Couplée aux données de l'essai "the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial" et de l'étude "Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study" portant sur un total de 706 cas et 706 témoins, cette étude analyse l'association entre les niveaux sériques de 904 espèces lipidiques et 252 acides gras et le risque de cancer du pancréas

Lipidomics and pancreatic cancer risk in two prospective studies

Naudin, Sabine ; Sampson, Joshua N. ; Moore, Steven C. ; Albanes, Demetrius ; Freedman, Neal D. ; Weinstein, Stephanie J. ; Stolzenberg-Solomon, Rachael

Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24 years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, NCT00002540) with 332 matched [...]

Menée à l'aide de données internationales 1946-2014 portant sur 119 709 hommes travaillant dans des mines d'uranium, cette étude analyse l'association entre une exposition cumulée au radon et le risque de cancer du poumon ainsi que la mortalité spécifique (7 754 décès)

Radon and lung cancer in the pooled uranium miners analysis (PUMA): highly exposed early miners and all miners

Kaitlin Kelly-Reif ; Stephen J Bertke ; Estelle Rage ; Paul A Demers ; Nora Fenske ; Veronika Deffner ; Michaela Kreuzer ; Jonathan Samet ; Mary K Schubauer-Berigan ; Ladislav Tomasek ; Lydia B Zablotska ; Charles Wiggins ; Dominique Laurier ; David B Richardson

Objectives: Radon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners. Methods: The pooled uranium miners analysis combines 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained between 1946 and 2014. The association between [...]

Menée dans les Antilles françaises auprès de 405 témoins et 145 patients atteints d'un cancer de la tête et du cou, cette étude analyse l'association entre les comportements sexuels, le risque d'infection par le papillomavirus humain (HPV) et le risque de développer la maladie

Association between sexual behaviour and head and neck cancer in the French West Indies: a case-control study based on an Afro-Caribbean population

Auguste, Aviane ; Gaete, Stanie ; Michineau, Léah ; Herrmann-Storck, Cécile ; Joachim, Clarisse ; Duflo, Suzy ; Deloumeaux, Jacqueline ; Luce, Danièle

Background: Worldwide, a significant proportion of head and neck cancers is attributed to the Human papillomavirus (HPV). It is imperative that we acquire a solid understanding of the natural history of this virus in head and neck squamous cell carcinoma (HNSCC) development. Our objective was to investigate the role of sexual behaviour in the occurrence of HNSCC in the French West Indies. Additionally, we evaluated the association of high risk of HPV (Hr-HPV) with sexual behaviour in risk of [...]

Menée en Chine sur la période 2013-2017 auprès de 101 370 patients souffrant d'hypertension (durée moyenne de suivi : 5,1 ans), cette étude analyse l'association entre une utilisation de médicaments antihypertenseurs et le risque de cancer (4 970 cas), par type et par classe de médicament

Association between use of antihypertensive drugs and the risk of cancer: a population-based cohort study in Shanghai

Wang, Suna ; Xie, Li ; Zhuang, Jianlin ; Qian, Ying ; Zhang, Guanglu ; Quan, Xiaowei ; Li, Lei ; Yu, Herbert ; Zhang, Weituo ; Zhao, Wensui ; Qian, Biyun

Background: Previously studies shown a potential risk of antihypertensive medicines in relation to cancer susceptibility, which creating significant debate in the scientific community and public concern. We sought to investigate the relationship between antihypertensive medicines and cancer risk, by drug type and class. Methods: We conducted a population-based cohort study and enrolled patients diagnosed with hypertension from community healthcare centers in Changning District, Shanghai, China. [...]

Menée par questionnaire auprès de 145 témoins et 168 patients atteints d'un rétinoblastome sporadique unilatéral, cette étude analyse l'association entre les nutriments apportés par la mère pendant la grossesse et le développement de la maladie chez l'enfant

The association between maternal nutrient intake during pregnancy and the risk of sporadic unilateral retinoblastoma among offspring

Jung, Eun Mi ; Bunin, Greta R. ; Ganguly, Arupa ; Johnson, Rebecca A. ; Spector, Logan G.

Previous studies have associated maternal diet during pregnancy with the development of sporadic unilateral retinoblastoma (RB), but few studies have focused on the role of individual nutrients. The aim of this study is to investigate the association between maternal nutrient intake during pregnancy and the development of sporadic unilateral RB in the offspring. A modified food frequency questionnaire, with additional questions on supplement use, was completed via a phone interview. Cases were [...]

Menée à l'aide de données de génotypage de l'étude OncoArray d'INTEGRAL-ILCCO portant sur 14 825 témoins et 18 221 patients atteints d'un cancer du poumon, cette étude analyse l'association entre la présence d'altérations chromosomiques en mosaïque dans les globules blancs et le risque de développer la maladie

Mosaic chromosomal alterations is associated with increased lung cancer risk: insight from the INTEGRAL-ILCCO cohort analysis

Cheng, Chao ; Hong, Wei ; Li, Yafang ; Xiao, Xiangjun ; McKay, James ; Han, Younghun ; Byun, Jinyoung ; Peng, Bo ; Albanes, Demetrios ; Lam, Stephen ; Tardon, Adonina ; Chen, Chu ; Bojesen, Stig E. ; Landi, Maria T. ; Johansson, Mattias ; Risch, Angela ; Bickeböller, Heike ; Wichmann, H. Erich ; Christiani, David C. ; Rennert, Gad ; Arnold, Susanne ; Goodman, Gary ; Field, John K. ; Davies, Michael P. A. ; Shete, Sanjay S. ; Le Marchand, Loic ; Liu, Geoffrey ; Hung, Rayjean J. ; Andrew, Angeline S. ; Kiemeney, Lambertus A. ; Zhu, Meng ; Shen, Hongbing ; Zienolddiny, Shan ; Grankvist, Kjell ; Johansson, Mikael ; Cox, Angela ; Hong, Yun-Chul ; Yuan, Jian-Min ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Brennan, Paul ; Li, Yong ; Gorlova, Olga ; Gorlov, Ivan ; Amos, Christopher I.

Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared to CH-related somatic mutations. A few recent studies indicated their potential link with non-hematological cancers, especially lung cancer. In this study, we investigated the association between mCAs and lung cancer using the high-density genotyping data from the OncoArray study of INTEGRAL-ILCCO, the largest single genetic study of lung cancer with [...]

Menée à l'aide de données canadiennes 1997-2003 portant sur 329 enfants atteints d'une tumeur cérébrale (âge : 0-15 ans), cette étude analyse l'association entre les antécédents médicaux de la mère et de l'enfant et le risque de développer la maladie

Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada

Cheng, Sierra ; McLaughlin, John R. ; Brown, M. Catherine ; Al-Sawaihey, Hamad ; Rutka, James ; Bouffet, Eric ; Hawkins, Cynthia ; Cairney, A. Elizabeth ; Ranger, Adrianna ; Fleming, Adam J. ; Johnston, Donna ; Grenberg, Mark ; Malkin, David ; Hung, Rayjean J.

Background: Studies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a child’s early-life medical history contribute to the development of childhood brain tumours (CBTs). This study examined associations between maternal and childhood medical history and the risk of CBTs. Methods: The Childhood Brain Tumour Epidemiology Study of Ontario (CBREO) examined children 0–15 years of age with newly diagnosed CBTs from 1997 to 2003. Multivariable [...]