Nota Bene Cancer
Nota Bene Cancer est un bulletin hebdomadaire de veille bibliographique. En libre accès, Nota Bene Cancer permet à ses abonnés de gagner du temps pour se tenir informé de l’actualité scientifique et médicale dans les divers domaines de la recherche sur les cancers.
Pour retrouver les publications signalées par Nota Bene Cancer (archives indexées à partir du n°127 du 1" mars 2012) :
Sommaire du n° 545 du 28 novembre 2022
Lutte contre les cancers
Qualité de vie, soins de support (1)
Mené sur 144 patients atteints d'un cancer de stade avancé, cet essai de phase IIB évalue la dose optimale et l'intérêt, du point de vue de la réduction des symptômes de détresse, de l'huile de cannabidiol (CBD)
Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (Med...
Mené sur 144 patients atteints d'un cancer de stade avancé, cet essai de phase IIB évalue la dose optimale et l'intérêt, du point de vue de la réduction des symptômes de détresse, de l'huile de cannabidiol (CBD)
Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD)
Janet Hardy ; Ristan Greer ; Georgie Huggett ; Alison Kearney ; Taylan Gurgenci ; Phillip Good
PURPOSE: To determine whether cannabidiol (CBD) oil can improve symptom distress in patients with advanced cancer receiving palliative care. METHODS: Participants were adults with advanced cancer and symptom distress (Edmonton Symptom Assessment Scale [ESAS] total score of ≥ 10/90) who received titrated CBD oil 100 mg/mL, 0.5 mL once daily to 2 mL three times a day, or matched placebo for 28 days. The primary outcome was ESAS total symptom distress score (TSDS) at day 14. Response was defined [...]
Observation (6)
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of the COVID-19 pandemic on breast, colorectal, lung, and prostate cancer stage at diagnosis according to race
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of the COVID-19 pandemic on breast, colorectal, lung, and prostate cancer stage at diagnosis according to race
Berrian, Jennifer ; Liu, Ying ; Ezenwajiaku, Nkiruka ; Moreno-Aspitia, Alvaro ; Holton, Sara J. ; Toriola, Adetunji T. ; Colditz, Graham A. ; Housten, Ashley J. ; Hall, Lannis ; Fiala, Mark A. ; Ademuyiwa, Foluso O.
Purpose : To determine if the COVID-19 pandemic has further exacerbated racial disparities in late-stage presentation of breast, colorectal, lung, and prostate cancers. Methods : We conducted a registry-based retrospective study of patients with newly reported diagnoses of breast, colorectal, lung, and prostate cancers between March 2019–June 2019 (pre-COVID-19) and March 2020–June 2020 (early-COVID-19). We compared the volume of new diagnoses and stage at presentation according to race between [...]
The Effects of an mRNA Covid-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
The Effects of an mRNA Covid-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
Frankel, Arthur Edward ; Capozzola, Tazio ; Andrabi, Raiees ; Ahn, Chul ; Zhou, Panpan ; He, Wan-ting ; Burton, Dennis R.
Immunocompromised cancer patients are at significant risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A method to identify those patients at highest risk is needed so that prophylactic measures may be employed. Serum antibodies to SARS-CoV-2 spike protein are important markers of protection against COVID-19 disease. We evaluated total and neutralizing antibody levels pre and post third booster vaccine and compared responses among different cancer-bearing and [...]
Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandem...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases
Galusic, Davor ; Basic-Kinda, Sandra ; Pijuk, Andela ; Milunovic, Vibor ; Dreta, Barbara ; Franjic, Neven ; Coha, Bozena ; Sincic-Petricevic, Jasminka ; Gacina, Petar ; Pejsa, Vlatko ; Lucijanic, Marko ; Aurer, Igor
Obinutuzumab (G) has become part of front-line treatment of follicular lymphoma (FL) based on results of a large randomized study. Data on patients treated outside of clinical trials are lacking. We have retrospectively investigated efficacy and safety of G-based immunochemotherapy regimens in 114 patients treated in a real-life setting during a period of 2 years, largely coinciding with the COVID-19 pandemic. The response rate was 93.8%; 18-months overall (OS) and progression-free survival [...]
Consequences of Discontinuing a 4/6 Cyclin D-Dependent Kinase Inhibitor During Endocrine Treatment in Hormone-Sensitive Metastatic Breast Cancer Pa...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Consequences of Discontinuing a 4/6 Cyclin D-Dependent Kinase Inhibitor During Endocrine Treatment in Hormone-Sensitive Metastatic Breast Cancer Patients in the Context of the COVID-19 Outbreak
Martin, Sophie ; Pflumio, Carole ; Trensz, Philippe ; Schaff-Wendling, Frédérique ; Weindling, Michal Kalish ; Fischbach, Cathie ; Pierard, Laure ; Limacher, Jean-Marc ; Nader, Rita ; Velten, Michel ; Petit, Thierry
Background: The impact of some hasty medical decision made during the first wave of the Coronavirus Disease 2019 (COVID-19) remains unknown. We have evaluated the consequences of one of these precautionary measures: the withdrawal of the cyclin D-dependent kinases 4/6 inhibitor (CDK4/6i) in patients whose metastatic disease was controlled by a combination of endocrine treatment and CDK 4/6i. Method: This study was noninterventional, retrospective, multicentric, and included 60 patients with HR+ [...]
Effect of the COVID-19 Pandemic on Place of Death Among Medicaid and Commercially Insured Patients With Cancer in Washington State
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Effect of the COVID-19 Pandemic on Place of Death Among Medicaid and Commercially Insured Patients With Cancer in Washington State
Laura E. Panattoni ; Cara L. McDermott ; Li Li ; Qin Sun ; Catherine R. Fedorenko ; Hayley A. Sanchez ; Karma L. Kreizenbeck ; Veena Shankaran ; Scott D. Ramsey
PURPOSE: The COVID-19 pandemic–related disruptions in health care delivery might have affected end-of-life care in patients with cancer. We examined changes in place of death and hospice support for Medicaid and commercially insured patients during the pandemic. PATIENTS AND METHODS: We linked Washington State cancer registry records with claims from Medicaid and two commercial insurers for patients with solid tumor age 18-64 years. The study included 322 Medicaid and 162 commercial patients [...]
Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy
Rottoli, Matteo ; Gori, Alice ; Pellino, Gianluca ; Flacco, Maria Elena ; Martellucci, Cecilia ; Spinelli, Antonino ; Poggioli, Gilberto ; COVID–Colorectal Cancer Study Group
Importance : Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. Objective : To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. Design, Setting, and Participants : This retrospective, multicenter cohort study included all [...]
COVID-19 and Cancer Patients in the Second Year of the Pandemic: Investigating Treatment Impact, Information Sources, and COVID-19-Related Knowledg...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
COVID-19 and Cancer Patients in the Second Year of the Pandemic: Investigating Treatment Impact, Information Sources, and COVID-19-Related Knowledge, Attitudes and Practices
Ugas, Mohamed A. ; Avery, Lisa ; Wang, Yanning ; Berlin, Alejandro ; Giuliani, Meredith E. ; Krzyzanowska, Monika ; Papadakos, Tina J. ; Quartey, Naa Kwarley ; Samoil, Diana ; Papadakos, Janet K.
Background: The novel coronavirus that has triggered the present COVID-19 pandemic continues to spread globally, resulting in widespread morbidity and mortality. Patients with cancer remain one of the most vulnerable subsets of the population to the disease. This study examined the effects of the pandemic on cancer patients’ treatment, psychology, knowledge, attitudes, and practices. Methods: A survey was emailed to 9861 patients at a cancer centre in Toronto, Canada. Descriptive results were [...]
Menée aux Etats-Unis à partir de données 2013-2016, cette étude de cohorte rétrospective analyse les prescriptions concomitantes d'opioïdes avec d'autres médicaments sédatifs, notamment les benzodiazépines et les gabapentinoïdes, après un diagnostic de cancer
Concurrent prescribing of opioids with other sedating medications after cancer diagnosis: a population-level analysis
Menée aux Etats-Unis à partir de données 2013-2016, cette étude de cohorte rétrospective analyse les prescriptions concomitantes d'opioïdes avec d'autres médicaments sédatifs, notamment les benzodiazépines et les gabapentinoïdes, après un diagnostic de cancer
Concurrent prescribing of opioids with other sedating medications after cancer diagnosis: a population-level analysis
Check, Devon K. ; Baggett, Christopher D. ; Kim, KyungSu ; Merlin, Jessica S. ; Oeffinger, Kevin C. ; Winn, Aaron N. ; Roberts, Megan C. ; Robinson, Timothy ; Dinan, Michaela A.
Purpose: Cancer is a major reason for concurrent prescription of opioids with other sedating medications—particularly benzodiazepines and gabapentinoids—yet population-based assessments of the extent and predictors of concurrent prescribing among clinically and demographically diverse patients with cancer are lacking. Methods: We conducted a retrospective cohort study of patients with non-metastatic cancer using North Carolina cancer registry data linked with Medicare and private insurance [...]
Menée à partir des données de la base GLOBOCAN portant sur 185 pays, cette étude estime, pour l'année 2020, le nombre d'enfants devenus orphelins à la suite d'un décès maternel par cancer
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020
Menée à partir des données de la base GLOBOCAN portant sur 185 pays, cette étude estime, pour l'année 2020, le nombre d'enfants devenus orphelins à la suite d'un décès maternel par cancer
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020
Guida, Florence ; Kidman, Rachel ; Ferlay, Jacques ; Schüz, Joachim ; Soerjomataram, Isabelle ; Kithaka, Benda ; Ginsburg, Ophira ; Mailhot Vega, Raymond B. ; Galukande, Moses ; Parham, Groesbeck ; Vaccarella, Salvatore ; Canfell, Karen ; Ilbawi, André M. ; Anderson, Benjamin O. ; Bray, Freddie ; dos-Santos-Silva, Isabel ; McCormack, Valerie
Despite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the resulting maternal orphans, who experience health and education disadvantages throughout their lives. We estimated the number of children who became maternal orphans in 2020 due to their mother dying from cancer in that year, for 185 countries worldwide and by cause of cancer-related death. Female cancer deaths—by country, cancer type and age (derived from GLOBOCAN estimates)—were [...]
Menée aux Etats-Unis à partir de données 2011-2017 portant sur 1 880 patients ayant survécu à un cancer (prostate, sein ou côlon), cette étude analyse l'association entre des comportements de santé, une obésité et le statut marital en fonction du type de cancer et de critères sociodémographiques
Health behaviors, obesity, and marital status among cancer survivors: a MEPS study
Menée aux Etats-Unis à partir de données 2011-2017 portant sur 1 880 patients ayant survécu à un cancer (prostate, sein ou côlon), cette étude analyse l'association entre des comportements de santé, une obésité et le statut marital en fonction du type de cancer et de critères sociodémographiques
Health behaviors, obesity, and marital status among cancer survivors: a MEPS study
Song, Lixin ; Guan, Ting ; Guo, Peiran ; Tan, Xianming ; Bryant, Ashley Leak ; Wood, William A. ; Sung, Anthony D. ; Kent, Erin Elizabeth ; Keyserling, Thomas C.
Purpose: Promoting positive health behaviors helps improve cancer survivors’ health outcomes during survivorship; however, little is known about whether health behaviors differ by marital status. The purpose is to examine whether health behaviors and obesity among cancer survivors vary by marital status and whether the type of cancer and sociodemographic factors influence the relationship. Methods: We examined smoking, physical activity, and body mass index (BMI) among 1880 individuals [...]
Menée aux Etats-Unis à partir de données portant sur 322 patients atteints d'un myélome multiple récemment diagnostiqué, cette étude de cohorte analyse l'effet, sur la survie globale, d'une sarcopénie identifiée à l'aide d'une tomodensitométrie avec segmentation d'image utilisant un algorithme d'apprentissage automatique
Sarcopenia identified by computed tomography imaging using a deep learning–based segmentation approach impacts survival in patients with newly diag...
Menée aux Etats-Unis à partir de données portant sur 322 patients atteints d'un myélome multiple récemment diagnostiqué, cette étude de cohorte analyse l'effet, sur la survie globale, d'une sarcopénie identifiée à l'aide d'une tomodensitométrie avec segmentation d'image utilisant un algorithme d'apprentissage automatique
Sarcopenia identified by computed tomography imaging using a deep learning–based segmentation approach impacts survival in patients with newly diagnosed multiple myeloma
Nandakumar, Bharat ; Baffour, Francis ; Abdallah, Nadine H. ; Kumar, Shaji K. ; Dispenzieri, Angela ; Buadi, Francis K. ; Dingli, David ; Lacy, Martha Q. ; Hayman, Suzanne R. ; Kapoor, Prashant ; Leung, Nelson ; Fonder, Amie ; Hobbs, Miriam ; Hwa, Yi Lisa ; Muchtar, Eli ; Warsame, Rahma ; Kourelis, Taxiarchis V. ; Go, Ronald S. ; Kyle, Robert A. ; Gertz, Morie A. ; Rajkumar, S. Vincent ; Klug, Jason ; Korfiatis, Panagiotis ; Gonsalves, Wilson I.
Background : Sarcopenia increases with age and is associated with poor survival outcomes in patients with cancer. By using a deep learning–based segmentation approach, clinical computed tomography (CT) images of the abdomen of patients with newly diagnosed multiple myeloma (NDMM) were reviewed to determine whether the presence of sarcopenia had any prognostic value. Methods : Sarcopenia was detected by accurate segmentation and measurement of the skeletal muscle components present at the level [...]
Menée aux Etats-Unis à partir de données 2004-2017 portant sur 37 566 patientes atteintes d'un cancer de l'ovaire de stade III/IV, cette étude analyse les disparités ethniques dans l'ordre et la nature des traitements reçus, puis analyse l'impact de ces disparités sur la mortalité
Neoadjuvant chemotherapy in ovarian cancer: Are there racial disparities in use and survival?
Menée aux Etats-Unis à partir de données 2004-2017 portant sur 37 566 patientes atteintes d'un cancer de l'ovaire de stade III/IV, cette étude analyse les disparités ethniques dans l'ordre et la nature des traitements reçus, puis analyse l'impact de ces disparités sur la mortalité
Neoadjuvant chemotherapy in ovarian cancer: Are there racial disparities in use and survival?
Amin, Saber A. ; Collin, Lindsay J. ; Setoguchi, Soko ; Satagopan, Jaya M. ; Buckley de Meritens, Alexandre ; Bandera, Elisa V.
Background: We investigated racial and ethnic disparities in treatment sequence (i.e., neoadjuvant chemotherapy (NACT) plus interval debulking surgery (IDS) vs. primary debulking surgery (PDS) plus adjuvant chemotherapy) among ovarian cancer patients and its contribution to disparities in mortality. Methods: Study included 37,566 women aged ≥18 years, diagnosed with stage III/IV ovarian cancer from the National Cancer Database (2004–2017). Logistic regression was used to compute odds ratios [...]
Approches psycho-sociales (1)
Menée à partir de données de deux études incluant un total de 149 patientes ayant survécu à un cancer du sein et 74 patients ayant survécu à un cancer colorectal, cette étude évalue l'intérêt d'un outil permettant de détecter la peur de la récidive de la maladie
Evaluating the capacity of the Distress Thermometer to detect high fear of cancer recurrence
Menée à partir de données de deux études incluant un total de 149 patientes ayant survécu à un cancer du sein et 74 patients ayant survécu à un cancer colorectal, cette étude évalue l'intérêt d'un outil permettant de détecter la peur de la récidive de la maladie
Evaluating the capacity of the Distress Thermometer to detect high fear of cancer recurrence
Deuning-Smit, Esther ; Custers, José A.E. ; Kwakkenbos, Linda ; Hermens, Rosella P.M.G. ; Prins, Judith B.
Objectives: Fear of cancer recurrence (FCR) is common and burdensome to patients, but often remains undetected. Oncology professionals report need for tools to improve FCR detection in routine care. Oncology care guidelines recommend the Distress Thermometer (DT) for distress screening, but it has not been validated for FCR. This study evaluated the capacity of the DT and accompanying problem list to detect FCR. Methods: Amalgamated data of two studies with 149 breast cancer and 74 colorectal [...]
