Menée aux Etats-Unis à partir de données 1989-1993 portant sur 4 279 personnes âgées d'au moins 65 ans (durée médiane de suivi : 13,3 ans ; âge moyen : 72,8 ans ; 57,3 % de femmes), cette étude évalue le risque de cancer du poumon chez les fumeurs pour lesquels le dépistage annuel par tomodensitométrie à faible dose n'est pas recommandé

Assessment of Lung Cancer Risk Among Smokers for Whom Annual Screening Is Not Recommended

Faselis, Charles ; Nations, Joel A. ; Morgan, Charity J. ; Antevil, Jared ; Roseman, Jeffrey M. ; Zhang, Sijian ; Fonarow, Gregg C. ; Sheriff, Helen M. ; Trachiotis, Gregory D. ; Allman, Richard M. ; Deedwania, Prakash ; Zeng-Trietler, Qing ; Taub, Daniel D. ; Ahmed, Amiya A. ; Howard, George ; Ahmed, Ali

The US Preventive Services Task Force does not recommend annual lung cancer screening with low-dose computed tomography (LDCT) for adults aged 50 to 80 years who are former smokers with 20 or more pack-years of smoking who quit 15 or more years ago or current smokers with less than 20 pack-years of smoking.To determine the risk of lung cancer in older smokers for whom LDCT screening is not recommended.This cohort study used the Cardiovascular Health Study (CHS) data sets obtained from the [...]

Menée à l'aide de données de la cohorte européenne EPIC et de la "UK Biobank" portant au total sur 465 686 personnes et menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 108 979 témoins et 12 906 patientes atteintes d'un cancer de l'endomètre, cette étude analyse l'association entre le tabagisme et le risque de développer la maladie

Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

Dimou, Niki ; Omiyale, Wemimo ; Biessy, Carine ; Viallon, Vivian ; Kaaks, Rudolf ; O'Mara, Tracy A. ; Aglago, Elom K. ; Ardanaz, Eva ; Bergmann, Manuela M. ; Bondonno, Nicola P. ; Braaten, Tonje ; Colorado-Yohar, Sandra M. ; Crous-Bou, Marta ; Dahm, Christina C. ; Fortner, Renée T. ; Gram, Inger T. ; Harlid, Sophia ; Heath, Alicia K. ; Idahl, Annika ; Kvaskoff, Marina ; Nøst, Therese H. ; Overvad, Kim ; Palli, Domenico ; Perez-Cornago, Aurora ; Sacerdote, Carlotta ; Sánchez, María-José ; Schulze, Matthias B. ; Severi, Gianluca ; Simeon, Vittorio ; Tagliabue, Giovanna ; Tjønneland, Anne ; Truong, Thérèse ; Tumino, Rosario ; Johansson, Mattias ; Weiderpass, Elisabete ; Murphy, Neil ; Gunter, Marc J. ; Lacey, Ben ; Allen, Naomi E. ; Dossus, Laure

Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données issues de "FinnGen" et de la "UK Biobank" portant sur 591 961 témoins et 3 998 patients atteints d'un cancer de la vessie, cette étude analyse l'association entre tabagisme, la consommation d'alcool et le risque de développer la maladie

The causal association between smoking, alcohol consumption and risk of bladder cancer: A univariable and multivariable Mendelian randomization study

Xiong, Jie ; Yang, Lan ; Deng, Yu-Qing ; Yan, Si-Yu ; Gu, Jia-Min ; Li, Bing-Hui ; Zi, Hao ; Ming, Dao-Jing ; Zeng, Xian-Tao ; Wang, Yong-Bo

Smoking and alcohol consumption are associated with bladder cancer risk in observational studies. We conducted a two-sample univariable and multivariable Mendelian randomization (MR) analysis to determine whether those associations are causal. We used 21, 126, 360, 39 single nucleotide polymorphisms (SNPs) as instrumental variables for number of cigarettes per day, lifetime smoking index, smoking initiation, and drinks per week, respectively. A total of 1,115 cases with bladder cancer and [...]

Menée sur la période 2005-2020 auprès de 1 515 patients atteints d'une cirrhose, cette étude analyse l'association entre une importante consommation d'alcool, le polymorphisme rs671 du gène ALDH2 ou une infection par le virus de l'hépatite B et le risque de carcinome hépatocellulaire

Association of Heavy Alcohol Intake and ALDH2 rs671 Polymorphism With Hepatocellular Carcinoma and Mortality in Patients With Hepatitis B Virus–Related Cirrhosis

Tsai, Ming-Chao ; Yang, Sien-Sing ; Lin, Chih-Che ; Wang, Wen-Lun ; Hsu, Yao-Chun ; Chen, Yaw-Sen ; Hu, Jui-Ting ; Lin, James Yu ; Yu, Ming-Lung ; Lin, Chih-Wen

The role of heavy alcohol intake, aldehyde dehydrogenase 2 gene (ALDH2) rs671 polymorphism, and hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) development and mortality remains uncertain.To investigate the association of heavy alcohol intake, ALDH2 rs671 polymorphism, and HBV infection with HCC development and mortality in patients with cirrhosis.This retrospective cohort study enrolled patients with cirrhosis with heavy alcoholism or/and HBV infection from January 2005 to [...]

Menée dans 10 pays européens à partir de données portant sur 450 112 participants (durée moyenne de suivi : 15 ans), cette étude de cohorte prospective analyse l'association entre une consommation d'alcool et le risque de cancer de la peau (14 037 cas)

Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and nutrition cohort (EPIC)

Mahamat-Saleh, Yahya ; Al-Rahmoun, Marie ; Severi G, Gianluca ; Ghiasvand, Reza ; Veierod, Marit B. ; Caini, Saverio ; Palli, Domenico ; Botteri, Edoardo ; Sacerdote, Carlotta ; Ricceri, Fulvio ; Lukic, Marko ; Sánchez, Maria J. ; Pala, Valeria ; Tumino, Rosario ; Chiodini, Paolo ; Amiano, Pilar ; Colorado-Yohar, Sandra ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Bonet, Catalina ; Katzke, Verena ; Kaaks, Rudolf ; Schulze, Matthias B. ; Overvad, Kim ; Dahm, Christina C. ; Antoniussen, Christian S. ; Tjønneland, Anne ; Kyrø, Cecilie ; Bueno-de-Mesquita, Bas ; Manjer, Jonas ; Jansson, Malin ; Esberg, Anders ; Mori, Nagisa ; Ferrari, Pietro ; Weiderpass, Elisabete ; Boutron-Ruault, Marie-Christine ; Kvaskoff, Marina

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% [...]

Menée auprès d'une cohorte multicentrique française incluant 16 086 personnes ayant été exposées professionnellement à l'amiante, cette étude analyse l'association entre la présence de plaques pleurales, révélée à l'aide d'un scanner, et l'incidence (176 cas) ou la mortalité du cancer du poumon (88 décès), en fonction du statut tabagique

Pleural plaques and risk of lung cancer in workers formerly occupationally exposed to asbestos: extension of follow-up

Gallet, Justine ; Laurent, François ; Paris, Christophe ; Clin, Bénédicte ; Gislard, Antoine ; Thaon, Isabelle ; Chammings, Soizick ; Gramond, Celine ; Ogier, Guy ; Ferretti, Gilbert ; Andujar, Pascal ; Brochard, Patrick ; Delva, Fleur ; Pairon, Jean-Claude ; Lacourt, Aude

Background: Occupational asbestos exposure is associated with pleural plaques (PP), a benign disease often seen as a marker of past exposure to asbestos and lung cancer. The association between these two diseases has not been formally proved, the aim of this study was to evaluate this association in the asbestos-related disease cohort (ARDCO) cohort. Methods: ARDCO is a French multicentric cohort including workers formerly occupationally exposed to asbestos from 2003 to 2005. CT scan was [...]

Menée en Finlande auprès de 33 359 femmes travaillant dans le secteur public (âge moyen : 40,6 ans), cette étude analyse l'association entre du travail posté, avec ou sans travail de nuit, et le risque de cancer du sein (1 129 cas), par catégorie d'âge

Shift work with and without night shifts and breast cancer risk in a cohort study from Finland

Härmä, Mikko ; Ojajärvi, Anneli ; Koskinen, Aki ; Lie, Jenny-Anne ; Hansen, Johnni

Objectives: To examine the association of shift work with and without night work with breast cancer among women in the public sector. Methods: Using the Finnish Public Sector cohort study (N=33 359, mean age of 40.6 years at baseline), we investigated the associations of shift work and potential confounders with incident breast cancer. Exposure to permanent day work or shift work was defined from first two consecutive surveys from 2000, 2004, 2008 or 2012 and past information on exposure in a [...]

Cette étude analyse l'association entre une infection bactérienne et la lymphomagenèse

Bacterial infection-driven lymphomagenesis

Vannata, Barbara ; Pirosa, Maria Cristina ; Bertoni, Francesco ; Rossi, Davide ; Zucca, Emanuele

Purpose: The first convincing evidence for a causal relationship between bacterial infection and lymphomagenesis came from the link between gastric lymphoma and chronic Helicobacter pylori gastritis. This review will summarize the current epidemiological, clinical, and biological evidence of a causative role of bacteria in the development of malignant lymphomas, particularly, the extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type. Recent findings: Other microorganisms [...]

Menée à partir de données américaines portant sur 143 886 patients atteints d'un cancer localisé de la prostate diagnostiqué entre 2000 et 2015 (âge médian : 65 ans), cette étude analyse l'association entre un traitement par radiothérapie et le risque de second cancer

Assessment of Second Primary Cancer Risk Among Men Receiving Primary Radiotherapy vs Surgery for the Treatment of Prostate Cancer

Bagshaw, Hilary P. ; Arnow, Katherine D. ; Trickey, Amber W. ; Leppert, John T. ; Wren, Sherry M. ; Morris, Arden M.

Shared decision-making is an important part of the treatment selection process among patients with prostate cancer. Updated information is needed regarding the long-term incidence and risk of second primary cancer after radiotherapy vs nonradiotherapy treatments, which may help to inform discussions of risks and benefits for men diagnosed with prostate cancer.To assess the current incidence and risk of developing a second primary cancer after receipt of radiotherapy vs nonradiotherapy [...]

Menée aux Etats-Unis auprès de 58 227 personnes, cette étude analyse l'association entre une utilisation d'anti-inflammatoires non stéroïdiens et le risque de mélanome

Use of nonsteroidal anti-inflammatory drugs and incidence of melanoma in the United States Radiologic Technologists study

Mai, Jim Z. ; Kitahara, Cari M. ; Sargen, Michael R. ; Little, Mark P. ; Alexander, Bruce H. ; Linet, Martha S. ; Tucker, Margaret A. ; Cahoon, Elizabeth K.

Although nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with both reduced and increased cutaneous melanoma risk, few studies have examined these associations by ultraviolet radiation (UVR) or personal sun-sensitivity. We examined the associations between NSAID use and first primary invasive cutaneous melanoma among 58,227 non-Hispanic white participants in the United States Radiologic Technologists cohort study. Poisson regression was used to calculate rate ratios (RRs) and [...]

Menée à l'aide de données 1995-2017 portant sur 148 016 Danoises recevant un traitement médical pour l'infertilité (durée médiane de suivi : 11,3 ans), cette étude analyse l'association entre ce traitement et le risque de tumeur du système nerveux central (328 cas)

Tumors of the central nervous system among women treated with fertility drugs: a population-based cohort study

Frandsen, Clarissa L. B. ; Jensen, Allan ; Poulsen, Frantz R. ; Møller, Maria ; Lindquist, Sofie ; Albieri, Vanna ; Nøhr, Bugge ; Kjær, Susanne K.

Purpose: To investigate the association between fertility drugs and tumors of the central nervous system (CNS). Methods: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995–2017). The study cohort was linked to national registers to obtain information on use of specific fertility drugs, cancer diagnoses, covariates, emigration, and vital status. Cox proportional hazard regression models were used to calculate hazard ratios [...]

Menée en Asie à partir de données portant sur 538 835 personnes dont 8 997 patients atteints d'un cancer gastrique, cette étude analyse l'association entre l'indice de masse corporelle et le risque de développer la maladie

Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants

Jang, Jieun ; Lee, Sangjun ; Ko, Kwang-Pil ; Abe, Sarah K. ; Rahman, Md. Shafiur ; Saito, Eiko ; Islam, Md. Rashedul ; Sawada, Norie ; Shu, Xiao-Ou ; Koh, Woon-Puay ; Sadakane, Atsuko ; Tsuji, Ichiro ; Kim, Jeongseon ; Oze, Isao ; Nagata, Chisato ; Tsugane, Shoichiro ; Cai, Hui ; Yuan, Jian-Min ; Gao, Yu-Tang ; Ozasa, Kotaro ; Matsuyama, Sanae ; Kanemura, Seiki ; Shin, Aesun ; Ito, Hidemi ; Wada, Keiko ; Sugawara, Yumi ; Chen, Yu ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Park, Sue K.

This study was performed to investigate the association between body mass index (BMI) and gastric cancer in East and Southeast Asia where most of gastric cancer is non-cardia gastric cancer.On the basis of 8,997 gastric cancer cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N = 538,835), we assessed gastric cancer risk according to BMI by calculating hazard ratios (HR) and 95% confidence intervals (CI) using the Cox proportional hazard regression [...]

Menée en Chine sur la période 1996-2000 à partir de données portant sur 72 807 femmes (période de suivi : 1 269 531 personnes-années ; 258 cas), cette étude de cohorte prospective analyse l'association entre des facteurs menstruels et reproductifs et le risque de cancer du foie

Menstrual factors, reproductive history and liver cancer risk: findings from a prospective cohort study in Chinese women

Tuo, Jia-Yi ; Li, Hong-Lan ; Wang, Jing ; Fang, Jie ; Tan, Yu-Ting ; Xiang, Yong-Bing

Background: Many studies suggested that menstrual and reproductive factors affected the gender disparity in liver carcinogenesis, but the results were inconsistent. Moreover, there are few studies in Asian populations. Therefore, our study was to explore the association of menstrual and reproductive factors on liver cancer risk in Chinese women. Methods: 72,807 women were recruited in 1996-2000 and followed until the end of 2016 in Shanghai, China. Cox regression models were used to estimate [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2020 (15 articles), cette étude identifie des facteurs de prédisposition au risque de cancer radio-induit chez les patients exposés avant l'âge de 25 ans

Cancer effects of low to moderate doses of ionising radiation in young people with cancer predisposing conditions: A systematic review

Canet, Malle ; Harbron, Richard ; Thierry-Chef, Isabelle ; Cardis, Elisabeth

Moderate to high doses of ionising radiation (IR) are known to increase risk of cancer, particularly following childhood exposure. Concerns remain regarding risks from lower doses and the role of cancer predisposing factors (CPFs) (genetic disorders, immunodeficiency, mutations/variants in DNA damage detection or repair genes) on radiation-induced cancer (RIC) risk. We conducted a systematic review of evidence that CPFs modify RIC risk in young people. Searches were performed in PubMed, Scopus, [...]

Menée à partir d'une revue de la littérature (11 études incluant un total de 3 975 cas), cette méta-analyse évalue l'association entre des variants constitutionnels hétérozygotes des gènes BRCA1/2, PALB2, ATM, CHEK2, MSH2, MSH6, MLH1 et PMS2 et le risque de cancer chez les enfants et les adolescents

Heterozygous BRCA1/2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents with Cancer

Kratz, Christian P ; Smirnov, Dmitrii ; Autry, Robert ; Jager, Natalie ; Waszak, Sebastian M ; Großhennig, Anika ; Berutti, Riccardo ; Wendorff, Mareike ; Hainaut, Pierre ; Pfister, Stefan M ; Prokisch, Holger ; Ripperger, Tim ; Malkin, David

Background : Genetic predisposition is a significant cause of cancer, yet little is known about the role of “adult cancer predisposition syndromes” in childhood cancer. We examined the extent to which heterozygous pathogenic germline variants in BRCA1, BRCA2, PALB2, ATM, CHEK2, MSH2, MSH6, MLH1, and PMS2 contribute to cancer risk in children and adolescents. Methods : We conducted a meta-analysis of 11 studies that incorporated comprehensive germline testing for children and adolescents with [...]

Menée auprès de patients atteints de diabète de type 1 (durée de suivi : 28 ans), cette étude analyse l'association entre la dose quotidienne d'insuline et le risque de cancer

Daily Insulin Dose and Cancer Risk Among Patients With Type 1 Diabetes

Zhong, Wenjun ; Mao, Yuanjie

Previous studies among persons with type 1 diabetes (T1D) found a higher incidence of certain cancers in this population compared with the general population. However, no studies have evaluated the risk factors of cancer incidence in T1D. In the present study, using data from the Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) study, we explored the associations of risk factors with cancer incidence in patients with T1D [...]

Menée à partir de données d'études d'association sur le génome entier et de données portant sur 32 476 témoins et 16 790 patients atteints d'un endobrachyoesophage (oesophage de Barrett) ou d'un adénocarcinome de l'oesophage, cette étude identifie 16 nouveaux loci associés au risque de développer un endobrachyoesophage et/ou un cancer de l'oesophage

GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Schröder, Julia ; Chegwidden, Laura ; Maj, Carlo ; Gehlen, Jan ; Speller, Jan ; Böhmer, Anne C. ; Borisov, Oleg ; Hess, Timo ; Kreuser, Nicole ; Venerito, Marino ; Alakus, Hakan ; May, Andrea ; Gerges, Christian ; Schmidt, Thomas ; Thieme, Rene ; Heider, Dominik ; Hillmer, Axel M. ; Reingruber, Julian ; Lyros, Orestis ; Dietrich, Arne ; Hoffmeister, Albrecht ; Mehdorn, Matthias ; Lordick, Florian ; Stocker, Gertraud ; Hohaus, Michael ; Reim, Daniel ; Kandler, Jennis ; Müller, Michaela ; Ebigbo, Alanna ; Fuchs, Claudia ; Bruns, Christiane J. ; Hölscher, Arnulf H. ; Lang, Hauke ; Grimminger, Peter P. ; Dakkak, Dani ; Vashist, Yogesh ; May, Sandra ; Görg, Siegfried ; Franke, Andre ; Ellinghaus, David ; Galavotti, Sara ; Veits, Lothar ; Weismüller, Josef ; Dommermuth, Jens ; Benner, Udo ; Rosch, Thomas ; Messmann, Helmut ; Schumacher, Brigitte ; Neuhaus, Horst ; Schmidt, Carsten ; Wissinowski, Thaddäus T. ; Nothen, Markus M. ; Dong, Jing ; Ong, Jue-Sheng ; Buas, Matthew F. ; Thrift, Aaron P. ; Vaughan, Thomas L. ; Tomlinson, Ian ; Whiteman, David C. ; Fitzgerald, Rebecca Claire ; Jankowski, Janusz ; Vieth, Michael ; Mayr, Andreas ; Gharahkhani, Puya ; MacGregor, Stuart ; Gockel, Ines ; Palles, Claire ; Schumacher, Johannes

Objective : Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett’s oesophagus (BE) as a precursor lesion, is the most prevalent EC subtype in the Western world. This study aims to contribute to better understand the genetic causes of BE/EA by leveraging genome wide association studies (GWAS), genetic correlation analyses and polygenic risk modelling. Design : We combined data from previous GWAS with new cohorts, increasing [...]

Menée à partir de données 1992-2015 des registres américains des cancers portant sur 320 296 témoins et 80 074 patients atteints d'un cancer du pancréas (âge : plus de 66 ans), cette étude analyse l'association entre des maladies auto-immunes et le risque de cancer du pancréas

Autoimmune conditions and pancreatic cancer risk in older American adults

Yuan, Fangcheng ; Pfeiffer, Ruth M. ; Julián-Serrano, Sachelly ; Arjani, Simran ; Barrett, Michael J. ; Koshiol, Jill ; Stolzenberg-Solomon, Rachael Z.

Pancreatic cancer (PC) is highly fatal, and its incidence is increasing in the United States. Population-based registry studies suggest associations between a few autoimmune conditions and PC risk, albeit based on a relatively small number of cases. We conducted a population-based, nested case-control study to examine the associations between autoimmune conditions and PC risk within the Surveillance, Epidemiology, and End Results Program (SEER)-Medicare population. Incident primary malignant PC [...]

Menée à partir des données de 3 études de cohortes américaines portant sur 1 306 patients atteints d'un cancer du poumon, cette étude analyse l'association entre le microbiome oral et le risque de développer la maladie, en fonction de l'âge, du statut tabagique et du sous-type histologique

The oral microbiome and lung cancer risk: An analysis of 3 prospective cohort studies

Vogtmann, Emily ; Hua, Xing ; Yu, Guoqin ; Purandare, Vaishnavi ; Hullings, Autumn G ; Shao, Dantong ; Wan, Yunhu ; Li, Shilan ; Dagnall, Casey L ; Jones, Kristine ; Hicks, Belynda D ; Hutchinson, Amy ; Caporaso, J Gregory ; Wheeler, William ; Sandler, Dale P ; Freeman, Laura E Beane ; Liao, Linda M ; Huang, Wen-Yi ; Freedman, Neal D ; Caporaso, Neil E ; Sinha, Rashmi ; Gail, Mitchell H ; Shi, Jianxin ; Abnet, Christian C

Previous studies suggested associations between the oral microbiome and lung cancer, but studies were predominantly cross-sectional and underpowered.Using a case-cohort design, 1,306 incident lung cancer cases were identified in the Agricultural Health Study, NIH-AARP Diet and Health Study, and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Referent subcohorts were randomly selected by strata of age, sex, and smoking history. DNA was extracted from oral wash specimens using the [...]

Menée en Chine auprès de 97 950 personnes (durée de suivi : 8,7 ans), cette étude analyse l'association entre la concentration plasmatique de protéine C-réactive haute sensibilité et le risque de cancer du poumon (890 cas)

Association between baseline C-reactive protein and the risk of lung cancer: a prospective population-based cohort study

Yin, Jian ; Wang, Gang ; Wu, Zheng ; Lyu, Zhangyan ; Su, Kai ; Li, Fang ; Feng, Xiaoshuang ; Guo, Lan-Wei ; Chen, Yuheng ; Xie, Shuanghua ; Cui, Hong ; Li, Jiang ; Ren, Jiansong ; Shi, Ju-Fang ; Chen, Shuohua ; Wu, Shouling ; Dai, Min ; Li, Ni ; He, Jie

C-reactive protein (CRP), a systemic marker of diagnosing chronic inflammation, has been associated with the incidence of multiple types of cancer. However, little is known about the impact of CRP on lung cancer incidence in Chinese population. A total of 97,950 participants without cancer at baseline (2006-2007) of the Kailuan Cohort Study were followed up. The concentration of plasma high-sensitivity CRP (hsCRP) was tested for all participants at baseline interview. Multivariable Cox [...]

Menée à partir de données portant sur 4 263 participants (durée médiane de suivi : 17,5 ans ; 118 cas de cancer), cette étude prospective analyse l'association entre la présence de bactéries buccales ou parodontales et le risque de cancer du poumon

Periodontal and other oral bacteria and risk of lung cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Zhou, Baijun ; Lu, Jiayun ; Beck, James D. ; Moss, Kevin L. ; Prizment, Anna E. ; Demmer, Ryan T. ; Porosnicu Rodriguez, Kori A. ; Joshu, Corinne E. ; Michaud, Dominique S. ; Platz, Elizabeth A.

Background: Evidence suggests that periodontal disease is associated with increased lung cancer risk, but whether periodontal pathogens are explanatory is unknown. We prospectively studied associations of pre-diagnostic circulating antibodies to oral bacteria and of periodontal bacteria in subgingival plaque with lung cancer. Methods: We included 4,263 cancer-free participants in the Atherosclerosis Risk in Communities study with previously measured serum IgG antibodies to 18 oral bacteria. In [...]

Menée à partir d'échantillons de sang prélevés chez 65 200 femmes (durée de suivi : 22 ans), cette étude analyse, au moyen de la spectroscopie par résonance magnétique, l'association entre des métabolites ou des sous-fractions de lipoprotéines et le risque à long terme de cancer du sein, en fonction du statut ménopausique

Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study

Debik, Julia ; Schäfer, Hartmut ; Andreassen, Trygve ; Wang, Feng ; Fang, Fang ; Cannet, Claire ; Spraul, Manfred ; Bathen, Tone F. ; Giskeødegård, Guro F.

Background: The aim of this study was to gain an increased understanding of the aetiology of breast cancer, by investigating possible associations between serum lipoprotein subfractions and metabolites and the long-term risk of developing the disease. Methods: From a cohort of 65,200 participants within the Trøndelag Health Study (HUNT study), we identified all women who developed breast cancer within a 22-year follow-up period. Using nuclear magnetic resonance (NMR) spectroscopy, 28 [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 1 890 protéines circulantes, 106 278 patientes atteintes d'un cancer du sein et 94 778 témoins, cette étude identifie 98 protéines circulantes associées à la maladie, par sous-type

Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomisation analysis

Shu, Xiang ; Zhou, Qin ; Sun, Xiaohui ; Flesaker, Michelle ; Guo, Xingyi ; Long, Jirong ; Robson, Mark E. ; Shu, Xiao-Ou ; Zheng, Wei ; Bernstein, Jonine L.

Background: The aetiologic role of circulating proteins in the development of breast cancer subtypes is not clear. We aimed to examine the potential causal effects of circulating proteins on the risk of breast cancer by intrinsic-like subtypes within the Mendelian randomisation (MR) framework. Methods: MR was performed using summary statistics from two sources: the INTERVAL protein quantitative trait loci (pQTL) Study (1890 circulating proteins and 3301 healthy individuals) and the Breast [...]