Cet article présente les recommandations de l'ASCO (American Society of Clinical Oncology) sur la prévention et la prise en charge des neuropathies périphériques induites par la chimiothérapie chez les adultes ayant survécu à un cancer

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

Hershman, Dawn L. ; Lacchetti, Christina ; Dworkin, Robert H. ; Lavoie Smith, Ellen M. ; Bleeker, Jonathan ; Cavaletti, Guido ; Chauhan, Cynthia ; Gavin, Patrick ; Lavino, Antoinette ; Lustberg, Maryam B. ; Paice, Judith ; Schneider, Bryan ; Smith, Mary Lou ; Smith, Tom ; Terstriep, Shelby ; Wagner-Johnston, Nina ; Bak, Kate ; Loprinzi, Charles L.

Purpose : To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. Methods : A systematic literature search identified relevant, randomized controlled trials (RCTs) for the treatment of CIPN. Primary outcomes included incidence and severity of neuropathy as measured by neurophysiologic changes, patient-reported outcomes, and quality of life. Results : A total of 48 [...]

Cet article présente des recommandations canadiennes, complétées et adoptées par l'ASCO (The American Society of Clinical Oncology), sur la détection, l'évaluation et la prise en charge des symptômes de fatigue chez les adultes ayant survécu à un cancer

Screening, Assessment, and Management of Fatigue in Adult Survivors of Cancer: An American Society of Clinical Oncology Clinical Practice Guideline Adaptation

Bower, Julienne E. ; Bak, Kate ; Berger, Ann ; Breitbart, William ; Escalante, Carmelita P. ; Ganz, Patricia A. ; Schnipper, Hester Hill ; Lacchetti, Christina ; Ligibel, Jennifer A. ; Lyman, Gary H. ; Ogaily, Mohammed S. ; Pirl, William F. ; Jacobsen, Paul B.

Purpose : This guideline presents screening, assessment, and treatment approaches for the management of adult cancer survivors who are experiencing symptoms of fatigue after completion of primary treatment. Methods : A systematic search of clinical practice guideline databases, guideline developer Web sites, and published health literature identified the pan-Canadian guideline on screening, assessment, and care of cancer-related fatigue in adults with cancer, the National Comprehensive Cancer [...]

Menée sur 101 patients atteints d'un cancer (âge : 30 à 77 ans), cette étude évalue l'effet d'un programme d'interventions, comportant des exercices physiques pendant quatre mois, sur la consommation maximale d'oxygène, les symptômes de fatigue liés à la maladie et la qualité de vie des patients durant et après le traitement

Changes in exercise capacity, quality of life and fatigue in cancer patients during an intervention

Banzer, W. ; Bernhörster, M. ; Schmidt, K. ; Niederer, D. ; Lungwitz, A. ; Thiel, C. ; Jäger, E. ; Vogt, L.

The study explored the interdependence of changes in oxygen uptake, quality of life and cancer-related side-effect fatigue during a 4-month exercise intervention. Participants were during adjuvant (curative) or palliative therapy and post-adjuvant therapy (finished within the previous 12 months). Aerobic exercise capacity (VO2peak), quality of life and fatigue symptom (EORTC QLQ-C30) were obtained in 101 cancer patients (30–77 years). After initial examination, patients participated in [...]

A partir d'une revue systématique de la littérature (10 articles), cette étude évalue l'intérêt de pratiquer des exercices physiques pour réduire les symptômes de fatigue liés au cancer du poumon

Exercise for the management of cancer-related fatigue in lung cancer: a systematic review

Paramanandam, V. S. ; Dunn, V.

Cancer-related fatigue is a common, persistent and disabling side-effect of the cancer and its treatments. Exercise, once was contraindicated, is now the key non-pharmacological management for cancer-related fatigue. However, the role of exercise in lung cancer cohort is not clear. A computerised database search was undertaken using keyword search in the CENTRAL, PubMed, EMBASE, CINAHL, SPORTDiscus, AMED and Web of Science. Ten relevant articles were reviewed; the evidence on this cohort was [...]

Mené sur 155 patients atteints d'un cancer de la tête et du cou traité par radiothérapie avec ou sans chimiothérapie, cet essai de phase III évalue l'efficacité de la doxépine en rinçage buccal pour réduire la douleur associée à une mucite buccale aiguë induite par les rayonnements ionisants

Doxepin Rinse Versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy With or Without Chemotherapy: A Phase III, Randomized, Double-Blind Trial (NCCTG-N09C6 [Alliance])

Leenstra, James L. ; Miller, Robert C. ; Qin, Rui ; Martenson, James A. ; Dornfeld, Kenneth J. ; Bearden, James D. ; Puri, Dev R. ; Stella, Philip J. ; Mazurczak, Miroslaw A. ; Klish, Marie D. ; Novotny, Paul J. ; Foote, Robert L. ; Loprinzi, Charles L.

Purpose : Painful oral mucositis (OM) is a significant toxicity during radiotherapy for head and neck cancers. The aim of this randomized, double-blind, placebo-controlled trial was to test the efficacy of doxepin hydrochloride in the reduction of radiotherapy-induced OM pain. Patients and Methods : In all, 155 patients were randomly allocated to a doxepin oral rinse or a placebo for the treatment of radiotherapy-related OM pain. Patients received a single dose of doxepin or placebo on day 1 [...]

Menée à partir de questionnaires auprès de 1 622 hommes adultes ayant survécu à un cancer pédiatrique et auprès de 274 témoins, cette étude américano-canadienne évalue le taux d'infertilité masculine auto-rapportée et identifie les facteurs de risque liés aux traitements anticancéreux

Male infertility in long-term survivors of pediatric cancer: a report from the childhood cancer survivor study

Wasilewski-Masker, K. ; Seidel, K. D. ; Leisenring, W. ; Mertens, A. C. ; Shnorhavorian, M. ; Ritenour, C. W. ; Stovall, M. ; Green, D. M. ; Sklar, C. A. ; Armstrong, G. T. ; Robison, L. L. ; Meacham, L. R.

Purpose : The purpose of this study was to assess the prevalence of male infertility and treatment-related risk factors in childhood cancer survivors. Methods : Within the Childhood Cancer Survivor Study, 1,622 survivors and 274 siblings completed the Male Health Questionnaire. The analysis was restricted to survivors (938/1,622; 57.8 %) and siblings (174/274; 63.5 %) who tried to become pregnant. Relative risks (RR) and 95 % confidence intervals (CI) for the prevalence of self-reported [...]

Menée à partir des données 2009-2010 du "California Behavioral Risk Factor Surveillance System" portant sur 18 807 adultes, cette étude évalue la prévalence de maladies chroniques chez les patients ayant survécu à un cancer (1 604 cas)

Chronic disease burden among cancer survivors in the California Behavioral Risk Factor Surveillance System, 2009–2010

Tarleton, HeatherP ; Ryan-Ibarra, Suzanne ; Induni, Marta

Purpose : The California Behavioral Risk Factor Surveillance System estimates that 56.6 % of cancer survivors report ever being diagnosed with a chronic disease. Few studies have assessed potential variability in comorbidity by cancer type. Methods : We used data collected from a representative sample of adult participants in the 2009 and 2010 California Behavioral Risk Factor Surveillance System (n = 18,807). Chronic diseases were examined with cancer survivorship in case/non-case and [...]

Menée à l'aide des données des registres municipaux et de données statistiques, cette étude néerlandaise évalue, par rapport à la population générale et en fonction du sexe, le risque de cancer et le risque de décès parmi 37 551 hommes et femmes de la cohorte EPIC-NL (âge : 20 à 70 ans ; durée moyenne de suivi : 14,9 ans)

Mortality and cancer incidence in the EPIC-NL cohort: impact of the healthy volunteer effect

Struijk, Ellen A. ; May, Anne M. ; Beulens, Joline W.J. ; van Gils, Carla H. ; Monninkhof, Evelyn M. ; van der Schouw, Yvonne T. ; Verschuren, Monique W.M. ; Boer, Jolanda M.A. ; Bueno-de-Mesquita, Bas H. ; Peeters, Petra H.M.

Background : Prospective cohort studies recruit relatively healthy population samples, resulting in lower morbidity and mortality rates than in the source population. This is known as the healthy volunteer effect. The aim of this study was to define the magnitude and the development over time of the healthy volunteer effect in the EPIC-NL cohort. Methods : We studied mortality rates in the EPIC-NL cohort, which comprises 37 551 men and women aged 20–70 years at recruitment in 1993–97. The date [...]

Menée aux Etats-Unis à partir de données portant sur 581 femmes atteintes d'un cancer épithélial de l'ovaire, cette étude évalue l'association entre le niveau socio-économique du quartier de résidence et les caractéristiques tumorales

The association between neighborhood socioeconomic status and ovarian cancer tumor characteristics

Peterson, CarynE ; Rauscher, GarthH ; Johnson, TimothyP ; Kirschner, CarolynV ; Barrett, RichardE ; Kim, Seijeoung ; Fitzgibbon, MarianL ; Joslin, CharlotteE ; Davis, FaithG

Purpose : Higher pathologic grade, suboptimal debulking surgery, and late-stage are markers of more aggressive and advanced ovarian cancer. Neighborhood socioeconomic status (SES) has been associated with more aggressive and advanced tumors for other cancer sites, and this may also be true for ovarian cancer. Methods : We examined the association between neighborhood SES and ovarian cancer tumor characteristics using data on 581 women diagnosed with epithelial ovarian cancer in Cook County, [...]

Menée à partir de questionnaires auprès de 149 patients atteints d'un cancer de la tête et du cou traité par radiothérapie ou chimioradiothérapie concomitante, cette étude prospective longitudinale identifie des symptômes survenant au cours du traitement et évalue leur degré de sévérité en fonction du type de traitement reçu

Patterns of symptom burden during radiotherapy or concurrent chemoradiotherapy for head and neck cancer : A prospective analysis using the University of Texas MD Anderson Cancer Center Symptom Inventory-Head and Neck Module

Rosenthal, David I. ; Mendoza, Tito R. ; Fuller, Clifton D. ; Hutcheson, Katherine A. ; Wang, X. Shelley ; Hanna, Ehab Y. ; Lu, Charles ; Garden, Adam S. ; Morrison, William H. ; Cleeland, Charles S. ; Gunn, G. Brandon

BACKGROUND : A prospective longitudinal study to profile patient-reported symptoms during radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) for head and neck cancer was performed. The goals were to understand the onset and trajectory of specific symptoms and their severity, identify clusters, and facilitate symptom interventions and clinical trial design. METHODS : Participants in this questionnaire-based study received RT or CCRT. They completed the University of Texas MD Anderson [...]

Cet article présente les recommandations canadiennes, complétées et adoptées par l'ASCO (The American Society of Clinical Oncology), sur l'évaluation et la prise en charge des symptômes d'anxiété et de dépression chez les adultes atteints d'un cancer

Screening, Assessment, and Care of Anxiety and Depressive Symptoms in Adults With Cancer: An American Society of Clinical Oncology Guideline Adaptation

Andersen, Barbara L. ; DeRubeis, Robert J. ; Berman, Barry S. ; Gruman, Jessie ; Champion, Victoria L. ; Massie, Mary Jane ; Holland, Jimmie C. ; Partridge, Ann H. ; Bak, Kate ; Somerfield, Mark R. ; Rowland, Julia H.

Purpose : A Pan-Canadian Practice Guideline on Screening, Assessment, and Care of Psychosocial Distress (Depression, Anxiety) in Adults With Cancer was identified for adaptation. Methods : American Society of Clinical Oncology (ASCO) has a policy and set of procedures for adapting clinical practice guidelines developed by other organizations. The guideline was reviewed for developmental rigor and content applicability. Results : On the basis of content review of the pan-Canadian guideline, the [...]

Menée en Chine sur 51 patients atteints d'un cancer rhinopharyngé traité par radiothérapie avec modulation d'intensité, cette étude prospective évalue leurs capacités cognitives, la qualité de leur sommeil et leur état psychologique

Cognitive function, mood, and sleep quality in patients treated with intensity-modulated radiation therapy for nasopharyngeal cancer: a prospective study

Mo, Yan-Lin ; Li, Ling ; Qin, Ling ; Zhu, Xiao-Dong ; Qu, Song ; Liang, Xia ; Wei, Zhou-Ji

Objective : The aim of this study was to prospectively evaluate the cognitive function, depression, anxiety, and sleep quality in patients with nasopharyngeal cancer (NPC) before and after intensity-modulated radiotherapy (IMRT). Methods : Eligible patients with newly diagnosed NPC treated with primary IMRT were recruited. A series of neuropsychological tests were performed within 1 week before and after IMRT. Cognitive function was measured with the Das–Naglieri cognitive assessment system. [...]

Menée à partir d'un modèle mathématique, cette étude compare le rapport coût-efficacité d'une radiothérapie avec modulation d'intensité et d'une radiothérapie conformationnelle 3D pour traiter un cancer anal

Cost-Effectiveness Analysis of Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Anal Cancer

Hodges, Joseph C. ; Beg, Muhammad S. ; Das, Prajnan ; Meyer, Jeffrey

Purpose : To compare the cost-effectiveness of intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3D-CRT) for anal cancer and determine disease, patient, and treatment parameters that influence the result. Methods and Materials : A Markov decision model was designed with the various disease states for the base case of a 65-year-old patient with anal cancer treated with either IMRT or 3D-CRT and concurrent chemotherapy. Health states accounting for rates [...]

Menée à partir des données de la base Medicare, cette étude américaine évalue le rapport coût-efficacité du bévacizumab chez les patientes atteintes d'un cancer avancé de l'ovaire à risque élevé de récidive

Bevacizumab in Treatment of High-Risk Ovarian Cancer—A Cost-Effectiveness Analysis

Chan, John K. ; Herzog, Thomas J. ; Hu, Lilian ; Monk, Bradley J. ; Kiet, Tuyen ; Blansit, Kevin ; Kapp, Daniel S. ; Yu, Xinhua

Objective : The objective of this study was to evaluate a cost-effectiveness strategy of bevacizumab in a subset of high-risk advanced ovarian cancer patients with survival benefit. Methods : A subset analysis of the International Collaboration on Ovarian Neoplasms 7 trial showed that additions of bevacizumab (B) and maintenance bevacizumab (mB) to paclitaxel (P) and carboplatin (C) improved the overall survival (OS) of high-risk advanced cancer patients. Actual and estimated costs of treatment [...]