Menée aux Etats-Unis à partir de données portant sur un total de 58 195 patients atteints d'un cancer récemment diagnostiqué et recevant un traitement anticancéreux (âge : 18-64 ans), cette étude transversale analyse l'association entre la légalisation de la marijuana thérapeutique (2012-2017), l'utilisation des opioïdes et des consultations en urgence ou des hospitalisations pour des douleurs

Medical Marijuana Legalization and Opioid- and Pain-Related Outcomes Among Patients Newly Diagnosed With Cancer Receiving Anticancer Treatment

Bao, Yuhua ; Zhang, Hao ; Bruera, Eduardo ; Portenoy, Russell ; Rosa, William E. ; Reid, M. Carrington ; Wen, Hefei

Importance : The past decade saw rapid declines in opioids dispensed to patients with active cancer, with a concurrent increase in marijuana use among cancer survivors possibly associated with state medical marijuana legalization. Objective : To assess the associations between medical marijuana legalization and opioid-related and pain-related outcomes for adult patients receiving cancer treatment. Design, Setting, and Participants : This cross-sectional study used 2012 to 2017 national [...]

Cette étude présente les recommandations de l'"American Society of Clinical Oncology" concernant l'utilisation des opioïdes pour soulager la douleur liée à la maladie ou à ses traitements chez des adultes atteints d'un cancer

Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline

Judith A. Paice ; Kari Bohlke ; Debra Barton ; David S. Craig ; Areej El-Jawahri ; Dawn L. Hershman ; Lynn R. Kong ; Geana P. Kurita ; Thomas W. LeBlanc ; Sebastiano Mercadante ; Kristina L. M. Novick ; Ramy Sedhom ; Carole Seigel ; Joanna Stimmel ; Eduardo Bruera

PURPOSE: To provide guidance on the use of opioids to manage pain from cancer or cancer treatment in adults. METHODS: A systematic review of the literature identified systematic reviews and randomized controlled trials of the efficacy and safety of opioid analgesics in people with cancer, approaches to opioid initiation and titration, and the prevention and management of opioid adverse events. PubMed and the Cochrane Library were searched from January 1, 2010, to February 17, 2022. American [...]

Menée en Inde à partir de données 2005-2019 portant sur des enfants atteints d'un cancer (âge : 0-19 ans), cette étude de cohorte rétrospective analyse les disparités, selon le sexe, dans l'incidence de la maladie

Sex disparity in childhood cancer in India: a multi-centre, individual patient data analysis

Bhatia, Kanu Priya ; Ganguly, Shuvadeep ; Sasi, Archana ; Kumar, Vivek ; Deo, Suryanarayana ; Agarwala, Sandeep ; Radhakrishnan, Venkatraman ; Swaminathan, Rajaraman ; Kapoor, Gauri ; Manoharan, Nalliah ; Malhotra, Sumit ; Pushpam, Deepam ; Bakhshi, Sameer

Background: Sex disparity and its determinants in childhood cancer in India remain unexplored, with scarce information available through summary statistics of cancer registries. This study analysed the degree of sex bias in childhood cancer in India and its clinical and demographical associations. Methods: In this retrospective, multicentre cohort study, we collected individual data of children (aged 0–19 years) with cancer extracted from the hospital-based records of three cancer centres in [...]

Menée en Australie sur la période 2001-2019 auprès de 12 723 personnes, cette étude analyse l'influence des comportements du cercle familial sur les comportements tabagiques des fumeurs souhaitant arrêter de fumer

Household composition and smoking behaviour in a prospective longitudinal Australian cohort

Saxby, Karinna ; Ireland, Andrew ; Ghijben, Peter ; Sweeney, Rohan ; Sia, Kah-Ling ; Chen, Esa ; Farrell, Michael ; McRobbie, Hayden ; Courtney, Ryan ; Petrie, Dennis

This study estimates the extent to which individuals’ smoking cessation and relapse patterns are associated with the smoking behaviour of their household members.Longitudinal data on household members’ smoking behaviour was sourced from a representative sample of 12,723 Australians who ever reported smoking between 2001 and 2019. Controlling for a rich set of confounders, multivariate regression analyses were used to predict the likelihood of smoking cessation and relapse given other household [...]

Menée au Royaume-Uni à partir de données portant sur 25 241 personnes (âge moyen : 61,8 ans ; durée moyenne de suivi : 6,9 ans), cette étude analyse l'association entre la pratique intermittente d'une activité physique vigoureuse, mesurée par un appareil portable, et la mortalité, notamment par cancer

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality

Stamatakis, Emmanuel ; Ahmadi, Matthew N. ; Gill, Jason M. R. ; Thøgersen-Ntoumani, Cecilie ; Gibala, Martin J. ; Doherty, Aiden ; Hamer, Mark

Wearable devices can capture unexplored movement patterns such as brief bursts of vigorous intermittent lifestyle physical activity (VILPA) that is embedded into everyday life, rather than being done as leisure time exercise. Here, we examined the association of VILPA with all-cause, cardiovascular disease (CVD) and cancer mortality in 25,241 nonexercisers (mean age 61.8 years, 14,178 women/11,063 men) in the UK Biobank. Over an average follow-up of 6.9 years, during which 852 deaths occurred, [...]

Menée à partir des données de la cohorte "Women’s Health Initiative" incluant 3 434 patientes atteintes d'un cancer après la ménopause, cette étude analyse l'association entre le potentiel inflammatoire de l'alimentation et la mortalité (durée médiane de suivi : 13 ans ; 1 156 décès)

Association between dietary inflammatory potential and mortality after cancer diagnosis in the Women’s Health Initiative

Zheng, Jiali ; Tabung, Fred K. ; Zhang, Jiajia ; Caan, Bette ; Hebert, James R. ; Kroenke, Candyce H. ; Ockene, Judith ; Shivappa, Nitin ; Steck, Susan E.

Background: Chronic inflammation is implicated in cancer prognosis and can be modulated by diet. We examined associations between post-diagnosis dietary inflammatory potential and mortality outcomes among post-menopausal women diagnosed with cancer in the Women’s Health Initiative (WHI). Methods: Energy-adjusted dietary inflammatory index scores (E-DII) were calculated from dietary and supplemental intake data collected on the first food frequency questionnaire following the diagnosis of [...]

Menée en Suède à partir de données portant sur 2 397 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë diagnostiquée entre 1988 et 2017 (âge moyen au diagnostic : 6,1 ans), cette étude de cohorte analyse l'évolution de la survie et de la mortalité

Mortality Among Pediatric Patients With Acute Lymphoblastic Leukemia in Sweden From 1988 to 2017

Björk-Eriksson, Thomas ; Boström, Martina ; Bryngelsson, Ing-Liss ; Lähteenmäki, Päivi M. ; Jarfelt, Marianne ; Kalm, Marie ; Olsson, Daniel S.

Importance : Acute lymphoblastic leukemia (ALL) constitutes 20% to 30% of all pediatric cancers. The 5-year overall survival among pediatric patients with ALL in high-income countries such as Sweden is currently more than 90%, but long-term unselected nationwide mortality data and mortality data in relation to the general population are lacking. Objective : To compare mortality between pediatric patients with ALL and the general population during a 30-year period in Sweden and to assess the [...]

Menée à partir des données 1975-2019 des registres américains des cancers, cette étude transversale analyse l'association entre les traitements autorisés par la "Food and Drug Administration" et la mortalité des patients atteints d'un mélanome

Melanoma Treatments and Mortality Rate Trends in the US, 1975 to 2019

Kahlon, Navkirat ; Doddi, Sishir ; Yousif, Rame ; Najib, Sana ; Sheikh, Taha ; Abuhelwa, Ziad ; Burmeister, Cameron ; Hamouda, Danae M.

Importance : Melanoma accounts for most of the deaths due to skin cancer. In the past decade, effective US Food and Drug Administration (FDA)–approved therapies for melanoma have emerged. Objective To review changes in the long-term melanoma mortality rate (MMR) trends in the US and determine whether they have any temporal association with the FDA approval of new agents. Design, Setting, and Participants: This cross-sectional study used population data from the Surveillance, Epidemiology, and [...]

Menée aux Etats-Unis sur les périodes 2001-2005 et 2014-2018, cette étude analyse les disparités, selon les Etats, dans l'incidence du carcinome épidermoïde de l'anus et dans la mortalité spécifique, en prenant en compte la prévalence du tabagisme et d'une infection par le VIH

State Variation in Squamous Cell Carcinoma of the Anus Incidence and Mortality, and Association With HIV/AIDS and Smoking in the United States

Haluk Damgacioglu ; Yueh-Yun Lin ; Ana Patricia Ortiz ; Chi-Fang Wu ; Zahed Shahmoradi ; Shiang Shiuan Shyu ; Ruosha Li ; Alan G. Nyitray ; Keith Sigel ; Gary M. Clifford ; Naomi Jay ; Vivian Colon Lopez ; Gregory M. Barnell ; Elizabeth Y. Chiao ; Elizabeth A. Stier ; Karen J. Ortiz-Ortiz ; Jeslie M. Ramos-Cartagena ; Kalyani Sonawane ; Ashish A. Deshmukh

PURPOSE: Squamous cell carcinoma of the anus (SCCA) incidence and mortality rates are rising in the United States. Understanding state-level incidence and mortality patterns and associations with smoking and AIDS prevalence (key risk factors) could help unravel disparities and provide etiologic clues. METHODS: Using the US Cancer Statistics and the National Center for Health Statistics data sets, we estimated state-level SCCA incidence and mortality rates. Rate ratios (RRs) were calculated to [...]

Menée à partir des données 2000-2018 des registres américains des cancers, cette étude analyse les disparités ethniques dans l'évolution de l'incidence du cancer du col de l'utérus, de la survie et de la mortalité, en fonction du sous-type histologique de la maladie

Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype

Camryn M. Cohen ; Nicolas Wentzensen ; Philip E. Castle ; Mark Schiffman ; Rosemary Zuna ; Rebecca C. Arend ; Megan A. Clarke

PURPOSE: We conducted an integrated population-based analysis of histologic subtype–specific cervical cancer incidence, survival, and incidence-based mortality by race and ethnicity, with correction for hysterectomy prevalence. METHODS: Using the SEER 21 and 18 registries, we selected primary cases of malignant cervical cancer diagnosed among women ≥ 15 years. We evaluated age-adjusted incidence rates among cases diagnosed between 2000 and 2018 (SEER21) and incidence-based mortality rates among [...]

Menée au Canada par questionnaires auprès de 503 patientes ayant survécu à un cancer de l'endomètre (durée médiane de suivi : 16,9 mois), cette étude de cohorte prospective évalue l'association entre l'alimentation avant et après le diagnostic (charge glycémique et caractère inflammatoire des aliments, qualité de l'alimentation), la survie globale et la survie sans maladie

Prospective Cohort of Pre- and Post-diagnosis Diet with Survival Outcomes: an Alberta Endometrial Cancer Cohort Study

Kokts-Porietis, Renée L. ; Morielli, Andria R. ; McNeil, Jessica ; Courneya, Kerry S. ; Cook, Linda S. ; Friedenreich, Christine M.

Background: The prognostic relationship between diet and endometrial cancer survival remains largely unknown. We sought to determine pre- and post-diagnosis dietary composition, glycemic load (GL), inflammatory potential (Dietary Inflammatory Index (DII)) and quality (Canadian-Health Eating Index (C-HEI) 2005) associations with disease-free (DFS) and overall survival (OS) among endometrial cancer survivors. Additionally, we assessed associations between dietary changes with OS and explored [...]

Menée aux Etats-Unis à partir de données portant sur un total de 936 patients atteints d'un cancer de la tête et du cou et inclus dans des essais, cette étude analyse la survie en fonction de l'origine ethnique

Racial Survival Disparities in Head and Neck Cancer Clinical Trials

Liu, Jeffrey C ; Egleston, Brian ; Blackman, Elizabeth ; Ragin, Camille

Background: Survival disparities between Black and White head and neck cancer patients are well documented, with access to care and socioeconomic status (SES) as major contributors. We set out to assess the role of self-reported race in head and neck cancer by evaluating treatment outcomes of subjects enrolled in clinical trials, where access to care and SES confounders are minimized. Methods: Clinical trial data from the Radiation Therapy Oncology Group studies were obtained. Studies were [...]

Menée au Danemark à partir de données portant sur 4 053 patients atteints d'un carcinome épidermoïde de l'oropharynx (âge médian : 61 ans), cette étude analyse les disparités sociéconomiques dans la survie globale à 5 ans

Association of Smoking, Comorbidity, Clinical Stage, and Treatment Intent With Socioeconomic Differences in Survival After Oropharyngeal Squamous Cell Carcinoma in Denmark

Olsen, Maja Halgren ; Frederiksen, Kirsten ; Lassen, Pernille ; Rotbøl, Charlotte ; Kjaer, Trille Kristina ; Johansen, Jørgen ; Primdahl, Hanne ; Andersen, Elo ; Kristensen, Claus Andrup ; Andersen, Maria ; Farhadi, Mohammad ; Overgaard, Jens ; Dalton, Susanne Oksbjerg ; Danish Head ; Neck Cancer Group

Importance : The socioeconomic gap in survival after cancer is pronounced among patients with head and neck cancer. Understanding the mechanisms of this gap is crucial to target intervention strategies. Objective : To investigate socioeconomic differences in survival after oropharyngeal squamous cell carcinoma (OPSCC) according to human papillomavirus (HPV) status and the extent to which smoking, comorbidity, clinical stage, and treatment intent explain the survival gap. Design, Setting, and [...]

Menée à partir de données portant sur des patients ayant survécu à un cancer et inclus dans un essai randomisé comparant l'intérêt d'une psychothérapie et de l'acupuncture pour traiter l'insomnie, cette étude analyse l'impact, sur l'efficacité du traitement, des attentes des patients concernant son efficacité

Does expectancy affect insomnia treatment response in cancer survivors receiving acupuncture and cognitive behavioral therapy?

Li, Xiaotong ; Bao, Ting ; Garland, Sheila N. ; Li, Susan Q. ; Yu, Jennifer ; Li, Yuelin ; Mao, Jun J.

Purpose : Insomnia negatively affects quality of life in cancer survivors. Expectations of insomnia treatment efficacy may influence response to intervention. We sought to determine whether pre-treatment outcome expectancy predicts response to two non-pharmacological interventions for insomnia among cancer survivors. Methods : We analyzed data from a randomized clinical trial that compared acupuncture versus cognitive behavioral therapy for insomnia (CBT-I) in cancer survivors. Patient [...]

A partir d'une revue systématique de la littérature publiée entre 2011 et 2022 (31 études), cette étude analyse l'efficacité de différents types d'interventions pour améliorer les fonctions cognitives altérées par un cancer (interventions psycho-pédagogiques, pharmacologiques, interventions à base de médecines alternatives et complémentaires, etc.)

Interventions promoting cognitive function in patients experiencing cancer related cognitive impairment: A systematic review

Oldacres, L. ; Hegarty, J. ; O’Regan, P. ; Murphy-Coakley, N. M. ; Saab, M.M.

Objective : To examine the effect of interventions used to enhance cognitive function in patients experiencing cancer-related cognitive impairment. Methods : Studies including adults with a non-metastatic cancer who have received chemotherapy as part of their treatment and who have undergone interventions targeting cancer-related cognitive impairment were included. Studies involving patients with metastatic cancer and pre-existing cognitive deficits were excluded. Academic Search Complete, [...]

Menée aux Etats-Unis par enquête auprès de 267 adolescents et jeunes adultes ayant survécu à un cancer (durée moyenne de survie : 8,3 ans), cette étude analyse leurs difficultés financières

The long-term financial experiences of adolescent and young adult cancer survivors

Thom, Bridgette ; Friedman, Danielle N. ; Aviki, Emeline M. ; Benedict, Catherine ; Watson, Samantha E. ; Zeitler, Michelle S. ; Chino, Fumiko

Background: Cancer-related financial hardship can negatively impact financial well-being and may prevent adolescent and young adult (AYA) cancer survivors (ages 15–39) from gaining financial independence. This analysis explored the financial experiences following diagnosis with cancer among AYA survivors. Methods: We conducted a cross-sectional, anonymous survey of a national sample of AYAs recruited online. The Comprehensive Score for Financial Toxicity (COST) and InCharge Financial [...]

Menée en Chine à partir de données portant sur 296 patients ayant survécu à un cancer pédiatrique (âge : 7-17 ans), cette étude analyse la présence d'une dépression en fonction du sexe

Sex differences in depression for childhood cancer survivors

ZHANG, Yafeng ; Li, Zhe ; WANG, Chunli ; ZHANG, Linqi ; GUO, Shufang ; LIN, Jia ; ZHOU, Chongchen ; ZHANG, Zhong ; HUO, Shan ; FAN, Lihua ; Ni, Xin

Objective: This study examines the differential association between sex and depression, and the possible mediating pathways. Methods: We analysed survey data from 296 (age 7-17.1 years) cancer survivors from three centres affiliated with Beijing Children's Hospital. Linear regression analysis was used to assess the association between sex and depression. Quantile regression analysis was used to estimate the regression coefficients (  [...]

Menée à partir de données de 9 essais européens incluant un total de 1 961 patients ayant survécu à un lymphome hodgkinien et de données portant sur 49 025 témoins en population générale, cette étude de cohorte analyse leur situation professionnelle, en lien avec les caractéristiques de la maladie et de l'exposition aux traitements anticancéreux

Employment situation among long-term Hodgkin lymphoma survivors in Europe: an analysis of patients from nine consecutive EORTC-LYSA trials

Juul, Sidsel J. ; Rossetti, Sára ; Kicinski, Michal ; van der Kaaij, Marleen A. E. ; Giusti, Francesco ; Meijnders, Paul ; Aleman, Berthe M. P. ; Raemaekers, John M. M. ; Kluin-Nelemans, Hanneke C. ; Spina, Michele ; Fermé, Christophe ; Renaud, Loïc ; Casasnovas, Olivier ; Stamatoullas, Aspasia ; André, Marc ; Le Bras, Fabien ; Plattel, Wouter J. ; Henry-Amar, Michel ; Hutchings, Martin ; Maraldo, Maja V.

Purpose: Little is known about the employment situation of long-term Hodgkin lymphoma (HL) survivors despite their young age at diagnosis and the favorable prognosis of the disease. In this cross-sectional study, we aim to describe the employment situation in a cohort of long-term HL survivors compared to the general population and investigate the associations with disease characteristics and treatment exposure. Methods: HL survivors > 25 years (n = 1961) were matched 1:25 to controls [...]

Menée à partir de données de deux enquêtes australiennes incluant 5 421 participants, cette étude analyse l'association entre une détresse psychologique et la participation au dépistage du cancer colorectal

Psychological distress and bowel cancer screening participation

Anderson, Laura E ; Ireland, Michael J ; Myers, Larry ; Avenell, Claire ; Connaughton, Tanaya ; Goodwin, Belinda C

Objective: To better understand barriers to participation in mail-out bowel cancer screening programs, two survey studies tested the relationship between psychological distress and self-reported bowel cancer screening. Methods: First, a nationally representative sample of Australians N = 5421 completed measures of bowel cancer screening and psychological distress (using the Kessler Psychological Distress Scale; K10). Second, N = 479 completed a survey measuring participation in the National [...]

Menée en Allemagne à partir de données portant sur 2 654 patientes ayant survécu à un cancer du sein, cette étude identifie les facteurs associés aux coûts restant à leur charge (frais de santé, aides à domicile) et à leur perte de revenus

Out-of-pocket payments and loss of income among long-term breast cancer survivors in Germany: a multi-regional population-based study

Schneider, Jana ; Hernandez, Diego ; Schlander, Michael ; Arndt, Volker ; Caesar study group ; on behalf of the, Ceasar study group

Purpose: This study aims to examine the magnitude of out of pocket (OOP) payments and income loss, as well as to identify socioeconomic and clinical factors among long-term breast cancer (BC) survivors in Germany. Methods: We examine data from 2654 long-term BC survivors in Germany that participated in the “CAncEr Survivorship – A multi-Regional population-based study” (CAESAR) and who were at least 5 years post diagnosis. BC-related OOP payments and income loss both within the 12 months prior [...]

Mené au Canada sur 350 patients âgés de plus de 70 ans et atteints d'un cancer (âge moyen : 76 ans), cet essai randomisé évalue l'intérêt, du point de vue de la qualité de vie, d'une évaluation et prise en charge gériatriques au début du traitement anticancéreux de première ou deuxième ligne (chimiothérapie, immunothérapie ou thérapie ciblée)

Impact of Geriatric Assessment and Management on Quality of Life, Unplanned Hospitalizations, Toxicity, and Survival for Older Adults With Cancer: The Randomized 5C Trial

Martine Puts ; Naser Alqurini ; Fay Strohschein ; Rama Koneru ; Ewa Szumacher ; Caroline Mariano ; Johanne Monette ; Tina Hsu ; Sarah Brennenstuhl ; Bianca McLean ; Aria Wills ; Arielle Berger ; Eitan Amir, MD, PhD ; Lindy Romanovsky ; Anson Li ; Rajin Mehta ; Monika Krzyzanowska ; Christine Elser ; Raymond Jang ; Anca Prica ; Doreen Wan-Chow-Wah ; Eric Pitters ; Urban Emmenegger ; Ines B. Menjak ; Simon Bergman ; Manon Lemonde ; Henriette Breunis ; Francois Béland ; Shabbir M.H. Alibhai

PURPOSE: American Society of Clinical Oncology recommends that older adults with cancer being considered for chemotherapy receive geriatric assessment (GA) and management (GAM), but few randomized controlled trials have examined its impact on quality of life (QOL). PATIENTS AND METHODS: The 5C study was a two-group parallel 1:1 single-blind multicenter randomized controlled trial of GAM for 6 months versus usual oncologic care. Eligible patients were age 70+ years, diagnosed with a solid tumor, [...]