Menée en Chine auprès de 1 199 cas et 1 212 témoins, cette étude évalue l'association entre l'indice et la charge glycémiques des aliments et le risque de cancer de l'endomètre

Association of Dietary Glycemic Index and Glycemic Load with Endometrial Cancer Risk Among Chinese Women

Xu, Wang Hong ; Xiang, Yong-Bing ; Zhang, Xianglan ; Ruan, Zhixian ; Cai, Hui ; Zheng, Wei ; Shu, Xiao-Ou

We evaluated the association of dietary glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer in a population-based, case-control study of 1199 endometrial cancer patients and 1212 age-frequency-matched controls in urban Shanghai, China, where diets are typically high in carbohydrates and have a high GL. Information on dietary habits, physical activity, and other relevant information was collected using a validated questionnaire, and anthropometric measurements were [...]

Menée en Italie auprès de 198 cas et 594 témoins, cette étude évalue l'association entre divers régimes alimentaires et le risque de carcinome du rhinopharynx

Nutrient-based dietary patterns and nasopharyngeal cancer: evidence from an exploratory factor analysis

Edefonti, V. ; Nicolussi, F. ; Polesel, J. ; Bravi, F. ; Bosetti, C. ; Garavello, W. ; La Vecchia, C. ; Bidoli, E. ; Decarli, A. ; Serraino, D. ; Calza, S. ; Ferraroni, M.

Background: To our knowledge, no study assessed the association between dietary patterns and nasopharyngeal carcinoma (NPC) in low-incidence areas. Methods: We examined this association in a hospital-based case–control study carried out in Italy between 1992 and 2008, including 198 incident NPC cases and 594 controls. A posteriori dietary patterns were identified through principal component factor analysis performed on 28 nutrients and minerals derived from a 78-item food-frequency [...]

A partir d'une revue de 117 méta-analyses, cette étude fait le point sur les divers facteurs de risque du cancer du pancréas

Risk factors for pancreatic cancer: a summary review of meta-analytical studies

Maisonneuve, Patrick ; Lowenfels, Albert B

Background: The aetiology of pancreatic cancer (PC) has been extensively studied and is the subject of numerous meta-analyses and pooled analyses. We have summarized results from these pooled and meta-analytical studies to estimate the fraction of PCs attributable to each of the identified risk factors. Methods: Using a comprehensive strategy, we retrieved 117 meta-analytical or pooled reports dealing with the association between specific risk factors and PC risk. We combined estimates of [...]

Menée en Chine auprès de 19 437 participantes, cette étude de cohorte prospective évalue l'association entre les niveaux de protéine C réactive et le risque de cancer

A prospective follow-up study of the relationship between C-Reactive Protein and human cancer risk in the Chinese Kailuan Female Cohort

Wang, Gang ; Li, Ni ; Chang, Sheng ; Bassig, Bryan A. ; Guo, Lanwei ; Ren, Jiansong ; Su, Kai ; Li, Fang ; Chen, Shuohua ; Wu, Shouling ; Zou, Yuhuan ; Dai, Min ; Zheng, Tongzhang ; He, Jie

Background: C - reactive protein (CRP) has been associated with cancer risk in some prospective studies. However, the associations have not been entirely consistent and have not been evaluated in Chinese females. We conducted a large population-based cohort study to investigate whether elevated levels of CRP at baseline are associated with an increased risk of cancer among Chinese females. Methods:19,437 women from the Chinese Kailuan Female Cohort were enrolled in the study in July 2006. [...]

Menée auprès de 2 548 participants issus de 98 familles présentant des mutations du gène PMS2, cette étude de cohorte européenne évalue les risques de cancer du côlon-rectum ou de l'endomètre associés à un syndrome de Lynch lié à ces mutations

Lynch Syndrome Caused by Germline PMS2 Mutations: Delineating the Cancer Risk

ten Broeke, Sanne W. ; Brohet, Richard M. ; Tops, Carli M. ; van der Klift, Heleen M. ; Velthuizen, Mary E. ; Bernstein, Inge ; Capellá Munar, Gabriel ; Gómez García, Encarna ; Hoogerbrugge, Nicoline ; Letteboer, Tom G.W. ; Menko, Fred H. ; Lindblom, Annika ; Mensenkamp, Arjen R. ; Moller, Pal ; van Os, Theo A. ; Rahner, Nils ; Redeker, Bert J.W. ; Sijmons, Rolf H. ; Spruijt, Liesbeth ; Suerink, Manon ; Vos, Yvonne J. ; Wagner, Anja ; Hes, Frederik J. ; Vasen, Hans F. ; Nielsen, Maartje ; Wijnen, Juul T.

Purpose : The clinical consequences of PMS2 germline mutations are poorly understood compared with other Lynch-associated mismatch repair gene (MMR) mutations. The aim of this European cohort study was to define the cancer risk faced by PMS2 mutation carriers. Methods Data were collected from 98 PMS2 families ascertained from family cancer clinics that included a total of 2,548 family members and 377 proven mutation carriers. To adjust for potential ascertainment bias, a modified segregation [...]

Menée aux Etats-Unis par questionnaire auprès de 331 mères d'enfants atteints de trisomie 21, cette étude évalue l'association entre des conditions liées au système immunitaire de l'enfant (asthme, eczéma, allergies, hypothyroïdie) ou à un diabète et le risque de leucémie aiguë

Immune-related conditions and acute leukemia in children with Down syndrome: A Children's Oncology Group report

Linabery, Amy M. ; Li, Wenchao ; Roesler, Michelle A ; Spector, Logan G. ; Gamis, Alan ; Olshan, Andrew F. ; Heerema, Nyla A ; Ross, Julie A.

Background: Children with Down syndrome (DS) have unique immune profiles and increased leukemia susceptibility. Methods: Mothers of 158 children with DS diagnosed with acute leukemia at 0-19 years in 1997-2002 and 173 children with DS but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression. Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (odds ratio=9.23, [...]

Menée auprès de 90 individus issus de 55 familles, puis validée sur 264 individus issus de 264 familles, cette étude américaine évalue l'association entre des mutations constitutionnelles du gène POT1 et le risque familial de gliome

Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

Bainbridge, Matthew N. ; Armstrong, Georgina N. ; Gramatges, M. Monica ; Bertuch, Alison A. ; Jhangiani, Shalini N. ; Doddapaneni, Harsha ; Lewis, Lora ; Tombrello, Joseph ; Tsavachidis, Spyros ; Liu, Yanhong ; Jalali, Ali ; Plon, Sharon E. ; Lau, Ching C. ; Parsons, Donald W. ; Claus, Elizabeth B. ; Barnholtz-Sloan, Jill ; Il’yasova, Dora ; Schildkraut, Joellen ; Ali-Osman, Francis ; Sadetzki, Siegal ; Johansen, Christoffer ; Houlston, Richard S. ; Jenkins, Robert B. ; Lachance, Daniel ; Olson, Sara H. ; Bernstein, Jonine L. ; Merrell, Ryan T. ; Wrensch, Margaret R. ; Walsh, Kyle M. ; Davis, Faith G. ; Lai, Rose ; Shete, Sanjay ; Aldape, Kenneth ; Amos, Christopher I. ; Thompson, Patricia A. ; Muzny, Donna M. ; Gibbs, Richard A. ; Melin, Beatrice S. ; Bondy, Melissa L. ; The Gliogene Consortium

Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing of 90 individuals from 55 families, we identified two families with mutations in POT1 (p.G95C, p.E450X), a member of the telomere shelterin complex, shared by both affected individuals in each family and predicted to impact DNA binding and TPP1 binding, respectively. Validation in a separate [...]