Menée à partir de données des cohortes "the Nurses’ Health Studies" portant sur 165 760 femmes, cette étude analyse l'effet d'une exposition précoce au tabagisme sur l'immunité systémique, la réponse tumorale (nombre de lymphocytes T) et le risque de cancer de l'ovaire

Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T Cell Tumor Immune Infiltration

Hathaway, Cassandra A. ; Wang, Tianyi ; Townsend, Mary K. ; Vinci, Christine ; Jake-Schoffman, Danielle E. ; Saeed-Vafa, Daryoush ; Moran Segura, Carlos ; Nguyen, Jonathan V. ; Conejo-Garcia, Jose R. ; Fridley, Brooke L. ; Tworoger, Shelley S.

Background: Exposure to cigarette smoke, particularly in early life, is modestly associated with ovarian cancer risk and may impact systemic immunity and the tumor immune response. However, no studies have evaluated whether cigarette smoke exposure impacts the ovarian tumor immune microenvironment. Methods: Participants in the Nurses’ Health Study (NHS) and NHSII reported on early life exposure to cigarette smoke and personal smoking history on questionnaires (n=165,760). Multiplex [...]

Menée à l'aide de données 1961-2005 de la "Nordic Occupational Cancer (NOCCA)" portant sur 2 898 patients atteints d'un cancer du rhinopharynx, cette étude identifie les facteurs de risque professionnel associés à la maladie

Occupational risk variation of nasopharyngeal cancer in the Nordic countries

Carpén, Timo ; Gille, Evelina ; Hammarstedt-Nordenvall, Lalle ; Hansen, Johnni ; Heikkinen, Sanna ; Lynge, Elsebeth ; Selander, Jenny ; Mehlum, Ingrid Sivesind ; Torfadottir, Jóhanna Eyrún ; Mäkitie, Antti ; Pukkala, Eero

Background: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study. Methods: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961–2005. The data on occupations were gathered from population censuses and cancer data from the national cancer [...]

Menée au Danemark à l'aide des données 1970-2018 du registre des cancers et auprès de 38 613 personnes habitant dans une zone partiellement contaminée par les polychlorobiphényles (PCB), cette étude analyse l'association entre une exposition résidentielle aux PCB en suspension dans l'air et le risque de cancer (3 431 cas)

Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls: A Danish Register-Based Cohort Study

Laura Deen ; Karin Sørig Hougaard ; Alice Clark ; Harald William Meyer ; Marie Frederiksen ; Lars Gunnarsen ; Helle Vibeke Andersen ; Thomas Hougaard ; Kajsa Kirstine Ugelvig Petersen ; Niels Erik Ebbehøj ; Jens Peter Bonde ; Sandra Søgaard Tøttenborg

Background: Polychlorinated biphenyls (PCBs) are biopersistent chemicals classified as human carcinogens. This classification is primarily based on evidence on higher-chlorinated PCBs found in food. The carcinogenic potential of airborne lower-chlorinated PCBs remains largely unexplored. Objectives: We aimed to investigate cancer risk following residential exposure to airborne PCBs. Methods: Cancer risk was examined in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort of 38,613 [...]

Menée à partir de données 1992-2015 des registres américains des cancers portant sur 372 696 patients atteints d'un cancer (prostate, poumon, côlon-rectum, vessie, lymphome non hodgkinien, mélanome ou oesophage) et de la base Medicare, cette étude analyse l'association entre une thérapie de remplacement de la testostérone et le risque de développer la maladie

Testosterone therapy and cancer risks among men in the SEER-Medicare linked database

Butler, Eboneé N. ; Zhou, Cindy Ke ; Curry, Michael ; McMenamin, Úna ; Cardwell, Christopher ; Bradley, Marie C. ; Graubard, Barry I. ; Cook, Michael B.

Background: We examined associations between two forms of testosterone therapy (TT) and risks of seven cancers among men. Methods: SEER-Medicare combines cancer registry data from the Surveillance, Epidemiology, and End Results programme with Medicare claims. Our population-based case–control study included incident cancer cases diagnosed between 1992–2015: prostate (n = 130,713), lung (n = 105,466), colorectal (n = 56,433), bladder (n = 38,873), non-Hodgkin lymphoma (n = 17,854), melanoma [...]

Menée auprès de 838 témoins et 838 patientes atteintes d'un cancer du col de l'utérus, cette étude analyse l'association entre une infection par le virus de l'hépatite B ou C et le risque de cancer du col de l'utérus

Hepatitis B or C viral infection and the risk of cervical cancer

Luo, Chuanfang ; Yu, Shuhui ; Zhang, Jinping ; Wu, Xingrao ; Dou, Zhongyan ; Li, Zheng ; Yang, E. ; Zhang, Lan

Background: The present study aimed to evaluate the effects of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on the risk of cervical cancer. Methods: We conducted a case–control study including 838 cervical cancer cases and 838 benign disease controls matched for age, ethnicity, and place of birth. Venous blood was tested for HBV and HCV serological markers. Multiple odds ratios (OR) and corresponding 95% confidence intervals (CI) for cervical cancer were estimated using logistic [...]

Menée en Australie auprès de 96 548 hommes, cette étude analyse l'association entre un diagnostic de mélanome (1 899 cas) et le risque de cancer de la prostate (3 677 cas)

Cutaneous melanoma, prostate-specific antigen testing and the subsequent risk of prostate cancer diagnosis: a prospective analysis of the 45 and Up Study

Egger, Sam ; Smith, David P. ; Patel, Manish I. ; Kimlin, Michael G. ; Armstrong, Bruce K. ; Nair-Shalliker, Visalini

Background: The association between cutaneous melanoma and subsequent risk of prostate cancer (PC) was examined in a large population-based cohort study. Methods: Male participants in the Sax Institute’s 45 and Up Study (Australia) were recruited between 2006 and 2009. Questionnaire data and linked administrative health data from the Centre for Health Record Linkage and Services Australia identified melanomas diagnosed between 1/1/1994 and 12 months before Study recruitment (i.e., between 2005 [...]

Menée à partir de données 1986-2016 portant sur 47 240 hommes inclus dans la cohorte "the Health Professionals Follow-Up Study" (durée médiane de suivi : 28,3 ans), cette étude analyse l'association entre une supplémentation en zinc (quantité et durée) et le risque de cancer agressif ou létal de la prostate (6 980 cas)

Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study

Zhang, Yiwen ; Song, Mingyang ; Mucci, Lorelei A. ; Giovannucci, Edward L.

Background: Zinc supplementation was hypothesized to have therapeutic potential against prostate cancer, but its influence on prostate cancer incidence especially at high doses is controversial. Methods: A total of 47,240 men from the Health Professionals Follow-up Study were followed from 1986 to 2016. Men reported their zinc supplement use at baseline and biennially thereafter. Clinical features of prostate cancer included stage, grade, lethal and aggressive (T4 or N1 or M1 or Gleason 8–10) [...]

Menée auprès d'une cohorte européenne de 69 460 patients ayant survécu à un cancer pédiatrique (âge : 0-20 ans), cette étude évalue le risque de cancer de la cavité buccale (145 cas ; âge médian au diagnostic : 32 ans) et identifie les facteurs associés

Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Sunguc, Ceren ; Hawkins, Michael M. ; Winter, David L. ; Dudley, Isabelle M. ; Heymer, Emma J. ; Teepen, Jop C. ; Allodji, Rodrigue S. ; Belle, Fabiën N. ; Bagnasco, Francesca ; Byrne, Julianne ; Bárdi, Edit ; Ronckers, Cecile M. ; Haddy, Nadia ; Gudmundsdottir, Thorgerdur ; Garwicz, Stanislaw ; Jankovic, Momcilo ; van der Pal, Helena J. H. ; Mazić, Maja Česen ; Schindera, Christina ; Grabow, Desiree ; Maule, Milena M. ; Kaatsch, Peter ; Kaiser, Melanie ; Fresneau, Brice ; Michel, Gisela ; Skinner, Roderick ; Wiebe, Thomas ; Sacerdote, Carlotta ; Jakab, Zsuzsanna ; Gunnes, Maria Winther ; Terenziani, Monica ; Winther, Jeanette F. ; Lähteenmäki, Päivi M. ; Zaletel, Lorna Zadravec ; Kuehni, Claudia E. ; Kremer, Leontien C. ; Haupt, Riccardo ; de Vathaire, Florent ; Hjorth, Lars ; Reulen, Raoul C.

Background: Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks. Methods: The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative [...]

Menée en Italie auprès de 4 631 personnes présentant une hémoglobinopathie, cette étude analyse le risque de cancer associé à cette pathologie (197 cas)

Incidence of cancer and related deaths in hemoglobinopathies: A follow-up of 4631 patients between 1970 and 2021

Origa, Raffaella ; Gianesin, Barbara ; Longo, Filomena ; Di Maggio, Rosario ; Cassinerio, Elena ; Gamberini, Maria Rita ; Pinto, Valeria Maria ; Quarta, Antonella ; Casale, Maddalena ; La Nasa, Giorgio ; Caocci, Giovanni ; Piroddi, Antonio ; Piolatto, Andrea ; Di Mauro, Alessandra ; Romano, Claudia ; Gigante, Antonia ; Barella, Susanna ; Maggio, Aurelio ; Graziadei, Giovanna ; Perrotta, Silverio ; Forni, Gian Luca

Background: The correlation between thalassemia and malignancies other than hepatocellular carcinoma (HCC) and the possible relationship between other hemoglobinopathies and tumor risk have been poorly evaluated. Methods: Eight Italian specialized centers evaluated the incidence of malignant neoplasms in hemoglobinopathies as well as their sites and features. The study cohort included 4631 patients followed between 1970 and 2021 (transfusion-dependent β-thalassemia, 55.6%; [...]