Menée auprès de 602 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë et auprès de 918 témoins, cette étude italienne évalue l'association entre une exposition prénatale ou postnatale à la fumée du tabac et le risque de développer la maladie durant l'enfance

Tobacco smoke and risk of childhood acute lymphoblastic leukemia: findings from the SETIL case–control study

Farioli, Andrea ; Legittimo, Patrizia ; Mattioli, Stefano ; Miligi, Lucia ; Benvenuti, Alessandra ; Ranucci, Alessandra ; Salvan, Alberto ; Rondelli, Roberto ; Conter, Valentino ; Magnani, Corrado

Purpose : Tobacco smoke could cause childhood acute lymphoblastic leukemia (ALL) through at least three pathways: (1) prenatal parental smoking; (2) fetal exposure through maternal smoking during pregnancy; and (3) childhood exposure to secondhand smoke (SHS). We tested these hypotheses in a large population-based case–control study (SETIL) primarily designed to evaluate the role of electromagnetic fields in childhood hematopoietic malignancies. Methods : From 1998 to 2003, we enrolled 602 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2013 (9 études cas-témoins), cette méta-analyse évalue l'association entre trois types de régimes alimentaires et le risque de carcinome épidermoïde de l'œsophage

Dietary patterns and oesophageal squamous cell carcinoma: a systematic review and meta-analysis

Liu, X. ; Wang, X. ; Lin, S. ; Yuan, J. ; Yu, I. T. S.

Background/Objective : Dietary patterns, which represent a complex integration of food and nutrients, have been used to explore the association between dietary factors and the risk of oesophageal cancer. However, the association remains unclear. This systematic review was performed to evaluate the relationship between dietary patterns and oesophageal squamous cell carcinoma (ESCC) by pooling available data from existing studies. Methods : Pertinent articles published up to the end of 2013 were [...]

Menée en Angleterre et au pays de Galles auprès d'une cohorte de 14 008 travailleurs de l'industrie chimique (durée de suivi : 73 ans), cette étude évalue l'association entre une exposition professionnelle au formaldéhyde et le risque de leucémie myéloïde, de cancer des voies respiratoires supérieures ou autres

Upper Airway Cancer, Myeloid Leukemia, and Other Cancers in a Cohort of British Chemical Workers Exposed to Formaldehyde

Coggon, David ; Ntani, Georgia ; Harris, E. Clare ; Palmer, Keith T.

The International Agency for Research on Cancer controversially has classified formaldehyde as causing nasopharyngeal carcinoma and myeloid leukemia. To provide further information on this question, we extended follow-up of a cohort of 14,008 chemical workers at 6 factories in England and Wales, covering the period 1941–2012. Mortality was compared with national death rates for England and Wales, and associations with incident upper airway cancer and leukemia were explored in nested [...]

Menée à partir de données de 13 études cas-témoins portant au total sur 8 236 mères, 8 169 pères et 29 051 témoins, cette étude évalue l'association entre une exposition professionnelle des parents aux pesticides et le risque de leucémie chez l'enfant

Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Bailey, Helen D. ; Fritschi, Lin ; Infante-Rivard, Claire ; Glass, Deborah C. ; Miligi, Lucia ; Dockerty, John D. ; Lightfoot, Tracy ; Clavel, Jacqueline ; Roman, Eve ; Spector, Logan G. ; Kaatsch, Peter ; Metayer, Catherine ; Magnani, Corrado ; Milne, Elizabeth ; Polychronopoulou, Sophia ; Simpson, Jill ; Rudant, Jérémie ; Sidi, Vasiliki ; Rondelli, Roberto ; Orsi, Laurent ; Kang, Alice Y. ; Petridou, Eleni ; Schüz, Joachim

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional [...]

Menée à partir des données d'un registre ukrainien portant sur une cohorte de 150 813 hommes étant intervenus sur les lieux de la centrale nucléaire de Tchernobyl après la catastrophe ("liquidateurs"), cette étude évalue l'incidence de cancer de la thyroïde sur la période 1986-2010

Thyroid cancer incidence in Chornobyl liquidators in Ukraine: SIR analysis, 1986–2010

Ostroumova, Evgenia ; Gudzenko, Nataliya ; Brenner, Alina ; Gorokh, Yevgeniy ; Hatch, Maureen ; Prysyazhnyuk, Anatoliy ; Mabuchi, Kiyohiko ; Bazyka, Dimitry

We studied thyroid cancer incidence in a cohort of 150,813 male Chornobyl clean-up workers (“liquidators”) from Ukraine by calculating standardized incidence ratio (SIR) using national cancer statistics. Follow-up began on the liquidator’s registration date with the Chornobyl State Registry of Ukraine (the earliest date was 05. 05. 1986) and continued through December 31, 2010, date of thyroid cancer diagnosis, date of death, or date of last known vital status, whichever came first. There were [...]

Menée auprès de 585 patientes atteintes d'un cancer du sein et de 1 170 témoins, cette étude évalue l'association entre le niveau urinaire de cadmium et le risque de cancer du sein par sous-type moléculaire (ER ou HER2)

Association between cadmium and breast cancer risk according to estrogen receptor and human epidermal growth factor receptor 2: epidemiological evidence

Strumylaite, L. ; Kregzdyte, R. ; Bogusevicius, A. ; Poskiene, L. ; Baranauskiene, D. ; Pranys, D.

The study aimed to examine the association between cadmium (Cd) and the risk of breast cancer according to estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). A hospital-based case-control study was carried out in 585 cases and 1,170 controls. Information on possible risk factors was collected via a structured questionnaire. Urinary Cd was determined by atomic absorption spectrometry. The ER and HER2 levels in tumor tissue were analyzed by immunohistochemistry. Logistic [...]

A partir d'une revue de la littérature (16 études, 12 010 cas et 77 970 témoins), cette méta-analyse évalue l'association entre des génotypes de l'apolipoprotéine E, une protéine impliquée principalement dans le métabolisme des lipoprotéines, et le risque de cancer

Association between apolipoprotein E genotype and cancer susceptibility: a meta-analysis

Anand, R. ; Prakash, S. S. ; Veeramanikandan, R. ; Kirubakaran, Richard

Background : Apolipoprotein E (ApoE), a protein primarily involved in lipoprotein metabolism, occurs in three isoforms (E2, E3 and E4). Studies evaluating the association between APOE genotype and incidence of malignancies have given inconclusive results. Objective : The objective of the present study was to analyze the association between APOE genotype and incidence of cancer by a meta-analysis. Methods : We conducted a literature search in the electronic databases for studies with information [...]

A partir d'une revue de la littérature (6 études cas-témoins), cette méta-analyse évalue l'association entre des polymorphismes du gène de la glutathion S-transférase et le risque d'ostéosarcome

The association of glutathione S-transferase polymorphisms in patients with osteosarcoma: evidence from a meta-analysis

Wang, Z. ; Xu, H. ; He, M. ; Wu, H. ; Zhu, Y. ; Su, Z.

Osteosarcoma is a life-threatening malignancy that often occurs in teenagers. Numerous studies have reported glutathione S-transferase polymorphisms are associated with osteosarcoma, but the results are inconclusive, partially because the sample size in each of published studies is relatively small. Therefore, we performed a meta-analysis of the published studies to estimate the association more accurately. To preciously examine the association between the glutathione S-transferase [...]

Menée auprès de 272 patients atteints d'un cancer agressif de la prostate et auprès de 272 témoins, cette étude met en évidence une absence d'association entre les niveaux plasmatiques de l'adiponectine ou du peptide c et le risque de développer la maladie

No Association of Plasma Levels of Adiponectin and c-peptide with Risk of Aggressive Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort

Stevens, V. L. ; Jacobs, E. J. ; Sun, J. ; Gapstur, S. M.

BACKGROUND : Obesity is associated with a higher risk of aggressive prostate cancer and alters circulating levels of insulin and adiponectin, two hormones that influence biologic processes implicated in carcinogenesis. Results of some studies showed associations of circulating levels of adiponectin, insulin, and c-peptide (a marker of insulin secretion) with aggressive prostate cancer, but the size of these studies was limited. METHODS : A nested case-control study of 272 aggressive prostate [...]

Menée sur 1 399 patients atteints d'un cancer colorectal et sur 838 témoins, cette étude analyse l'association entre 35 polymorphismes à simple nucléotide de 10 gènes de la lignée germinale et le risque de cancer colorectal ou la survie des patients

Colorectal cancer risk and patients’ survival: influence of polymorphisms in genes somatically mutated in colorectal tumors

Huhn, Stefanie ; Bevier, Melanie ; Pardini, Barbara ; Naccarati, Alessio ; Vodickova, Ludmila ; Novotny, Jan ; Vodicka, Pavel ; Hemminki, Kari ; Försti, Asta

Purpose : The first two studies aiming for the high-throughput identification of the somatic mutation spectrum of colorectal cancer (CRC) tumors were published in 2006 and 2007. Using exome sequencing, they described 69 and 140 candidate cancer genes (CAN genes), respectively. We hypothesized that germline variants in these genes may influence CRC risk, similar to APC, which is causing CRC through germline and somatic mutations. Methods : After excluding the well-established CRC genes APC, [...]

Nichée dans l'étude de cohorte EPIC, cette étude évalue, en fonction de l'utilisation ou non d'un traitement hormonal substitutif, l'association entre le niveau sérique de prolactine avant diagnostic et le risque de cancer du sein chez les femmes ménopausées ou en préménopause (2 250 cas et 2 250 témoins)

Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort

Tikk, K. ; Sookthai, D. ; Johnson, T. ; Rinaldi, S. ; Romieu, I. ; Tjønneland, A. ; Olsen, A. ; Overvad, K. ; Clavel-Chapelon, F. ; Baglietto, L. ; Boeing, H. ; Trichopoulou, A. ; Lagiou, P. ; Trichopoulos, D. ; Palli, D. ; Pala, V. ; Tumino, R. ; Rosso, S. ; Panico, S. ; Agudo, A. ; Menendez, V. ; Sánchez, M.-J. ; Amiano, P. ; Castaño, J.M. Huerta ; Ardanaz, E. ; Bueno-de-Mesquita, H.B. ; Monninkhof, E. ; Onland-Moret, C. ; Andersson, A. ; Sund, M. ; Weiderpass, E. ; Khaw, K.-T. ; Key, T.J. ; Travis, R.C. ; Gunter, M.J. ; Riboli, E. ; Dossus, L. ; Kaaks, R.

Background : Experimental and epidemiological evidence suggests that prolactin might play a role in the etiology of breast cancer. We analyzed the relationship of pre-diagnostic circulating prolactin levels with the risk of breast cancer by menopausal status, use of postmenopausal hormone replacement therapy (HRT) at blood donation, and by estrogen and progesterone receptor-status of the breast tumors. Methods : Conditional logistic regression was used to analyze the data from a case-control [...]

Menée en Chine auprès de 1 557 ouvriers travaillant dans une cokerie (fours à coke), cette étude analyse l'association entre 25 polymorphismes à simple nucléotide liés au risque de cancer du poumon et les dommages causés à l'ADN par les hydrocarbures aromatiques polycycliques

Associations between 25 lung cancer risk-related SNPs and polycyclic aromatic hydrocarbon-induced genetic damage in coke oven workers

Dai, X. ; Deng, S. ; Wang, T. ; Qiu, G. ; Li, J. ; Yang, B. ; Feng, W. ; He, X. ; Deng, Q. ; Ye, J. ; Zhang, W. ; He, M. ; Zhang, X. ; Guo, H. ; Wu, T.

Background : Genome-wide association studies have identified multiple SNPs associated with lung cancer. However, whether these SNPs are associated with genetic damage, a crucial event in cancer initiation and evolution, is still unknown. We aimed to establish associations between these SNPs and genetic damage caused by the ubiquitous carcinogens, polycyclic aromatic hydrocarbons (PAHs). Methods : We cross-sectionally investigated the associations between SNPs from published genome-wide [...]