Menée à partir de données portant sur 9 877 patients atteints d'un cancer (âge moyen : 67,1 ans) et 45 877 témoins (âge moyen : 66,2 ans), cette étude de cohorte rétrospective analyse l'intérêt d'un outil permettant de prédire le risque à 10 ans de développer des fractures

Fracture Risk Prediction Using the Fracture Risk Assessment Tool in Individuals With Cancer

Ye, Carrie ; Leslie, William D. ; Al-Azazi, Saeed ; Yan, Lin ; Lix, Lisa M. ; Czaykowski, Piotr ; McCloskey, Eugene V. ; Johansson, Helena ; Harvey, Nicholas C. ; Kanis, John A. ; Singh, Harminder

Importance : The Fracture Risk Assessment Tool (FRAX) is a fracture risk prediction tool for 10-year probability of major osteoporotic fracture (MOF) and hip fracture in the general population. Whether FRAX is useful in individuals with cancer is uncertain. Objective : To determine the performance of FRAX for predicting incident fractures in individuals with cancer. Design, Setting, and Participants :This retrospective population-based cohort study included residents of Manitoba, Canada, with [...]

A partir d'une revue systématique de la littérature publiée depuis 2012 (37 articles), cette étude identifie les symptômes physiques non gastro-intestinaux et psychiques chez les patients atteints d'un cancer colorectal ayant été traité

Non-gastrointestinal symptom burden following colorectal cancer treatment—a systematic review

Fernandes, Darren ; Nelson, David ; Ortega, Marishona ; Siriwardena, Aloysius Niroshan ; Law, Graham ; Andreyev, Jervoise

Background: Colorectal cancer is one of the most common malignancies worldwide. Improvements in screening and treatment have allowed for earlier detection and longer survival. However, treatments, which may involve surgery, radiotherapy and/or chemotherapy, often lead to patients developing both gastrointestinal and non-gastrointestinal symptoms that can persist long term. This systematic review aims to understand better the non-gastrointestinal symptoms that patients develop after colorectal [...]

Mené sur 144 patientes atteintes d'un cancer primitif du sein, cet essai de phase II évalue l'effet d'une thérapie comportant des exercices physiques (marche sur tapis roulant) sur l'intensité de la dose de chimiothérapie, sa tolérabilité et son efficacité du point de vue du taux de réponse complète

Effects of exercise therapy on chemotherapy delivery and response in primary breast cancer: A secondary analysis of a randomized trial

Iyengar, Neil M. ; Scott, Jessica M. ; Lee, Jasme ; Lavery, Jessica A. ; Foug, Katherine L. ; Lee, Catherine P. ; Michalski, Meghan G. ; Chun, Su S. ; Harrison, Jenna ; Moskowitz, Chaya S. ; Jones, Lee W.

Background: Whether structured exercise therapy improves chemotherapy delivery, tolerability, and tumor response is unclear. Methods: This was a secondary analysis of a phase 2 trial investigating exercise therapy (n = 72) versus usual care (n = 72) in patients with primary breast cancer. Exercise therapy comprised individualized treadmill walking three times weekly for 20–50 minutes per session at 55%–100% of pretreatment exercise capacity. Chemotherapy delivery was assessed according to the [...]

A partir d'une revue systématique de la littérature (67 articles), cette étude analyse la qualité de vie des patientes atteintes d'un carcinome canalaire in situ ainsi que les outils permettant d'évaluer cette qualité de vie

Quality of life issues in patients with ductal carcinoma in situ: a systematic review

Rajeswaran, Thenugaa ; Gojsevic, Milena ; Chan, Adrian Wai ; Wong, Henry C. Y. ; Lee, Shing Fung ; Bernard, Rhys ; Marta, Gustavo Nader ; Pogoda, Katarzyna ; Kwan, Jennifer Y. Y. ; Kuszaj, Olivia ; Day, Marley ; Behroozian, Tara ; Bleiker, Eveline M. A. ; Wong, Cindy ; Kikawa, Yuichiro ; Tane, Kaori ; Velikova, Galina ; Marcou, Yiola ; Bjelic-Radisic, Vesna ; Karam, Irene ; Al-Khaifi, Muna ; Kennedy, Samantha K. F. ; Chow, Edward

Purpose: Ductal carcinoma in situ (DCIS) of the breast is one of the most common pre-invasive cancers diagnosed in women. Quality of life (QoL) is extremely important to assess in studies including these patients due to the favorable prognosis of the disease. The primary objective of this systematic review was to compile a comprehensive list of QoL issues, all existing QoL assessment tools, and patient-reported outcome measures used to assess DCIS. Methods: A search was conducted on Ovid [...]

Menée par enquête auprès de 143 jeunes patientes ayant survécu à un cancer du sein (âge inférieur ou égal à 40 ans), cette étude prospective analyse leurs expériences concernant l'allaitement

Breastfeeding experiences among young breast cancer survivors: A survey study

Sella, Tal ; Sorouri, Kimia ; Rosenberg, Shoshana M. ; Loucks, Maggie ; Kirkner, Gregory ; Snow, Craig ; Ruddy, Kathryn J. ; Gelber, Shari I. ; Tamimi, Rulla M. ; Peppercorn, Jeffrey M. ; Schapira, Lidia ; Borges, Virginia F. ; Come, Steven E. ; Warner, Ellen ; Partridge, Ann H.

Background: Following breast cancer (BC), many young women are interested in future childbearing and some may wish to breastfeed. However, limited information is available regarding their lactation experiences. Methods: Participants in the Young Women's Breast Cancer Study, a multicenter, prospective cohort study of women ≤40 years diagnosed with stage 0–III BC between 2006–2016 and who reported one or more live births following diagnosis, were surveyed about pregnancy and breastfeeding after [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2022 (30 études), cette étude analyse les expériences et les besoins des aidants de patients atteints d'un cancer de la tête et du cou

Experiences and Needs of Carers of Patients With Head and Neck Cancer: A Systematic Review

Rogers, Simon N. ; Tsai, Hao-Hsuan ; Cherry, Mary Gemma ; Patterson, Joanne M. ; Semple, Cherith Jane

Purpose: The needs of head and neck cancer (HNC) carers tends to be poorly addressed as most support systems are directed towards patients. This systematic review synthesises the existing qualitative evidence from carers for adult HNC patients to explore their experiences and needs as a basis to inform the initial development of an item prompt list for HNC carers for use in routine clinical practice. Methods: Seven electronic databases were searched from their inception until November 2022, [...]

Menée aux Etats-Unis à partir de données portant sur 3 441 patients atteints d'un carcinome hépatocellulaire diagnostiqué entre 2006 et 2019 (âge médian : 65 ans), cette étude de cohorte rétrospective analyse les facteurs associés à l'évolution de la survie

Survival Outcomes Among Patients With Hepatocellular Carcinoma in a Large Integrated US Health System

Yilma, Mignote ; Houhong Xu, Richie ; Saxena, Varun ; Muzzin, Monica ; Tucker, Lue-Yen ; Lee, Jeffrey ; Mehta, Neil ; Mukhtar, Nizar

Importance : Hepatocellular carcinoma (HCC) is the leading oncologic cause of death among patients with cirrhosis, but large studies examining mortality trends are lacking. Objective : To evaluate survival among patients with HCC in one of the largest integrated health care systems in the US. Design, Setting, and Participants : This retrospective cohort study included 3441 adult patients who received a diagnosis of HCC between January 1, 2006, and December 31, 2019, with end of follow-up on [...]

Menée à partir de données portant sur 890 adolescents et jeunes adultes atteints d'un sarcome osseux (ostéosarcome et sarcome d'Ewing ; âge : 15-39 ans ; durée médiane de suivi : 59,7 mois) et vivant dans des pays à faible ou moyen revenu, cette étude de cohorte prospective analyse les stratégies thérapeutiques, les difficultés psychosociales et la survie sans événement

Ten-year follow-up of outcomes, patterns of care, and psychosocial burden in adolescent and young adult patients with bone sarcomas from a large cohort in a low-income and middle-income country

Bajpai, Jyoti ; Sarkar, Laboni ; Rath, Sushmita ; Chandrasekharan, Arun ; Panda, Goutam ; Jakar, Dharmpal ; Pawar, Akash ; Ghosh, Jaya ; Laskar, Siddhartha ; Rekhi, Bharat ; Khanna, Nehal ; Manjali, Jifmi Jose ; Ramadwar, Mukta ; Purandare, Nilendu ; Bhargava, Prabhat ; Chakrabarty, Nivedita ; Gala, Kunal ; Kembhavi, Yogesh ; Rangarajan, Venkatesh ; Banavali, Shripad ; Gupta, Sudeep

Background: The care of adolescents and young adults (AYAs) with bone sarcomas involves unique challenges. The objectives of this study were to identify challenges and evaluate long-term outcomes of these patients from India who received treatment with novel protocols. Methods: This prospective cohort study included AYA patients (aged 15–39 years) with osteosarcoma and Ewing sarcoma (ES), who were treated uniformly at the authors' institute using unique protocols (OGS-12 and EFT-2001) from 2011 [...]

Menée à partir de données des registres américains des cancers portant sur 972 763 patientes atteintes d'un cancer du sein diagnostiqué entre 1975 et 2017, cette étude analyse l'évolution, sur la période 2000-2017, de la mortalité spécifique en fonction du stade de la maladie au diagnostic

Trends in breast cancer specific death by clinical stage at diagnoses between 2000-2017

Marczyk, Michal ; Kahn, Adriana ; Silber, Andrea ; Rosenblit, Mariya ; Digiovanna, Michael P ; Lustberg, Maryam ; Pusztai, Lajos

Background: Approximately 40,000 individuals die from metastatic breast cancer each year. We examined what fractions of annual breast cancer-specific death (BCSD) are due to stage I, II, III, IV disease and if these proportions changed over time. Methods: We used data from SEER covering 1975 to 2017. After filtering for female sex at birth, one primary tumor type, surgery, AJCC (6th edition) stage > 0, no bilateral cancer, and survival data available, the final analysis included 972,763 [...]

Menée aux Pays-Bas à partir de données portant sur 1 382 patients ayant survécu à un cancer pédiatrique (âge moyen : 36 ans ; âge lors du diagnostic : inférieur ou égal à 18 ans), cette étude identifie les facteurs associés à leur fonctionnement psychosocial

Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study

Maas, Anne ; Maurice-Stam, Heleen ; Feijen, E. A. M ; Teepen, Jop C. ; van der Aa-van Delden, Alied M. ; Streefkerk, Nina ; van Dulmen-den Broeder, Eline ; Tissing, Wim J. E. ; Loonen, Jacqueline J. ; van der Pal, Helena J. H. ; de Vries, Andrica C. H. ; van den Heuvel-Eibrink, Marry M. ; Ronckers, Cecile ; Neggers, Sebastian ; Bresters, Dorine ; Louwerens, Marloes ; Versluys, Birgitta A. B. ; van der Heiden-van der Loo, Margriet ; Kremer, Leontien C. M. ; Grootenhuis, Martha ; DCCSS-LATER Study Group

Objective: This study examines the association between psychosocial risk and protective factors and a wide range of psychosocial outcomes including emotional, social, cognitive, and physical domains in childhood cancer survivors (CCS). Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed questionnaires on psychosocial risk and protective factors (Benefit and [...]

Menée aux Etats-Unis à partir de données portant sur 229 adultes ayant survécu à un cancer pédiatrique (âge moyen : 39,6 ans), cette étude de cohorte rétrospective analyse les facteurs associés à la peur de la récidive de la maladie

Fear of Cancer Recurrence in Adult Survivors of Childhood Cancer

Pizzo, Alex ; Leisenring, Wendy M. ; Stratton, Kayla L. ; Lamoureux, Élisabeth ; Flynn, Jessica S. ; Alschuler, Kevin ; Krull, Kevin R. ; Jibb, Lindsay A. ; Nathan, Paul C. ; Olgin, Jeffrey E. ; Stinson, Jennifer N. ; Armstrong, Gregory T. ; Alberts, Nicole M.

Importance : Fear of cancer recurrence is common among survivors of adult-onset cancer and associated with increased distress, functional impairment, and health care utilization. However, little is known about the prevalence and risk factors of fear of cancer recurrence among adult survivors of childhood cancer who are also at high risk for subsequent malignant neoplasms. Objective : To characterize the prevalence of and risk factors for clinically significant fear of cancer recurrence in adult [...]

A partir d'une revue systématique de la littérature publiée entre 2007 et 2012 (11 études, 938 patients), cette méta-analyse évalue l'effet, sur la santé psychologique des patients, d'interventions destinées aux dyades aidants-patients

Effects of dyadic interventions on psychological outcomes among cancer patients with non-active treatment: a systematic review and meta-analysis

Thana, Kanjana ; Miller, Megan ; Chintanawat, Rojanee ; Reangsing, Chuntana

Objective: Cancer and its treatment can generate substantial psychological distress (depression and anxiety). The objective of this systematic review and meta-analysis is to explore the effectiveness of dyadic interventions on psychological outcomes in cancer patients with non-active treatment and to test subgroup analyses to explore the source of heterogeneity affecting effect sizes. Design: Systematic searching across eight databases identified studies related to dyadic interventions for [...]

A partir d'une revue de la littérature publiée depuis 2013 (51 études), cette étude identifie les facteurs associés au risque de symptômes d'anxiété chez les patients ayant survécu à un cancer colorectal

Factors associated with anxiety in colorectal cancer survivors: a scoping review

Shin, Juehyun ; Gibson, Jessie S. ; Jones, Randy A. ; Debnam, Katrina J.

Purpose: Anxiety is one of the most common psychological issues among colorectal cancer (CRC) survivors. It can interact with physical symptoms, impacting cancer progression, survival, and quality of life. This scoping review aims to explore the factors associated with anxiety in patients with CRC and the instruments used to measure anxiety. Methods: Using Arksey and O’Malley’s (2005) framework for the scoping review, studies investigating anxiety in CRC patients published in CINAHL, PubMed, [...]

Menée en Chine à partir de données portant sur 202 patients atteints d'un cancer gastro-intestinal de stade avancé et recevant des soins palliatifs, cette étude de cohorte prospective analyse l'impact du statut nutritionnel sur la survie

The relationship between nutritional status and prognosis in advanced gastrointestinal cancer patients in palliative care: a prospective cohort study

Mao, Ting ; Yorke, Janelle ; Zhang, Xiaoju ; Shi, Yan ; Wang, Jingyi ; Kong, Xiaoqian ; Lam, Katherine Ka Wai ; Liu, Qi ; Yang, Funa ; Ho, Ka Yan

Objective: The study aimed to determine the nutritional status and its prognostic effect on the survival of patients with advanced gastrointestinal cancer. Methods: A prospective cohort study design was conducted in a tertiary hospital in Shanghai, China. The study consisted of 202 advanced gastrointestinal (GI) cancer patients from a palliative care unit. The following data were collected from the patients: biochemical indicators, i.e., anemia (hemoglobin levels), albumin, pre-albumin, [...]