A partir d'une revue systématique de la littérature (8 études de cohorte, 11 études cas-témoins), cette méta-analyse évalue l'association entre une consommation d'alcool et le risque de second cancer primitif chez des patients atteints d'un cancer des voies aérodigestives supérieures

Alcohol drinking and second primary cancer risk in patients with upper aerodigestive tract cancers: A systematic review and meta-analysis of observational studies

Druesne-Pecollo, Nathalie ; Keita, Youssouf ; Touvier, Mathilde ; Chan, Doris SM ; Norat, Teresa ; Hercberg, Serge ; Latino-Martel, Paule

Background: We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT: oral cavity, pharynx, larynx and oesophagus) cancer. Methods: PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random effects models were used to estimate summary relative [...]

Menée dans huit provinces du Canada sur la période 1994-1997 auprès de 1 681 cas et de 2 053 témoins, cette étude en population masculine évalue l'association entre une exposition professionnelle à la silice cristalline et le risque de cancer du poumon

Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men

Kachuri, Linda ; Villeneuve, Paul J. ; Parent, Marie-Élise ; Johnson, Kenneth C. ; the Canadian Cancer Registries Epidemiology, Group ; Harris, Shelley A.

Crystalline silica is a recognized carcinogen, but the association with lung cancer at lower levels of exposure has not been well characterized. This study investigated the relationship between occupational silica exposure and lung cancer and the combined effects of cigarette smoking and silica exposure on lung cancer risk. A population-based case-control study was conducted in eight Canadian provinces between 1994 and 1997. Self-reported questionnaires were used to obtain a lifetime [...]

A partir d'échantillons sériques prélevés sur 268 cas et sur 222 témoins âgés de 40 à 79 ans, cette étude en population suédoise évalue l'association entre la présence d'anticorps anti Helicobacter pylori et le risque d'adénocarcinome de l'estomac

A CagA-independent cluster of antigens related to the risk of noncardia gastric cancer: Associations between Helicobacter pylori antibodies and gastric adenocarcinoma explored by multiplex serology

Song, Huan ; Michel, Angelika ; Nyrén, Olof ; Ekström, Anna-Mia ; Pawlita, Michael ; Ye, Weimin

Because of the differences in bacterial epitopes and host characteristics, infections with Helicobacter pylori (H. pylori) induce different immune responses. We explored the possibility that certain antibody response patterns are more closely linked to gastric adenocarcinoma (GAC) than others. In a Swedish population-based case-control study, serum samples were obtained from 268 cases and 222 controls, aged 40–79 years and frequency-matched according to age and sex. We measured antibodies [...]

A partir d'une revue de 74 méta-analyses, cette étude fait le point sur l'association entre l'utilisation de médicaments communément prescrits et le risque de divers cancers

Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses

Ioannidis, J. P. A. ; Zhou, Y. ; Chang, C. Q. ; Schully, S. D. ; Khoury, M. J. ; Freedman, A. N.

Several commonly used medications have been associated with increased cancer risk in the literature. Here, we evaluated the strength and consistency of these claims in published meta-analyses. We carried out an umbrella review of 74 meta-analysis articles addressing the association of commonly used medications (antidiabetics, antihyperlipidemics, antihypertensives, antirheumatics, drugs for osteoporosis, and others) with cancer risk where at least one meta-analysis in the medication class [...]

Menée en Australie auprès de 4 215 patients atteints d'un mélanome de stade III et de 3 563 patients atteints d'un mélanome de stade IV, cette étude analyse le risque d'un second mélanome primitif chez les patients n'ayant pas reçu de traitement par inhibiteur de BRAF

Incidence of New Primary Melanomas After Diagnosis of Stage III and IV Melanoma

Zimmer, Lisa ; Haydu, Lauren E. ; Menzies, Alexander M. ; Scolyer, Richard A. ; Kefford, Richard F. ; Thompson, John F. ; Schadendorf, Dirk ; Long, Georgina V.

Purpose : New primary melanomas (NPMs) have developed in some patients with metastatic melanoma treated with BRAF inhibitors. We sought to determine the background incidence of spontaneous NPMs after a diagnosis of American Joint Committee on Cancer/International Union Against Cancer stage III or IV melanoma in patients not treated with a BRAF inhibitor. Patients and Methods : Patients diagnosed with stage III or IV melanoma at Melanoma Institute Australia between 1983 and 2008 were analyzed, [...]

Menée aux Etats-Unis auprès de 724 603 femmes âgées de 40 à 79 ans, cette étude de cohorte analyse l'association entre la densité mammaire et le risque de cancer de l'ovaire

Investigation of Mammographic Breast Density as a Risk Factor for Ovarian Cancer

Wernli, Karen J. ; O’Meara, Ellen S. ; Kerlikowske, Karla ; Miglioretti, Diana L. ; Muller, Carolyn Y. ; Onega, Tracy ; Sprague, Brian L. ; Henderson, Louise M. ; Buist, Diana S. M.

Background : Endogenous hormones and growth factors that increase mammographic breast density could increase ovarian cancer risk. We examined whether high breast density is associated with ovarian cancer risk. Methods : We conducted a cohort study of 724 603 women aged 40 to 79 years with 2 506 732 mammograms participating in the Breast Cancer Surveillance Consortium from 1995 to 2009. Incident epithelial ovarian cancer was diagnosed in 1373 women. We used partly conditional Cox regression to [...]

Menée auprès de deux cohortes distinctes (376 et 255 patientes, âge médian : 50 ans), cette étude analyse l'association entre des variations dans l'expression de 177 protéines, l'appartenance ethnique et le sous-type histologique de cancer du sein

Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes

Chavez-MacGregor, Mariana ; Liu, Shuying ; De Melo-Gagliato, Debora ; Chen, Huiqin ; Do, Kim-Anh ; Pusztai, Lajos ; Symmans, W. Fraser ; Nair, Lakshmy ; Hortobagyi, Gabriel N. ; Mills, Gordon B. ; Meric-Bernstam, Funda ; Gonzalez-Angulo, Ana M

Background: Differences in gene or protein expression patterns between breast cancers according to race/ethnicity and cancer subtype. Methods: Transcriptional profiling was performed using Affymetrix HG-U133A platform in 376 patients and reverse phase protein array analysis (RPPA) was done for 177 proteins in 255 patients from a separate cohort. Unsupervised clustering was conducted, as well as supervised comparison by race and tumor subtype. Standard statistical methods, BRB-Array tools and [...]

Cette étude passe en revue l'intérêt des modèles théoriques de transmission infectieuse pour évaluer le rôle des infections dans l'étiologie des cancers

Infection transmission and chronic disease models in the study of infection-associated cancers

Baussano, I. ; Franceschi, S. ; Plummer, M.

In the last three decades, the appreciation of the role of infections in cancer aetiology has greatly expanded. Among the 13 million new cancer cases that occurred worldwide in 2008, around 2 million (16%) were attributable to infections. Concurrently, the approach to prevention of infection-related cancers is shifting from cancer control to infection control, for example, vaccination and the detection of infected individuals. In support of this change, the use of infection transmission models [...]