A partir des données de la cohorte américaine "Iowa Women's Health Study" incluant 28 555 participantes, cette étude évalue l'association entre une ingestion de nitrates et de nitrites et le risque de cancer de l'ovaire après la ménopause

Nitrate and nitrite ingestion and risk of ovarian cancer among postmenopausal women in Iowa

Inoue-Choi, Maki ; Jones, Rena R. ; Anderson, Kristin E. ; Cantor, Kenneth P. ; Cerhan, James R. ; Krasner, Stuart ; Robien, Kim ; Weyer, Peter J. ; Ward, Mary H.

Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds (NOC), potential human carcinogens. We evaluated the association of nitrate and nitrite ingestion with postmenopausal ovarian cancer risk in the Iowa Women's Health Study. Among 28,555 postmenopausal women, we identified 315 incident epithelial ovarian cancers from 1986 to 2010. Dietary nitrate and nitrite intakes were assessed at baseline using food frequency questionnaire data. Drinking water source at home [...]

Couplée aux données de la cohorte "American Cancer Society Cancer Prevention Study-II" et portant sur 227 cas et 557 témoins, cette étude évalue l'association entre les niveaux d'anticorps circulants de trois polyomavirus humains et le risque de lymphome non hodgkinien

Prediagnostic Circulating Polyomavirus Antibody Levels and Risk of non-Hodgkin Lymphoma

Teras, Lauren R. ; Rollison, Dana E. ; Pawlita, Michael ; Michel, Angelika ; Blase, Jennifer L ; Willhauck-Fleckenstein, Martina ; Gapstur, Susan M.

Background: Three human polyomaviruses have been classified as probable (MCV) or possible carcinogens (BKV, JCV), but few epidemiologic studies have examined associations between this growing class of viruses and risk of non-Hodgkin lymphoma (NHL). Methods: Associations between polyomavirus antibodies and NHL incidence were examined using data from the American Cancer Society Cancer Prevention Study-II. This nested case-control study included 227 NHL cases and 557 controls. Prediagnostic [...]

Menée entre 2010 et 2013 aux Etats-Unis auprès de 1 230 participants infectés par le VIH ou à risque d'infection, cette étude longitudinale identifie les facteurs associés au risque d'infection orale par le papillomavirus humain ainsi qu'à sa persistance

Risk Factors for Acquisition and Clearance of Oral Human Papillomavirus Infection Among HIV-Infected and HIV-Uninfected Adults

Beachler, Daniel C. ; Sugar, Elizabeth A. ; Margolick, Joseph B. ; Weber, Kathleen M. ; Strickler, Howard D. ; Wiley, Dorothy J. ; Cranston, Ross D. ; Burk, Robert D. ; Minkoff, Howard ; Reddy, Susheel ; Xiao, Weihong ; Guo, Yingshi ; Gillison, Maura L. ; D'Souza, Gypsyamber

Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, yet the risk factors for and natural history of oral HPV infection are largely unknown. In 2010–2011, a US-based longitudinal cohort study of 761 human immunodeficiency virus (HIV)-infected and 469 at-risk HIV-uninfected participants from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study was initiated. Semiannually collected oral rinses were evaluated for 37 HPV genotypes using [...]

Menée aux Etats-Unis à partir des données de la cohorte "Breast Cancer Detection Demonstration Project" incluant 40 013 participantes, cette étude prospective évalue l'association entre la durée du sommeil et le risque de cancer du sein, en fonction du statut du récepteur hormonal

Sleep duration and breast cancer risk in the Breast Cancer Detection Demonstration Project follow-up cohort

Qian, X. ; Brinton, L. A. ; Schairer, C. ; Matthews, C. E.

Background: Short sleep has been hypothesised to increase the risk of breast cancer. However, little is known about the association between sleep and different subtypes of breast cancer defined by hormone receptor status. Methods: Among 40 013 women in the Breast Cancer Detection Demonstration Project, including 1846 incident breast cancer cases, we prospectively examined self-reported weekday and weekend sleep duration in relation to breast cancer risk. We used multivariate Cox proportional [...]

Menée en Corée auprès de 1 492 cas et 1 492 témoins, cette étude multicentrique évalue l'association entre l'indice de masse corporelle à l'adolescence et le risque de cancer de l'estomac

Obesity at adolescence and gastric cancer risk

Song, Minkyo ; Choi, Ji-Yeob ; Yang, JaeJeong ; Sung, Hyuna ; Lee, Yunhee ; Lee, Hwi-Won ; Kong, Seong-Ho ; Lee, Hyuk-Joon ; Kim, Hyung-Ho ; Kim, SangGyun ; Yang, Han-Kwang ; Kang, Daehee

Background and objective : During the last few decades, prevalence of obesity has risen rapidly worldwide, markedly in children and adolescents. Epidemiologic studies have associated obesity to several cancer types, yet little is known for the effect of early life exposure to obesity on cancer risk in later life, especially in gastric cancer. Thus, the present study aimed to investigate the association of body mass index (BMI) of adolescence and the risk of gastric cancer. Methods : A [...]

Menée à Taïwan auprès de 39 384 participants âgés de plus de 40 ans ayant participé, depuis 1999, à un programme de dépistage de cancer colorectal par test de recherche de sang occulte dans les selles, cette étude de cohorte prospective évalue l'association entre un syndrome de l'intestin irritable et le risque de néoplasie colorectale

Irritable bowel syndrome and the incidence of colorectal neoplasia: a prospective cohort study with community-based screened population in Taiwan

Chang, H. C. ; Yen, A. M. F. ; Fann, J. C. Y. ; Chiu, S. Y. H. ; Liao, C. S. ; Chen, H. H. ; Yang, K. C. ; Chen, L. S. ; Lin, Y. M.

Background: We aim to report the prevalence of irritable bowel syndrome (IBS) and elucidate the influence of IBS on the incidence of colorectal neoplasm through a community-screening-based, longitudinal follow-up study. Methods: We enroled 39 384 community residents aged 40 years or older who had participated in a community-based colorectal cancer-screening programme with an immunochemical faecal occult test since 1999. We followed a cohort that was free of colorectal neoplasm (excluding [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (17 études, 1 987 753 individus), cette méta-analyse évalue l'association entre une dyslipidémie et le risque de cancer colorectal

Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies

Yao, Xu ; Tian, Zhong

Purpose : The findings from epidemiologic studies of dyslipidemia and colorectal cancer risk have been conflicting. We performed a dose–response meta-analysis of published prospective studies to assess the aforementioned association. Methods : Relevant studies that reported the association between the components of dyslipidemia (serum triglyceride, total cholesterol, and high-/low-density lipoprotein cholesterol) and colorectal cancer risk were identified by searching PubMed until the end of [...]

A partir de données de dix études incluant un total de 7 020 cas et 7 631 témoins, cette étude évalue l'association entre 19 polymorphismes à simple nucléotide des gènes liés à l'adiponectine ou à ses récepteurs et le risque de cancer colorectal

Genetic variants of adiponectin and risk of colorectal cancer

Song, Mingyang ; Gong, Jian ; Giovannucci, Edward L. ; Berndt, Sonja I. ; Brenner, Hermann ; Chang-Claude, Jenny ; Curtis, Keith R. ; Harrison, Tabitha A. ; Hoffmeister, Michael ; Hsu, Li ; Jiao, Shuo ; Le Marchand, Loic ; Potter, John D. ; Schoen, Robert E. ; Seminara, Daniela ; Slattery, Martha L. ; White, Emily ; Wu, Kana ; Ogino, Shuji ; Fuchs, Charles S. ; Hunter, David J. ; Tworoger, Shelley S. ; Hu, Frank B. ; Rimm, Eric ; Jensen, Majken ; Peters, Ulrike ; Chan, Andrew T.

Circulating adiponectin has been associated with lower risk of colorectal cancer (CRC). Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) associated with adiponectin levels. However, it is unclear whether these SNPs are associated with CRC risk. In addition, previous data on SNPs in the adiponectin pathway and their associations with CRC are inconsistent. Therefore, we examined 19 SNPs in genes related to adiponectin or its receptors and their [...]

A partir d'une revue systématique de la littérature (6 études observationnelles, 2 776 cas), cette méta-analyse évalue l'association entre un excès de tissu adipeux viscéral et le risque de cancer colorectal

Visceral Adiposity and Colorectal Adenomas: Dose-Response Meta-Analysis of Observational Studies

Keum, N. ; Lee, D.H. ; Kim, R. ; Greenwood, D.C. ; Giovannucci, E.L.

Background : Obesity-related hormonal and metabolic perturbations implicated in colorectal carcinogenesis are mainly driven by visceral adipose tissue (VAT) rather than subcutaneous adipose tissue (SAT). Yet, most epidemiologic studies have examined the relationship between excess adiposity and colorectal neoplasia using body mass index (BMI) and waist circumference (WC). Due to the inability of BMI and WC to distinguish VAT from SAT, they are likely to have underestimated the true association. [...]

Menée sur 4 401 cas de cancer de l'endomètre et 28 758 témoins, cette étude identifie un nouveau locus situé sur la région chromosomique 5p15 en association avec une augmentation du risque de la maladie

Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk

Carvajal-Carmona, LuisG ; O’Mara, TracyA ; Painter, JodieN ; Lose, FelicityA ; Dennis, Joe ; Michailidou, Kyriaki ; Tyrer, JonathanP ; Ahmed, Shahana ; Ferguson, Kaltin ; Healey, CatherineS ; Pooley, Karen ; Beesley, Jonathan ; Cheng, Timothy ; Jones, Angela ; Howarth, Kimberley ; Martin, Lynn ; Gorman, Maggie ; Hodgson, Shirley ; Wentzensen, Nicholas ; Fasching, PeterA ; Hein, Alexander ; Beckmann, MatthiasW ; Renner, StefanP ; Dörk, Thilo ; Hillemanns, Peter ; Dürst, Matthias ; Runnebaum, Ingo ; Lambrechts, Diether ; Coenegrachts, Lieve ; Schrauwen, Stefanie ; Amant, Frederic ; Winterhoff, Boris ; Dowdy, SeanC ; Goode, EllenL ; Teoman, Attila ; Salvesen, HelgaB ; Trovik, Jone ; Njolstad, TormundS ; Werner, HenricaM J. ; Scott, RodneyJ ; Ashton, Katie ; Proietto, Tony ; Otton, Geoffrey ; Wersäll, Ofra ; Mints, Miriam ; Tham, Emma ; Hall, Per ; Czene, Kamila ; Liu, Jianjun ; Li, Jingmei ; Hopper, JohnL ; Southey, MelissaC ; Ekici, ArifB ; Ruebner, Matthias ; Johnson, Nichola ; Peto, Julian ; Burwinkel, Barbara ; Marme, Frederik ; Brenner, Hermann ; Dieffenbach, AidaK ; Meindl, Alfons ; Brauch, Hiltrud ; Lindblom, Annika ; Depreeuw, Jeroen ; Moisse, Matthieu ; Chang-Claude, Jenny ; Rudolph, Anja ; Couch, FergusJ ; Olson, JanetE ; Giles, GrahamG ; Bruinsma, Fiona ; Cunningham, JulieM ; Fridley, BrookeL ; Børresen-Dale, Anne-Lise ; Kristensen, VesselaN ; Cox, Angela ; Swerdlow, AnthonyJ ; Orr, Nicholas ; Bolla, ManjeetK ; Wang, Qin ; Weber, RachelPalmieri ; Chen, Zhihua ; Shah, Mitul ; Pharoah, PaulD P. ; Dunning, AlisonM ; Tomlinson, Ian ; Easton, DouglasF ; Spurdle, AmandaB ; Thompson, DeborahJ

Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer. To evaluate the role of genetic variants at the TERT–CLPTM1L region in endometrial cancer risk, we carried out comprehensive fine-mapping analyses of genotyped and imputed SNPs using a custom Illumina iSelect array which includes dense SNP coverage of this [...]

Menée sur 3 cohortes indépendantes comprenant un total de 6 014 hommes, cette étude suggère que, en induisant une perte du chromosome Y dans les cellules sanguines, le tabagisme augmente le risque de tumeurs non hématologiques

Smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P. ; Rasi, Chiara ; Lönn, Mikael ; Davies, Hanna ; Ingelsson, Martin ; Giedraitis, Vilmantas ; Lannfelt, Lars ; Magnusson, Patrik K. E. ; Lindgren, Cecilia M. ; Morris, Andrew P. ; Cesarini, David ; Johannesson, Magnus ; Tiensuu Janson, Eva ; Lind, Lars ; Pedersen, Nancy L. ; Ingelsson, Erik ; Forsberg, Lars A.

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non–sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We [...]