Menée à l'aide de données chinoises portant sur 512 726 adultes (âge : 30-79 ans ; durée médiane de suivi : 11 ans ; 59 % de femmes), cette étude analyse l'association entre le tabagisme et l'incidence de 476 maladies dont des cancers (59 716 cas)

Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study

Chan, Ka Hung ; Wright, Neil ; Xiao, Dan ; Guo, Yu ; Chen, Yiping ; Du, Huaidong ; Yang, Ling ; Millwood, Iona Y. ; Pei, Pei ; Wang, Junzheng ; Turnbull, Iain ; Gilbert, Simon ; Avery, Daniel ; Kartsonaki, Christiana ; Yu, Canqing ; Chen, Junshi ; Lv, Jun ; Clarke, Robert ; Collins, Rory ; Peto, Richard ; Li, Liming ; Wang, Chen ; Chen, Zhengming ; Bennett, Derrick ; Boxall, Ruth ; Burgess, Sushila ; Chan, Peter Ka Hung ; Clarke, Johnathan ; Mohamed, Ahmed Edris ; Fry, Hannah ; Hill, Mike ; Im, Becky Pek Kei ; Iona, Andri ; Kakkoura, Maria ; Lam, Hubert ; Lin, Kuang ; Mazidi, Mohsen ; Morris, Sam ; Nie, Qunhua ; Pozarickij, Alfred ; Ryder, Paul ; Said, Saredo ; Schmidt, Dan ; Sherliker, Paul ; Stevens, Rebecca ; Walters, Robin ; Wang, Lin ; Yang, Xiaoming ; Yao, Pang ; Han, Xiao ; Hou, Can ; Xia, Qingmei ; Liu, Chao ; Chen, Naying ; Liu, Duo ; Tang, Zhenzhu ; Chen, Ningyu ; Jiang, Qilian ; Lan, Jian ; Li, Mingqiang ; Liu, Yun ; Meng, Fanwen ; Meng, Jinhuai ; Pan, Rong ; Qin, Yulu ; Wang, Ping ; Wang, Sisi ; Wei, Liuping ; Zhou, Liyuan ; Dong, Caixia ; Ge, Pengfei ; Ren, Xiaolan ; Li, Zhongxiao ; Mao, Enke ; Wang, Tao ; Zhang, Hui ; Zhang, Xi ; Chen, Jinyan ; Hu, Ximin ; Wang, Xiaohuan ; Guo, Zhendong ; Li, Huimei ; Li, Yilei ; Weng, Min ; Wu, Shukuan ; Yan, Shichun ; Zou, Mingyuan ; Zhou, Xue ; Guo, Ziyan ; Kang, Quan ; Li, Yanjie ; Yu, Bo ; Xu, Qinai ; Chang, Liang ; Fan, Lei ; Feng, Shixian ; Zhang, Ding ; Zhou, Gang ; Gao, Yulian ; He, Tianyou ; He, Pan ; Hu, Chen ; Sun, Huarong ; Zhang, Xukui ; Chen, Biyun ; Fu, Zhongxi ; Huang, Yuelong ; Liu, Huilin ; Xu, Qiaohua ; Yin, Li ; Long, Huajun ; Xu, Xin ; Zhang, Hao ; Zhang, Libo ; Su, Jian ; Tao, Ran ; Wu, Ming ; Yang, Jie ; Zhou, Jinyi ; Zhou, Yonglin ; Hu, Yihe ; Hua, Yujie ; Jin, Jianrong ; Liu, Fang ; Liu, Jingchao ; Lu, Yan ; Ma, Liangcai ; Tang, Aiyu ; Zhang, Jun ; Cheng, Liang ; Du, Ranran ; Gao, Ruqin ; Li, Feifei ; Li, Shanpeng ; Liu, Yongmei ; Ning, Feng ; Pang, Zengchang ; Sun, Xiaohui ; Tian, Xiaocao ; Wang, Shaojie ; Zhai, Yaoming ; Zhang, Hua ; Hou, Wei ; Lv, Silu ; Chen, Xiaofang ; Wu, Xianping ; Zhang, Ningmei ; Zhou, Weiwei ; Li, Jianguo ; Liu, Jiaqiu ; Luo, Guojin ; Sun, Qiang ; Zhong, Xunfu ; Gong, Weiwei ; Hu, Ruying ; Wang, Hao ; Wang, Meng ; Yu, Min ; Chen, Lingli ; Gu, Qijun ; Pan, Dongxia ; Wang, Chunmei ; Xie, Kaixu ; Zhang, Xiaoyi

Background: Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues to increase in men. Large nationwide prospective studies linked to different health records can help to periodically assess disease burden attributed to smoking. We aimed to examine associations of smoking with incidence of and mortality from an extensive range of diseases in China. Methods: We analysed data from the prospective China Kadoorie Biobank, which recruited [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2021 (109 études), cette méta-analyse évalue la relation dose-effet entre le tabagisme et le risque de cancer du col de l'utérus

Dose-risk relationships between cigarette smoking and cervical cancer: a systematic review and meta-analysis

Malevolti, Maria Chiara ; Lugo, Alessandra ; Scala, Marco ; GALLUS, Silvano ; GORINI, Giuseppe ; Lachi, Alessio ; CARRERAS, Giulia

Objective: Cervical cancer (CC) is the fourth most frequent cancer worldwide. Cigarette smoking has been shown to influence CC risk in conjunction with human papillomavirus (HPV) infection. The aim of this study is to provide the most accurate and updated estimate of this association and its dose-response relationship. Methods: Using an innovative approach for the identification of original publications, we conducted a systematic review and meta-analysis of studies published up to January 2021. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2022 (17 études), cette méta-analyse évalue l'association entre la quantité de yaourt consommée et la mortalité par cancer (20 554 décès)

Yogurt consumption and risk of mortality from all causes, CVD and cancer: a comprehensive systematic review and dose–response meta-analysis of cohort studies

Tutunchi, Helda ; Naghshi, Sina ; Naemi, Mohammad ; Naeini, Fatemeh ; Esmaillzadeh, Ahmad

Objectives: To quantify the dose–response relation between yogurt consumption and risk of mortality from all causes, CVD and cancer. Design: Systematic review and meta-analysis. Setting: We conducted a comprehensive search of PubMed/Medline, ISI Web of Science and Scopus databases through August 2022 for cohort studies reporting the association of yogurt consumption with mortality from all causes, CVD and cancer. Summary relative risks (RR) and 95 % CI were calculated with a random-effects [...]

Menée à l'aide d'échantillons de tissus sains et de tissus tumoraux frais prélevés chez 135 patients atteints d'un cancer du pénis, cette étude analyse la prévalence du papillomavirus humain (HPV) par sous-type

Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study

Kristiansen, Sinja ; Bjartling, Carina ; Torbrand, Christian ; Grelaud, Diane ; Lindström, Martin ; Svensson, Åke ; Forslund, Ola

Background: HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies of HPV in penile cancer have been performed using paraffin-embedded tissue, argued to be at risk for contaminated HPV analysis. Viral activity of HPV, by the use of HPV mRNA expression is well studied in cervical cancer, but seldom studied in penile cancer. The aim was to [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2020 (25 études, 111,6 millions de patients adultes ; 83,4 % de femmes), cette méta-analyse évalue le risque de cancer lié aux rayonnements ionisants des tomodensitogrammes

CT Scans and Cancer Risks: A Systematic Review and Dose-response Meta-analysis

Cao, Chun-Feng ; Ma, Kun-Long ; Shan, Hua ; Liu, Tang-Fen ; Zhao, Si-Qiao ; Wan, Yi ; Jun, Zhang ; Wang, Hai-Qiang

Background: There is still uncertainty on whether ionizing radiation from CT scans can increase the risks of cancer. This study aimed to identify the association of cumulative ionizing radiation from CT scans with pertaining cancer risks in adults. Methods: Five databases were searched from their inception to November 15, 2020. Observational studies reporting cancer risks from CT scans in adults were included. The main outcome included quantified cancer risks as cancer case numbers in [...]

Menée à partir des données d'une étude portant sur 147 885 femmes ménopausées (durée médiane de suivi : 18,9 ans), cette étude analyse l'association entre la présence d'un diabète de type 2, l'utilisation de médicaments antidiabétiques comme la metformine et le risque de lymphome non hodgkinien (1 637 cas)

Diabetes, Metformin Use, and Risk of Non-Hodgkin's Lymphoma in Postmenopausal Women: A Prospective Cohort Analysis in the Women's Health Initiative

Wang, Zikun ; Phillips, Lawrence S. ; Rohan, Thomas E. ; Ho, Gloria YF ; Shadyab, Aladdin H. ; Bidulescu, Aurelian ; Rudick, Charles N. ; Pan, Kathy ; Chen, Zhongxue ; Luo, Juhua

Epidemiologic evidence is limited about associations between T2DM, metformin, and the risk of non-Hodgkin's lymphoma (NHL). We aimed to examine associations between T2DM, metformin, and the risk of NHL in the Women's Health Initiative (WHI) Study. Information on T2DM status (diabetes status/types of antidiabetic drug use/diabetes duration) from study enrollment and during follow-up were assessed. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate associations of [...]

Menée à partir de données 2003-2018 de l'Assurance maladie coréenne portant sur 43 683 témoins et 78 320 patientes atteintes d'un cancer du sein avant la ménopause (âge moyen : 42,1 ans ; durée moyenne de suivi : 6 ans), cette étude analyse l'association entre une hormonothérapie adjuvante par tamoxifène et le risque de cancer de l'endomètre (426 cas) ou d'autres maladies utérines

Risk of Endometrial Polyps, Hyperplasia, Carcinoma, and Uterine Cancer After Tamoxifen Treatment in Premenopausal Women With Breast Cancer

Ryu, Ki-Jin ; Kim, Min Sun ; Lee, Ji Yoon ; Nam, Seunghyun ; Jeong, Hye Gyeong ; Kim, Tak ; Park, Hyuntae

The association of tamoxifen use with the risk of uterine diseases, such as endometrial cancer, in premenopausal women with breast cancer remains controversial. However, many studies have reported an increased risk of uterine disease among postmenopausal tamoxifen users.To investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer.A nationwide, population-based, retrospective longitudinal cohort study [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 340 152 personnes (durée médiane de suivi : 15,3 ans), cette étude analyse l'association entre la taille, le poids, l'indice de masse corporelle ou le tour de hanches et le risque de cancer (47 110 cas)

Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study

Sedlmeier, Anja M. ; Viallon, Vivian ; Ferrari, Pietro ; Peruchet-Noray, Laia ; Fontvieille, Emma ; Amadou, Amina ; Seyed Khoei, Nazlisadat ; Weber, Andrea ; Baurecht, Hansjörg ; Heath, Alicia K. ; Tsilidis, Kostas ; Kaaks, Rudolf ; Katzke, Verena ; Inan-Eroglu, Elif ; Schulze, Matthias B. ; Overvad, Kim ; Bonet, Catalina ; Ubago-Guisado, Esther ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Perez-Cornago, Aurora ; Pala, Valeria ; Tumino, Rosario ; Sacerdote, Carlotta ; Pasanisi, Fabrizio ; Borch, Kristin B. ; Rylander, Charlotta ; Weiderpass, Elisabete ; Gunter, Marc J. ; Fervers, Beatrice ; Leitzmann, Michael F. ; Freisling, Heinz

Background: Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers. Methods: We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women [...]

Menée à partir du séquençage de l'exome entier de 418 patients pédiatriques atteints d'un cancer, cette étude analyse l'association entre des variants constitutionnels de CHECK2 et le risque de développer la maladie

The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients

Wagener, Rabea ; Walter, Carolin ; Auer, Franziska ; Alzoubi, Deya ; Hauer, Julia ; Fischer, Ute ; Varghese, Julian ; Dugas, Martin ; Borkhardt, Arndt ; Brozou, Triantafyllia

Predisposing CHEK2 germline variants are associated with various adult-type malignancies, whereas their impact on cancer susceptibility in childhood cancer is unclear. To understand the frequency of germline variants in the CHEK2 gene and their impact on pediatric malignancies, we used whole-exome sequencing to search for CHEK2 variants in the germlines of 418 children diagnosed with cancer in our clinics. Moreover, we performed functional analysis of the pathogenic CHEK2 variants to analyze [...]

Menée auprès d'une cohorte européenne de 69 460 patients ayant survécu au moins 5 ans à un cancer infantile diagnostiqué entre 1940 et 2008, cette étude analyse le risque de développer un lymphome (140 cas)

Risk of subsequent primary lymphoma in a cohort of 69,460 five-year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

Dudley, Isabelle M. ; Sunguc, Ceren ; Heymer, Emma J. ; Winter, David L. ; Teepen, Jop C. ; Belle, Fabiën N. ; Bárdi, Edit ; Bagnasco, Francesca ; Gudmundsdottir, Thorgerdur ; Skinner, Roderick ; Michel, Gisela ; Byrne, Julianne ; Øfstaas, Hilde ; Jankovic, Momcilo ; Mazić, Maja Česen ; Mader, Luzius ; Loonen, Jaqueline ; Garwicz, Stanislaw ; Wiebe, Thomas ; Alessi, Daniela ; Allodji, Rodrigue S. ; Haddy, Nadia ; Grabow, Desiree ; Kaatsch, Peter ; Kaiser, Melanie ; Maule, Milena M. ; Jakab, Zsuzsanna ; Gunnes, Maria Winther ; Terenziani, Monica ; Zaletel, Lorna Zadravec ; Kuehni, Claudia E. ; Haupt, Riccardo ; de Vathaire, Florent ; Kremer, Leontien C. ; Lähteenmäki, Päivi M. ; Winther, Jeanette F. ; Hjorth, Lars ; Hawkins, Michael M. ; Reulen, Raoul C.

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non-Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan-European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and [...]

Menée à l'aide de l'analyse de 7 745 polymorphismes à simple nucléotide de 29 gènes et menée à partir de données portant sur 221 897 témoins et 14 666 patients atteints d'un adénocarcinome canalaire du pancréas, cette étude identifie un variant de susceptibilité à la maladie (rs1412832 dans CDKN2B-AS1/ANRIL)

Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk

Giaccherini, Matteo ; Farinella, Riccardo ; Gentiluomo, Manuel ; Mohelnikova-Duchonova, Beatrice ; Kauffmann, Emanuele Federico ; Palmeri, Matteo ; Uzunoglu, Faik ; Soucek, Pavel ; Petrauskas, Dalius ; Cavestro, Giulia Martina ; Zykus, Romanas ; Carrara, Silvia ; Pezzilli, Raffaele ; Puzzono, Marta ; Szentesi, Andrea ; Neoptolemos, John ; Archibugi, Livia ; Palmieri, Orazio ; Milanetto, Anna Caterina ; Capurso, Gabriele ; van Eijck, Casper H. J. ; Stocker, Hannah ; Lawlor, Rita T. ; Vodicka, Pavel ; Lovecek, Martin ; Izbicki, Jakob R. ; Perri, Francesco ; Kupcinskaite-Noreikiene, Rita ; Götz, Mara ; Kupcinskas, Juozas ; Hussein, Tamás ; Hegyi, Peter ; Busch, Olivier R. ; Hackert, Thilo ; Mambrini, Andrea ; Brenner, Hermann ; Lucchesi, Maurizio ; Basso, Daniela ; Tavano, Francesca ; Schottker, Ben ; Vanella, Giuseppe ; Bunduc, Stefania ; Petrányi, Ágota ; Landi, Stefano ; Morelli, Luca ; Canzian, Federico ; Campa, Daniele

Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in this study. We conducted a multi-phase study analysing 7,745 single nucleotide polymorphisms (SNPs) from 29 genes reported to harbour a high-penetrance PDAC-associated mutation in at least one [...]

Menée à partir de données 2006-2019 de la "UK Biobank" portant sur 3 951 témoins et 832 patients atteints d'un cancer du poumon et menée à l'aide de données 2010-2021 de la "Mass General Brigham Biobank" portant sur 652 témoins et 141 patients, cette étude analyse l'association entre une hématopoïèse clonale et le risque de cancer du poumon

Clonal Hematopoiesis and Risk of Incident Lung Cancer

Ruiyi Tian ; Brian Wiley ; Jie Liu ; Xiaoyu Zong ; Buu Truong ; Stephanie Zhao ; Md Mesbah Uddin ; Abhishek Niroula ; Christopher A. Miller ; Semanti Mukherjee ; Brendan T. Heiden ; Jingqin Luo ; Varun Puri ; Benjamin D. Kozower ; Matthew J. Walter ; Li Ding ; Daniel C. Link ; Christopher I. Amos ; Benjamin L. Ebert ; Ramaswamy Govindan ; Pradeep Natarajan ; Kelly L. Bolton ; Yin Cao

PURPOSE: To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. METHODS: Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with [...]

Menée à l'aide du séquençage de l'exome entier de 664 patients atteints d'un neuroblastome et de 822 témoins, cette étude identifie des variants constitutionnels rares associés au risque de développer la maladie

Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma

Bonfiglio, Ferdinando ; Lasorsa, Vito Alessandro ; Cantalupo, Sueva ; D'Alterio, Giuseppe ; Aievola, Vincenzo ; Boccia, Angelo ; Ardito, Martina ; Furini, Simone ; Renieri, Alessandra ; Morini, Martina ; Stainczyk, Sabine ; Westermann, Frank ; Paolella, Giovanni ; Eva, Alessandra ; Iolascon, Achille ; Capasso, Mario

Background: Neuroblastoma (NB) is the most common solid extracranial paediatric tumour. Genome-wide association studies have driven the discovery of common risk variants, but no large study has investigated the contribution of rare variants to NB susceptibility. Here, we conducted a whole-exome sequencing (WES) of 664 NB cases and 822 controls and used independent validation datasets to identify genes with rare risk variants and involved pathways. Methods: WES was performed at 50× depth and [...]