A partir d'une revue systématique de la littérature (59 études européennes, 54 études américaines, 22 études chinoises et 13 études asiatiques), cette étude présente une estimation de la mortalité par cancer du poumon associée au tabagisme, en fonction des habitudes tabagiques et le sous-type histologique de la tumeur

Indirectly estimated absolute lung cancer mortality rates by smoking status and histological type based on a systematic review

Lee, Peter ; Forey, Barbara

BACKGROUND:National smoking-specific lung cancer mortality rates are unavailable, and studies presenting estimates are limited, particularly by histology. This hinders interpretation. We attempted to rectify this by deriving estimates indirectly, combining data from national rates and epidemiological studies. METHODS:We estimated study-specific absolute mortality rates and variances by histology and smoking habit (never/ever/current/former) based on relative risk estimates derived from studies [...]

Menée à partir des données des 122 264 participantes de la cohorte "California Teachers Study", cette étude américaine évalue l'association entre le tabagisme et le risque de cancer colorectal

Risk of colorectal cancer associated with active smoking among female teachers

Hurley, Susan ; Goldberg, Debbie ; Nelson, DavidO ; Lu, Yani ; Henderson, Katherine ; Bernstein, Leslie ; Reynolds, Peggy

Purpose : The objective of this study was to examine the risk of colorectal cancer associated with active smoking among members of the California Teachers Study (CTS), a large cohort of female public school employees for whom highly detailed smoking information is available. Methods : The analysis was conducted among the 122,264 CTS participants who lived in California at cohort entry in 1995/1996, had no prior history of colorectal cancer, and provided detailed smoking information. 1,205 cases [...]

Menée à Singapour auprès de 61 321 participants, cette étude de cohorte prospective évalue l'association entre une consommation de viande grillée et le risque d'adénocarcinome du poumon

Fried meat intake is a risk factor for lung adenocarcinoma in a prospective cohort of Chinese men and women in Singapore

Butler, Lesley M. ; Montague, Julia A. ; Koh, Woon-Puay ; Wang, Renwei ; Yu, Mimi C. ; Yuan, Jian-Min

Probable human carcinogens are generated during Chinese-style high-temperature cooking of meat and have been detected in the ambient air and on the meat surface. While the inhalation of these compounds is an established risk factor for lung cancer, exposure via fried meat consumption has not yet been prospectively evaluated as a risk factor. The relationship between fried meat intake and lung cancer risk was investigated using data from a prospective cohort study among Chinese in Singapore. [...]

Couplée à la cohorte "Southern Community Cohort Study", cette étude incluant 546 cas et 2 184 témoins évalue et compare, pour les femmes blanches et pour les femmes noires, l'association entre un comportement sédentaire, une activité physique et le risque de cancer du sein

Sedentary behavior, physical activity, and likelihood of breast cancer among black and white women: a report from the Southern Community Cohort Study

Cohen, Sarah S. ; Matthews, Charles E. ; Bradshaw, Patrick T. ; Lipworth, Loren ; Buchowski, Maciej S. ; Signorello, Lisa B. ; Blot, William J.

Increased physical activity has been shown to be protective for breast cancer although few studies have examined this association in black women. In addition, limited evidence to date indicates that sedentary behavior may be an independent risk factor for breast cancer. We examined sedentary behavior and physical activity in relation to subsequent incident breast cancer in a nested case-control study within 546 cases (374 among black women) and 2,184 matched controls enrolled in the Southern [...]

A partir des données de la cohorte européenne EPIC incluant 241 465 participants, cette étude évalue l'association entre certaines catégories d'emplois, des expositions professionnelles à divers facteurs de risque et le risque de leucémie myéloïde ou lymphoïde

Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Saberi Hosnijeh, Fatemeh ; Christopher, Yvette ; Peeters, Petra ; Romieu, Isabelle ; Xun, Wei ; Riboli, Elio ; Raaschou-Nielsen, Ole ; Tjønneland, Anne ; Becker, Nikolaus ; Nieters, Alexandra ; Trichopoulou, Antonia ; Bamia, Christina ; Orfanos, Philip ; Oddone, Enrico ; Luján-Barroso, Leila ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; Molina-Montes, Esther ; Wareham, Nick ; Vineis, Paolo ; Vermeulen, Roel

Objectives : Established risk factors for leukaemia do not explain the majority of leukaemia cases. Previous studies have suggested the importance of occupation and related exposures in leukaemogenesis. We evaluated possible associations between job title and selected hazardous agents and leukaemia in the European Prospective Investigation into Cancer and Nutrition. Methods : The mean follow-up time for 241 465 subjects was 11.20 years (SD 2.42 years). During the follow-up period, 477 incident [...]

A partir des données du registre taïwanais des cancers portant sur la période 1982-1986, cette étude écologique évalue l'association entre une exposition à des sols contaminés par des métaux lourds (arsenic, cadmium, chrome, cuivre, mercure, nickel, plomb, zinc) et le risque de cancer du poumon par sous-type histologique

Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: an ecological study

Huang, Hsien-Hung ; Huang, Jing-Yang ; Lung, Chia-Chi ; Wu, Chih-Lung ; Ho, Chien-Chang ; Sun, Yi-Hua ; Ko, Pei-Chieh ; Su, Shih-Yung ; Chen, Shih-Chang ; Liaw, Yung-Po

BACKGROUND:Numerous studies have examined the association between heavy metal contamination (including arsenic [As], cadmium [Cd], chromium [Cr], copper [Cu], mercury [Hg], nickel [Ni], lead [Pb], and zinc [Zn]) and lung cancer. However, data from previous studies on pathological cell types are limited, particularly regarding exposure to low-dose soil heavy metal contamination. The purpose of this study was to explore the association between soil heavy metal contamination and lung cancer [...]

Menée en population néerlandaise à partir d'échantillons tumoraux de 223 patients (145 hommes, 78 femmes, âge médian : 65 ans), cette étude montre que la présence du papillomavirus humain dans une tumeur pulmonaire signifie qu'il s'agit d'une métastase d'un cancer primitif HPV+

High-Risk Human Papillomavirus-Positive Lung Cancer: Molecular Evidence for a Pattern of Pulmonary Metastasis

van Boerdonk, Robert A.A. ; Daniels, Johannes M.A. ; Bloemena, Elisabeth ; Krijgsman, Oscar ; Steenbergen, Renske D.M. ; Brakenhoff, Ruud H. ; Grünberg, Katrien ; Ylstra, Bauke ; Meijer, Chris J.L.M. ; Smit, Egbert F. ; Snijders, Peter J.F. ; Heideman, Daniëlle A.M.

Introduction: Infection with high-risk types of human papillomavirus (hrHPV) is associated with cervical, anogenital, and oropharyngeal cancers. Since a causal contribution of hrHPV infection to lung cancer (LC) is still a matter of debate, a comprehensive study was performed to delineate hrHPV involvement in LC, using a Dutch study population. Methods: Archival tissue specimens from 223 patients (145 men, 78 women, median age 65 years, range 27-87 years), who presented with cancer in the [...]

A partir d'une revue de la littérature épidémiologique, cette étude fait le point sur l'association entre une infection par Helicobacter pylori et le risque de cancer du poumon

Helicobacter Pylori Infection and Lung Cancer: A Review of an Emerging Hypothesis

Deng, Bo ; Li, Yafei ; Zhang, Yao ; Bai, Li ; Yang, Ping

Helicobacter pylori (Hp) is one of the most common bacteria infecting humans. Recently, certain extragastric manifestations, linked to Hp infection, have been widely investigated, suggesting that Hp infection might be a “systemic” disease. Accumulating yet limited evidence points to a potential association between Hp infection and lung cancer risk. Epidemiologic studies have shown that odds ratios (estimated relative risks) of lung cancer with Hp infection range from 1.24 to 17.78 compared to [...]

A partir des données de l'assurance maladie de Taïwan portant sur 6 418 patients traités par l'amiodarone entre 1997 et 2008 (durée médiane de suivi : 2,6 ans), cette étude analyse l'association entre l'amiodarone et le risque de cancer (280 cas)

Amiodarone and the risk of cancer

Su, Vincent Yi-Fong ; Hu, Yu-Wen ; Chou, Kun-Ta ; Ou, Shuo-Ming ; Lee, Yu-Chin ; Lin, Elizabeth Ya-Hsuan ; Chen, Tzeng-Ji ; Tzeng, Cheng-Hwai ; Liu, Chia-Jen

BACKGROUND In postmarketing surveillance, the US Food and Drug Administration has reported the development of lung masses, thyroid cancer, and skin cancer after amiodarone therapy. METHODS Using the Taiwan National Health Insurance Research database, the authors conducted a population-based cohort study. Patients who were treated with amiodarone between 1997 and 2008 were enrolled. Those with antecedent cancer were excluded. Standardized incidence ratios (SIRs) of cancers were calculated to [...]

Menée en Suède auprès de 53 076 patients atteints d'une arthrite rhumatoïde et 162 743 individus en population générale, cette étude de cohorte prospective évalue l'association entre un traitement avec des inhibiteurs TNF et le risque de mélanome malin

Rheumatoid arthritis, anti-tumour necrosis factor therapy, and risk of malignant melanoma: nationwide population based prospective cohort study from Sweden

Pauline Raaschou ; Julia F Simard ; Marie Holmqvist ; Johan Askling

Objectives : To investigate the potential association between tumour necrosis factor (TNF) inhibitor treatment and malignant melanomas in rheumatoid arthritis, melanoma risks in rheumatoid arthritis patients not treated with biological drugs, and risk of all site cancer with TNF inhibitors as used in rheumatoid arthritis. Design : Population based cohort study. Setting : Prospectively recorded data from national clinical, health, and demographic registers in Sweden 2001-10. Patients with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2011 (33 études, 14 435 cas et 10 583 témoins), cette méta-analyse évalue l'association entre un polymorphisme du gène

TNF-β +252 A>G polymorphism and susceptibility to cancer

Yang, Lin ; Feng, Rennan ; Liu, Guiyou ; Liao, Mingzhi ; Zhang, Liangcai ; Wang, Wenbo

Objective : Tumor necrosis factor-

Menée auprès de 357 cas et 405 témoins, cette étude américaine évalue l'association entre le niveau sanguin de folates à la naissance et le risque de leucémie pédiatrique

Blood levels of folate at birth and risk of childhood leukemia

Chokkalingam, Anand P ; Chun, Danielle S ; Noonan, Emily J ; Pfeiffer, Christine M ; Zhang, Mindy ; Month, Stacy R ; Taggart, Denah R ; Wiemels, Joseph L. ; Metayer, Catherine ; Buffler, Patricia A

Background: A role for folate in cancer etiology has long been suspected due to folate's function as a cofactor in DNA methylation and maintenance of DNA synthesis. Previous case-control studies examining the association between risk of childhood acute lymphoblastic leukemia (ALL) and mothers' self-reported folate intake and supplementation have been inconclusive. Methods: We utilized a quantitative microbiologic assay to measure newborn folate concentrations in archived dried bloodspots [...]

A partir d'une revue systématique de la littérature publiée entre 1997 et 2010 (40 études), cette méta-analyse évalue l'association entre trois polymorphismes (D1822V, E1317Q et I1307K) du gène APC et le risque de néoplasie colorectale

APC Polymorphisms and the Risk of Colorectal Neoplasia: A HuGE Review and Meta-Analysis

Liang, Jing ; Lin, Chunqing ; Hu, Fulan ; Wang, Fan ; Zhu, Lin ; Yao, Xiaoping ; Wang, Yibaina ; Zhao, Yashuang

Adenomatous polyposis coli gene (APC) polymorphisms may influence the risk for colorectal neoplasia. However, results thus far have been inconclusive. We performed a systematic literature search of the Medline, Embase, Cochrane Collaboration, and HuGE databases and reviewed the references of pertinent articles through May 2012. Odds ratios with 95% confidence intervals were used to estimate the association between 3 APC polymorphisms (D1822V, E1317Q, and I1307K) and colorectal neoplasia. In [...]

A partir des données de 27 études (13 465 cas de cancer colorectal et 20 430 témoins ; 4 844 cas d'adénome colorectal et 11 743 témoins), cette méta-analyse évalue l'association entre le polymorphisme A2756G du gène MTR et le risque d'adénome ou de cancer colorectal

Methionine Synthase A2756G Polymorphism and Risk of Colorectal Adenoma and Cancer: Evidence Based on 27 Studies

Ding, Weixing ; Zhou, Dong-lei ; Jiang, Xun ; Lu, Lie-sheng

Methionine synthase (MTR), which plays a central role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation. However, studies on the association between MTR A2756G polymorphism and CRC/CRA remain conflicting. We conducted a meta-analysis of 27 studies, including 13465 cases and 20430 controls for CRC, and 4844 cases and [...]

Menée dans les pays de l'Europe du nord sur une cohorte de 63 495 parents au premier degré de 11 206 patients atteints d'un cancer thyroïdien non médullaire diagnostiqué entre 1955 et 2009, cette étude analyse le risque de cancer de la thyroïde en fonction de l'histologie et de l'âge au diagnostic

Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: a joint study from five Nordic countries

Fallah, Mahdi ; Pukkala, Eero ; Tryggvadottir, Laufey ; Olsen, Jörgen H ; Tretli, Steinar ; Sundquist, Kristina ; Hemminki, Kari

Background We aimed to estimate lifetime cumulative risk of thyroid cancer (CRTC) in first-degree relatives of patients with non-medullary thyroid cancers (NMTC), including papillary (PTC)/follicular/oxyphilic/anaplastic thyroid carcinoma, by histology and age at diagnosis in patients and their relatives. Design A population-based cohort of 63 495 first-degree relatives of 11 206 NMTC patients diagnosed in 1955–2009 in Nordic countries was followed for cancer incidence. Standardised incidence [...]