Menée aux Pays-Bas, cette étude de cohorte prospective incluant 565 participants évalue l'association entre le recours à une supplémentation alimentaire et le risque de récidive d'un adénome colorectal

Dietary supplement use is not associated with recurrence of colorectal adenomas: A prospective cohort study

Heine-Bröring, Renate C. ; Winkels, Renate M. ; Botma, Akke ; Wahab, Peter J. ; Tan, Adriaan C. I. T. L. ; Nagengast, Fokko M. ; Witteman, Ben J. M. ; Kampman, Ellen

Diet and lifestyle influence colorectal adenoma recurrence. The role of dietary supplement use in colorectal adenoma recurrence remains controversial. In this prospective cohort study, we examined the association between dietary supplement use, total colorectal adenoma recurrence and advanced adenoma recurrence. Colorectal adenoma cases (n=565) from a former case-control study, recruited between 1995 and 2002 were prospectively followed until 2008. Adenomas with a diameter of ≥1 cm and/or [...]

A partir des données de la cohorte européenne EPIC incluant 469 339 hommes, cette étude évalue l'association entre une consommation de macronutriments et le risque de carcinome urothélial (durée médiane de suivi : 11,3 ans)

Macronutrient intake and risk of urothelial cell carcinoma in the european investigation into cancer and nutrition (EPIC)

Allen, Naomi E. ; Appleby, Paul N. ; Key, Timothy J. ; Bueno-de-Mesquita, H. B. ; Ros, Martine M. ; Kiemeney, Lambertus A. L. M. ; Tjønneland, Anne ; Roswall, Nina ; Overvad, Kim ; Weikert, Steffen ; Boeing, Heiner ; Chang-Claude, Jenny ; Teucher, Birgit ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Palli, Domenico ; Sieri, Sabina ; Peeters, Petra ; Quirós, Jose Ramón ; Jakszyn, Paula ; Molina-Montes, Esther ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Dorronsoro, Miren ; Khaw, Kay-Tee ; Wareham, Nick ; Ljungberg, Börje ; Hallmans, Göran ; Ehrnström, Roy ; Ericson, Ulrika ; Gram, Inger Torhild ; Parr, Christine L. ; Trichopoulou, Antonia ; Karapetyan, Tina ; Dilis, Vardis ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Fagherrazzi, Guy ; Romieu, Isabelle ; Gunter, Marc J. ; Riboli, Elio

Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of [...]

A partir d'une revue de la littérature publiée depuis 2002, cette étude évalue notamment l'association entre des traitements hormonaux substitutifs de la ménopause et divers types de cancer

Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendations

Nelson, Heidi D. ; Walker, Miranda ; Zakher, Bernadette ; Mitchell, Jennifer

Background: Menopausal hormone therapy to prevent chronic conditions is currently not recommended because of its adverse effects.Purpose: To update evidence about the effectiveness of hormone therapy in reducing risk for chronic conditions and adverse effects, and to examine whether outcomes vary among women in different subgroups.Data Sources: MEDLINE (January 2002 to November 2011), Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (through the 3rd [...]

Menée sur 88 paires d'échantillons de tissu tumoral et de tissu sain prélevés sur des patients atteints d'un carcinome hépatocellulaire (81 cas associés au virus de l'hépatite B, 7 autres cas), cette étude met en évidence les régions d'intégration du génome viral dans le génome de l'hôte

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

Sung, Wing-Kin ; Zheng, Hancheng ; Li, Shuyu ; Chen, Ronghua ; Liu, Xiao ; Li, Yingrui ; Lee, Nikki P. ; Lee, Wah H. ; Ariyaratne, Pramila N. ; Tennakoon, Chandana ; Mulawadi, Fabianus H. ; Wong, Kwong F. ; Liu, Angela M. ; Poon, Ronnie T. ; Fan, Sheung Tat ; Chan, Kwong L. ; Gong, Zhuolin ; Hu, Yujie ; Lin, Zhao ; Wang, Guan ; Zhang, Qinghui ; Barber, Thomas D. ; Chou, Wen-Chi ; Aggarwal, Amit ; Hao, Ke ; Zhou, Wei ; Zhang, Chunsheng ; Hardwick, James ; Buser, Carolyn ; Xu, Jiangchun ; Kan, Zhengyan ; Dai, Hongyue ; Mao, Mao ; Reinhard, Christoph ; Wang, Jun ; Luk, John M.

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV [...]

A partir des données de la cohorte "Women’s Health Initiative" incluant 145 765 femmes âgées de 50 à 79 ans, cette étude évalue l'association entre un diabète et le risque de cancer gastrointestinal

Diabetes mellitus as a risk factor for gastrointestinal cancers among postmenopausal women

Luo, Juhua ; Chlebowski, Rowan ; Liu, Simin ; McGlynn, Katherine ; Parekh, Niyati ; White, Donna ; Margolis, Karen

Objectives While diabetes has been linked to several cancers in the gastrointestinal (GI) tract, findings have been mixed for sites other than colorectal and liver cancer. We used the Women’s Health Initiative (WHI) data and conducted a comprehensive assessment of associations between diabetes and GI malignancy (esophagus, stomach, liver, biliary, pancreas, colon, and rectal). Methods A total of 145,765 postmenopausal women aged 50–79 enrolled in the WHI were followed for a mean 10.3 years. Cox [...]

A partir des données de la cohorte européenne EPIC, cette étude évalue l'association entre l'obésité abdominale, la prise de poids pendant l'âge adulte et le risque d'un cancer du foie ou des voies biliaires

Abdominal Obesity, Weight Gain during Adulthood and Risk of Liver and Biliary Tract Cancer in a European Cohort

Schlesinger, Sabrina ; Aleksandrova, Krasimira ; Pischon, Tobias ; Fedirko, Veronika ; Jenab, Mazda ; Trepo, Elisabeth ; Boffetta, Paolo ; Dahm, Christina C. ; Overvad, Kim ; Tjønneland, Anne ; Halkjær, Jytte ; Fagherazzi, Guy ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Boeing, Heiner ; Trichopoulou, Antonia ; Bamia, Christina ; Lagiou, Pagona ; Palli, Domenico ; Grioni, Sara ; Panico, Salvatore ; Tumino, Rosario ; Vineis, Paolo ; Bas Bueno-de-Mesquita, H. ; van den Berg, Saskia ; Peeters, Petra H. M. ; Braaten, Tonje ; Weiderpass, Elisabete ; Quirós, J. Ramón ; Travier, Noemie ; Sánchez, María-José ; Navarro, Carmen ; Barricarte, Aurelio ; Dorronsoro, Miren ; Lindkvist, Björn ; Regner, Sara ; Werner, Mårten ; Sund, Malin ; Khaw, Kay-Tee ; Wareham, Nicholas ; Travis, Ruth C. ; Norat, Teresa ; Wark, Petra A. ; Riboli, Elio ; Nöthlings, Ute

General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intra- (IBDC) and extrahepatic bile duct system [...]

Cette étude européenne (837 cas et 1 154 témoins) évalue l'association entre 21 polymorphismes à simple nucléotide du locus ASIP sur le chromosome 20q11 et le risque de mélanome

Variants at chromosome 20 (ASIP locus) and melanoma risk

Maccioni, Livia ; Rachakonda, P. Sivaramakrishna ; Scherer, Dominique ; Bermejo, Justo Lorenzo ; Planelles, Dolores ; Requena, Celia ; Hemminki, Kari ; Nagore, Eduardo ; Kumar, Rajiv

ASIP locus on chromosome 20q11 is implicated, as shown by genome wide association studies (GWAS), in phenotype variation and melanoma risk. We genotyped 837 melanoma cases and 1154 controls for 21 single nucleotide polymorphisms (SNPs) informative for 495 polymorphisms at the locus. Our data showed an increased risk of melanoma (OR 1.27, 95%CI 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP. The main effect of rs4911414, as reported previously, was in tandem [...]

Menée sur des familles néerlandaises affectées par un cancer du pancréas sans mélanome, cette étude évalue la fréquence de mutations du gène CDKN2A dans cette population

Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas

Harinck, Femme ; Kluijt, Irma ; van der Stoep, Nienke ; Oldenburg, Rogier A ; Wagner, Anja ; Aalfs, Cora M ; Sijmons, Rolf H ; Poley, Jan-Werner ; Kuipers, Ernst J ; Fockens, Paul ; van Os, Theo A M ; Bruno, Marco J

Background CDKN2A-mutation carriers run a high risk of developing melanomas and have an increased risk of developing pancreatic cancer (PC). Familial PC (FPC) patients with a personal history or family history of melanomas are therefore offered CDKN2A-mutation analysis. In contrast, CDKN2A testing in FPC families without a history of melanomas is not generally recommended. The aim of this study was to evaluate the frequency of CDKN2A-mutations in FPC families without melanomas.Methods Data were [...]

A partr d'une méta-analyse de 5 études d'association sur le génome entier (total : 8 682 cas, 9 649 témoins) et d'une cohorte impliquant 21 096 cas et 19 555 témoins, cette étude identifie trois nouveaux loci de susceptibilité au cancer colorectal

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Dunlop, Malcolm G. ; Dobbins, Sara E. ; Farrington, Susan Mary ; Jones, Angela M. ; Palles, Claire ; Whiffin, Nicola ; Tenesa, Albert ; Spain, Sarah ; Broderick, Peter ; Ooi, Li-Yin ; Domingo, Enric ; Smillie, Claire ; Henrion, Marc ; Frampton, Matthew ; Martin, Lynn ; Grimes, Graeme ; Gorman, Maggie ; Semple, Colin ; Ma, Yusanne P. ; Barclay, Ella ; Prendergast, James ; Cazier, Jean-Baptiste ; Olver, Bianca ; Penegar, Steven ; Lubbe, Steven ; Chander, Ian ; Carvajal-Carmona, Luis G. ; Ballereau, Stephane ; Lloyd, Amy ; Vijayakrishnan, Jayaram ; Zgaga, Lina ; Rudan, Igor ; Theodoratou, Evropi ; Starr, John M. ; Deary, Ian ; Kirac, Iva ; Kovacevic, Dujo ; Aaltonen, Lauri A. ; Renkonen-Sinisalo, Laura ; Mecklin, Jukka-Pekka ; Matsuda, Koichi ; Nakamura, Yusuke ; Okada, Yukinori ; Gallinger, steven ; Duggan, David J. ; Conti, David ; Newcomb, Polly ; Hopper, John ; Jenkins, Mark A. ; Schumacher, Fredrick ; Casey, Graham ; Easton, Douglas ; Shah, Mitul ; Pharoah, Paul ; Lindblom, Annika ; Liu, Tao ; Smith, Christopher G. ; West, Hannah ; Cheadle, Jeremy P. ; Midgley, Rachel ; Kerr, David J. ; Campbell, Harry ; Tomlinson, Ian P. ; Houlston, Richard S.

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10−10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10−10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10−10) This brings the [...]

Menée à Mexico, cette étude en population (1 000 cas et 1 074 témoins) évalue l'association entre le niveau sérique de vitamine D et le risque de cancer du sein

Serum 25-hydroxyvitamin D and risk of breast cancer: results of a large population-based case–control study in Mexican women

Fedirko, Veronika ; Torres-Mejía, Gabriela ; Ortega-Olvera, Carolina ; Biessy, Carine ; Angeles-Llerenas, Angelica ; Lazcano-Ponce, Eduardo ; Saldaña-Quiroz, Vicente ; Romieu, Isabelle

Purpose Epidemiologic studies have suggested that higher levels of circulating vitamin D may reduce breast cancer risk, but no studies have investigated this association among women in developing countries, and very few studies have further investigated this association according to menopausal status. Methods A population-based case–control study in Mexico with 1,000 incident breast cancer cases aged 35–69 years, enrolled shortly after diagnosis (0–6 days) and frequency-matched to 1,074 [...]

Couplée à la cohorte française E3N incluant 50 704 participantes, cette étude évalue l'association entre la taille, la hauteur du tronc, la taille des jambes et le risque de cancer du sein

Height, sitting height and leg length in relation with breast cancer risk in the E3N cohort

Fagherazzi, Guy ; Vilier, Alice ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Mesrine, Sylvie

Background: If height is a well-established risk factor for breast cancer (BC), leg length and sitting height are usually considered as better candidate biomarkers of growth hormone exposure than height, respectively in pre- and postpuberty. Methods: Risk of BC associated with quartiles of height, sitting height and leg length were estimated in the French E3N cohort (N=50,704, including 2,065 BC cases), stratified on both menopausal and hormone receptor statuses. Results: Height was associated [...]

Cette étude américaine (1 447 cas et 1 453 témoins) évalue l'association entre un diabète et le risque de cancer du sein ainsi que la mortalité spécifique ou toutes causes

The association of diabetes with breast cancer incidence and mortality in the Long Island Breast Cancer Study Project

Cleveland, Rebecca ; North, Kari ; Stevens, June ; Teitelbaum, Susan ; Neugut, Alfred ; Gammon, Marilie

Purpose Diabetes has been associated with increased risk of breast cancer in a number of epidemiologic studies, but its effects on survival among women diagnosed with breast cancer have been examined less frequently. Importantly, prior investigations have rarely considered the influence of factors associated with diabetes such as obesity, age at diabetes diagnosis, duration of diabetes, or diabetes treatments. Methods We evaluated the effect of self-reported diabetes on breast cancer incidence [...]

A partir d'une revue de la littérature (34 études), cette méta-analyse évalue le risque de second cancer du sein chez des survivantes d'un lymphome hodgkinien

Risk of second breast cancer in female Hodgkin's lymphoma survivors: a meta-analysis

Ibrahim, Ezzeldin ; Abouelkhair, Khaled ; Kazkaz, Ghieth ; Al-Masri, Osama ; Al-Foheidi, Meteb

BACKGROUND:Women treated for Hodgkin's lymphoma (HL) have an elevated risk of developing second breast cancer (SBC) compared with the general population. We planned this meta-analysis to quantify the long-term risk of SBC and analyze the contributing risk factors among HL survivors.METHODS:According to predefined selection criteria, literature search identified 34 studies that were included in the analyses.RESULTS:After eliminating overlapping or duplicate data, 957 incidences of SBC were [...]

Croisée avec les données du registre norvégien des cancers entre 1999 et 2008, cette étude de cohorte incluant 338 051 femmes évalue l'association entre le poids du placenta lors de leur dernier accouchement et le risque de cancer du sein

Placental weight and breast cancer risk in young women: a registry-based cohort study from Norway

Opdahl, Signe ; Alsaker, Mirjam D.K. ; Romundstad, Pal R. ; Eskild, Anne ; Vatten, Lars J.

Background:Pregnancy has a short term risk increasing effect on breast cancer that may be attributed to growth promoting effects of pregnancy hormones on prevalent but undetected tumors. Results of two previous studies suggested that placental weight may be positively associated with breast cancer risk. Methods:In a cohort of 338 051 women followed from 1999 to 2008, based on data linkage between the Medical Birth Registry of Norway and the Cancer Registry of Norway, we assessed whether [...]

A partir des données de 3 cohortes, cette étude (391 cas et 712 témoins) évalue les relations entre des polymorphismes des gènes associés aux hormones sexuelles, le niveau d'hormones sexuelles circulantes et le risque de cancer de l'endomètre

Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer

Lundin, Eva ; Wirgin, Isaac ; Lukanova, Annekatrin ; Afanasyeva, Yelena ; Krogh, Vittorio ; Axelsson, Tomas ; Hemminki, Kari ; Clendenen, Tess V. ; Arslan, Alan A. ; Ohlson, Nina ; Sieri, Sabina ; Roy, Nirmal ; Koenig, Karen L. ; Idahl, Annika ; Berrino, Franco ; Toniolo, Paolo ; Hallmans, Göran ; Försti, Asta ; Muti, Paola ; Lenner, Per ; Shore, Roy E. ; Zeleniuch-Jacquotte, Anne

Background: The role of estrogen and progesterone in the development of endometrial cancer is well documented. Few studies have examined the association of genetic variants in sex hormone-related genes with endometrial cancer risk. Methods: We conducted a case-control study nested within three cohorts to examine the association of endometrial cancer risk with polymorphisms in hormone-related genes among 391 cases (92% postmenopausal at diagnosis) and 712 individually-matched controls. We also [...]

A partir des données de l'essai "PLCO Cancer Screening", cette étude (375 cas et 375 témoins) évalue l'association entre le niveau sérique de vitamine D et le risque de cancer de la vessie

Serum vitamin D and risk of bladder cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

Mondul, Alison M. ; Weinstein, Stephanie J. ; Horst, Ronald L. ; Purdue, Mark P. ; Albanes, Demetrius

Background: The one previous prospective study of vitamin D status and risk of urinary bladder cancer found that male smokers with low serum 25-hydroxy-vitamin D(25(OH)D) were at a nearly 2-fold increased risk. We conducted an analysis of serum 25(OH)D and risk of bladder cancer in the Prostate, Lung, Colorectal, and Ovarian(PLCO) Cancer Screening Study, and examined whether serum vitamin D binding protein (DBP) concentration confounded or modified the association. Methods: 375 cases of bladder [...]