Menée par enquête auprès de 8 307 fumeurs, cette étude analyse l'association entre un tabagisme quotidien ou non quotidien et la perception des risques de cancer liés au tabac

Associations of Daily Versus Nondaily Smoking, Tobacco-Related Risk Perception, and Cancer Diagnosis Among Adults in the Population Assessment of Tobacco and Health (PATH) Study

Land, Stephanie R ; Baker, Laura ; Bachand, Jacqueline ; Twesten, Jenny ; Reyes-Guzman, Carolyn M ; Kaufman, Annette R

Nondaily smoking has become increasingly common among cigarette smokers. Our objective was to determine whether current daily versus nondaily smoking differed by tobacco-related risk perceptions (TRRPs), demographic factors, and cancer history.Participants were all adult current smokers in three consecutive years (Waves 1–3) of the longitudinal cohort Population Assessment of Tobacco and Health Study (N=8,307). The primary analysis was weighted logistic regression of daily versus nondaily [...]

Menée au Japon sur la période 1995-2015 par questionnaire auprès de 80 952 personnes, cette étude analyse l'association entre la consommation de légumes et de fruits et le risque de cancer de la vessie (401 cas), en fonction du sexe et du statut tabagique

Vegetable and fruit intake and the risk of bladder cancer: Japan Public Health Center-based prospective study

Narii, Nobuhiro ; Sobue, Tomotaka ; Zha, Ling ; Kitamura, Tetsuhisa ; Sawada, Norie ; Iwasaki, Motoki ; Inoue, Manami ; Yamaji, Taiki ; Tsugane, Shoichiro

Background: Vegetable and fruit consumption may have a protective effect against several types of cancer. However, evidence suggesting that increased intake of vegetables and fruits, their subtypes, or the antioxidant nutrients they contain in abundance decreases the risk of bladder cancer is limited. Methods: This study included 80,952 participants from the Japan Public Health Center-based Prospective Study, who responded to a food frequency questionnaire in a 5-year follow-up survey in [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2021 (20 études), cette méta-analyse évalue l'association entre une exposition aux particules fines athmosphériques et le risque de cancer gastro-intestinal, ainsi que la mortalité associée

Exposure to Outdoor Particulate Matter Air Pollution and Risk of Gastrointestinal Cancers in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Evidence

Natalie Pritchett ; Emily C. Spangler ; George M. Gray ; Alicia A. Livinski ; Joshua N. Sampson ; Sanford M. Dawsey ; Rena R. Jones

Background: Outdoor air pollution is a known lung carcinogen, but research investigating the association between particulate matter (PM) and gastrointestinal (GI) cancers is limited. Objectives: We sought to review the epidemiologic literature on outdoor PM and GI cancers and to put the body of studies into context regarding potential for bias and overall strength of evidence. Methods: We conducted a systematic review and meta-analysis of epidemiologic studies that evaluated the association of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2021 (5 études, 19 812 patients), cette méta-analyse évalue l'association entre une maladie inflammatoire chronique de l'intestin apparue pendant l'enfance et le risque de cancer (715 cas)

Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease: A Meta-analysis of Population-Based Studies

Elmahdi, Rahma ; Lemser, Camilla E. ; Thomsen, Sandra B. ; Allin, Kristine H. ; Agrawal, Manasi ; Jess, Tine

Because the incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing, knowledge of the long-term risk of cancer in this patient population is required.To evaluate the relative rate of cancer among patients with pediatric-onset IBD.A comprehensive systematic search was performed of MEDLINE and Embase from the date of database inception to October 31, 2021.All unselected, population-based cohort studies of pediatric-onset IBD assessing the risk of cancer were included. Tertiary [...]

Menée en Norvège et en Suède sur la période 1987-2016 auprès de 142 008 patients atteints d'une colite ulcéreuse ou de la maladie de Crohn (durée médiane de suivi : 10 ans), cette étude analyse le risque de développer un adénocarcinome de l'intestin grêle (66 cas) ou une tumeur neuroendocrine (57 cas)

Inflammatory bowel disease and risk of adenocarcinoma and neuroendocrine tumors in the small bowel

Yu, J. ; Refsum, E. ; Perrin, V. ; Helsingen, L. M. ; Wieszczy, P. ; Løberg, M. ; Bretthauer, M. ; Adami, H. O. ; Ye, W. ; Blom, J. ; Kalager, M.

Background: Uncertainty prevails about the magnitude of excess risk of small bowel cancer in patients with inflammatory bowel disease (IBD). Patients and Methods: To quantify the risk of small bowel adenocarcinoma and neuroendocrine tumors in patients with ulcerative colitis (UC) and Crohn’s disease (CD), we undertook a population-based cohort study of all IBD-patients diagnosed in Norway and Sweden from 1987 through 2016. Patients were followed through linkage to national registers. We [...]

Menée à l'aide des données d'une cohorte américaine et d'une cohorte norvégienne portant au total sur 360 patients atteints d'un gliome, cette étude analyse l'association entre une séropositivité à 6 types d'herpèsvirus humains et le risque de gliome

Prospective investigation of herpesvirus infection and risk of glioma

Coghill, Anna E. ; Kim, YoungChul ; Hodge, James M. ; Bender, Noemi ; Smith-Warner, Stephanie A. ; Teras, Lauren R. ; Grimsrud, Tom K. ; Waterboer, Tim ; Egan, Kathleen M.

Glioma is an aggressive neoplasm of the brain with poorly understood etiology. A limited number of pathogens have been examined as glioma risk factors, but data from prospective studies with infection status determined before disease are lacking. Herpesviruses comprise a large family of DNA viruses that infect humans and are linked to a range of chronic diseases. We conducted a prospective evaluation of the association between antibody to 6 human herpesviruses and glioma risk in the Janus Serum [...]

Menée en Corée auprès de 14 265 822 adultes (durée moyenne de suivi : 13,7 ans), cette étude analyse l'association entre l'indice de masse corporelle et le risque de carcinome hépatocellulaire (47 308 cas)

Impact of overweight and obesity on the risk of hepatocellular carcinoma: a prospective cohort study in 14.3 million Koreans

Jun, Baek Gyu ; Kim, Moonho ; Shin, Hwang Sik ; Yi, Jee-Jeon ; Yi, Sang-Wook

Background: Whether obesity and being overweight, defined by body mass index (BMI), increase hepatocellular carcinoma (HCC) has been less apparent in Asian populations. Methods: Overall, 14,265,822 Korean adults who underwent routine health examinations during 2003–2006 were followed up for HCC. Multivariable-adjusted hazard ratios (HRs) associated with BMI were calculated. Results: During 13.7 years (mean) of follow-up, 47,308 individuals developed HCC. HRs of HCC associated with BMIs of [...]

Menée à l'aide d'échantillons sanguins collectés auprès de 1 303 témoins et 703 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre une hyperglycémie (évaluée par les taux d'hémoglobine A1c, du peptide C et de la protéine C réactive) et le risque de développer la maladie, en fonction du stade et du grade de la tumeur

Biomarkers of glucose homeostasis and inflammation with risk of prostate cancer: A case-cohort study

Wang, Ying ; Gapstur, Susan M. ; Newton, Christina C. ; McCullough, Marjorie L. ; Pollak, Michael N. ; Campbell, Peter T.

Background: Few prospective studies have examined biomarkers of glucose homeostasis or inflammation with prostate cancer risk by tumor stage or grade. Methods: We conducted a case-cohort study to examine associations of pre-diagnosis hemoglobin A1c (HbA1c), c-peptide, and c-reactive protein (CRP) with prostate cancer risk overall and stratified by tumor stage and grade. The study included 390 non-aggressive (T1-2, N0, M0 and Gleason score <8) and 313 aggressive cases (T3-4, or N1, or M1, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (47 études), cette méta-analyse évalue l'association entre la taille atteinte à l'âge adulte et le risque de cancer ou d'adénome colorectal

Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review and Meta-Analysis

Zhou, Elinor ; Wang, Lin ; Santiago, Celina N. ; Nanavati, Julie ; Rifkin, Samara ; Spence, Emma ; Hylind, Linda M. ; Gills, Joell J. ; La Luna, Louis ; Kafonek, David R. ; Cromwell, David M. ; Drewes, Julia L. ; Sears, Cynthia L. ; Giardiello, Francis M. ; Mullin, Gerard

Background: The influence of anthropometric characteristics on colorectal neoplasia biology is unclear. We conducted a systematic review and meta-analysis to determine if adult-attained height is independently associated with the risk of colorectal cancer or adenoma. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, and Web of Science from inception to August 2020 for studies on the association between adult-attained height and colorectal cancer or adenoma. The original data from the [...]

Cette étude fait le point sur les variants génétiques associés au risque de forme familiale de cancer non médullaire de la thyroïde

Genetic susceptibility to hereditary non-medullary thyroid cancer

Kamani, Tina ; Charkhchi, Parsa ; Zahedi, Afshan ; Akbari, Mohammad R.

Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Although syndromic NMTC has well-known genetic risk factors, the gene(s) responsible for the vast majority of non-syndromic FNMTC cases are yet to be [...]

Menée à partir des données de 2 cohortes australiennes portant sur 1 165 personnes (âge moyen : 36-64 ans), cette étude analyse l'association entre l'âge au premier rapport sexuel et le risque de cancer de l'oropharynx lié à une infection par le papillomavirus humain

Sexual debut and association with oral HPV infection, persistence and oropharyngeal cancer - an analysis of two Australian cohorts

Antonsson, Annika ; de Souza, Marjorie M. A. ; Panizza, Benedict J. ; Whiteman, David C.

Oropharyngeal cancer is increasingly caused by human papillomavirus (HPV), and this increase is believed to be caused by changing sexual behaviour. It has been hypothesised that an immune response to HPV through sexual intercourse is much stronger than an immune response elicited from oral sex. Therefore, people who have their debut of oral sex before or at the same time as sexual intercourse would have a weaker immune response to HPV and hence be more likely to develop a persistent oral HPV [...]