Mené sur 84 patients atteints d'un cancer de stade avancé, cet essai randomisé contrôlé évalue l'efficacité de la dexaméthasone pour réduire les symptômes de fatigue associés à la maladie

Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer

Yennurajalingam, Sriram ; Frisbee-Hume, Susan ; Palmer, J. Lynn ; Delgado-Guay, Marvin O. ; Bull, Janet ; Phan, Alexandria T. ; Tannir, Nizar M. ; Litton, Jennifer Keating ; Reddy, Akhila ; Hui, David ; Dalal, Shalini ; Massie, Lisa ; Reddy, Suresh K. ; Bruera, Eduardo

Purpose : Cancer-related fatigue (CRF) is the most common symptom in patients with advanced cancer. The primary objective of this prospective, randomized, double-blind, placebo-controlled study was to compare the effect of dexamethasone and placebo on CRF. Patients and Methods : Patients with advanced cancer with ≥ three CRF-related symptoms (ie, fatigue, pain, nausea, loss of appetite, depression, anxiety, or sleep disturbance) ≥ 4 of 10 on the Edmonton Symptom Assessment Scale (ESAS) were [...]

Menée sur 108 patientes ayant survécu à un cancer du sein de stade I-IIIa, cette étude transversale évalue l'effet de l'inactivité physique sur leur état physique et leur état psychophysiologique

Influence of physical inactivity in psychophysiological state of breast cancer survivors

Ariza-García, A. ; Galiano-Castillo, N. ; Cantarero-Villanueva, I. ; Férnandez-Lao, C. ; Díaz-Rodríguez, L. ; Arroyo-Morales, M.

Physical inactivity has been postulated as mediator of the relationship between cancer-related symptoms and psychoneurobiological alterations. The aim of the study was to evaluate the influence of physical inactivity level on mood state, fitness level as well as on salivary markers of the hypothalamic–pituitary–adrenal axis (cortisol) and the SNS (

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2012 (10 études), cette étude analyse l'efficacité de programmes d'interventions pour augmenter l'activité physique chez les patientes ayant reçu un traitement pour un cancer du sein

A qualitative synthesis of trials promoting physical activity behaviour change among post-treatment breast cancer survivors

Short, CamilleE ; James, EricaL ; Stacey, Fiona ; Plotnikoff, RonaldC

Background : Health outcome trials have provided strong evidence that participating in regular physical activity can improve the quality of life and health of post-treatment breast cancer survivors. Focus is now needed on how to promote changes in physical activity behaviour among this group. Purpose : This systematic review examines the efficacy of behavioural interventions for promoting physical activity among post-treatment breast cancer survivors. Methods : Behavioural intervention studies [...]

A partir de données du registre suédois du cancer portant sur 76 876 patients atteints d'un cancer du côlon-rectum, du poumon, de la prostate ou du sein et à partir des données du registre des médicaments prescrits, cette étude évalue l'association entre l'utilisation de faibles doses d'aspirine et les caractéristiques de la maladie selon le système TNM

Low-dose aspirin use and cancer characteristics: a population-based cohort study

Jonsson, F. ; Yin, L. ; Lundholm, C. ; Smedby, K. E. ; Czene, K. ; Pawitan, Y.

Background : Long-term daily use of aspirin has been associated with reduced cancer mortality. To explore this association, we compared tumour TNM characteristics among aspirin users with those among non-users. Methods : From the Swedish Cancer Register, we identified patients diagnosed with colorectal, lung, prostate and breast cancers between 2006 and 2009 and matched them to the Swedish Prescribed Drug Register to obtain information on low-dose aspirin use prior to diagnosis. Contingency [...]

Menée sur 631 patients atteints d'un lymphome folliculaire de grade 1 à 3 récemment diagnostiqué (âge médian : 60 ans ; durée médiane de suivi : 60 mois), cette étude évalue, dans le cadre d'une immunochimiothérapie à base de rituximab, le taux de transformation histologique à 5 ans ainsi que la survie globale des patients

Rates and Outcomes of Follicular Lymphoma Transformation in the Immunochemotherapy Era: A Report From the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource

Link, Brian K. ; Maurer, Matthew J. ; Nowakowski, Grzegorz S. ; Ansell, Stephen M. ; Macon, William R. ; Syrbu, Sergei I. ; Slager, Susan L. ; Thompson, Carrie A. ; Inwards, David J. ; Johnston, Patrick B. ; Colgan, Joseph P. ; Witzig, Thomas E. ; Habermann, Thomas M. ; Cerhan, James R.

Purpose : This study sought to characterize transformation incidence and outcome for patients with follicular lymphoma (FL) in a prospective observational series begun after diffusion of rituximab use. Patients and Methods : Patients with newly diagnosed FL were prospectively enrolled onto the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource from 2002 to 2009. Patients were actively followed for re-treatment, clinical or pathologic [...]

A partir de données portant sur 134 293 patients atteints d'un cancer du poumon non à petites cellules diagnostiqué en Angleterre entre 2004 et 2008, cette étude analyse l'association entre un nombre élevé de résections pratiquées annuellement dans un hôpital et la survie des patients en fonction de leur âge, de leur statut socioéconomique et de leurs comorbidités

High Procedure Volume Is Strongly Associated With Improved Survival After Lung Cancer Surgery

Lüchtenborg, Margreet ; Riaz, Sharma P. ; Coupland, Victoria H. ; Lim, Eric ; Jakobsen, Erik ; Krasnik, Mark ; Page, Richard ; Lind, Michael J. ; Peake, Michael D. ; Møller, Henrik

Purpose : Studies have reported an association between hospital volume and survival for non–small-cell lung cancer (NSCLC). We explored this association in England, accounting for case mix and propensity to resect. Methods : We analyzed data on 134,293 patients with NSCLC diagnosed in England between 2004 and 2008, of whom 12,862 (9.6%) underwent surgical resection. Hospital volume was defined according to number of patients with resected lung cancer in each hospital in each year of diagnosis. [...]

Menée sur 1 951 patientes atteintes d'un cancer du sein de stade précoce sans envahissement ganglionnaire (durée médiane de suivi : 12,5 ans), cette étude rétrospective identifie diverses formes de récidive en fonction des principaux sous-types tumoraux

Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node–Negative Disease : Results From International Breast Cancer Study Group Trials VIII and IX

Metzger-Filho, Otto ; Sun, Zhuoxin ; Viale, Giuseppe ; Price, Karen N. ; Crivellari, Diana ; Snyder, Raymond D. ; Gelber, Richard D. ; Castiglione-Gertsch, Monica ; Coates, Alan S. ; Goldhirsch, Aron ; Cardoso, Fatima

Purpose : To retrospectively evaluate the pattern of recurrence and outcome of node-negative breast cancer (BC) according to major subtypes. Patients and Methods : In all, 1,951 patients with node-negative, early-stage BC randomly assigned in International Breast Cancer Study Group Trials VIII and IX with centrally reviewed pathology data were included. BC subtypes were defined as triple negative (TN; n = 310), human epidermal growth factor receptor 2 (HER2) positive (n = 369), and hormone [...]

Menée sur 285 patientes ayant reçu une radiothérapie pelvienne et/ou une chimiothérapie pour un cancer de l'utérus ou un cancer du col utérin (âge moyen : 59 ans), cette étude évalue l'incidence de fractures par insuffisance osseuse et identifie les facteurs de risque associés

Insufficiency fractures in patients treated with pelvic radiotherapy and chemotherapy for uterine and cervical cancer

Mehmood, Q. ; Beardwood, M. ; Swindell, R. ; Greenhalgh, S. ; Wareham, T. ; Barraclough, L. ; Livsey, J. ; Davidson, S. E.

Insufficiency fractures are recognised consequences of radiotherapy in gynaecological malignancy with reported incidences between 2.7% and 89%. We aimed to determine the incidence and risk factors for insufficiency fractures in patients receiving radical pelvic radiotherapy for uterine and cervical cancer. A case-note review was undertaken of patients treated between January 2007 and December 2008. Insufficiency fractures were identified from radiographs, computed tomography and magnetic [...]

Menée à partir d'échantillons tumoraux prélevés sur 175 patientes atteintes d'un cancer invasif du col de l'utérus, cette étude brésilienne multicentrique analyse la distribution des sous-types de papillomavirus humain

Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil

de Oliveira, Cristina ; Fregnani, Jose ; Carvalho, Jesus ; Longatto-Filho, Adhemar ; Levi, Jose

Background : Invasive cervical cancer is the second most common malignant tumor affecting Brazilian women. Knowledge on Human Papillomavirus (HPV) genotypes in invasive cervical cancer cases is crucial to guide the introduction and further evaluate the impact of new preventive strategies based on HPV. We aimed to provide updated comprehensive data about the HPV types’ distribution in patients with invasive cervical cancer. Methods : Fresh tumor tissue samples of histologically confirmed [...]

Menée aux Pays-bas, cette étude rétrospective de cohorte évalue la prévalence de lésions cancéreuses ou pré-cancéreuses du col de l'utérus chez 195 femmes dont le partenaire de vie est atteint d'un cancer du pénis

Patients with penile cancer and the risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis

de Bruijn, Roderick E. ; Heideman, Daniëlle A. M. ; Kenter, Gemma G. ; van Beurden, Marc ; van Tinteren, Harm ; Horenblas, Simon

Objective : To determine if female partners of patients with penile cancer have more cervical lesions and neoplasia than would be expected from population-based data. Patients and Methods : We included all consecutive patients with primary penile carcinoma in the period 2004–2010. Results of Dutch cervical cancer screening were used to consider (pre)malignant cervical lesions in female partners of patients with penile cancer. Results : In all, 206 women were included. Gynaecological information [...]

Menée dans le Nord de l'Espagne à partir de données de registres médicaux et à partir d'échantillons tumoraux inclus en paraffine après prélèvement sur 248 patients atteints d'un carcinome épidermoïde des amygdales ou de la base de la langue, cette étude espagnole évalue l'évolution de la prévalence du papillomavirus humain sur la période 1990-2009

Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990–2009)

Rodrigo, Juan P. ; Heideman, Daniëlle A. M. ; García-Pedrero, Juana M. ; Fresno, Manuel F. ; Brakenhoff, Ruud H. ; Díaz Molina, Juan P. ; Snijders, Peter J. F. ; Hermsen, Mario A.

Recent studies support an important role for human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC), although the incidence varies widely depending on the geographic location and time period studied. The aim of this study was to determine the proportion of HPV in a large cohort of OPSCC in northern Spain in the years 1990–2009. Clinical records and paraffin embedded tumor specimens of 248 consecutive patients surgically treated for OPSCC (140 tonsillar and 108 base of [...]