A partir d'une revue systématique de la littérature et des recommandations internationales existant sur le sujet, cette étude de la Société allemande d'hématologie et d'oncologie médicale présente ses recommandations relatives à l'utilisation d'un traitement prophylactique par facteurs de croissance granulocytaire (G-CSF) pour la prévention des complications infectieuses chez des patients atteints de cancer et recevant une chimiothérapie

Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy—evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO)

Vehreschild, J. J. ; Böhme, A. ; Cornely, O. A. ; Kahl, C. ; Karthaus, M. ; Kreuzer, K.-A. ; Maschmeyer, G. ; Mousset, S. ; Ossendorf, V. ; Penack, O. ; Vehreschild, M. J. G. T. ; Bohlius, J.

Background : Current evidence on myelopoietic growth factors is difficult to overview for the practicing haematologist/oncologist. International guidelines are sometimes conflicting, exclude certain patient groups, or cannot directly be applied to the German health system. This guideline by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO) gives evidence-based recommendations for the use of G-CSF, pegylated G-CSF, and biosimilars to [...]

A partir d'une revue systématique de la littérature, cette étude analyse les recommandations existantes pour la prise en charge de la douleur associée aux traitements et examens de diagnostic chez les patients atteints de cancer

Pain related to cancer treatments and diagnostic procedures: a no man's land?

Ripamonti, C. I. ; Bossi, P. ; Santini, D. ; Fallon, M.

Background : While guidelines are available for the management of cancer-related pain, little attention is given to the assessment and treatment of pain caused by treatments and diagnostic procedures in cancer patients. Methods : We evaluated the literature on pain related to cancer treatment and diagnostic procedures within a critical analysis. Results : The data available are sparse, suggesting that little attention has been directed at this important aspect of oncology. This points to [...]

A partir d'une revue systématique de la littérature (11 études, 1 557 participantes), cette étude analyse l'efficacité et la sécurité de médicaments probiotiques, utilisés principalement pour traiter les diarrhées sévères, chez les patients atteints de cancer

The Efficacy and Safety of Probiotics in People with Cancer: A Systematic Review

Redman, M. G. ; Ward, E. J. ; Phillips, R. S.

Background : Probiotics are living microorganisms that are generally thought of as being beneficial to the recipient. They have been shown to be effective in people with acute infectious diarrhoea, and cost-effective in antibiotic-associated diarrhoea. Probiotics may have a role in people with cancer, as various cancer treatments often lead to diarrhoea. However, as people with cancer are often immunocompromised, it is important to assess for adverse events such as infection, which could [...]

Menée au Royaume-Uni par entretiens auprès de 16 professionnels de santé, cette étude qualitative analyse leurs opinions et leurs expériences en matière de prise en charge de la douleur chez des patients atteints d'un cancer de stade avancé

“We all talk about it as though we’re thinking about the same thing.” Healthcare professionals’ goals in the management of pain due to advanced cancer: a qualitative study

Rebecca, Bhatia ; Jane, Gibbins ; Karen, Forbes ; Colette, Reid

Purpose : Unfortunately, several barriers impede successful management of cancer pain including those relating to the assessment and measurement of pain. There is currently no consensus as to what constitutes good pain control or what healthcare professionals are aiming to achieve in the management of pain for patients with advanced cancer. This study aimed to explore healthcare professionals’ views and experiences to elicit what they are aiming to achieve in managing pain for patients with [...]

Cette étude présente les recommandations de la Société italienne d'oncologie médicale relatives à la vaccination de la grippe saisonnière pour les patients atteints de cancer

Vaccination for seasonal influenza in patients with cancer: recommendations of the Italian Society of Medical Oncology (AIOM)

Pedrazzoli, P. ; Baldanti, F. ; Donatelli, I. ; Castrucci, M.R. ; Puglisi, F. ; Silvestris, N. ; Cinieri, S.

Background : Influenza virus causes annual epidemics in the winter-spring season with significant morbidity in the general population and important mortality in high-risk groups, including cancer patients. Opinions on the suitability of patients with malignancies not undergoing active treatment and in different phases of antineoplastic therapy, to receive influenza vaccination vary considerably among oncologists, sometimes even within one center. Methods : We reviewed available data, including [...]

A partir d'une revue systématique de la littérature publiée de 1974 à 2013, cette étude analyse l'association entre une thérapie analgésique à base d'opioïdes et un hypogonadisme chez des patients atteints de cancer

A systematic review of opioid effects on the hypogonadal axis of cancer patients

McWilliams, Kerry ; Simmons, Claribel ; Laird, BarryJ ; Fallon, MarieT

Purpose : Opioids are the mainstay of analgesic therapy in patients with cancer-related pain. While many of the side effects of opioids are well documented, the effect on the hypogonadal axis is less well understood. The aim of this systematic review is to examine the relationship between opioid therapy and hypogonadism in patients with cancer. Methods : An electronic search of the following databases was undertaken: MEDLINE, Embase and CINAHL from 1974 to August 2013. To be eligible for [...]

A partir de données issues d'un essai de phase III évaluant le sunitib et l'interféron-alpha pour le traitement d'un carcinome métatastique à cellules rénales, cette étude analyse le degré de fatigue associée au sunitinib et son impact sur la qualité de vie autodéclarée des patients

Characterizing fatigue associated with sunitinib and its impact on health-related quality of life in patients with metastatic renal cell carcinoma

Cella, David ; Davis, Mellar P. ; Négrier, Sylvie ; Figlin, Robert A. ; Michaelson, M. Dror ; Bushmakin, Andrew G. ; Cappelleri, Joseph C. ; Sandin, Rickard ; Korytowsky, Beata ; Charbonneau, Claudie ; Matczak, Ewa ; Motzer, Robert J.

BACKGROUND Using phase 3 trial data for sunitinib versus interferon (IFN)-α in treatment-naive patients with metastatic renal cell carcinoma, retrospective analyses characterized sunitinib-associated fatigue and its impact on patient-reported health-related quality of life (HRQoL). METHODS : Patients received sunitinib at a dose of 50 mg/day on a schedule of 4 weeks on/2 weeks off (375 patients) or IFN-α at a dose of 9 MU subcutaneously 3 times per week (360 patients). HRQoL was self-assessed [...]

Menée au Canada par entretiens auprès de neuf survivantes d'un cancer du sein, cette étude qualitative analyse leurs expériences relatives à une intervention visant à perdre du poids et à pratiquer une activité physique

Breast cancer survivors’ perspectives on a weight loss and physical activity lifestyle intervention

Balneaves, LyndaG ; Patten, Cheri ; Truant, TracyL O. ; Kelly, MaryT ; Neil, SarahE ; Campbell, KristinL

Purpose : The purpose of this study is to qualitatively describe the experiences of breast cancer survivors who took part in a successful 24-week lifestyle intervention aimed at weight loss. The aim was to inform future study designs and lifestyle interventions. Methods : Nine women who completed the lifestyle intervention took part in either a focus group or telephone interviews with trained facilitators who were not involved in the delivery of the intervention. Interviews were transcribed [...]

Cette étude passe en revue l'évolution de l'incidence, de la survie et de la mortalité associées au cancer de l'estomac, ainsi que les facteurs de risque environnementaux ou génétiques, et les statégies de détection précoce et de prévention

Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

Karimi, Parisa ; Islami, Fahrad ; Anandasabapathy, Sharmila ; Freedman, Neal D. ; Kamangar, Farin

Less than a century ago, gastric cancer (GC) was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, GC remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. We first discuss the descriptive epidemiology of GC, including its incidence, survival, and mortality, including trends over time. Next, we characterize the risk factors for [...]

A partir des données de la cohorte "Iowa Women's Health Study" incluant 2 118 survivantes d'un cancer après la ménopause, cette étude prospective évalue l'association entre une supplémentation en multivitamines et en vitamines E, la qualité du régime alimentaire et la mortalité

The association between postdiagnosis dietary supplement use and total mortality differs by diet quality among older female cancer survivors

Inoue-Choi, Maki ; Greenlee, Heather ; Oppeneer, Sarah J. ; Robien, Kim

Background: Dietary supplements are widely used by cancer survivors. However, health effects among older cancer survivors are unclear. Methods: We used the Iowa Women's Health Study, a prospective cohort study with 2,118 postmenopausal women with a confirmed cancer diagnosis (1986-2002), to evaluate the association between postdiagnosis dietary supplement use assessed in 2004 and subsequent all-cause mortality. Risk of death was evaluated using multivariable-adjusted Cox proportional hazards [...]

A partir des données de 21 registres des cancers en France, cette étude analyse l'évolution de l'incidence de 19 types de cancers solides ainsi que la mortalité, sur la période 1980–2012

Cancer incidence and mortality in France over the 1980–2012 period: Solid tumors

Binder-Foucard, F. ; Bossard, N. ; Delafosse, P. ; Belot, A. ; Woronoff, A. S. ; Remontet, L.

Background : Cancer incidence and mortality estimates for 19 cancers (among solid tumors) are presented for France between 1980 and 2012. Methods : Incidence data were collected from 21 local registries and correspond to invasive cancers diagnosed between 1975 and 2009. Mortality data for the same period were provided by the Institut national de la santé et de la recherche médicale. The national incidence estimates were based on the use of mortality as a correlate of incidence. The observed [...]

Menée à partir des données de la cohorte "Childhood Cancer Survivor Study" portant sur 14 359 survivants d'un cancer de l'enfance (cancer diagnostiqué avant l'âge de 21 ans) et sur 4 301 témoins, cette étude analyse l'incidence de pathologies graves et la mortalité en fonction de l'âge

Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study

Armstrong, Gregory T. ; Kawashima, Toana ; Leisenring, Wendy ; Stratton, Kayla ; Stovall, Marilyn ; Hudson, Melissa M. ; Sklar, Charles A. ; Robison, Leslie L ; Oeffinger, Kevin C.

Purpose : The first generation of childhood cancer survivors is now aging into their fourth and fifth decades of life, yet health risks across the aging spectrum are not well established. Methods : Analyses included 14,359 5-year survivors from the Childhood Cancer Survivor Study, who were first diagnosed when they were younger than 21 years old and who received follow-up for a median of 24.5 years after diagnosis (range, 5.0 to 39.3 years) along with 4,301 of their siblings. Among the [...]

A partir des données d'une cohorte allemande incluant 1 491 participants, cette étude analyse l'association entre le lieu où sont dispensés les traitements par inihibiteurs de tyrosine kinase (hôpital municipal, cabinet médical, CHU) et la survie des patients atteints d'une leucémie myéloïde chronique

The impact of healthcare settings on survival time of patients with chronic myeloid leukemia

Lauseker, Michael ; Hasford, Joerg ; Pfirrmann, Markus ; Hehlmann, Rüdiger

With the introduction of tyrosine kinase inhibitors the treatment of chronic myeloid leukemia (CML) patients has migrated extensively to municipal hospitals (MH) and office-based physicians (OBP). Thus we wanted to check whether the health care setting has an impact on outcome. Based on 1491 patients of the German CML study IV, we compared the outcomes of patients from teaching hospitals (TH) to those from MH and OBP. Adjusting for age, EUTOS score, Karnofsky performance status, year of [...]

Menée aux Etats-Unis auprès de 1 068 femmes blanches, 1 670 femmes d'origine hispanique, 993 femmes afro-américaines et 674 femmes d'origine asatique âgées de 18 à 79 ans lors du diagnostic d'un cancer du sein, cette étude analyse l'association entre le statut socioéconomique du lieu de résidence, le statut socioéconomique indidivuel et la survie des patientes

Impact of neighborhood and individual socioeconomic status on survival after breast cancer varies by race/ethnicity: The Neighborhood and Breast Cancer Study

Shariff-Marco, Salma ; Yang, Juan ; John, Esther M. ; Sangaramoorthy, Meera ; Hertz, Andrew ; Koo, Jocelyn ; Nelson, David ; Schupp, Clayton W. ; Shema, Sarah J. ; Cockburn, Myles ; Satariano, William A. ; Yen, Irene H. ; Ponce, Ninez A. ; Winkleby, Marilyn A. ; Keegan, Theresa H.M. ; Gomez, Scarlett L.

Background: Research is limited on the independent and joint effects of individual- and neighborhood-level socioeconomic status (SES) on breast cancer survival across different racial/ethnic groups. Methods: We studied individual-level SES, measured by self-reported education, and a composite neighborhood SES (nSES) measure in females (1,068 non-Hispanic whites, 1,670 Hispanics, 993 African-Americans, and 674 Asian-Americans), aged 18-79 years and diagnosed 1995-2008, in the San Francisco Bay [...]

Menée aux Etats-Unis auprès de survivantes d'un cancer du sein de stade I à IIIA diagnostiqué entre 1995 et 1999, cette étude de cohorte prospective multiethnique évalue l'association entre des changements dans la longueur des télomères des leucocytes du sang péripérique et la mortalité

Change in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors

Duggan, Catherine ; Risques, Rosana ; Alfano, Catherine ; Prunkard, Donna ; Imayama, Ikuyo ; Holte, Sarah ; Baumgartner, Kathy ; Baumgartner, Rick ; Bernstein, Leslie ; Ballard-Barbash, Rachel ; Rabinovitch, Peter ; McTiernan, Anne

Background : Progressive telomere shortening with cell division is a hallmark of aging. Short telomeres are associated with increased cancer risk, but there are conflicting reports about telomere length and mortality in breast cancer survivors. Methods : We measured peripheral blood leukocyte telomere length at two time points in women enrolled in a multiethnic, prospective cohort of stage I to stage IIIA breast cancer survivors diagnosed between 1995 and 1999 with a median follow-up of 11.2 [...]

Menée en Australie auprès de 221 grands-parents d'enfants atteints de cancer et de 134 témoins (âge moyen : 65, 47 ans), cette étude analyse la prévalence de symptômes d'anxiété et de dépression, ainsi que les obstacles à l'accès à des soins psychosociaux

Grandparents of children with cancer: a controlled study of distress, support, and barriers to care

Wakefield, Claire E. ; Drew, Donna ; Ellis, Sarah J. ; Doolan, Emma L. ; McLoone, Jordana K. ; Cohn, Richard J.

Objective : For families under stress, positive grandparental relationships provide a valued ‘safety net’. However, coping with family stressors can place a heavy burden on older individuals who may be experiencing declining health/energy themselves. This mixed-methods study assessed the prevalence of distress in grandparents of children with, and without, cancer, aiming to identify predictors of grandparental distress and quantify their barriers to care. Methods : Two hundred twenty-one [...]

Menée en Allemagne auprès de 20 survivants à long terme d'un cancer pédiatrique (âge : supérieur à 15 ans), cette étude analyse l'efficacité d'une intervention psychosociale, comportementale et cognitive en ligne pour diminuer les symptômes d'anxiété et de stress post-traumatique

Efficacy of an internet-based cognitive-behavioral intervention for long-term survivors of pediatric cancer: a pilot study

Seitz, DianaChristineMaria ; Knaevelsrud, Christine ; Duran, Gabriele ; Waadt, Sabine ; Loos, Sabine ; Goldbeck, Lutz

Purpose : Long-term survivors of pediatric cancer have an increased risk of post-traumatic stress symptoms (PTSS) and dysfunctional anxiety. However, there is a lack of evidence-based psychotherapy tailored to the needs of this target group. In this single-arm pilot study, an Internet-based psychological intervention (“Onco-STEP”) for adolescent and young adult survivors was developed, and its efficacy in reducing PTSS and anxiety was evaluated. Methods : Former patients of pediatric cancer [...]

Menée à Singapour par questionnaire auprès de 154 infirmières en oncologie, cette étude analyse l'efficacité d'un programme pédagogique sur les soins psychosociaux pour améliorer leurs connaissances et leurs comportements en pratique clinique

Knowledge, attitudes, and practice behaviors (KAPb) of nurses and the effectiveness of a training program in psychosocial cancer care

Mahendran, Rathi ; Chua, Joanne ; Peh, ChaoXu ; Lim, HaikelA ; Ang, EmilyN K. ; Lim, SiewEng ; Kua, EeHeok

Purpose : Psychosocial distress in oncology patients may significantly interfere with their health outcomes and quality of life. Nurses work closely with their patients and are in the best position to screen for distress and provide timely intervention. It is thus important for nurses working in oncology settings to be equipped and prepared to address distressing psychosocial issues. The present study aims to investigate the impact of a training program in psychosocial care on nurses’ [...]

A partir d'une revue systématique de la littérature (27 études, 4 494 patients), cette méta-analyse évalue la prévalence de symptômes d'anxiété et de dépression chez des patients atteints d'un cancer de la prostate, avant, pendant et après les traitements

Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates

Watts, Sam ; Leydon, Geraldine ; Birch, Brian ; Prescott, Philip ; Lai, Lily ; Eardley, Susan ; Lewith, George

Objectives : To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage. Design : Systematic review and meta-analysis. Participants : 4494 patients with prostate cancer from primary research investigations. Primary outcome measure : The prevalence of clinical depression and anxiety in patients with prostate cancer as a function of treatment stage. Results : We identified 27 full journal [...]

Cette étude du reséau européen des registres de cancer présente des recommandations en matière d'enregistrement des données cliniques et épidémiologiques des cancers hématologiques

Towards optimal clinical and epidemiological registration of haematological malignancies: Guidelines for recording progressions, transformations and multiple diagnoses

Gavin, Anna ; Rous, Brian ; Marcos-Gragera, Rafael ; Middleton, Richard ; Steliarova-Foucher, Eva ; Maynadie, Marc ; Zanetti, Roberto ; Visser, Otto

Haematological malignancies (HM) represent over 6% of the total cancer incidence in Europe and affect all ages, ranging between 45% of all cancers in children and 7% in the elderly. Thirty per cent of childhood cancer deaths are due to HM, 8% in the elderly. Their registration presents specific challenges, mainly because HM may transform or progress in the course of the disease into other types of HM. In the context of cancer registration decisions have to be made about classifying subsequent [...]