Cancer incidence among Nordic airline cabin crew
Menée auprès de 10 066 membres du personnel navigant en cabine finlandais, islandais, norvégiens et suédois, cette étude de cohorte évalue l'association entre une exposition professionnelle aux rayonnements cosmiques, des perturbations du rythme circadien et le risque de cancer chez ces employés de l'aviation civile
Résumé en anglais
Airline cabin crew are occupationally exposed to cosmic radiation and jet lag with potential disruption of circadian rhythms. This study assesses the influence of work-related factors in cancer incidence of cabin crew members. A cohort of 8,507 female and 1,559 male airline cabin attendants from Finland, Iceland, Norway, and Sweden was followed for cancer incidence for a mean follow-up time of 23.6 years through the national cancer registries. Standardised incidence ratios (SIRs) were defined as ratios of observed and expected numbers of cases. A case-control study nested in the cohort (excluding Norway) was conducted to assess the relation between the estimated cumulative cosmic radiation dose and cumulative number of flights crossing six time zones (indicator of circadian disruption) and cancer risk. Analysis of breast cancer was adjusted for parity and age at first live birth. Among female cabin crew, a significantly increased incidence was observed for breast cancer (SIR 1.50, 95% confidence interval (95% CI) 1.32-1.69), leukaemia (1.89, 95% CI 1.03-3.17), and skin melanoma (1.85, 95% CI 1.41-2.38). Among men, significant excesses in skin melanoma (3.00, 95% CI 1.78-4.74), non-melanoma skin cancer (2.47, 95% CI 1.18-4.53), Kaposi sarcoma (86.0, 95% CI 41.2-158), and alcohol-related cancers (combined SIR 3.12, 95% CI 1.95-4.72) were found. This large study with complete follow-up and comprehensive cancer incidence data shows an increased incidence of several cancers, but according to the case-control analysis, excesses appear not to be related to the cosmic radiation or circadian disruptions from crossing multiple time zones. © 2012 Wiley-Liss, Inc.
