cet essai randomisé analyse l'efficacité d'un programme d'exercices physiques et de marche à domicile pour diminuer les symptômes d'anxiété et de dépression liés au cancer

Randomised controlled trial on the effectiveness of home-based walking exercise on anxiety, depression and cancer-related symptoms in patients with lung cancer

Chen, H. M. ; Tsai, C. M. ; Wu, Y. C. ; Lin, K. C. ; Lin, C. C.

Background: Although exercise has been addressed as an adjuvant treatment for anxiety, depression and cancer-related symptoms, limited studies have evaluated the effectiveness of exercise in patients with lung cancer. Methods: We recruited 116 patients from a medical centre in northern Taiwan, and randomly assigned them to either a walking-exercise group (n=58) or a usual-care group (n=58). We conducted a 12-week exercise programme that comprised home-based, moderate-intensity walking for [...]

Menée en Australie auprès de 545 survivants d'un cancer hématologique (âge : de 18 à 80 ans), cette étude évalue l'efficacité d'un outil permettant de mesurer leurs perceptions relatives à la qualité des "soins centrés sur le patient"

The quality of patient-centred care: haematological cancer survivors' perceptions

Tzelepis, Flora ; Sanson-Fisher, Robert W. ; Hall, Alix E. ; Carey, Mariko L. ; Paul, Christine L. ; Clinton-McHarg, Tara

Objective : Patient-reported outcome measures (PROMs) that assess the quality of patient-centred cancer care have failed to measure all six patient-centredness dimensions endorsed by the Institute of Medicine (IOM). This study is the first to use the Quality of Patient-Centered Cancer Care (QPCCC) measure that covers all six IOM patient-centredness dimensions to examine haematological cancer survivors' perceptions of care and characteristics associated with perceived quality of care. Methods : [...]

Menée à New York, cette étude analyse le rapport coût-efficacité d'une intervention par des coordonnateurs de santé pour améliorer l'adhésion de populations défavorisées au dépistage du cancer colorectal par coloscopie

Cost-effectiveness of patient navigation to increase adherence with screening colonoscopy among minority individuals

Ladabaum, Uri ; Mannalithara, Ajitha ; Jandorf, Lina ; Itzkowitz, Steven H.

BACKGROUND : Colorectal cancer (CRC) screening is underused by minority populations, and patient navigation increases adherence with screening colonoscopy. In this study, the authors estimated the cost-effectiveness of navigation for screening colonoscopy from the perspective of a payer seeking to improve population health. METHODS : A validated model of CRC screening was informed with inputs from navigation studies in New York City (population: 43% African American, 49% Hispanic, 4% white, 4% [...]