Menée à l'aide d'une méthode de randomisation mendélienne et de données issues de 34 études d'association sur le génome entier, cette étude analyse l'association entre le tabagisme, la consommation d'alcool et de café et le risque de cancer de l'ovaire

Association of smoking, alcohol, and coffee consumption with the risk of ovarian cancer and prognosis: a mendelian randomization study

Liu, Sicong ; Feng, Songwei ; Du, Furong ; Zhang, Ke ; Shen, Yang

Objective: Currently, the association between smoking, alcohol, and coffee intake and the risk of ovarian cancer (OC) remains conflicting. In this study, we used a two-sample mendelian randomization (MR) method to evaluate the association of smoking, drinking and coffee consumption with the risk of OC and prognosis. Methods: Five risk factors related to lifestyles (cigarettes per day, smoking initiation, smoking cessation, alcohol consumption and coffee consumption) were chosen from the [...]

Menée au Canada auprès de 902 témoins et 495 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre la consommation d'alcool au cours de la vie et le risque de développer la maladie

Alcohol intake and the risk of epithelial ovarian cancer

L’Espérance, Kevin ; Grundy, Anne ; Abrahamowicz, Michal ; Arseneau, Jocelyne ; Gilbert, Lucy ; Gotlieb, Walter H. ; Provencher, Diane ; Koushik, Anita

Purpose: To investigate the association between alcohol intake over the lifetime and the risk of overall, borderline, and invasive ovarian cancer. Methods: In a population-based case–control study of 495 cases and 902 controls, conducted in Montreal, Canada, average alcohol intake over the lifetime and during specific age periods were computed from a detailed assessment of the intake of beer, red wine, white wine and spirits. Multivariable logistic regression was used to estimate odds ratios [...]

Menée depuis 1995 auprès de 485 931 personnes, cette étude analyse l'association entre les potentiels inflammatoire et insulinémique de l'alimentation, évalués à l'aide d'un système de score, et le risque de carcinome hépatocellulaire (635 cas) ainsi que la mortalité par maladie hépatique chronique (993 décès)

Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma and chronic liver disease mortality

Long, Lu ; Liu, Xing ; Petrick, Jessica ; Liu, Wanqing ; Lee, Jeffrey K ; Liao, Linda ; Lai, Michelle J ; Yang, Wanshui ; Libermann, Towia A ; Roberts, Lewis R ; McGlynn, Katherine A ; Tabung, Fred K ; Zhang, Xuehong

Diet modulates inflammation and insulin response and may be an important modifiable factor in the primary prevention of hepatocellular carcinoma (HCC) and chronic liver disease (CLD). We developed the empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores to assess the inflammatory and insulinemic potentials of diet.We prospectively examined the associations of EDIP and EDIH at baseline with the following HCC risk and CLD mortality.We [...]

Menée à Singapour à l'aide de données d'une étude portant sur 61 321 personnes (âge : 45-74 ans ; durée moyenne de suivi : 19,5 ans), cette étude analyse l'association entre un régime pauvre en glucides et le risque de cancer colorectal (2 520 cas)

Low-Carbohydrate Diet Score and the Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study

Yu, Yi-Chuan ; Paragomi, Pedram ; Jin, Aizhen ; Wang, Renwei ; Schoen, Robert E. ; Koh, Woon-Puay ; Yuan, Jian-Min ; Luu, Hung N.

Background: Colorectal cancer (CRC) is common cancer with a high mortality rate. Low-carbohydrate diet (LCD) score holistically evaluates the LCD pattern from carbohydrate, protein, and fat intake. Epidemiologic data of LCD-CRC association are sparse. Methods: We evaluated the associations between LCD (i.e., total, animal- and plant-based) and CRC risk in the Singapore Chinese Health Study, a population-based prospective cohort study including 61,321 Chinese in Singapore who were 45-74 years [...]

Menée en France auprès de 702 patients atteints d'un cancer du poumon, cette étude analyse la survie des patients ayant été exposés professionnellement à l'amiante (180 cas)

Occupational asbestos exposure and survival among lung cancer patients

Noelle, Hugo ; Pérol, Olivia ; Pérol, Maurice ; Avrillon, Virginie ; Belladame, Elodie ; Fayette, Jérôme ; Fournié, Françoise ; Swalduz, Aurelie ; Dessemon, Juliette ; Blay, Jean-Yves ; Neidhardt, Eve-Marie ; Saintigny, Pierre ; Tabutin, Mayeul ; Boussageon, Maxime ; Praud, Delphine ; Charbotel, Barbara ; Fervers, Beatrice

Objective: This study investigated the association between occupational asbestos exposure (OAE) and survival in patients with histologically confirmed lung cancer (LC). Methods: This monocentric study was conducted in the Comprehensive Cancer Centre Léon Bérard, Lyon, France. A systematic screening has been in place since 2014 for occupational exposure to carcinogens using a self-assessment questionnaire sent to all patients newly diagnosed with histologically confirmed LC identified through [...]

Menée aux Pays-Bas à l'aide de données administratives portant sur 11 861 personnes, cette étude analyse le risque de cancer chez les patients ayant survécu à un infarctus du myocarde avec sus-décalage du segment ST (1 809 patients, 115 cas de cancer)

Risk of cancer after ST-segment-elevation myocardial infarction

Leening, Maarten J. G. ; Bouwer, Nathalie I. ; Ikram, M. Arfan ; Kavousi, Maryam ; Ruiter, Rikje ; Boersma, Eric ; van den Bos, Ewout-Jan ; Weevers, Auke P. J. D. ; Deckers, Jaap W. ; Levin, Mark-David

Analyses from administrative databases have suggested an increased cancer incidence among individuals who experienced a myocardial infarction, especially within the first 6 months. It remains unclear to what extent this represents an underlying biological link, or can be explained by detection of pre-symptomatic cancers and shared risk factors.Cancer incidence among 1809 consecutive patients surviving hospitalization for thrombotic ST-segment-elevation myocardial infarction (STEMI; mean age [...]

Menée à partir de données de 12 études d'association sur le génome entier incluant au total 376 759 cas de cancer (12 localisations) et 532 864 témoins d'ascendance européenne, cette étude identifie 15 nouveaux loci de susceptibilité à la maladie

Genome-Wide Analyses Characterize Shared Heritability Among Cancers and Identify Novel Cancer Susceptibility Regions

Lindström, Sara ; Wang, Lu ; Feng, Helian ; Majumdar, Arunabha ; Huo, Sijia ; Macdonald, James ; Harrison, Tabitha ; Turman, Constance ; Chen, Hongjie ; Mancuso, Nicholas ; Bammler, Theo ; Breast Cancer Association Consortium ; Gallinger, Steve ; Gruber, Stephen B ; Gunter, Marc J ; Le Marchand, Loic ; Moreno, Víctor ; Offit, Kenneth ; Colorectal Transdisciplinary Study , Colon Cancer Family Registry Study , Genetics ; Epidemiology Of Colorectal Cancer Consortium ; De Vivo, Immaculata ; O’Mara, Tracy A ; Spurdle, Amanda B ; Tomlinson, Ian ; Endometrial Cancer Association Consortium ; Fitzgerald, Rebecca ; Gharahkhani, Puya ; Gockel, Ines ; Jankowski, Janusz ; MacGregor, Stuart ; Schumacher, Johannes ; Barnholtz-Sloan, Jill ; Bondy, Melissa L ; Houlston, Richard S ; Jenkins, Robert B ; Melin, Beatrice ; Wrensch, Margaret ; Brennan, Paul ; Christiani, David ; Johansson, Mattias ; McKay, James ; Aldrich, Melinda C ; Amos, Christopher I ; Landi, Maria Teresa ; Tardon, Adonina ; International Lung Cancer Consortium ; Bishop, D Timothy ; Demenais, Florence ; Goldstein, Alisa M ; Iles, Mark M ; Kanetsky, Peter A ; Law, Matthew H ; Ovarian Cancer Association Consortium ; Amundadottir, Laufey T ; Stolzenberg-Solomon, Rachael ; Wolpin, Brian M ; Pancreatic Cancer Cohort Consortium ; Klein, Alison ; Petersen, Gloria ; Risch, Harvey ; Pancreatic Cancer Case-Control Consortium ; the PRACTICAL consortium ; Chanock, Stephen J ; Purdue, Mark P ; Scelo, Ghislaine ; Pharoah, Paul ; Kar, Siddhartha ; Hung, Rayjean J ; Pasaniuc, Bogdan ; Kraft, Peter

The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from twelve cancer genome-wide association studies (GWAS) to quantify pair-wise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.We collected GWAS summary statistics for twelve solid cancers based on 376,759 cancer cases and 532,864 controls of European ancestry. The included cancer types were breast, colorectal, endometrial, [...]

Menée aux Etats-Unis à partir de données 1995-2018 d'une étude portant sur 453 859 personnes, cette étude analyse l'évolution de la part des carcinomes à cellules rénales attribuable au surpoids et à l'obésité chez les patients âgés d'au moins 60 ans

Impact of Overweight and Obesity on U.S. Renal Cell Carcinoma Incidence Trends (1995–2018)

Luo, Qianlai ; Hofmann, Jonathan N. ; Pfeiffer, Ruth M. ; Kitahara, Cari M. ; Song, Minkyo ; Shiels, Meredith S.

In the U.S., renal cell carcinoma (RCC) incidence and the prevalence of obesity, an established risk factor for RCC, have been increasing for several decades. RCC is more common among older individuals. We sought to quantify the contribution of excess adiposity to the rising incidence of RCC among individuals 60 years or older. NIH-AARP Diet and Health Study data (n=453,859 participants, enrolled in 1995–1996, age at enrollment 50–71 years) were used to estimate multivariable-adjusted hazard [...]