A partir d'une revue systématique de la littérature (11 études), cette étude fait le point sur les méthodes permettant d'évaluer la durée, ajustée sur la qualité de vie, d'une période sans symptôme lié à la maladie, ni toxicité liée au traitement, chez des patients atteints de cancer

Quality-adjusted time without symptoms or toxicity (Q-TWiST): patient-reported outcome or mathematical model? A systematic review in cancer

Tate, Wendy R. ; Skrepnek, Grant H.

Objective : Successful cancer treatment is defined as an increase in overall survival and/or progression-free survival. Despite their importance, these metrics omit patient quality of life. Quality-adjusted time without symptoms or toxicity (Q-TWiST) was developed to adjust survival gained, accounting for quality of life. The purpose of this systematic review was to assess the methods reported in cancer literature to determine Q-TWiST values and how these are currently translated to the clinic. [...]

Mené aux Etats-Unis auprès de 46 survivantes d'un cancer du sein, cet essai randomisé évalue l'association entre des facteurs psychosociaux, une activité physique et la qualité du sommeil

Inflammation and psychosocial factors mediate exercise effects on sleep quality in breast cancer survivors: pilot randomized controlled trial

Rogers, Laura Q. ; Fogleman, Amanda ; Trammell, Rita ; Hopkins-Price, Patricia ; Spenner, Allison ; Vicari, Sandra ; Rao, Krishna ; Courneya, Kerry S. ; Hoelzer, Karen ; Robbs, Randall ; Verhulst, Steven

Objective : To improve mechanistic understanding, this pilot randomized controlled trial examined mediators of an exercise intervention effects on sleep in breast cancer survivors (BCS). Methods : Forty-six postmenopausal BCS (≤Stage II, off primary treatment) were randomized to a 3-month exercise intervention or control group. Intervention included 160 min/week of moderate intensity aerobic walking, twice weekly resistance training (resistance bands), and six discussion groups (to improve [...]

Menée aux Etats-Unis auprès de 328 participantes, cette étude analyse les programmes de suivi et de prise en charge de l'après cancer, les expériences de survivantes d'un cancer du sein âgées de plus de 65 ans, leur utilisation de ces programmes, ainsi que leur survie

Associations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901

Faul, LeighAnne ; Luta, Gheorghe ; Sheppard, Vanessa ; Isaacs, Claudine ; Cohen, HarveyJ ; Muss, HymanB ; Yung, Rachel ; Clapp, JonathanD ; Winer, Eric ; Hudis, Clifford ; Tallarico, Michelle ; Wang, Julhy ; Barry, WilliamT ; Mandelblatt, JeanneS

Purpose : Survivorship care plans (SCP) are recommended for all cancer patients and could be especially useful to survivors 65 years and over (“older”). This study examined receipt of SCPs among older breast cancer survivors and whether SCPs were associated with improved patient-reported outcomes. Methods : Three hundred and twenty-eight older women diagnosed with invasive, nonmetastatic breast cancer between 2007–2011 were recruited from 78 cooperative-group sites. Participants completed [...]

A partir de données nationales américaines, cette étude analyse l'évolution de la mortalité par maladie chronique hépatique ou par cancer du foie, sur les trente dernières années

Temporal trends in population-based death rates associated with chronic liver disease and liver cancer in the United States over the last 30 years

Kim, Yuhree ; Ejaz, Aslam ; Tayal, Amit ; Spolverato, Gaya ; Bridges, John F. P. ; Anders, Robert A. ; Pawlik, Timothy M.

BACKGROUND : The health and economic burden from liver disease in the United States is substantial and rising. The objective of this study was to characterize temporal trends in mortality from chronic liver disease and liver cancer and the incidence of associated risk factors using population-based data over the past 30 years. METHODS : Population-based mortality data were obtained from the National Vital Statistics System, and population estimates were derived from the national census for US [...]

Menée aux Etats-Unis auprès de 2 571 cas et 7 713 témoins sur la période 1996-2005, cette étude analyse les facteurs associés au risque d'hospitalisation liée aux effets secondaires à long terme des traitements chez des survivants d'un cancer de l'enfance ou de l'adolescence

Risk of Hospitalization for Survivors of Childhood and Adolescent Cancer

Kirchhoff, Anne C. ; Fluchel, Mark N. ; Wright, Jennifer ; Ying, Jian ; Sweeney, Carol ; Bodson, Julia ; Stroup, Antoinette M. ; Smith, Ken R. ; Fraser, Alison ; Kinney, Anita Y.

Background: Childhood cancer survivors may be at increased risk of hospitalization because of cancer-related late effects. Methods: Using data from population-based research resources in Utah, we identified childhood and adolescent cancer survivors who were diagnosed from 1973 to 2005 (N = 2,571). We selected a comparison cohort based on birth year and sex (N = 7,713). Hospitalizations from 1996 to 2010, excluding pregnancy and delivery, were determined from discharge records. Multivariable [...]

Menée en Italie auprès de 241 participants, cette étude multicentrique analyse les caractéristiques cliniques, les traitements, les comorbidités et la survie de patients âgés de plus de 70 ans atteints d'un mésothéliome pleural malin, sur la période 2005-2010

Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey

Ceresoli, G. L. ; Grosso, F. ; Zucali, P. A. ; Mencoboni, M. ; Pasello, G. ; Ripa, C. ; Degiovanni, D. ; Simonelli, M. ; Bruzzone, A. ; Dipietrantonj, C. ; Piccolini, E. ; Beretta, G. D. ; Favaretto, A. G. ; Giordano, L. ; Santoro, A. ; Botta, M.

Background: The incidence of malignant pleural mesothelioma (MPM) in elderly patients is increasing. There are no specific guidelines for their management. Methods: The clinical records of elderly patients (70 years old) with MPM referred from January 2005 to November 2011 to six Italian Centres were reviewed. Age, gender, histology, International Mesothelioma Interest Group (IMIG) stage, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), Charlson Comorbidity Index (CCI) and [...]

Menée auprès de 1 240 participants, cette étude rétrospective évalue l'association entre un diabète, l'utilisation de médicaments antidiabétiques et la survie de patients atteints de myélome multiple

The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma

Wu, W. ; Merriman, K. ; Nabaah, A. ; Seval, N. ; Seval, D. ; Lin, H. ; Wang, M. ; Qazilbash, M. H. ; Baladandayuthapani, V. ; Berry, D. ; Orlowski, R. Z. ; Lee, M. H. ; Yeung, S. C. J.

Background: Insulin/insulin-like growth factor-1 signalling may underlie the promoting effect of type 2 diabetes on cancer. This study examined the association of diabetes, including steroid-induced diabetes (SID), and the impact of anti-diabetic medication on clinical outcomes of multiple myeloma (MM). Methods: A retrospective review was conducted of 1240 MM patients. Overall survival (OS) and MM disease status prior to death were analysed. Results: Diabetic patients had a significantly [...]

A partir des données de deux essais randomisés incluant 1 406 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 1991 et 1998, cette étude britannique analyse les disparités socioéconomiques dans la survie des patientes

No socioeconomic inequalities in ovarian cancer survival within two randomised clinical trials

Abdel-Rahman, M. E. ; Butler, J. ; Sydes, M. R. ; Parmar, M. K. B. ; Gordon, E. ; Harper, P. ; Williams, C. ; Crook, A. ; Sandercock, J. ; Swart, A. M. ; Rachet, B. ; Coleman, M. P.

Background: Ovarian cancer is the leading cause of death among cancers of the female genital tract, with poor outcomes despite chemotherapy. There was a persistent socioeconomic gradient in 1-year survival in England and Wales for more than 3 decades (1971–2001). Inequalities in 5-year survival persisted for more than 20 years but have been smaller for women diagnosed around 2000. We explored one possible explanation. Methods: We analysed data on 1406 women diagnosed with ovarian cancer during [...]

Menée en Angleterre à partir des données de bases de statistiques hospitalières, cette étude analyse les facteurs associés à des admissions dans les services d'urgences hospitalières pour des patients ayant été traités pour un cancer colorectal

Identifying patients at risk of emergency admission for colorectal cancer

Wallace, D. ; Walker, K. ; Kuryba, A. ; Finan, P. ; Scott, N. ; van der Meulen, J.

Background: Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative database of all admissions to English National Health Service hospitals, which includes data on mode of admission. Methods: We identified all adults included in the NBCA with a [...]

A partir des données d'un registre international des cancers familiaux du côlon, cette étude analyse et compare les caractéristiques épidémiologiques et clinicopathologiques d'un cancer familial colorectal de type X, d'un syndrome de Lynch et d'un cancer colorectal non héréditaire

Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer

Shiovitz, S. ; Copeland, W. K. ; Passarelli, M. N. ; Burnett-Hartman, A. N. ; Grady, W. M. ; Potter, J. D. ; Gallinger, S. ; Buchanan, D. D. ; Rosty, C. ; Win, A. K. ; Jenkins, M. ; Thibodeau, S. N. ; Haile, R. ; Baron, J. A. ; Marchand, L. L. ; Newcomb, P. A. ; Lindor, N. M.

Background: Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and ‘non-familial’ (non-AC1) CRC cases. Methods: From the Colon Cancer Family Registry, FCCTX (n=173), LS [...]

A partir des données de la cohorte européenne EPIC incluant 3 859 participants, cette étude évalue l'association entre une consommation, avant un diagnostic de cancer, de produits laitiers, de calcium d'origine alimentaire et la survie des patients atteints d'un cancer colorectal

Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival - results from the EPIC cohort study

Dik, Vincent K. ; Murphy, Neil ; Siersema, Peter D. ; Fedirko, Veronika ; Jenab, Mazda ; Kong, So Y. ; Hansen, Camilla P. ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Dossus, Laure ; Racine, Antoine ; Bastide, Nadia ; Li, Kuanrong ; Kühn, Tilman ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Barbitsioti, Antonia ; Palli, Domenico ; Contiero, Paolo ; Vineis, Paolo ; Tumino, Rosario ; Panico, Salvatore ; Peeters, Petra H. M. ; Weiderpass, Elisabete ; Skeie, Guri ; Hjartåker, Anette ; Amiano, Pilar ; Sánchez, María-José ; Fonseca-Nunes, Ana ; Barricarte, Aurelio ; Chirlaque, María-Dolores ; Redondo, Maria-Luisa ; Jirström, Karin ; Manjer, Jonas ; Nilsson, Lena M. ; Wennberg, Maria ; Bradbury, Kathryn E. ; Khaw, Kay-Tee ; Wareham, Nicholas ; Cross, Amanda J. ; Riboli, Elio ; Bueno-de-Mesquita, H. Bas

Background : We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods : Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox [...]

Menée aux Pays-Bas par entretiens auprès de 95 patientes atteintes d'un cancer de l'endomètre, cette étude analyse leurs préférences relatives aux options thérapeutiques et leur participation dans la prise de décision

Treatment preferences and involvement in treatment decision making of patients with endometrial cancer and clinicians

Kunneman, M. ; Pieterse, A. H. ; Stiggelbout, A. M. ; Nout, R. A. ; Kamps, M. ; Lutgens, L. C. H. W. ; Paulissen, J. ; Mattheussens, O. J. A. ; Kruitwagen, R. F. P. M. ; Creutzberg, C. L.

Background: Vaginal brachytherapy (VBT) in high–intermediate-risk endometrial cancer (EC) provides a significant reduction in the risk of local cancer recurrence, but without survival benefit and with increased mucosal atrophy. Five-year local control is estimated to be similar for VBT and a watchful waiting policy (WWP), in which patients receive VBT combined with external radiation in case of a recurrence. Our aim was to assess treatment preferences of EC patients and clinicians regarding VBT [...]

Menée aux Etats-Unis par questionnaire auprès de 2 524 femmes, cette étude analyse les facteurs cognitifs et émotionnels associés à leur perception du risque personnel de cancer de l'ovaire

Cognitive and affective influences on perceived risk of ovarian cancer

Peipins, Lucy A. ; McCarty, Frances ; Hawkins, Nikki A. ; Rodriguez, Juan L. ; Scholl, Lawrence E. ; Leadbetter, Steven

Introduction : Studies suggest that both affective and cognitive processes are involved in the perception of vulnerability to cancer and that affect has an early influence in this assessment of risk. We constructed a path model based on a conceptual framework of heuristic reasoning (affect, resemblance, and availability) coupled with cognitive processes involved in developing personal models of cancer causation. Methods : From an eligible cohort of 16 700 women in a managed care organization, [...]

Menée aux Etats-Unis auprès de 66 patients ayant été traités pour un cancer de la prostate, cette étude analyse l'association entre leurs comportements sexuels et leurs symptômes dépressifs

Sexual self-schema and depressive symptoms after prostate cancer

Hoyt, Michael A. ; Carpenter, Kristen M.

Introduction : The years following prostate cancer treatment are characterized by changes in sexual functioning and risk for depressive symptoms. Sexual self-schema (SSS) is a cognitive generalization about sexual aspects of the self that are associated with sexual behavior, affect, and the processing of sexually relevant information. This study tested if men's SSS moderates the impact of sexual morbidity on depressive symptoms. Methods : Men (N = 66) treated for localized prostate cancer in [...]

Menée aux Etats-Unis auprès de 43 patients atteints d'un cancer de la tête et du cou (âge: de 32 à 78 ans), cette étude prospective longitudinale évalue l'association entre leur image corporelle et des symptômes dépressifs après les traitements

Body image and depressive symptoms in patients with head and neck cancer: an important relationship

Rhoten, BethanyA ; Deng, Jie ; Dietrich, MaryS ; Murphy, Barbara ; Ridner, SheilaH

Purpose : The purpose of this study is to examine the relationship between body image and depressive symptoms in patients who have been treated for head and neck cancer. Methods : This is a prospective, longitudinal analysis. Body image and depressive symptoms were measured in patients diagnosed with head and neck cancer at baseline, end of treatment, 6 weeks post-treatment, and 12 weeks post-treatment. Body image was measured using the Body Image Quality of Life Inventory, and depressive [...]

Cette étude analyse le retour sur investissement des fonds publics et privés investis dans la recherche publique sur le cancer, sur la période 1976-1995, en prenant en compte l'amélioration de la santé et de la survie des patients au Royaume-Uni

Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes

Glover, Matthew ; Buxton, Martin ; Guthrie, Susan ; Hanney, Stephen ; Pollitt, Alexandra ; Grant, Jonathan

BACKGROUND:Building on an approach developed to assess the economic returns to cardiovascular research, we estimated the economic returns from UK public and charitable funded cancer-related research that arise from the net value of the improved health outcomes. METHODS:To assess these economic returns from cancer-related research in the UK we estimated: 1) public and charitable expenditure on cancer-related research in the UK from 1970 to 2009; 2) net monetary benefit (NMB), that is, the health [...]