Menée à partir d'une revue systématique de la littérature publiée entre 2000 et 2021 (15 études), cette étude analyse les facteurs facilitant ou entravant la participation à une activité physique des enfants, adolescents et jeunes adultes ayant survécu à un cancer

Barriers and facilitators to physical activity participation for child, adolescent, and young adult cancer survivors: a systematic review

Adamovich, Tatsiana ; Watson, Rebecca ; Murdoch, Sydney ; Giovino, Liana ; Kulkarni, Sunket ; Luchak, Michael ; Smith-Turchyn, Jenna

Purpose : The aim of this systematic review is to explore and describe the barriers and facilitators to physical activity (PA) participation for child, adolescent, and young adult cancer survivors. Methods : MEDLINE, Embase, AMED, CINAHL, Cochrane, and Web of Science were searched for manuscripts published between January 2000 and February 2021. To be included in this review, studies had to report qualitative or quantitative data on barriers and facilitators to PA participation in child (4 [...]

Mené en Italie sur 60 patients atteints d'un cancer, cet essai multicentrique de phase III évalue l'efficacité, pour traiter une anémie induite par une chimiothérapie, d'une supplémentation en fer encaspulé dans une membrane sucrosomiale et dispensée par voie orale en combinaison avec des agents stimulant l'érythropoïèse

Randomized trial of sucrosomial iron supplementation in patients with chemotherapy-related anemia treated with ESA

Zuccarini, Andrea ; Cicognini, Daniela ; Tancredi, Richard ; Ferrari, Alessandra ; Rizzo, Gianpiero ; Lasagna, Angioletta ; Caccialanza, Riccardo ; Cavanna, Luigi ; Orlandi, Elena ; Biasini, Claudia ; Molinaro, Peppina ; Garigliano, Danula ; Costantino, Angela ; Moroni, Mauro ; Perrone, Lorenzo ; Alessio, Niccolò Leandro ; Rovati, Bianca ; Ferretti, Virginia Valeria ; Klersy, Catherine ; Pedrazzoli, Paolo

Background : Iron supplementation improves the erythropoiesis-stimulating agents’ (ESAs) response in chemotherapy-related anemia. The primary aim of our study is to assess the efficacy of sucrosomial iron, a new oral iron formulation, in cancer patients with chemotherapy-induced anemia treated with ESAs. The secondary objectives included the efficacy into two subgroups of patients (iron replete and functional iron deficiency) between the two study arms, safety and the effect on transfusion [...]

A partir d'une revue systématique de la littérature (47 études), cette étude analyse les besoins en soins des patients ayant survécu à un lymphome

Living with or beyond lymphoma: A rapid review of the unmet needs of lymphoma survivors

Boland, Vanessa ; Drury, Amanda ; Sheaf, Greg ; Brady, Anne-Marie

Objective : to establish an understanding of the unmet needs of people living with or beyond a lymphoma diagnosis. Survivors of lymphoma are at increased risk of unmet needs due to cancer, treatment-related toxicities and extended survivorship. Despite the rapidly growing numbers of lymphoma survivors, their needs and research priorities are underserved and undervalued, therefore left largely unaddressed. Methods : A rapid review method and reflexive thematic analysis approach assimilated [...]

Cette étude passe en revue les facteurs associés au développement d'une mucite buccale chez les patients atteints d'un cancer de la tête et du cou

Confounding factors in the assessment of oral mucositis in head and neck cancer

Lorini, Luigi ; Perri, Francesco ; Vecchio, Stefania ; Belgioia, Liliana ; Vinches, Marie ; Brana, Irene ; Elad, Sharon ; Bossi, Paolo

Treatment of locally advanced head and neck carcinoma not amenable for surgical resection or resected with high-risk features is usually based on (chemo-)radiation treatment. Oral mucositis represents one of the main side effects of (chemo-)radiation, with an important impact on quality of life and causing approximately 20% of early interruption of treatment, leading to a suboptimal dose administered. Treatment and prevention of oral mucositis have a central role in the therapeutic pathways of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2021 (13 essais randomisés, 650 patients), cette étude analyse l'efficacité des antioxydants oraux et topiques pour prévenir et traiter une mucite buccale chez des patients atteints d'un cancer de la tête et du cou et recevant une radiothérapie et/ou une chimiothérapie

Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses

Raza, Afsheen ; Karimyan, Nelli ; Watters, Amber ; Emperumal, Chitra P. ; Al-Eryani, Kamal ; Enciso, Reyes

Purpose : To evaluate the effectiveness of antioxidants in the prevention and management of oral mucositis in adults undergoing radiotherapy and/or chemotherapy with diagnosed head and neck cancer (HNC) compared to placebo intervention. Methods : Cochrane, EMBASE, PubMed, and Web of Science databases were used to search for randomized controlled trials (RCTs) comparing oral or topical antioxidants with placebo in clinically diagnosed HNC adult patients receiving radiotherapy with/without [...]

Menée à partir des données 2003-2012 de registres des cancers de 54 pays, cette étude analyse l'évolution de l'incidence du cancer de l'oesophage et de l'estomac en fonction du sexe et du sous-type de la maladie

Global and national trends in the age-specific sex ratio of esophageal cancer and gastric cancer by subtype

Wang, Shaoming ; Zheng, Rongshou ; Arnold, Melina ; Abnet, Christian ; Zeng, Hongmei ; Zhang, Siwei ; Chen, Ru ; Sun, Kexin ; Li, Li ; An, Lan ; Bray, Freddie ; Wei, Wenqiang ; He, Jie

A male predominance was observed in esophageal and gastric cancers, though present limited data has revealed variations by age. We aim to investigate the global age-specific sex differences in esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia cancer (GCC), and gastric non-cardia cancer (GNCC). Data on esophageal and gastric cancers incidence by diagnosis year, sex, histology, subsite, and age group were extracted from 171 registries in 54 countries [...]

Menée aux Etats-Unis à partir de données portant sur 304 patientes atteintes d'un cancer du sein (âge médian : 48 ans), cette étude de cohorte prospective analyse les disparités ethniques dans les facteurs associés au risque de développer un lymphoedème

Risk Factors and Racial and Ethnic Disparities in Patients With Breast Cancer–Related Lymphedema

Montagna, Giacomo ; Zhang, Jennifer ; Sevilimedu, Varadan ; Charyn, Jillian ; Abbate, Kelly ; Gomez, Ethan A. ; Mehrara, Babak ; Morrow, Monica ; Barrio, Andrea V.

Importance : Risk factors for breast cancer–related lymphedema (BCRL) after axillary lymph node dissection (ALND) are poorly understood. Objective : To evaluate rates of and risk factors associated with BCRL in a prospective cohort of women treated with ALND. Design, Setting, and Participants : This prospective BCRL screening study performed at a tertiary cancer center enrolled women with breast cancer 18 years and older undergoing breast surgery and unilateral ALND in the primary setting or [...]

Menée à partir des données 1960-2014 du registre suédois des cancers portant sur 29 579 patientes atteintes d'un cancer du col de l'utérus, cette étude analyse l'évolution de l'incidence de la maladie et de la survie nette en fonction du sous-type morphologique et du stade au diagnostic

Time trends for incidence and net survival of cervical cancer in Sweden 1960-2014 - A nationwide population-based study

Sundqvist, Avalon ; Moberg, Louise ; Dickman, Paul W. ; Högberg, Thomas ; Borgfeldt, Christer

Background: The aim was to investigate time trends for incidence and long-term net survival in the morphologic subtypes and stages of cervical cancer in Sweden during the period 1960-2014. Methods: Women with invasive cervical cancer were identified through the Swedish Cancer Registry. Incidence and net survival were calculated according to morphology, age at diagnosis, and FIGO stage at diagnosis. Results: In total, 29,579 cases of invasive cervical cancer between 1960 and 2014 were included. [...]

Menée en Allemagne par enquête en ligne auprès de 121 patients atteints d'un cancer, cette étude analyse l'association entre l'anxiété liée à la mort et la peur de la récidive de la maladie

Death anxiety as general factor to fear of cancer recurrence

Berlin, Pia ; von Blanckenburg, Pia

Objective : Fear of cancer recurrence or progress is strongly related to death anxiety in cancer patients, but due to lack of conceptualization and measurement methods, the relationship was not analyzed quantitatively before. The aim of the present study was to investigate the conceptual relationship of both constructs, with death anxiety expected to be the general construct. Methods : Cancer patients (N=121) participated in an online study. They provided information on socio-demographical, [...]

Menée en Belgique auprès de 74 patientes ayant survécu à un cancer du sein, cette étude transversale analyse les facteurs psychologiques associés à leur peur de la récidive de la maladie après les traitements anticancéreux

Psychological factors associated with clinical fear of cancer recurrence in breast cancer patients in the early survivorship period

Waroquier, Pauline ; France Delevallez ; Darius Razavi ; Isabelle Merckaert

Objectives : Clinical fear of cancer recurrence (FCR) is highly prevalent among breast cancer patients and appears early in the disease trajectory. A better understanding of psychological factors associated with clinical FCR is essential to guide screening and intervention development. This cross-sectional study aimed to assess the contribution of attentional bias, intrusive thoughts, metacognitive beliefs, intolerance of uncertainty, thought suppression, and worry to clinical FCR in breast [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d'une intervention intensive de sevrage tabagique pour des patients atteints d'un cancer (jusqu'à 11 séances de conseils et médicaments gratuits)

Cost-effectiveness of Implementing Smoking Cessation Interventions for Patients With Cancer

Levy, Douglas E. ; Regan, Susan ; Perez, Giselle K. ; Muzikansky, Alona ; Friedman, Emily R. ; Rabin, Julia ; Rigotti, Nancy A. ; Ostroff, Jamie S. ; Park, Elyse R.

Importance : Guidelines recommend cancer care clinicians offer smoking cessation treatment. Cost analyses will help stakeholders understand and plan for implementation of cessation programs. Objective : To estimate the incremental cost per quit (ICQ) of adopting an intensive smoking cessation intervention among patients undergoing treatment at cancer care clinics, from a clinic perspective. Design, Setting, and Participants : This economic evaluation, a secondary analysis of the Smokefree [...]

Mené aux Etats-Unis sur 1 191 patients atteints d'un cancer métastatique (âge moyen : 62,2 ans), cet essai randomisé évalue l'intérêt, du point de vue de la qualité de vie, d'un système électronique leur permettant de déclarer leurs symptômes pendant les traitements anticancéreux

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial

Basch, Ethan ; Schrag, Deborah ; Henson, Sydney ; Jansen, Jennifer ; Ginos, Brenda ; Stover, Angela M. ; Carr, Philip ; Spears, Patricia A. ; Jonsson, Mattias ; Deal, Allison M. ; Bennett, Antonia V. ; Thanarajasingam, Gita ; Rogak, Lauren J. ; Reeve, Bryce B. ; Snyder, Claire ; Bruner, Deborah ; Cella, David ; Kottschade, Lisa A. ; Perlmutter, Jane ; Geoghegan, Cindy ; Samuel-Ryals, Cleo A. ; Given, Barbara ; Mazza, Gina L. ; Miller, Robert ; Strasser, Jon F. ; Zylla, Dylan M. ; Weiss, Anna ; Blinder, Victoria S. ; Dueck, Amylou C.

Importance : Electronic systems that facilitate patient-reported outcome (PRO) surveys for patients with cancer may detect symptoms early and prompt clinicians to intervene. Objective : To evaluate whether electronic symptom monitoring during cancer treatment confers benefits on quality-of-life outcomes. Design, Setting, and Participants : Report of secondary outcomes from the PRO-TECT (Alliance AFT-39) cluster randomized trial in 52 US community oncology practices randomized to electronic [...]

Cet article passe en revue les technologies et applications de e-santé utilisées dans la pratique médicale en oncologie et présente des stratégies pour faciliter leur intégration dans l'organisation des soins des patients

Digital Health Applications in Oncology: An Opportunity to Seize

Parikh, Ravi B ; Basen-Enquist, Karen M ; Bradley, Cathy ; Estrin, Deborah ; Levy, Mia ; Lichtenfeld, J Leonard ; Malin, Bradley ; McGraw, Deven ; Meropol, Neal J ; Oyer, Randall A ; Sheldon, Lisa Kennedy ; Shulman, Lawrence N

Digital health advances have transformed many clinical areas including psychiatric and cardiovascular care. However, digital health innovation is relatively nascent in cancer care, which represents the fastest-growing area of health care spending. Opportunities for digital health innovation in oncology include patient-facing technologies that improve patient experience, safety, and patient-clinician interactions; clinician-facing technologies that improve their ability to diagnose pathology and [...]

Cette étude passe en revue les données concernant l'incidence du cancer de l'anus, le rôle du dépistage, les avancées thérapeutiques et les toxicités associées

Anal Cancer: Emerging Standards in a Rare Rare Disease

Cathy Eng ; Kristen K. Ciombor ; May Cho ; Jennifer A. Dorth ; Lakshmi N. Rajdev ; David P. Horowitz ; Marc J. Gollub ; Alexandre A. Jácome ; Natalie A. Lockney ; Roberta L. Muldoon ; Mary Kay Washington ; Brittany A. O'Brian ; Amala Benny ; Cody M. Lebeck Lee ; Al B. Benson III ; Karyn A. Goodman ; Van Karlyle Morris

The social stigma surrounding an anal cancer diagnosis has traditionally prevented open discussions about this disease. However, as recent treatment options and an increasing rate of diagnoses are made worldwide, awareness is growing. In the United States alone, 9,090 individuals were expected to be diagnosed with anal cancer in 2021. The US annual incidence of squamous cell carcinoma of the anus continues to increase by 2.7% yearly, whereas the mortality rate increases by 3.1%. The main risk [...]

Cette étude française présente les indicateurs de qualité et de sécurité des soins développés par l'Institut National du Cancer et la Haute Autorité de Santé pour la prise en charge des patientes atteintes d'un cancer du sein

Monitoring breast cancer care quality at national and local level using the French National Cancer Cohort

Houzard, Sophie ; Courtois, Emilie ; Le Bihan Benjamin, Christine ; Erbault, Marie ; Arnould, Laurent ; Barranger, Emmanuel ; Coussy, Florence ; Couturaud, Benoît ; Cutuli, Bruno ; de Cremoux, Patricia ; de Reilhac, Pia ; de Seze, Chantal ; Foucaut, Aude-Marie ; Gompel, Anne ; Honore, Stephane ; Lesur, Anne ; Mathelin, Carole ; Verzaux, Laurent ; Bousquet, Philippe-Jean

The French National Cancer Institute has developed, in partnership with the French National Authority for Health, breast cancer-specific Care Quality and Safety Indicators (BC QIs). With regard to the most common form of cancer, our aim is to support local and national quality initiatives, to improve BC pathways and outcomes, reduce heterogeneity of practice and regional inequities. In this study, we measure the BC QIs available in the French National medico-administrative cancer database, the [...]