Menée à l'aide de données de la "UK Biobank" portant sur 403 170 personnes, cette étude analyse l'effet de polymorphismes liés à la vitamine D sur l'association entre la concentration sérique en 25-hydroxyvitamine D et le risque de cancer colorectal (5 053 cas)

Serum vitamin D concentration, vitamin D-related polymorphisms, and colorectal cancer risk

Li, Jiaoyuan ; Qin, Shifan ; Zhang, Shanshan ; Lu, Yifan ; Shen, Qian ; Cheng, Liming ; Zhong, Rong

Serum 25-Hydroxyvitamin D (25(OH)D) has been demonstrated to be associated with risk of colorectal cancer (CRC). However, it remains unclear whether this association was modified by vitamin D-related polymorphisms. We evaluated association of serum 25(OH)D concentrations with CRC risk among 403,170 participants from UK Biobank Project. Two variants of vitamin D binding protein (VDBP), rs4588 and rs7041, were included to estimate the binding affinity of 25(OH)D to VDBP, and three variants of [...]

Menée en Suisse par enquête réalisée auprès de 5 524 étudiants universitaires sur la période 2020-2021 (âge médian : 23 ans ; 70 % de femmes), cette étude analyse leurs connaissances, leurs expériences et leurs attitudes vis-à-vis de la vaccination contre le papillomavirus humain lors de consultations en médecine générale

Assessment of Human Papillomavirus Vaccination in Primary Care Among Swiss University Students

Jäger, Levy ; Senn, Oliver ; Rosemann, Thomas ; Plate, Andreas

Human papillomavirus vaccination coverage rates lie below desired thresholds in Switzerland. Because general practitioners are the main contact for the relatively rare health issues of many Swiss young adults, primary care offers an important opportunity to provide catch-up human papillomavirus vaccination.To examine the knowledge, experiences, and attitudes of Swiss university students in the context of receiving human papillomavirus vaccination during primary care visits.This [...]

Menée aux Etats-Unis sur la période 2019-2021 auprès de 1 227 hommes non vaccinés contre le papillomavirus humain (HPV) (âge : 18-25 ans), cette étude analyse l'efficacité d'une intervention en ligne pour promouvoir la vaccination contre le HPV auprès des jeunes hommes ayant des rapports sexuels avec des hommes

Efficacy of the Outsmart HPV Intervention: A Randomized Controlled Trial to Increase HPV Vaccination among Young Gay, Bisexual, and Other Men Who Have Sex with Men

Reiter, Paul L. ; Gower, Amy L. ; Kiss, Dale E. ; Shoben, Abigail B. ; Katz, Mira L. ; Bauermeister, Jose A. ; Paskett, Electra D. ; McRee, Annie-Laurie

Background: Routine human papillomavirus (HPV) vaccination is recommended for young adults, yet many young gay, bisexual, and other men who have sex with men (YGBMSM) remain unvaccinated. We report the efficacy of Outsmart HPV, a web-based HPV vaccination intervention for YGBMSM. Methods: From 2019-2021, we recruited YGBMSM in the United States who were ages 18-25 and unvaccinated against HPV (n=1,227). Participants were randomized to receive either: (a) Outsmart HPV content online and monthly [...]

Menée en Australie à partir de données de registres et menée à l'aide d'un questionnaire et d'échantillons de salive collectés auprès de 911 personnes (âge : 18-70 ans), cette étude analyse la prévalence d'une infection orale liée au papillomavirus humain (HPV) en fonction du statut vaccinal HPV

Oral HPV infection and HPV vaccination in an Australian cohort

de Souza, Marjorie M.A. ; Hartel, Gunter ; Olsen, Catherine M. ; Whiteman, David C. ; Antonsson, Annika

Human papillomavirus (HPV)-related oropharyngeal cancer (OPC) is increasing in incidence, yet very little is known about oral HPV infection in the general population. In this Australian-based study we assess oral HPV prevalence according to HPV vaccination status. Participants of the Oral Diversity Study were Australian residents, aged 18-70 years, who filled out a questionnaire about lifestyle and sexual behaviour, and donated a saliva sample in 2020-21. We obtained permission to access HPV [...]