A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (21 études), cette méta-analyse évalue le risque de second cancer lié au tabagisme

Cigarette smoking and risk of second primary cancer: a systematic review and meta-analysis

Phua, Zhi Jing ; MacInnis, Robert J. ; Jayasekara, Harindra

Approximately 5% of the population are living with a diagnosis of cancer. Recent improvements in survival following a diagnosis of cancer have led to an increase in second primary cancers (SPCs) worldwide. Their aetiology remains largely unknown with a large proportion believed to be related to modifiable lifestyle factors. We conducted a systematic review and meta-analysis of published data that evaluated an association between cigarette smoking and risk of SPC. Studies were identified by [...]

Menée à l'aide d'un modèle murin, cette étude analyse l'effet, sur la tumorigenèse pulmonaire, d'une exposition chronique à la fumée de narguilé

Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung

Hassane, Maya ; Rahal, Zahraa ; Karaoghlanian, Nareg ; Zhang, Jiexin ; Sinjab, Ansam ; Wong, Justin W. ; Lu, Wei ; Scheet, Paul ; Lee, J. Jack. ; Raso, Maria Gabriela ; Solis, Luisa M. ; Fujimoto, Junya ; Chami, Hassan ; Shihadeh, Alan L. ; Kadara, Humam

Effects of waterpipe smoking on lung pathobiology and carcinogenesis remain sparse despite the worldwide emergence of this tobacco vector. To address this gap, we investigated the effects of chronic waterpipe smoke (WPS) exposure on lung pathobiology, host immunity, and tumorigenesis using an experimental animal model that is prone to tobacco carcinogens and an exploratory observational analysis of human waterpipe smokers and non-smokers. Mice exhibited elevated incidence of lung tumors [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2021 (27 articles), cette étude analyse l'association entre une consommation de boissons édulcorées et le risque de cancer

Sugar-Sweetened Beverages and Cancer Risk: A Narrative Review

Arroyo-Quiroz, Carmen ; Brunauer, Regina ; Alavez, Silvestre

Cancer continues to be a major public health challenge worldwide, not only for being one of the leading causes of death but also because the number of incident cases is projected to grow in the next decades. Meanwhile, sugar-sweetened beverages (SSB) consumption has risen since the past century and constitutes a considerable fraction of added sugars in daily diet. Several studies have analyzed the relationship between SSB intake and health and found substantial evidence for effects on obesity, [...]

Menée à partir des données 1985-2015 d'une étude portant sur 27 111 hommes et menée à l'aide d'une méta-analyse d'études de cohortes prospectives (908 390 participants), cette étude analyse l'association entre la quantité quotidienne de chocolat consommée et la mortalité globale et par cause à long terme

Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis

Zhao, Bin ; Gan, Lu ; Yu, Kai ; Mannisto, Satu ; Huang, Jiaqi ; Albanes, Demetrius

Chocolate is a rich dietary source of various bioactive flavonoid compounds. Despite being one of the most popular foods worldwide, the association between chocolate consumption and long-term mortality remains unclear. The objective of this study is to determine the associations between chocolate consumption and long-term overall and cause-specific mortality, to evaluate dose–response and potential mediators, and to conduct an updated meta-analysis based on prospective cohort studies. We [...]

Menée à partir de données 1984-2014 des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" portant sur 121 111 personnes, cette étude analyse l'association entre la consommation de boissons édulcorées ou de fructose et l'incidence du cancer colorectal (2 733 cas) ainsi que la mortalité spécifique par sous-site anatomique (901 décès)

Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite

Yuan, Chen ; Joh, Hee-Kyung ; Wang, Qiao-Li ; Zhang, Yin ; Smith-Warner, Stephanie A ; Wang, Molin ; Song, Mingyang ; Cao, Yin ; Zhang, Xuehong ; Zoltick, Emilie S ; Hur, Jinhee ; Chan, Andrew T ; Meyerhardt, Jeffrey A ; Ogino, Shuji ; Ng, Kimmie ; Giovannucci, Edward L ; Wu, Kana

Recent preclinical research strongly suggests that dietary sugars can enhance colorectal tumorigenesis by direct action, particularly in the proximal colon that unabsorbed fructose reaches.We aimed to examine long-term consumption of sugar-sweetened beverages (SSBs) and total fructose in relation to incidence and mortality of colorectal cancer (CRC) by anatomic subsite.We followed 121,111 participants from 2 prospective US cohort studies, the Nurses’ Health Study (1984–2014) and Health [...]

Menée en Chine sur la période 2011-2018 auprès de 1 307 patientes atteintes d'un cancer du sein et 1 050 témoins, cette étude multicentrique analyse l'association entre une consommation d'aliments en conserve (viande séchée, légumes marinés, viande en conserve, fruits/légumes en conserve) et le risque de développer la maladie

Associations between Preserved foods and Breast Cancer Risk in Hong Kong Chinese Women

LEE, Priscilla Ming Yi ; Kwok, Chi-hei ; Tsoi, Yee-kei ; Wu, Cherry ; LAW, Sze-hong ; Tsang, Koon-ho ; Yeung, Yiu-cheong ; Chan, W.C. ; Tse, Gary M. ; YUEN, Karen Ka-wan ; HUNG, Ray Ka Wai ; Wang, Feng ; Tse, Lap Ah

Preserved food such as cured foods may contain nitrate and nitrite that may contribute to the breast cancer development. Evidence on the associations between these preserved food intakes and risk of breast cancer is sparse. This study aimed to examine the associations between preserved foods (i.e. cured meat, pickled vegetables, canned meat, canned fruit/vegetables) and breast cancer risk in Hong Kong Chinese women. A total of 1307 breast cancer cases and 1050 age-matched controls were [...]

Menée à partir de données 1993-1998 portant sur 68 132 femmes ménopausées (âge : 50-79 ans), cette étude analyse l'association entre l'inflammation ou l'insulinémie induites par l'alimentation et le risque de cancer du sein de l'intervalle (317 cas)

Diet-Driven Inflammation and Insulinemia and Risk of Interval Breast Cancer

Zhang, Zhenzhen ; Tabung, Fred K. ; Jin, Qi ; Curran, Grace ; Irvin, Veronica L. ; Shannon, Jackilen ; Velie, Ellen M. ; Manson, JoAnn E. ; Simon, Michael S. ; Vitolins, Mara ; Valencia, Celina I. ; Snetselaar, Linda ; Jindal, Sonali ; Schedin, Pepper

Interval breast cancers (IBCs) emerge after a non-suspicious mammogram and before the patient?s next scheduled screen. Risk factors associated with IBC have not been identified. This study evaluated if the empirical dietary inflammatory pattern (EDIP) or empirical dietary index for hyperinsulinemia (EDIH) scores are associated with IBC compared to screen-detected breast cancer. Data were from women 50?79?years-old in the Women?s Health Initiative cohort who completed food frequency [...]

Menée à partir des données 2005-2015 de la cohorte "AGRICAN" portant sur 181 842 agriculteurs français, cette étude analyse l'association entre le type d'activité agricole (5 types de bétails et 13 types de cultures) et le risque de cancer colorectal (5 168 cas), par sous-site anatomique

Colorectal cancer among farmers in the AGRICAN cohort study

Talibov, Madar ; Tual, Séverine ; Morlais, Fabrice ; Meryet-Figuiere, Matthieu ; Boulanger, Mathilde ; Bouvier, Veronique ; Perrier, Stéphanie ; Clin, Bénédicte ; Baldi, Isabelle ; Lebailly, Pierre ; Dabakuyo-Yonli, S. ; Bara, S. ; Bouvier, A. M. ; Busquet, T. ; Colonna, M. ; Coureau, G. ; Delanoé, M. ; Grosclaude, P. ; Guizard, A. V. ; Herbrecht, P. ; Laplante, J. J. ; Lapôtre-Ledoux, B. ; Launoy, G. ; Lenoir, D. ; Hammas, K. ; Marcotullio, E. ; Maynadié, M. ; Molinié, F. ; Monnereau, A. ; Paumier, A. ; Jarriges, J. ; Thibaudier, J. M. ; Troussard, X. ; Velten, M. ; Wavelet, E. ; Woronoff, A. S.

Objectives: Specific farming types and tasks have rarely been studied in relation to colorectal cancer (CRC). We evaluated associations between 5 types of livestock and 13 types of crops in relation to CRC and its subsites within the Agriculture and Cancer (AGRICAN) study. Methods: AGRICAN cohort includes 181,842 agricultural workers living in 11 French geographical areas. Data on farming types and tasks was collected by self-administered questionnaires. We identified 2 609 CRC, 972 right [...]

Menée en Suède à l'aide de données du registre de la santé dentaire portant sur 5 millions de personnes, cette étude analyse l'association entre la santé dentaire (carie, infection du canal radiculaire, inflammation légère, parodontite) et le risque de cancer de l'oesophage (2 017 cas)

Poor oral health and esophageal cancer risk: a nationwide cohort study

Zhang, Ji ; Bellocco, Rino ; Sandborgh-Englund, Gunilla ; Yu, Jingru ; Sällberg Chen, Margaret ; Ye, Weimin

Background: Previous research indicates that poor dental health increases risks for certain types of cancers, including esophageal cancer. This study aimed to investigate the association with esophageal cancer using Swedish Dental Health Register. Methods: This is a prospective cohort study. The exposures were dental diagnoses classified into healthy, caries, root canal infection, mild inflammation, and periodontitis, as well as number of remaining teeth, at baseline and during multiple visits. [...]

Menée au Pays-Bas à partir de données de questionnaires portant sur 120 852 personnes âgées de 55 à 69 ans et menée à l'aide de données des registres néerlandais du cancer et de pathologie (durée de suivi : 20,3 ans), cette étude analyse l'association entre la présence d'un diabète sucré et le risque de cancer d'origine primitive inconnue (963 cas)

Type 2 diabetes mellitus and cancer of unknown primary risk: results from the Netherlands Cohort Study

Hermans, Karlijn E.P.E. ; Haque, Sharmi ; van den Brandt, Piet A. ; Loef, Caroline ; Jansen, Rob L.H. ; Schouten, Leo J.

Objective: Cancer of unknown primary (CUP) is a metastatic malignancy with an unidentifiable primary tumour origin. Previous studies suggest that type 2 diabetes mellitus (T2DM) and CUP risk are associated. This study examines the association in greater depth by investigating T2DM status, T2DM duration, T2DM age at diagnosis, and medication that was being used in relation to CUP. Methods: Data were utilized from the Netherlands Cohort Study, a prospective cohort that includes 120 852 [...]

Menée à partir de données de la "UK Biobank" portant sur 216 702 personnes (durée médiane de suivi : 8 ans), cette étude analyse l'effet du variant rs10830963 du gène du récepteur de la mélatonine 1B (MTNR1B) sur l'association entre le chronotype et le risque de cancer du sein (2 367 cas) ou de la prostate (2 866 cas)

The role of MTNR1B polymorphism on circadian rhythm-related cancer: a UK Biobank cohort study

Wu, Jiafei ; Tan, Xiao

A common G risk allele in the melatonin receptor 1B (MTNR1B, rs10830963) gene has been associated with altered melatonin signaling and secretion. Given that melatonin possesses anti-cancerogenic properties, we hypothesized that breast and prostate cancer risks vary by rs10830963 genotype. A total of 216,702 participants from the UK Biobank without cancer at baseline (aged 56.4 ± 8.0 years, 50.79% female) were included. Multivariable Cox regression adjusting for known risk factors for breast or [...]

Menée à partir des données de 2 études d'association sur le génome entier portant au total sur 78 109 patients atteints d'un cancer du poumon et 251 837 témoins, puis validée sur 1 666 patients et 6 664 témoins, cette méta-analyse identifie 8 nouveaux loci de susceptibilité à la maladie

Genetic analysis of lung cancer and the germline impact on somatic mutation burden

Gabriel, Aurélie A G ; Atkins, Joshua R ; Penha, Ricardo C C ; Smith-Byrne, Karl ; Gaborieau, Valérie ; Voegele, Catherine ; Abedi-Ardekani, Behnoush ; Milojevic, Maja ; Olaso, Robert ; Meyer, Vincent ; Boland, Anne ; Deleuze, Jean François ; Zaridze, David ; Mukeriya, Anush ; Swiatkowska, Beata ; Janout, Vladimir ; Schejbalova, Miriam ; Mates, Dana ; Stojšić, Jelena ; Ognjanovic, Miodrag ; the ILCCO consortium ; Witte, John S ; Rashkin, Sara R ; Kachuri, Linda ; Hung, Rayjean J ; Kar, Siddhartha ; Brennan, Paul ; Sertier, Anne-Sophie ; Ferrari, Anthony ; Viari, Alain ; Johansson, Mattias ; Amos, Christopher I ; Foll, Matthieu ; McKay, James D

Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking propensity and DNA repair genes, but further work is required to identify susceptibility variants.To identify LC susceptibility loci, a family history-based genome-wide association (GWAx) study of LC (48,843 European “proxy” LC cases, 195,387 controls) was combined with previously LC GWAS (29,266 cases, 56,450 [...]

Menée à partir de données portoricaines portant sur 315 patientes atteintes d'un cancer du sein et 348 témoins, cette étude analyse l'association entre des caractéristiques anthropométriques et le risque de développer la maladie, en fonction de l'origine ethnique

Anthropometric measures and breast cancer risk among Hispanic women in Puerto Rico

Ramírez-Marrero, F. A. ; Nazario, C. M. ; Rosario-Rosado, R. V. ; Schelske-Santos, M. ; Mansilla-Rivera, I. ; Nie, J. ; Hernández-Santiago, J. ; Freudenheim, J. L.

Introduction: Increased risk of postmenopausal breast cancer associated with anthropometric measures including Body Mass Index (BMI), adult weight gain, and waist circumference has been observed in North American and European populations, but little evidence is available for Hispanic women. Breast cancer is the leading type of cancer, and leading cause of cancer-related deaths among Hispanic women in Puerto Rico (PR). However, compared with the United States, breast cancer incidence rates are [...]

Menée à partir de données de l'Assurance maladie coréenne portant sur 483 564 femmes ayant réalisé une mammographie de dépistage sur la période 2009-2014 et âgées d'au moins 75 ans, cette étude analyse l'association entre la densité mammaire, l'indice de masse corporelle et le risque de cancer du sein chez les femmes âgées

Mammographic Breast Density, Body Mass Index, and Risk of Breast Cancer in Korean Women Aged 75 Years and Older

Tran, Thi Xuan Mai ; Kim, Soyeoun ; Song, Huiyeon ; Park, Boyoung

Mammographic breast density and body mass index (BMI) are strong risk factors of breast cancer, but few studies have investigated these factors in older women. This study assessed the association between breast density, BMI, and the breast cancer risk among women aged ≥75 years. We included women who underwent breast cancer screening between 2009-2014 and were followed up until 2020. Breast density was measured using Breast Imaging Reporting and Data System. BMI was classified into three [...]

A partir des données de 3 études menées en Italie et en Suisse auprès de 920 patientes atteintes d'un cancer de l'endomètre et de 1 700 témoins, cette étude analyse l'association entre la présence de kystes ovariens et le risque de développer la maladie, en fonction de l'indice de masse corporelle

Effect modification of body mass index on the association between ovarian cysts and endometrial cancer

Collatuzzo, Giulia ; Etienne, Mickdaelle ; Factor, Stephanie H. ; Maso, Luigino Dal ; Polesel, Jerry ; Crispo, Anna ; Levi, Fabio ; Parazzini, Fabio ; Negri, Eva ; La Vecchia, Carlo ; Boffetta, Paolo

Background: Ovarian cysts represent a common condition among women. Epidemiologic studies are inconsistent in determining if women with cysts are more likely to develop endometrial cancer (EC) regardless of overweight/obesity. We investigated the combined role of cysts and body mass index (BMI) on EC risk. Methods: We pooled data from three case-control studies conducted in Italy and Switzerland on 920 women with EC and 1700 controls. The prevalence of cysts was 5% among both cases and [...]