A partir des données de la cohorte européenne EPIC incluant 142 203 hommes et 334 999 femmes, cette étude évalue l'association entre une consommation alimentaire de fer et de magnésium et le risque de cancer du pancréas

Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Molina-Montes, Esther ; Wark, Petra A. ; Sánchez, María-José ; Norat, Teresa ; Jakszyn, Paula ; Luján-Barroso, Leila ; Michaud, Dominique S. ; Crowe, Francesca ; Allen, Naomi ; Khaw, Kay-Tee ; Wareham, Nicholas ; Trichopoulou, Antonia ; Adarakis, George ; Katarachia, Helen ; Skeie, Guri ; Henningsen, Maria ; Broderstad, Ann Ragnhild ; Berrino, Franco ; Tumino, Rosario ; Palli, Domenico ; Mattiello, Amalia ; Vineis, Paolo ; Amiano, Pilar ; Barricarte, Aurelio ; Huerta, José-María ; Duell, Eric J. ; Quirós, José-Ramón ; Ye, Weimin ; Sund, Malin ; Lindkvist, Björn ; Johansen, Dorthe ; Overvad, Kim ; Tjønneland, Anne ; Roswall, Nina ; Li, Kuanrong ; Grote, Verena A. ; Steffen, Annika ; Boeing, Heiner ; Racine, Antoine ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Peeters, Petra H. M. ; Siersema, Peter D. ; Fedirko, Veronika ; Jenab, Mazda ; Riboli, Elio ; Bueno-de-Mesquita, Bas

Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. Since diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. 142,203 men and 334,999 women, recruited between 1992 and [...]

A partir des données de la "Multiethnic cohort study" incluant 165 717 participants, cette étude évalue l'association entre une consommation alimentaire de viande, les amines hétérocycliques formés lors de la cuisson et le risque de cancer colorectal

Meat consumption, heterocyclic amines, and colorectal cancer risk: The multiethnic cohort study

Ollberding, Nicholas J. ; Wilkens, Lynne R. ; Henderson, Brian E. ; Kolonel, Laurence N. ; Le Marchand, Loic

Greater consumption of red and processed meat has been associated with an increased risk of colorectal cancer in several recent meta-analyses. Heterocyclic amines (HCAs) have been hypothesized to underlie this association. In this prospective analysis conducted within the Multiethnic Cohort Study, we examined whether greater consumption of total, red, or processed meat was associated with the risk of colorectal cancer among 165,717 participants who completed a detailed food frequency [...]

Menée auprès de 10 066 membres du personnel navigant en cabine finlandais, islandais, norvégiens et suédois, cette étude de cohorte évalue l'association entre une exposition professionnelle aux rayonnements cosmiques, des perturbations du rythme circadien et le risque de cancer chez ces employés de l'aviation civile

Cancer incidence among Nordic airline cabin crew

Pukkala, Eero ; Helminen, Mika ; Haldorsen, Tor ; Hammar, Niklas ; Kojo, Katja ; Linnersjö, Anette ; Rafnsson, Vilhjálmur ; Tulinius, Hrafn ; Tveten, Ulf ; Auvinen, Anssi

Airline cabin crew are occupationally exposed to cosmic radiation and jet lag with potential disruption of circadian rhythms. This study assesses the influence of work-related factors in cancer incidence of cabin crew members. A cohort of 8,507 female and 1,559 male airline cabin attendants from Finland, Iceland, Norway, and Sweden was followed for cancer incidence for a mean follow-up time of 23.6 years through the national cancer registries. Standardised incidence ratios (SIRs) were defined [...]

A partir des données de l'étude américaine "Women's Health Initiative" incluant 119 726 participantes ménopausées, cette étude prospective analyse l'association entre la prise de statines et le risque de mélanome

Prospective analysis of association between use of statins and melanoma risk in the Women's Health Initiative

Jagtap, Deepa ; Rosenberg, Carol A. ; Martin, Lisa W. ; Pettinger, Mary ; Khandekar, Janardan ; Lane, Dorothy ; Ockene, Ira ; Simon, Michael S.

BACKGROUND: Melanoma is the most lethal form of skin cancer, with an estimated 68,130 new cases and 8700 deaths in the United States in 2010. The increasing incidence and high death rate associated with metastatic disease support the need to focus on prevention. The authors used data from the Women's Health Initiative (WHI) to assess whether 3-hydroxy-3 methylglutaryl coenzyme A inhibitors (statins) are associated with a decreased risk of melanoma. METHODS: The study population consisted of [...]

A partir d'une revue de la littérature (11 études), cette méta-analyse évalue l'association entre des polymorphismes à simple nucléotide du promoteur 819 du gène de l'interleukine 10 et le risque de cancer de l'estomac

Interleukin-10-819 promoter polymorphism in association with gastric cancer risk

Xue, Huiping ; Lin, Bing ; An, Jianfu ; Zhu, Yuyuan ; Huang, Gang

BACKGROUND:Potential functional allele T/C single nucleotide polymorphism (SNP) of Interleukin 10 (IL-10) promoter 819 (rs1800871) has been implicated in gastric cancer risk. We aimed to explore the role of T/C SNP of IL-10 -819 in the susceptibility to gastric cancer through a systematic review and meta-analysis.METHODS:Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. 11 studies were ultimately eligible for the [...]

A partir d'une revue de la littérature (26 études prospectives), cette méta-analyse évalue l'association entre l'excès de poids, l'obésité et le risque de cancer primitf du foie

Excess body weight and the risk of primary liver cancer: An updated meta-analysis of prospective studies

Chen, Yi ; Wang, Xiaolin ; Wang, Jianhua ; Yan, Zhiping ; Luo, Jianjun

To provide a quantitative assessment of the association between excess body weight (EBW) and the risk of primary liver cancer (PLC), we performed an updated meta-analysis of prospective observational studies. We searched PUBMED and EMBASE for studies of body mass index and the risk of PLC published through 15 th September 2011. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. The meta-regression and stratified [...]

A partir des données de 24 études cas-témoins (24 380 cas et 23 305 témoins), cette analyse évalue l'association entre une histoire familiale de cancer du poumon et l'augmentation du risque de ce cancer

Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

Coté, Michele L. ; Liu, Mei ; Bonassi, Stefano ; Neri, Monica ; Schwartz, Ann G. ; Christiani, David C. ; Spitz, Margaret R. ; Muscat, Joshua E. ; Rennert, Gad ; Aben, Katja K. ; Andrew, Angeline S. ; Bencko, Vladimir ; Bickeböller, Heike ; Boffetta, Paolo ; Brennan, Paul ; Brenner, Hermann ; Duell, Eric J. ; Fabianova, Eleonora ; Field, John K. ; Foretova, Lenka ; Friis, Søren ; Harris, Curtis C. ; Holcatova, Ivana ; Hong, Yun-Chul ; Isla, Dolores ; Janout, Vladimir ; Kiemeney, Lambertus A. ; Kiyohara, Chikako ; Lan, Qing ; Lazarus, Philip ; Lissowska, Jolanta ; Le Marchand, Loic ; Mates, Dana ; Matsuo, Keitaro ; Mayordomo, Jose I. ; McLaughlin, John R. ; Morgenstern, Hal ; Müeller, Heiko ; Orlow, Irene ; Park, Bernard J. ; Pinchev, Mila ; Raji, Olaide Y. ; Rennert, Hedy S. ; Rudnai, Peter ; Seow, Adeline ; Stücker, Isabelle ; Szeszenia-Dabrowska, Neonila ; Dawn Teare, M. ; Tjønnelan, Anne ; Ugolini, Donatella ; van der Heijden, Henricus F. M. ; Wichmann, Erich ; Wiencke, John K. ; Woll, Penella J. ; Yang, Ping ; Zaridze, David ; Zhang, Zuo-Feng ; Etzel, Carol J. ; Hung, Rayjean J.

Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer [...]

Menée in vitro et sur trente femmes en surpoids ou obèses, cette étude met en évidence un mécanisme permettant de rendre compte d'un risque accru de cancer du sein hormono-sensible chez les femmes obèses

Increased Levels of COX-2 and Prostaglandin E2 Contribute to Elevated Aromatase Expression in Inflamed Breast Tissue of Obese Women

Subbaramaiah, Kotha ; Morris, Patrick G. ; Zhou, Xi Kathy ; Morrow, Monica ; Du, Baoheng ; Giri, Dilip ; Kopelovich, Levy ; Hudis, Clifford A. ; Dannenberg, Andrew J.

Obesity is a risk factor for hormone receptor-positive breast cancer in postmenopausal women. Estrogen synthesis is catalyzed by aromatase, which is encoded by CYP19. We previously showed that aromatase expression and activity are increased in the breast tissue of overweight and obese women in the presence of characteristic inflammatory foci [crown-like structures of the breast (CLS-B)]. In preclinical studies, proinflammatory prostaglandin E2 (PGE2) is a determinant of aromatase expression. We [...]

A partir des données de l'étude "CARE" menée en population américaine, cette étude multicentrique (1 644 cas et 1 451 témoins) analyse l'association entre des variants de plusieurs gènes associés au métabolisme des œstrogènes et des disparités ethniques dans le risque de cancer du sein

Estrogen-related genes and their contribution to racial differences in breast cancer risk

Reding, Kerryn ; Chen, Chu ; Lowe, Kimberly ; Doody, David ; Carlson, Christopher ; Chen, Christina ; Houck, John ; Weiss, Linda ; Marchbanks, Polly ; Bernstein, Leslie ; Spirtas, Robert ; McDonald, Jill ; Strom, Brian ; Burkman, Ronald ; Simon, Michael ; Liff, Jonathan ; Daling, Janet ; Malone, Kathleen

Racial differences in breast cancer risk, including the risks of hormone receptor subtypes of breast cancer, have been previously reported. We evaluated whether variation in genes related to estrogen metabolism ( COMT , CYP1A1 , CYP1B1 , CYP17A1 , CYP19A1 , ESR1 , GSTM1 , GSTP1 , GSTT1 , HSD17B1 , SULT1A1 , and UGT1A1 ) contributes to breast cancer risk and/or racial differences in risk within the CARE study, a multi-centered, population-based case–control study of breast cancer. Genetic [...]

Menée sur deux cohortes en population chinoise (206 cas et 180 témoins, 329 cas et 345 témoins), cette étude identifie des polymorphismes à simple nucléotide, situés à proximité du locus HLA-A, en association avec une susceptibilité au cancer du rhino-pharynx

Further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near HLA-A locus in Southern Chinese

Zhao, Manli ; Cai, Hongbing ; Li, Xin ; Zheng, Hang ; Yang, Xuexi ; Fang, Weiyi ; Zhang, Longcheng ; Wei, Ganguan ; Li, Ming ; Yao, Kaitai

BACKGROUND:Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially the region near HLA-A locus, was regarded as a major candidate region bearing NPC genetic susceptibility loci in many previous studies including two recent genome-wide association (GWA) studies. To provide further evidence for the NPC susceptibility in the region near HLA-A [...]