Menée sur 20 patients atteints d'un cancer et présentant une thrombocytopénie liée à la chimiothérapie, cette étude rétrospective évalue l'efficacité, du point de vue du taux de plaquettes sanguines, et la toxicité du romiplostime

Romiplostim for management of chemotherapy-induced thrombocytopenia

Parameswaran, R. ; Lunning, M. ; Mantha, S. ; Devlin, S. ; Hamilton, A. ; Schwartz, G. ; Soff, G.

Purpose : Chemotherapy-induced thrombocytopenia (CIT) can cause delay or reduction in subsequent courses of chemotherapy. Here, we report on a series of 20 patients who had protracted CIT and were treated with romiplostim, a thrombopoietin receptor agonist. Patients and methods : We performed a retrospective review of the use of romiplostim for dose-limiting CIT at Memorial Sloan–Kettering Cancer Center from 2010–2012. Romiplostim was initiated at 1–2 mcg/kg weekly, with dose escalation by 1 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2013 (4 essais, 374 patients au total), cette étude évalue l'efficacité, du point de vue du taux de réponse, et la sécurité de la moxibustion, une technique de stimulation par la chaleur de points d'acupuncture, pour réduire les symptômes de fatigue liés aux traitements chez les patients atteints d'un cancer

The effectiveness and safety of moxibustion for treating cancer-related fatigue: a systematic review and meta-analyses

Lee, Seunghoon ; Jerng, UiMin ; Liu, Yan ; Kang, JungWon ; Nam, Dongwoo ; Lee, Jae-dong

Purpose : Among cancer patients, cancer-related fatigue (CRF) is one of the most common symptoms and adversely affects physical ability and quality of life even several years after treatment. This study aims to evaluate the current evidence for moxibustion in patients with CRF. Methods : Eighteen databases were searched from their inception to April 2013. All randomized controlled trials (RCTs) of moxibustion for treating CRF without language restriction were considered for inclusion. The risk [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2012 (24 essais), cette étude évalue l'intérêt d'utiliser en routine des mesures rapportées par les patients pour améliorer leur qualité de vie et la qualité des soins durant les traitements anticancéreux

What Is the Value of the Routine Use of Patient-Reported Outcome Measures Toward Improvement of Patient Outcomes, Processes of Care, and Health Service Outcomes in Cancer Care? A Systematic Review of Controlled Trials

Kotronoulas, Grigorios ; Kearney, Nora ; Maguire, Roma ; Harrow, Alison ; Di Domenico, David ; Croy, Suzanne ; MacGillivray, Stephen

Purpose : The systematic use of patient-reported outcome measures (PROMs) has been advocated as an effective way to standardize cancer practice. Yet, the question of whether PROMs can lead to actual improvements in the quality of patient care remains under debate. This review examined whether inclusion of PROM in routine clinical practice is associated with improvements in patient outcomes, processes of care, and health service outcomes during active anticancer treatment. Methods : A systematic [...]

Menée à partir d'une enquête en ligne auprès de 183 oncologues ou infirmières spécialisées en oncologie, cette étude néerlandaise identifie les obstacles à une évaluation médicale spécifique en routine des personnes âgées avant traitement

Geriatric oncology in the Netherlands: a survey of medical oncology specialists and oncology nursing specialists

Jonker, J. M. ; Smorenburg, C. H. ; Schiphorst, A. H. ; van Rixtel, B. ; Portielje, J. E. A. ; Hamaker, M. E.

To identify ways to improve cancer care for older patients, we set out to examine how older patients in the Netherlands are currently being evaluated prior to oncological treatment and to explore the potential obstacles in the incorporation of a geriatric evaluation, using a web-based survey sent to Dutch medical oncology specialists and oncology nursing specialists. The response rate was 34% (183 out of 544). Two-thirds of respondents reported that a geriatric evaluation was being used, [...]

Menées à partir des données de quatre registres américains des cancers portant sur 715 patientes atteintes d'un cancer du col de l'utérus et à l'aide de questionnaires et d'entretiens, cette étude évalue leur qualité de vie à long terme (4 à 28 ans après le diagnostic) en fonction de facteurs socio-démographiques

Quality of life and disparities among long-term cervical cancer survivors

Greenwald, HowardP ; McCorkle, Ruth ; Baumgartner, Kathy ; Gotay, Carolyn ; Neale, AnneVictoria

Purpose : Little population-based research has been done on social, economic, and environmental factors affecting quality of life (QOL) among long-term cancer survivors. This research assesses the impact of disease and nondisease factors on QOL among long-term survivors of cervical cancer. Methods : In a collaborative, observational study, data were obtained from cancer registries, interviews, and self-administered questionnaires. Comparisons of QOL were made between women with cervical cancer [...]

Menée à partir de données californiennes portant sur 33 032 patients atteints d'un lymphome diffus à grandes cellules B diagnostiqué sur la période 1988-2009, cette étude compare, en fonction de facteurs socio-économiques et de l'appartenance ethnique, l'évolution de la mortalité spécifique avant et après l'introduction du rituximab en 2001

Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era

Tao, Li ; Foran, James M. ; Clarke, Christina A. ; Gomez, Scarlett L. ; Keegan, Theresa H. M.

Despite advances in treatment, including the introduction of rituximab, survival after diffuse large B-cell lymphoma (DLBCL) remains heterogeneous. However, no studies have considered the association between neighborhood socioeconomic status (SES) and race/ethnicity on mortality after DLBCL before (1988-2000) and after (2001-2009) the introduction of rituximab. We studied all 33,032 patients diagnosed with DLBCL in 1988-2009 in California for vital status through December 31, 2010. Patients [...]

Menée à partir des données des registres allemands des cancers portant sur 72 742 patientes atteintes d'un cancer du sein diagnostiqué entre 1999 et 2010, cette étude analyse sur une période de 12 ans l'évolution des pratiques chirurgicales dans quatre régions allemandes après la publication de recommandations sur la prise en charge de la maladie

Is primary surgery of breast cancer patients consistent with German guidelines? Twelve-year trend of population-based clinical cancer registry data

Schrodi, S. ; Niedostatek, A. ; Werner, C. ; Tillack, A. ; Schubert-Fritschle, G. ; Engel, J.

This population-based analysis aimed to describe the 12-year trend of primary surgery following the introduction of national guidelines for the management of breast cancer in Germany, thus the implementation of breast-conserving surgery (BCS) for pT1/2-tumours and the implementation of sentinel lymph node biopsy (SLNB). Cancer registry data from 72 742 breast cancer patients diagnosed between 1999 and 2010 in four different regions in Germany were used. Descriptive statistics and multivariate [...]

Menée dans le comté de New Haven (Etats-Unis) à partir de données médicales et socio-démographiques portant sur la période 2008-2011 (âge des femmes : 20 à 39 ans), cette étude analyse la relation entre l'appartenance ethnique, la composition ethnique du quartier de résidence, son niveau socio-économique et le taux de lésions cervicales de haut grade

Interactive effects of individual and neighborhood race and ethnicity on rates of high-grade cervical lesions

Waggaman, Christina ; Julian, Pamela ; Niccolai, Linda M.

We estimated the main and interactive effects of individual race/ethnicity (black, Hispanic, white) and area race, ethnicity, and poverty (proportions of the female population black, Hispanic, and living below the federal poverty level at the census tract level, respectively) on rates of high-grade cervical lesions among young women. Using data from a statewide surveillance system during 2008–2011, we found a marginally significant interaction (P < 0.05) between individual race/ethnicity and [...]

Menée sur 101 patients atteints d'un cancer de stade avancé et traités dans une unité de soins palliatifs, cette étude transversale espagnole identifie les facteurs psychologiques et physiques associés aux demandes des patients relatives à l'euthanasie

Physical and psychological factors and the wish to hasten death in advanced cancer patients

Villavicencio-Chávez, Christian ; Monforte-Royo, Cristina ; Tomás-Sábado, Joaquín ; Maier, Markus A. ; Porta-Sales, Josep ; Balaguer, Albert

Background : Qualitative research suggests that the wish to hasten death (WTHD) in the advanced stages of disease is mainly related to overall suffering. This quantitative study explores the relationship between the WTHD and psychological and physical factors, including survival, in patients with advanced cancer. Methods : Cross-sectional study of 101 advanced cancer patients admitted to an acute Palliative Care Unit (PCU) and followed-up for survival. Patients were assessed using the Schedule [...]

Menée en Australie à partir de questionnaires, cette étude compare la performance de trois systèmes de score pour diagnostiquer une dépression chez les patients atteints d'un cancer de la prostate (191 cas)

Diagnosing ‘male’ depression in men diagnosed with prostate cancer: the next step in effective translational psycho-oncology interventions?

Sharpley, Christopher F. ; Bitsika, Vicki ; Christie, David R. H.

Background : Depression in men diagnosed with prostate cancer is associated with several adverse outcomes. However, some data suggest that standard methods of assessing depression in males via the criteria for Major Depressive Disorder (MDD) may omit several extra key symptoms of male depression. Therefore, this study tested the comparative effects of standard MDD-based diagnostic criteria for depression and criteria for ‘male depression’ in a sample of men diagnosed with prostate cancer. [...]

Menée à partir des données de trois enquêtes auprès d'une cohorte de 412 patientes atteintes d'un cancer du sein et nées entre 1946 et 1951, cette étude australienne évalue l'association entre le soutien social et la qualité de vie des patientes

Social support and health-related quality of life in women with breast cancer: a longitudinal study

Leung, Janni ; Pachana, Nancy A. ; McLaughlin, Deirdre

Objectives : A breast cancer diagnosis is a distressing event that impacts on physical and psychological functioning. This study examined the longitudinal relationships among a diagnosis of breast cancer, social support, and health-related quality of life (HRQOL). Methods : Participants were 412 women from the 1946–1951 birth cohort of the Australian Longitudinal Study on Women's Health who self-reported a new diagnosis of breast cancer between 1998 and 2007. The three surveys of longitudinal [...]

Menée à l'aide d'un modèle mathématique, cette étude évalue le rapport coût-efficacité d'un test moléculaire basé sur l'expression de 14 gènes et destiné à prédire le risque de décès chez les patients atteints d'un cancer du poumon non à petites cellules, non épidermoïde de stade précoce

Cost-Effectiveness of a 14-Gene Risk Score Assay to Target Adjuvant Chemotherapy in Early Stage Non-Squamous Non-Small Cell Lung Cancer

Roth, Joshua A. ; Billings, Paul ; Ramsey, Scott D. ; Dumanois, Robert ; Carlson, Josh J.

Purpose. Life Technologies has developed a 14-gene molecular assay that provides information about the risk of death in early stage non-squamous non-small cell lung cancer patients after surgery. The assay can be used to identify patients at highest risk of mortality, informing subsequent treatments. The objective of this study was to evaluate the cost-effectiveness of this novel assay. Patients and Methods. We developed a Markov model to estimate life expectancy, quality-adjusted life years [...]