Mené aux Etats-Unis sur 247 patientes ayant survécu à un cancer du sein (âge : moins de 50 ans), cet essai évalue l'effet de deux interventions sur la santé psychique, le stress et les marqueurs de l'inflammation

Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes

Bower, Julienne E ; Partridge, Ann H ; Wolff, Antonio C ; Cole, Steve W ; Irwin, Michael R ; Thorner, Elissa D ; Joffe, Hadine ; Petersen, Laura ; Crespi, Catherine M ; Ganz, Patricia A

Background : The Pathways to Wellness trial tested the efficacy of two interventions for younger breast cancer survivors: mindful awareness practices (MAPs) and survivorship education (SE). This planned secondary analysis examines intervention effects on stress, positive psychological outcomes, and inflammation (Clincaltrials.gov NCT03025139). Methods : Women diagnosed with breast cancer at or before age 50 who had completed treatment and had elevated depressive symptoms were randomly assigned [...]

Menée aux Etats-Unis à partir de données portant sur 2 089 enfants atteints d'un cancer, cette étude analyse l'association entre la pauvreté infantile et la survie

Persistent Child Poverty and Mortality in a Cohort of Children with Cancer in Alabama

Hoppmann, Anna L. ; Dai, Chen ; Daves, Marla ; Imran, Hamayun ; Whelan, Kimberly ; Kenzik, Kelly ; Bhatia, Smita

BACKGROUND: One fifth of US counties are designated persistent child poverty counties (>/=20% of children in poverty since 1980). The association between a persistent child poverty environment and mortality in children with cancer is unknown. METHODS: Our cohort includes 2,089 children with cancer (2000-2016) in Alabama. We used multivariable cox proportional hazards modeling (adjusted for sociodemographics/clinical characteristics) to assess mortality by persistent child poverty designation [...]

Menée au Royaume-Uni, cette étude analyse l'association entre les caractéristiques environnementales du voisinage (présence d'espaces verts, d'équipements sportifs, de boutiques d'alimentation à emporter, ...) et les disparités socioéconomiques dans les hospitalisations liées au cancer

Neighborhood environment and socioeconomic inequalities in cancer admissions: a prospective study using UK Biobank and linked hospital records

Mason, Kate E. ; Pearce, Neil ; Cummins, Steven

Purpose : Neighborhood environments may influence cancer risk. Average population effect estimates might mask differential effects by socioeconomic position. Improving neighborhood environments could inadvertently widen health inequalities if important differences are overlooked. Methods : Using linked records of hospital admissions in UK Biobank, we assessed associations between admission with a primary diagnosis of cancer (any/breast/colorectal), and exposure to neighborhood greenspace, [...]

Menée à partir de données portant sur 44 855 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre l'utilisation d'anxiolytiques ou de sédatifs pendant une chimiothérapie adjuvante et la persistance de cette utilisation après le traitement anticancéreux

New and Persistent Sedative-Hypnotic Use after Adjuvant Chemotherapy for Breast Cancer

Cogan, Jacob C ; Raghunathan, Rohit R ; Beauchemin, Melissa P ; Accordino, Melissa K ; Huang, Yongmei ; Elkin, Elena B ; Melamed, Alexander ; Wright, Jason D ; Hershman, Dawn L

Background : Sedative-hypnotic medications are used to treat chemotherapy-related nausea, anxiety and insomnia. However, prolonged sedative-hypnotic use can lead to dependence, misuse and increased healthcare utilization. We aimed to estimate the rates at which patients who receive adjuvant chemotherapy for breast cancer become new persistent users of sedative-hypnotic medications, specifically benzodiazepines and non-benzodiazepine sedative-hypnotics (Z-drugs). Methods : Using the MarketScan [...]

Menée auprès de 295 patientes atteintes d'un cancer du sein et âgées de plus de 65 ans, cette étude de cohorte prospective analyse l'association entre les niveaux de biomarqueurs de l'inflammation avant une chimiothérapie adjuvante et la dégradation de l'état du patient après le traitement

Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study

Jingran Ji ; Can-Lan Sun ; Harvey J. Cohen ; Timothy Synold ; Hyman Muss ; Mina S. Sedrak

PURPOSE : Older breast cancer survivors are at increased risk of clinical decline after adjuvant chemotherapy. This study aimed to evaluate whether inflammatory markers assessed before adjuvant chemotherapy are associated with chemotherapy-induced clinical decline in a population of fit older adults with breast cancer. METHODS : In a prospective study of women age ≥ 65 years with stage I-III breast cancer treated with chemotherapy, we measured interleukin-6 (IL-6) and C-reactive protein (CRP) [...]

Menée en Australie par entretiens auprès de 24 hommes atteints d'un cancer localisé de la prostate à faible risque de récidive et de 12 partenaires de vie, cette étude identifie les facteurs socio-écologiques influençant leur prise de décision thérapeutique

Social ecological influences on treatment decision-making in men diagnosed with low risk, localised prostate cancer

McIntosh, Megan ; Opozda, Melissa J. ; Short, Camille E. ; Galvão, Daniel A. ; Tutino, Rebecca ; Diefenbach, Michael ; Ehdaie, Behfar ; Nelson, Christian

Objective : Individuals diagnosed with low risk, localised prostate cancer (PCa) face a difficult decision between active surveillance (AS) and definitive treatment. We aimed to explore perceived influences on treatment decision-making from the patient and partner's perspectives. Methods : Patients (and partners) who met AS criteria and had chosen their treatment were recruited. Semi-structured individual interviews were conducted via telephone to explore experiences of diagnosis, impact on [...]

Menée au Liban à partir de données portant sur 112 patientes atteintes d'un cancer du sein traité par chimiothérapie (âge moyen : 56 ans), cette étude transversale analyse l'association entre des facteurs cliniques et génétiques et des déficiences cognitives auto-déclarées

Clinical and genetic factors associated with self-reported cognitive deficits in women with breast cancer: the “CAGE-Cog” study

Hajj, Aline ; Khoury, Rita ; Hachem, Roula ; Awad, Aya ; Hallit, Souheil ; Sacre, Hala ; Nasr, Fady ; Karak, Fadi El ; Chahine, Georges ; Kattan, Joseph ; Khabbaz, Lydia Rabbaa

Background : Breast cancer patients undergoing chemotherapy treatment are at particular risk of experiencing acute cognitive impairment leading to daily challenges in decision-making and reduced quality of life and functional autonomy. The aim was to assess the relationship between clinical and genetic factors and cognitive function in a sample of patients with breast cancer undergoing chemotherapy. Methods : A cross-sectional study was carried out between November 2017 and June 2019 on women [...]

Menée au Japon auprès de 1 157 patients atteints d'un cancer de stade avancé et pris en charge dans des unités de soins palliatifs, cette étude de cohorte prospective identifie les facteurs associés à la "qualité du décès"

Factors associated with good death of patients with advanced cancer: a prospective study in Japan

Ikari, Tomoo ; Hiratsuka, Yusuke ; Cheng, Shao-Yi ; Miyashita, Mitsunori ; Morita, Tatsuya ; Mori, Masanori ; Uneno, Yu ; Amano, Koji ; Uehara, Yuko ; Yamaguchi, Takashi ; Maeda, Isseki ; Inoue, Akira

Purpose : It is important for palliative care providers to identify what factors are associated with a “good death” for patients with advanced cancer. We aimed to identify factors associated with a “good death” evaluated by the Good Death Scale (GDS) score among inpatients with advanced cancer in palliative care units (PCUs) in Japan. Methods : The study is a sub-analysis of a multicenter prospective cohort study conducted in Japan. All variables were recorded on a structured data collecting [...]

Menée en Belgique par enquête auprès de 80 patients atteints d'un cancer incurable, cette étude transversale identifie les facteurs associés à leur intention de discuter avec leur médecin des soins palliatifs

Identification of the most important factors related to people with cancer starting a palliative care conversation: A survey study

Scherrens, Anne-Lore ; Beernaert, Kim ; Deliens, Luc ; Lapeire, Lore ; De Laat, Martine ; Biebuyck, Christine ; Geboes, Karen ; Van Praet, Charles ; Moors, Ine ; Deforche, Benedicte ; Cohen, Joachim

OBJECTIVE : A late conversation about palliative care needs can lead to suboptimal care in the final months/weeks of life. Insight into factors related to patients’ communication about palliative care is needed. This study aims to identify the factors associated with starting/intending to start a conversation about palliative care with the physician. METHODS : We performed a cross-sectional interviewer-administered survey among people with incurable cancer. Purposive sampling was used, taking [...]

Cette étude présente les recommandations de la "Society for Integrative Oncology" et de l'"American Society of Clinical Oncology" concernant les approches d'oncologie intégrative dans la prise en charge de la douleur des patients atteints d'un cancer

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

Jun J. Mao ; Nofisat Ismaila ; Ting Bao ; Debra Barton ; Eran Ben-Arye ; Eric L. Garland ; Heather Greenlee ; Thomas Leblanc ; Richard T. Lee ; Ana Maria Lopez ; Charles Loprinzi ; Gary H. Lyman ; Jodi MacLeod ; Viraj A. Master ; Kavitha Ramchandran ; Lynne I. Wagner ; Eleanor M. Walker ; Deborah Watkins Bruner ; Claudia M. Witt ; Eduardo Bruera

PURPOSE : The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS : The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature [...]