Menée en Norvège auprès de 126 patients atteints de cancer et traités dans des unités de soins palliatifs, cette étude analyse la prévalence des morbidités de la cavité buccale indépendantes de la localisation du cancer

Oral health is an important issue in end-of-life cancer care

Wilberg, Petter ; Hjermstad, Marianne ; Ottesen, Stig ; Herlofson, Bente

Purpose This study aims to assess the prevalence of oral morbidity in patients receiving palliative care for cancers outside the head and neck region and to investigate if information concerning oral problems was given. Methods Patients were recruited from two Norwegian palliative care inpatient units. All patients went through a face-to-face interview, completed the Edmonton Symptom Assessment System (ESAS) covering 10 frequent cancer-related symptoms, and went through an oral examination [...]

Mené pendant 12 mois, cet essai randomisé évalue l'efficacité d'un programme d'exercices physiques à domicile pour des patients atteints d'un cancer de la prostate et ayant reçu une hormonothérapie anti-androgénique

A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy

Lee, C. Ellen ; Leslie, William ; Lau, Y.K. James

BACKGROUND:Androgen deprivation therapy (ADT) is the mainstay therapy for men with prostate cancer. However, there are musculoskeletal side effects from ADT that increase the risk for osteoporosis and fracture, and can compromise the quality of life of these individuals. The objectives of this study are to determine the efficacy of a home-based walking exercise program in promoting bone health, physical function and quality of life in men with prostate cancer receiving ADT.METHODS:A 12-month [...]

Menée auprès de 241 participants, cette étude européenne évalue la qualité de vie de patients ayant subi une résection hépatique pour traiter des métastases d'un cancer colorectal

Patient-Reported Outcomes After Hepatic Resection of Colorectal Cancer Metastases

Rees, Jonathan R. ; Blazeby, Jane M. ; Fayers, Peter ; Friend, Elizabeth A. ; Welsh, Fenella K.S. ; John, Timothy G. ; Rees, Myrddin

Purpose Hepatic resection of colorectal carcinoma (CRC) liver metastases is increasing, but evidence for the impact of surgery on patient-reported outcomes (PROs) is limited. This study aimed to describe comprehensively the impact of liver surgery for CRC hepatic metastases on PROs.Patients and Methods Consecutive patients selected for hepatic resection completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–C30 and Quality of Life [...]

Mené auprès de 229 patientes ayant reçu divers traitements pour un cancer du sein, cet essai randomisé évalue l'efficacité d'une intervention permettant de réduire leur stress et d'améliorer leur bien-être

Effectiveness of Mindfulness-Based Stress Reduction in Mood, Breast- and Endocrine-Related Quality of Life, and Well-Being in Stage 0 to III Breast Cancer: A Randomized, Controlled Trial

Hoffman, Caroline J. ; Ersser, Steven J. ; Hopkinson, Jane B. ; Nicholls, Peter G. ; Harrington, Julia E. ; Thomas, Peter W.

Purpose To assess the effectiveness of mindfulness-based stress reduction (MBSR) for mood, breast- and endocrine-specific quality of life, and well-being after hospital treatment in women with stage 0 to III breast cancer.Patients and Methods A randomized, wait-listed, controlled trial was carried out in 229 women after surgery, chemotherapy, and radiotherapy for breast cancer. Patients were randomly assigned to the 8-week MBSR program or standard care. Profile of Mood States (POMS; primary [...]

Menée en Ecosse sur la période 2000-2007, cette étude en population analyse l'évolution des disparités socioéconomiques dans l'incidence du cancer du poumon et du cancer des voies aérodigestives supérieures, en fonction de l'âge, du sexe de l'individu et du sous-type de la tumeur

Socioeconomic inequalities in incidence of lung and upper aero-digestive tract cancer by age, tumour subtype and sex: A population-based study in Scotland (2000–2007)

Sharpe, Katharine H. ; McMahon, Alex D. ; McClements, Paula ; Watling, Chris ; Brewster, David H. ; Conway, David I.

Background Lung and upper aero-digestive tract (UADT) cancer risk is associated with socioeconomic inequality (SEI) but the degree of socioeconomic burden by age, tumour subtype, and sex is not known. Methods We reviewed 216,305 cases excluding non melanoma skin cancer (All Cancer) comprising 37,274 lung; 8216 head and neck; and 6534 oesophageal cancers from 2000 to 2007 classified into anatomical or morphology subtypes. Deprivation was measured using the Scottish Index of Multiple Deprivation [...]

Menée aux Etats-Unis entre 2004 et 2007, cette étude de cohorte multicentrique incluant 2 744 participants analyse les disparités ethniques dans l'âge au diagnostic d'un lymphome folliculaire ainsi que dans les traitements

Racial differences in presentation and management of follicular non-Hodgkin lymphoma in the United States

Nabhan, Chadi ; Byrtek, Michelle ; Taylor, Michael D. ; Friedberg, Jonathan W. ; Cerhan, James R. ; Hainsworth, John D. ; Miller, Thomas P. ; Hirata, Jamie ; Link, Brian K. ; Flowers, Christopher R.

BACKGROUND: Racial differences in follicular lymphoma (FL) in the United States have not been investigated. METHODS: The National LymphoCare Study is a multicenter, longitudinal, observational cohort study collecting data on treatment patterns and outcomes for patients with newly diagnosed FL in the United States between 2004 and 2007 without any predefined, study-specific intervention. The authors investigated differences between white (W) patients, African American (AA) patients, and Hispanic [...]

A partir des données du registre danois des cancers gynécologiques portant sur la période 2005-2009, cette étude analyse l'associatin entre le statut socioéconomique des femmes et le stade au diagnostic de leur cancer du col de l'utérus

Socioeconomic position and stage of cervical cancer in Danish women diagnosed 2005-2009

Ibfelt, Else ; Kjaer, Susanne K. ; Johansen, Christoffer ; Høgdall, Claus ; Steding-Jessen, Marianne ; Frederiksen, Kirsten ; Frederiksen, Birgitte L. ; Osler, Merete ; Dalton, Susanne Oksbjerg

Background: To reduce social disparities in cervical cancer survival, it is important to understand the mechanisms by which social position influence cancer prognosis. We investigated the relations between socioeconomic factors, comorbidity, time since last Papanicolau smear and stage at diagnosis in Danish women with cervical cancer. Methods: We identified 1651 cervical cancer cases diagnosed 2005-2009 from the Danish Gynaecological Cancer Database. Date of diagnosis, clinical cancer stage, [...]

Menée en Italie auprès de neuf patients enfants et adolescents atteints d'un esthésioneuroblastome, une tumeur rare du nerf olfactif, cette étude décrit les principales caractéristiques histologiques de la maladie ainsi que ses modes de traitements

Esthesioneuroblastoma in pediatric and adolescent age. A report from the TREP project in cooperation with the Italian Neuroblastoma and Soft tissue sarcoma Committees

Bisogno, Gianni ; Soloni, Pietro ; Conte, Massimo ; Podda, Marta ; Ferrari, Andrea ; Garaventa, Alberto ; Luksch, Roberto ; Cecchetto, Giovanni

BACKGROUND:Esthesioneuroblastoma (ENB) is a rare, aggressive tumor with no established treatment in children. We analyzed a series of pediatric ENB patients with the aim of improving our knowledge of this disease.METHODS:9 patients (6 males; age 0.9-18 years, median 9.9) were identified by searching the AIEOP (Italian Association of Pediatric Hematology and Oncology) registry and the national databases of rare tumors, soft tissue sarcomas (STS) and neuroblastomas. The data on the cases included [...]

Menée auprès d'une cohorte de 6 205 survivantes d'un cancer du sein et de 2 297 survivants d'un cancer colorectal, cette étude américaine analyse leur adhésion aux recommandations de suivi et de soins après leur traitement

Adherence to surveillance care guidelines after breast and colorectal cancer treatment with curative intent

Salloum, Ramzi G. ; Hornbrook, Mark C. ; Fishman, Paul A. ; Ritzwoller, Debra P. ; O'Keeffe Rossetti, Maureen C. ; Elston Lafata, Jennifer

BACKGROUND: Evidence-based guidelines recommend routine surveillance, including office visits and testing, to detect new and recurrent disease among survivors of breast and colorectal cancer. The extent to which surveillance practice is consistent with guideline recommendations or may vary by age is not known. METHODS: Cohorts of adult patients diagnosed with breast (n = 6205) and colorectal (n = 2297) cancer between 2000 and 2008 and treated with curative intent in 4 geographically diverse [...]

Menée au Royaume-Uni auprès de 290 patients atteints de quatre types de cancer, cette étude de cohorte prospective évalue les facteurs cliniques, psychologiques et sociodémographiques prédictifs du retour à l'emploi après leur traitement

Distinct work-related, clinical and psychological factors predict return to work following treatment in four different cancer types

Cooper, Alethea F. ; Hankins, Matthew ; Rixon, Lorna ; Eaton, Emma ; Grunfeld, Elizabeth A.

Objective Many factors influence return to work (RTW) following cancer treatment. However specific factors affecting RTW across different cancer types are unclear. This study examined the role of clinical, sociodemographic, work and psychological factors in RTW following treatment for breast, gynaecological, head and neck, and urological cancer. Methods A 12-month prospective questionnaire study was conducted with 290 patients. Cox regression analyses were conducted to calculate hazard ratios [...]

A partir d'une revue systématique de la littérature (15 études), cette étude analyse les aspects psychosociaux du suivi des patients atteints d'un mélanome de stade I et II après leur traitement

Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature

Rychetnik, Lucie ; McCaffery, Kirsten ; Morton, Rachael ; Irwig, Les

Background Patients treated for melanoma are advised to have lifelong full body skin examinations. Extended intervals between examinations have been proposed, but although this may be clinically effective, psychosocial aspects of follow-up are not well understood. This systematic review summarised patient and clinician preferences, experiences and adherence with recommended follow-up of stage I/II melanoma. Methods Medline, PsycINFO, CINAHL, Embase, Cochrane Library, ACP Journal Club and NHS [...]

Menée en Australie auprès de 52 patientes dont le diagnostic de cancer du sein a été suivi par un test génétique de recherche d'une mutation BRCA 1/2, cette étude qualitative analyse leur ressenti et leurs perceptions vis-à-vis de ces tests génétiques révélant un haut risque de cancer de l'ovaire et de cancer métachrone du sein

Are we being overly cautious? A qualitative inquiry into the experiences and perceptions of treatment-focused germline BRCA genetic testing amongst women recently diagnosed with breast cancer

Zilliacus, E. ; Meiser, B. ; Gleeson, M. ; Watts, K. ; Tucker, K. ; Lobb, E. ; Mitchell, G.

Purpose Women with breast cancer, who are found to be BRCA 1/2 mutation carriers, have a high risk of ovarian cancer and metachronous breast cancer. Treatment-focused genetic testing (TFGT), offered around the time of diagnosis, allows genetic test results to inform surgical treatment decisions. However, concern has been raised that offering TFGT at this time may overly increase psychological burden. This study aimed to qualitatively explore women’s attitudes and experiences of TFGT. Methods [...]

Menée au Danemark sur la période 1994-2010 auprès de 21 213 patientes atteintes d'un cancer du sein, cette étude en population analyse l'association entre la perte de la personne partageant leur vie, le risque de récidive du cancer et la mortalité

Loss of partner and breast cancer prognosis - a population-based study, Denmark, 1994-2010

Olsen, M. H. ; Bidstrup, P. E. ; Frederiksen, K. ; Rod, N. H. ; Gronbak, M. ; Dalton, S. O. ; Johansen, C.

Background: The extent to which experiencing a stressful life event influences breast cancer prognosis remains unknown, as the findings of the few previous epidemiological studies are inconsistent. This large population-based study examines the association between a common major life event, loss of a partner and breast cancer recurrence and all-cause mortality. Methods: N=21 213 women diagnosed with a first primary breast cancer 1994–2006, who had a cohabiting partner in the 4 years before [...]

A partir d'une revue de la littérature (81 études), cette étude analyse les relations financières entres les industries pharmaceutiques et les auteurs d'études économiques évaluant le rapport coût-efficacité de nouvelles thérapies ciblées en oncologie

Financial Relationships in Economic Analyses of Targeted Therapies in Oncology

Valachis, Antonis ; Polyzos, Nikolaos P. ; Nearchou, Andreas ; Lind, Pehr ; Mauri, Davide

Purpose A potential financial relationship between investigators and pharmaceutical manufacturers has been associated with an increased likelihood of reporting favorable conclusions about a sponsor's proprietary agent in pharmacoeconomic studies. The purpose of this study is to investigate whether there is an association between financial relationships and outcome in economic analyses of new targeted therapies in oncology.Materials and Methods We searched PubMed (last update June 2011) for [...]

Cette étude européenne plaide pour le maintien de programmes de dépistage des cancers pendant une période de crise économique

Cancer screening and health system resilience: Keys to protecting and bolstering preventive services during a financial crisis

Martin-Moreno, Jose M. ; Anttila, Ahti ; von Karsa, Lawrence ; Alfonso-Sanchez, Jose L. ; Gorgojo, Lydia

The aim of this paper is to elucidate the rationale for sustaining and expanding cost-effective, population-based screening services for breast, cervical and colorectal cancers in the context of the current financial crisis. Our objective is not only to promote optimal delivery of high-quality secondary cancer prevention services, but also to underline the importance of strengthening comprehensive cancer control, and with it, health system response to the complex care challenges posed by all [...]

Menée auprès de patientes américaines atteintes d'un cancer du sein, cette étude analyse les effets secondaires de la radiothérapie externe, en particulier les effets associés à sa toxicité sévère pour la peau, puis estime les coûts liés aux traitements non médicaux des symptômes dermatologiques

Acute skin toxicity-related, out-of-pocket expenses in patients with breast cancer treated with external beam radiotherapy

Schnur, Julie ; Graff Zivin, Joshua ; Mattson, David ; Green, Sheryl ; Jandorf, Lina ; Wernicke, A. ; Montgomery, Guy

Purpose Acute skin toxicity is one of the most common side effects of breast cancer radiotherapy. To date, no one has estimated the nonmedical out-of-pocket expenses associated with this side effect. The primary aim of the present descriptive, exploratory study was to assess the feasibility of a newly developed skin toxicity costs questionnaire. The secondary aims were to: (1) estimate nonmedical out-of-pocket costs, (2) examine the nature of the costs, (3) explore potential background [...]

A partir des données de la cohorte "MIRROR" incluant 366 participantes, cette étude analyse le rapport coût-efficacité d'une thérapie systémique adjuvante pour traiter des patientes atteintes d'un cancer du sein à faible risque de récidive présentant un nodule isolé ou des micrométastases

Cost-effectiveness of adjuvant systemic therapy in low-risk breast cancer patients with nodal isolated tumor cells or micrometastases

de Boer, M. ; Adang, E. M. M. ; Van Dycke, K. C. G. ; van Dijck, J. A. A. M. ; Borm, G. F. ; Seferina, S. C. ; van Deurzen, C. H. M. ; van Diest, P. J. ; Bult, P. ; Donders, A. R. T. ; Tjan-Heijnen, V. C. G.

Background: The cost-effectiveness of adjuvant systemic therapy in patients with low-risk breast cancer and nodal isolated tumor cells or micrometastases is unknown.Patients and methods: A cost-effectiveness analysis of adjuvant systemic therapy was carried out using the costs per 1% event prevented after 5 years of follow-up as incremental cost-effectiveness ratio (ICER). Secondary objective was to establish when adjuvant systemic therapy becomes cost saving. Patients included in the MIRROR [...]

Menée en Norvège, cette étude analyse le rapport coût-efficacité de deux stratégies de dépistage du cancer du col de l'utérus, l'une par cytologie et l'autre par recherche du papillomavirus humain

Cost-effectiveness of cervical cancer screening with primary human papillomavirus testing in Norway

Burger, E. A. ; Ortendahl, J. D. ; Sy, S. ; Kristiansen, I. S. ; Kim, J. J.

Background: New screening technologies and vaccination against human papillomavirus (HPV), the necessary cause of cervical cancer, may impact optimal approaches to prevent cervical cancer. We evaluated the cost-effectiveness of alternative screening strategies to inform cervical cancer prevention guidelines in Norway. Methods: We leveraged the primary epidemiologic and economic data from Norway to contextualise a simulation model of HPV-induced cervical cancer. The current cytology-only [...]

Menée à partir des données de 14 interviews de survivants d'un cancer, cette étude qualitative canadienne analyse leurs besoins en communication avec le médecin sur la fin des traitements et la vie après le cancer

Patient perceptions of communications on the threshold of cancer survivorship: implications for provider responses

Thorne, Sally ; Stajduhar, Kelli

Introduction Although high quality professional–patient communication is recognized as fundamental to effective cancer care, less attention has been paid to developing an evidence basis for communications surrounding the stage of the cancer journey when primary cancer treatment concludes, management responsibilities shift from oncology specialist services into the generalist care domain, and the patient transitions beyond patienthood and into survivorship. Methods Using applied qualitative [...]

Cet article américain présente les actions spécifiques d'un programme financé par le National Cancer Institute en direction des survivants d'un cancer appartenant à des populations défavorisées

Enhancing life after cancer in diverse communities

Kaur, Judith S. ; Coe, Kathryn ; Rowland, Julia ; Braun, Kathryn L. ; Conde, Francisco A. ; Burhansstipanov, Linda ; Heiney, Sue ; Kagawa-Singer, Marjorie ; Lu, Qian ; Witte, Catherine

BACKGROUND: Although large numbers of cancer survivors exist in every community, including minority communities, there is a significant gap in knowledge about best practices for these patients. METHODS: The Community Networks Program, funded by the National Cancer Institute Center to Reduce Cancer Health Disparities, has developed and tested unique services for these communities. These programs have used community-based participatory research techniques under a framework of diffusion of [...]

Menée auprès de 171 patients atteints de cancer, cette étude portugaise analyse le recours aux médicaments sédatifs dans les unités de soins palliatifs

A survey of the sedation practice of Portuguese palliative care teams

Gonçalves, Ferraz ; Cordero, Aida ; Almeida, Ana ; Cruz, Arlindo ; Rocha, Céu ; Feio, Madalena ; Silva, Paula ; Barbas, Salomé ; Neves, Sandra

Aim The purpose of this study is to study the practice of sedation by Portuguese palliative care teams. Methods The teams included on the website of the Portuguese Association for Palliative Care were invited to participate. Data from all the patients sedated between April and June 2010 were recorded. Sedation was defined as the intentional administration of sedative drugs for symptom control, except insomnia, independently of the consciousness level reached. Results Of the 19 teams invited [...]

Mené auprès de 151 patients nouvellement diagnostiqués avec un cancer du poumon métastatique non à petites cellules, cet essai randomisé évalue la dépression et la survie des patients associées à l'administration précoce de soins palliatifs

Depression and Survival in Metastatic Non–Small-Cell Lung Cancer: Effects of Early Palliative Care

Pirl, William F. ; Greer, Joseph A. ; Traeger, Lara ; Jackson, Vicki ; Lennes, Inga T. ; Gallagher, Emily R. ; Perez-Cruz, Pedro ; Heist, Rebecca S. ; Temel, Jennifer S.

Purpose In a randomized trial, early palliative care (EPC) in patients with metastatic non–small-cell lung cancer (NSCLC) was observed to improve survival. In a secondary analysis, we explored the hypothesis that the survival benefit resulted from improving depression.Patients and Methods In total, 151 patients with newly diagnosed metastatic NSCLC participated in a randomized trial of EPC integrated with standard oncology care versus standard oncology care alone. Depression was assessed at [...]

Menée au Royaume-Uni, cette étude plaide pour la prise en compte des données complètes de datation (jour, mois, année) pour estimer correctement la survie des patients atteints de cancer dans les études en population

Full dates (day, month, year) should be used in population-based cancer survival studies

Woods, Laura M. ; Rachet, Bernard ; Ellis, Libby ; Coleman, Michel P.

Accurate survival estimates are essential for monitoring cancer survival trends, for health care planning and for resource allocation. In order to obtain precise estimates of survival, full dates (day, month and year) rather than partial dates (month and year) are required. In some jurisdictions, however, cancer registries are constrained from providing full dates on the grounds of confidentiality. The bias resulting from the use of partial dates in the estimation and comparison of survival [...]