A partir des données de plusieurs études cas-témoins, cette étude internationale analyse l'association entre une exposition professionnelle à diverses substances carcinogènes et le risque de cancer du poumon chez des professionnels de la maçonnerie

Lung cancer risk among bricklayers in a pooled analysis of case–control studies

Consonni, Dario ; Matteis, Sara De ; Pesatori, Angela C. ; Bertazzi, Pier Alberto ; Olsson, Ann C. ; Kromhout, Hans ; Peters, Susan ; Vermeulen, Roel C. H. ; Pesch, Beate ; Brüning, Thomas ; Kendzia, Benjamin ; Behrens, Thomas ; Stücker, Isabelle ; Guida, Florence ; Wichmann, Heinz-Erich ; Brüske, Irene ; Landi, Maria Teresa ; Caporaso, Neil E. ; Gustavsson, Per ; Plato, Nils ; Tse, Lap Ah ; Yu, Ignatius Tak-Sun ; Jöckel, Karl-Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Merletti, Franco ; Richiardi, Lorenzo ; Simonato, Lorenzo ; Forastiere, Francesco ; Siemiatycki, Jack ; Parent, Marie-Élise ; Tardon, Adonina ; Boffetta, Paolo ; Zaridze, David ; Chen, Ying ; Field, John K. ; t Mannetje, Andrea ; Pearce, Neil ; McLaughlin, John ; Demers, Paul ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Rudnai, Peter ; Fabianova, Eleonora ; Stanescu Dumitru, Rodica ; Bueno-de-Mesquita, Bas ; Schüz, Joachim ; Straif, Kurt

Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case–control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) [...]

Menée à l'aide d'un modèle murin exprimant le gène BRAF(V600E), cette étude met en évidence des mécanismes par lesquels, via l'apparition de mutations du gène TP53, les rayonnements ultraviolets favorisent le développement d'un mélanome

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

Viros, Amaya ; Sanchez-Laorden, Berta ; Pedersen, Malin ; Furney, Simon J. ; Rae, Joel ; Hogan, Kate ; Ejiama, Sarah ; Girotti, Maria Romina ; Cook, Martin ; Dhomen, Nathalie ; Marais, Richard

Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear. The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event. To investigate how UVR accelerates oncogenic BRAF-driven melanomagenesis, we used a BRAF(V600E) mouse model. In mice expressing BRAF(V600E) in their melanocytes, a single dose of UVR that mimicked mild sunburn in humans induced clonal [...]

Menée aux Etats-Unis, cette étude cas-témoins analyse l'association entre des facteurs hormonaux féminins, dont l'utilisation d'une contraception orale, et le risque de gliome

A pooled multisite analysis of the effects of female reproductive hormones on glioma risk

Krishnamachari, Bhuma ; Il’yasova, Dora ; Scheurer, MichaelE ; Bondy, MelissaL ; Wrensch, Margaret ; Davis, FaithG

Purpose : The association between female reproductive factors and glioma risk is unclear, but most published studies have been limited by small sample size. We conducted a pooled multisite study of pre- and postmenopausal women, investigating the effect of female reproductive factors, including hormonal medications. Methods : Unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (95 % CIs) assessing the effects of female reproductive factors and [...]

A partir des données de la cohorte "Cancer Prevention Study-II Nutrition Cohort" et d'études précédemment publiées, cette méta-analyse fait le point sur l'association entre une infection par le virus d'Epstein-Barr et le risque de lymphome non hodgkinien

Epstein-Barr virus and risk of non-Hodgkin lymphoma in the cancer prevention study-II and a meta-analysis of serologic studies

Teras, Lauren R. ; Rollison, Dana E. ; Pawlita, Michael ; Michel, Angelika ; Brozy, Johannes ; de Sanjose, Silvia ; Blase, Jennifer L. ; Gapstur, Susan M.

Epstein-Barr virus (EBV) causes rare, malignant lymphomas. The role of EBV in other non-Hodgkin lymphomas (NHLs) remains unclear, but mildly reduced immune function could lead to reactivation of EBV and subsequent NHL. We examined the association between prospectively-collected plasma EBV antibodies and NHL risk in the Cancer Prevention Study-II (CPS-II) Nutrition Cohort and conducted a meta-analysis of our and published results. The CPS-II study included 225 NHL cases and 2:1 matched controls. [...]

Menée à Taïwan et couplée à une cohorte de 561 participants, cette étude cas-témoins évalue l'association entre le niveau plasmatique d'adipokines et le risque de carcinome hépatocellulaire chez des individus infectés par le virus de l'hépatite B

Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus infected carriers: a prospective study in Taiwan

Chen, Chi-Ling ; Yang, Wei-Shiung ; Yang, Hwai-I ; Chen, Chung-Fei ; You, San-Lin ; Wang, Li-Yu ; Lu, Sheng-Nan ; Liu, Chun-Jen ; Kao, Jia-Horng ; Chen, Pei-Jer ; Chen, Ding-Shinn ; Chen, Chien-Jen

Background:Obesity is considered a risk factor for hepatocellular carcinoma (HCC); The relationship between adipocytokine and HCC in hepatitis B virus (HBV) carriers remains unclear. We prospectively investigated the association of adiponectin, leptin and visfatin levels with HCC. Methods: We conducted a nested case-control study in a community-based cohort with 187 incident HCC and 374 HCC-free HBV carriers. Unconditional logistic regression was conducted to estimate the odds ratios and 95 [...]

A partir des données d'une étude de cohorte finlandaise et de deux études de cohorte américaines portant sur 729 cas et 907 témoins, cette étude analyse l'association entre le niveau de concentration sérique de

Serum transforming growth factor-β1 and risk of pancreatic cancer in three prospective cohort studies

Jacobs, EricJ ; Newton, ChristinaC ; Silverman, DebraT ; Nogueira, LeticiaM ; Albanes, Demetrius ; Mannisto, Satu ; Pollak, Michael ; Stolzenberg-Solomon, RachaelZ

Purpose : Clinically evident chronic pancreatitis is a strong risk factor for pancreatic cancer. A small Japanese cohort study previously reported that pre-diagnostic serum transforming growth factor-

Menée aux Etats-Unis auprès 77 485 femmes ménopausées, cette étude de cohorte prospective analyse l'association entre une histoire de maladie parodontale et le risque de cancer du poumon

History of periodontal disease diagnosis and lung cancer incidence in the Women’s Health Initiative Observational Study

Mai, Xiaodan ; LaMonte, MichaelJ ; Hovey, KathleenM ; Nwizu, Ngozi ; Freudenheim, JoL ; Tezal, Mine ; Scannapieco, Frank ; Hyland, Andrew ; Andrews, ChristopherA ; Genco, RobertJ ; Wactawski-Wende, Jean

Purpose : While some evidence suggests that periodontal disease (PD) might be positively associated with lung cancer, prospective studies in women are limited. Previous findings may reflect residual confounding by smoking. The study aims to determine whether history of PD diagnosis is associated with incident lung cancer in a large cohort of postmenopausal women. Methods : Prospective analyses were conducted in a cohort of 77,485 postmenopausal women enrolled in the Women’s Health Initiative [...]

A partir d'une revue systématique de la littérature publiée de 1999 à 2012 (38 études), cette méta-analyse fait le point sur l'association entre des polymorphismes du gène GSTT1 et le risque de cancer de la prostate

GSTT1 Polymorphism and the Risk of Developing Prostate Cancer

Zhou, Tian-Biao ; Drummen, Gregor P. C. ; Jiang, Zong-Pei ; Qin, Yuan-Han

A possible association between glutathione S-transferase theta 1 gene (GSTT1) polymorphism and the risk of developing prostate cancer is currently hotly debated, but evidence from various epidemiologic studies remains unclear. This investigation was performed to assess whether an association between GSTT1 polymorphism and prostate cancer risk exists by using meta-analysis to combine comparable studies, thereby increasing sample size and statistical significance, as well as to identify patterns [...]

A partir des données de la cohorte européenne EPIC portant sur 139 131 participants, cette étude évalue l'association entre un diabète et le risque de cancer de la prostate

Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Tsilidis, Konstantinos K. ; Allen, Naomi E. ; Appleby, Paul N. ; Rohrmann, Sabine ; Nöthlings, Ute ; Arriola, Larraitz ; Gunter, Marc J. ; Chajès, Veronique ; Rinaldi, Sabina ; Romieu, Isabelle ; Murphy, Neil ; Riboli, Elio ; Tzoulaki, Ioanna ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Boeing, Heiner ; Pischon, Tobias ; Dahm, Christina C. ; Overvad, Kim ; Quirós, J. Ramón ; Fonseca-Nunes, Ana ; Molina-Montes, Esther ; Gavrila Chervase, Diana ; Ardanaz, Eva ; Khaw, Kay T. ; Wareham, Nick J. ; Roswall, Nina ; Tjønneland, Anne ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Trichopoulou, Antonia ; Palli, Domenico ; Pala, Valeria ; Tumino, Rosario ; Vineis, Paolo ; Bueno-de-Mesquita, H. Bas ; Malm, Johan ; Orho-Melander, Marju ; Johansson, Mattias ; Stattin, Pär ; Travis, Ruth C. ; Key, Timothy J.

The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up [...]

Menée aux Etats-Unis auprès de 1 000 cas et 991 témoins issus d'une grande cohorte multiethnique, cette étude évalue l'association entre des polymorphismes du gène IGF1 et le risque de cancer de la prostate chez les hommes d'origine afro-américaine

Fine-mapping IGF1 and prostate cancer risk in African Americans: The Multiethnic Cohort Study

Giorgi, Elena E. ; Stram, Daniel O. ; Taverna, Darin ; Turner, Stephen ; Schumacher, Fredrick ; Haiman, Christopher A. ; Lum-Jones, Annette ; Tirikainen, Maarit ; Caberto, Christian ; Duggan, David ; Henderson, Brian E. ; Le Marchand, Loic ; Cheng, Iona

Genetic variation at IGF1 has been linked to prostate cancer risk. However, the specific predisposing variants have not been identified. In this study, we fine-mapped the IGF1 locus for prostate cancer risk in African Americans. We conducted targeted Roche GS-Junior 454 resequencing of a 156kb region of IGF1 in 80 African American aggressive prostate cancer cases. 334 IGF1 SNPs were examined for their association with prostate cancer risk in 1,000 African American prostate cancer cases and 991 [...]

Menée en Suède auprès de 14 267 survivants d'un carcinome à cellules rénales diagnostiqué de 1990 à 2010, cette étude analyse le risque subséquent de cancer chez des survivants ayant des antécédents familiaux de carcinome à cellules rénales ou d'hémangioblastome

Risk of subsequent cancers in renal cell carcinoma survivors with a family history

Chen, Tianhui ; Fallah, Mahdi ; Sundquist, Kristina ; Liu, Hao ; Hemminki, Kari

Background : This study aimed at elucidating the effect of family history on the development of subsequent cancers in renal cell carcinoma (RCC) survivors and aimed at assessing whether the interactions between risks of subsequent cancers in RCC survivors and familial risk of subsequent cancer are additive or multiplicative interactions. Methods : A population-based cohort (Swedish Family-Cancer Database) of 14,267 RCC patients diagnosed in 1990–2010 was followed for cancer incidence. [...]

A partir de données d'études d'association sur le génome entier, cette étude met en évidence une association entre des polymorphismes à simple nucléotide situés à proximité des gènes TERC et TERT, la longueur des télomères dans les leucocytes et le risque de gliome

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

Walsh, Kyle M. ; Codd, Veryan ; Smirnov, Ivan V. ; Rice, Terri ; Decker, Paul A. ; Hansen, Helen M. ; Kollmeyer, Thomas ; Kosel, Matthew L. ; Molinaro, Annette M. ; McCoy, Lucie S. ; Bracci, Paige M. ; Cabriga, Belinda S. ; Pekmezci, Melike ; Zheng, Shichun ; Wiemels, Joseph L. ; Pico, Alexander R. ; Tihan, Tarik ; Berger, Mitchell S. ; Chang, Susan M. ; Prados, Michael D. ; Lachance, Daniel H. ; O'Neill, Brian Patrick ; Sicotte, Hugues ; Eckel-Passow, Jeanette E. ; Engage Consortium Telomere Group ; van der Harst, Pim ; Wiencke, John K. ; Samani, Nilesh J. ; Jenkins, Robert B. ; Wrensch, Margaret R.

Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10−9) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between [...]