A partir d'une méta-analyse pangénomique portant sur 175 672 personnes incluses dans 6 cohortes japonaises, cette étude identifie des loci du gène ALDH2 pouvant influencer l'association entre le génotype rs671 (lié à la consommation d'alcool) et le risque de cancer de l'oesophage

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people

Koyanagi, Yuriko N. ; Nakatochi, Masahiro ; Namba, Shinichi ; Oze, Isao ; Charvat, Hadrien ; Narita, Akira ; Kawaguchi, Takahisa ; Ikezaki, Hiroaki ; Hishida, Asahi ; Hara, Megumi ; Takezaki, Toshiro ; Koyama, Teruhide ; Nakamura, Yohko ; Suzuki, Sadao ; Katsuura-Kamano, Sakurako ; Kuriki, Kiyonori ; Nakamura, Yasuyuki ; Takeuchi, Kenji ; Hozawa, Atsushi ; Kinoshita, Kengo ; Sutoh, Yoichi ; Tanno, Kozo ; Shimizu, Atsushi ; Ito, Hidemi ; Kasugai, Yumiko ; Kawakatsu, Yukino ; Taniyama, Yukari ; Tajika, Masahiro ; Shimizu, Yasuhiro ; Suzuki, Etsuji ; Hosono, Yasuyuki ; Imoto, Issei ; Tabara, Yasuharu ; Takahashi, Meiko ; Setoh, Kazuya ; The BioBank Japan Project ; Matsuda, Koichi ; Nakano, Shiori ; Goto, Atsushi ; Katagiri, Ryoko ; Yamaji, Taiki ; Sawada, Norie ; Tsugane, Shoichiro ; Wakai, Kenji ; Yamamoto, Masayuki ; Sasaki, Makoto ; Matsuda, Fumihiko ; Okada, Yukinori ; Iwasaki, Motoki ; Brennan, Paul ; Matsuo, Keitaro

An East Asian–specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (GCKR, KLB, and ADH1B) in wild-type homozygotes and six (GCKR, ADH1B, ALDH1B1, ALDH1A1, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2021 (29 études), cette méta-analyse évalue l'association entre une exposition professionnelle aux gaz d'échappement des moteurs diesel et le risque de cancer du foie ou du pancréas

Occupational exposure to diesel exhausts and liver and pancreatic cancers: a systematic review and meta-analysis

Sassano, Michele ; Collatuzzo, Giulia ; Teglia, Federica ; Boffetta, Paolo

Background: Diesel exhaust (DE) is human carcinogen with sufficient evidence only for lung cancer. Systematic evidence on other cancer types is scarce, thus we aimed to systematically review current literature on the association between occupational DE exposure and risk of liver and pancreatic cancers. Methods: We performed a systematic literature review to identify cohort studies on occupational DE exposure and risk of cancers other than lung. We computed pooled relative risks (RRs) and [...]

Menée à l'aide de données de 22 cohortes incluses dans l'étude "PSY-CA" portant sur 437 827 personnes, cette méta-analyse évalue l'effet, sur l'incidence des cancers (36 961 cas), de 9 facteurs psychosociaux et de 7 comportements de santé

Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Basten, Maartje ; Pan, Kuan-Yu ; van Tuijl, Lonneke A. ; de Graeff, Alexander ; Dekker, Joost ; Hoogendoorn, Adriaan W. ; Lamers, Femke ; Ranchor, Adelita V. ; Vermeulen, Roel ; Portengen, Lützen ; Voogd, Adri C. ; Abell, Jessica ; Awadalla, Philip ; Beekman, Aartjan T. F. ; Bjerkeset, Ottar ; Boyd, Andy ; Cui, Yunsong ; Frank, Philipp ; Galenkamp, Henrike ; Garssen, Bert ; Hellingman, Sean ; Huisman, Martijn ; Huss, Anke ; Keats, Melanie R. ; Kok, Almar A. L. ; Krokstad, Steinar ; van Leeuwen, Flora E. ; Luik, Annemarie I. ; Noisel, Nolwenn ; Payette, Yves ; Penninx, Brenda W. J. H. ; Rissanen, Ina ; Roest, Annelieke M. ; Rosmalen, Judith G. M. ; Ruiter, Rikje ; Schoevers, Robert A. ; Soave, David ; Spaan, Mandy ; Steptoe, Andrew ; Stronks, Karien ; Sund, Erik R. ; Sweeney, Ellen ; Twait, Emma L. ; Teyhan, Alison ; Verschuren, W. M. Monique ; van der Willik, Kimberly D. ; Geerlings, Mirjam I.

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, [...]

Menée auprès de 48 patientes atteintes d'un cancer du sein de stade précoce et présentant un syndrome de Li-Fraumeni (âge médian : 39 ans), cette étude analyse l'incidence des tumeurs induites par la radiothérapie en fonction de la dose et de la technique utilisée

Frequency of radiotherapy-induced malignancies in Li-Fraumeni Syndrome patients with early-stage breast cancer and influence of the radiotherapy technique

Petry, Vanessa ; Bonadio, Renata Colombo ; Moutinho, Karina ; Leite, Luiz Senna ; Testa, Laura ; Cohn, Daniela J. B. Heinemann ; Cagnacci, Allyne Carneiro ; Kim, Veronica E. H. ; Estevez-Diz, Maria Del Pilar ; Fragoso, Maria Candida Barrisson Villares

Introduction: Breast cancer (BC) is the most common malignancy in female patients with Li-Fraumeni Syndrome (LFS), a condition associated with an increased risk of various malignancies, including radiotherapy-induced malignancies (RIM) within previously irradiated areas. Our study aimed to assess the incidence of RIM in LFS patients with early-stage breast cancer (eBC) treated with adjuvant radiotherapy (RT), including the impact of RT dose and technique. Methods: We examined patients with a [...]

Menée à partir de données de la "UK Biobank" portant sur 395 304 personnes (durée médiane de suivi : 11 ans), cette étude analyse l'association entre un score métabolique de résistance à l'insuline et le risque de cancer du poumon

The association between METS-IR, an indirect index for insulin resistance, and lung cancer risk

Wang, Guoqing ; Zhu, Zhaopeng ; Wang, Yi ; Zhang, Qiang ; Sun, Yungang ; Pang, Guanlian ; Ge, Wenjing ; Ma, Zhimin ; Ma, Huimin ; Gong, Linnan ; Ma, Hongxia ; Shao, Feng ; Zhu, Meng

Insulin resistance has been reported to increase the risk of breast, prostate and colorectal cancer. However, the role of insulin resistance and its interaction with genetic risk in the development of lung cancer remains controversial. Therefore, we aimed to explore the association between a novel metabolic score for insulin resistance (METS-IR) and lung cancer risk. A total of 395 304 participants without previous cancer at baseline were included. The Cox proportional hazards regression model [...]

Menée auprès de 761 témoins et 761 patients atteints d'un cancer colorectal et inclus dans la cohorte "Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial", cette étude analyse l'association entre les taux sériques de N-oxyde de triméthylamine ou de ses précurseurs (choline, L-carnitine et bétaïne) et le risque de développer la maladie

Associations of serum trimethylamine N-oxide and its precursors with colorectal cancer risk in the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial Cohort

Byrd, Doratha A. ; Zouiouich, Semi ; Karwa, Smriti ; Li, Xinmin S. ; Wang, Zeneng ; Sampson, Joshua N. ; Loftfield, Erikka ; Huang, Wen-Yi ; Hazen, Stanley L. ; Sinha, Rashmi

Background: Dietary intake influences gut microbiome composition, which in turn may be associated with colorectal cancer (CRC). Associations of the gut microbiome with colorectal carcinogenesis may be mediated through bacterially regulated, metabolically active metabolites, including trimethylamine N-oxide (TMAO) and its precursors, choline, L-carnitine, and betaine. Methods: Prospective associations of circulating TMAO and its precursors with CRC risk were investigated. TMAO, choline, betaine, [...]