Menée à partir de données portant sur 2 212 témoins et 1 521 patientes atteintes d'un cancer invasif du sein diagnostiqué entre 1985 et 2008 avant l'age de 55 ans, cette étude analyse l'association entre le tabagisme, la radiothérapie et le risque de cancer du sein controlatéral

Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women

Reiner, Anne S ; Watt, Gordon P ; John, Esther M ; Lynch, Charles F ; Brooks, Jennifer D ; Mellemkjær, Lene ; Boice, John D, Jr. ; Knight, Julia A ; Concannon, Patrick ; Smith, Susan A ; Liang, Xiaolin ; Woods, Meghan ; Shore, Roy ; Malone, Kathleen E ; Bernstein, Leslie ; The WECARE Collaborative Study Group ; Bernstein, Jonine L

Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually-matched case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1,521 CBC cases and 2,212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between 1985–2008 at age <55 years. [...]

Menée aux Etats-Unis à partir de données portant sur 94 217 femmes âgées de 26 à 45 ans, cette étude de cohorte prospective analyse l'association entre une alimentation et des modes de vie favorisant un hyperinsulinisme et le risque de cancer colorectal (durée de suivi : 24 ans ; 332 cas)

Prospective Evaluation of Dietary and Lifestyle Pattern Indices with Risk of Colorectal Cancer in a Cohort of Younger Women

Yue, Y. ; Hur, J. ; Cao, Y. ; Tabung, F. K. ; Wang, M. ; Wu, K. ; Song, M. ; Zhang, X. ; Liu, Y. ; Meyerhardt, J. A. ; Ng, K. ; Smith-Warner, S. A. ; Willett, W. C. ; Giovannucci, E.

Background : Although colorectal cancer (CRC) incidence in the US is declining overall, its incidence is increasing among those younger than 50 years of age. The reasons underlying the increasing trend are largely unknown, although behavioral changes, such as unhealthy diet and lifestyle factors, may be partially responsible. Design : A prospective cohort study included 94,217 women aged 26-45 years at baseline. Validated anthropometric measures and lifestyle information were self-reported [...]

Menée aux Etats-Unis à partir de données portant sur 43 563 participantes, cette étude de cohorte analyse l'association entre le potentiel inflammatoire de l'alimentation, un indicateur caractérisant l'équilibre oxydant-antioxydant lié à l'alimentation et le risque de cancer du sein (durée moyenne de suivi : 8,4 ans ; 2 619 cas)

Dietary inflammatory potential, oxidative balance score, and risk of breast cancer: findings from the Sister Study

Park, Yong-Moon Mark ; Shivappa, Nitin ; Petimar, Joshua ; Hodgson, M. Elizabeth ; Nichols, Hazel B. ; Steck, Susan E. ; Hebert, James R. ; Sandler, Dale P.

Diet, inflammation, and oxidative stress may be important in breast carcinogenesis, but evidence on the role of the inflammatory and pro‐oxidative potential of dietary patterns is limited. Energy adjusted‐Dietary Inflammatory Index (E‐DII TM) and dietary oxidative balance score (D‐OBS) were calculated for 43,563 Sister Study cohort participants who completed a Block 1998 food frequency questionnaire at enrollment in 2003‐2009 and satisfied eligibility criteria. D‐OBS was validated using [...]

Menée en Chine à partir de données portant sur 510 137 participants, cette étude prospective analyse l'association entre la présence de calculs biliaires et le risque de cancer gastrointestinal (durée de suivi : 10 ans ; 17 598 cas)

Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese

Pang, Yuanjie ; Lv, Jun ; Kartsonaki, Christiana ; Guo, Yu ; Yu, Canqing ; Chen, Yiping ; Yang, Ling ; Bian, Zheng ; Millwood, Iona Y. ; Walters, Robin G. ; Li, Xiaojun ; Zou, Ju ; Holmes, Michael V. ; Chen, Junshi ; Chen, Zhengming ; Li, Liming

Background : Gallstone disease (GSD) is associated with a higher risk of gastrointestinal (GI) cancer. However, it is unclear whether the associations are causal. Methods : The prospective China Kadoorie Biobank (CKB) recorded 17,598 cases of GI cancer among 510,137 participants without cancer at baseline during 10 years of follow-up. Cox regression was used to estimate hazard ratios (HRs) for specific cancer by GSD status and duration. Mendelian randomisation was conducted to assess the [...]

Menée à partir des données de 7 études prospectives en Europe et aux Etats-Unis incluant 667 916 participants (âge médian : 62,3 ans), cette étude analyse l'association entre la présence d'un diabète et le risque de cancer (prostate, sein, colorectal et tous types de cancers combinés ; durée médiane de suivi : 10,5 ans)

Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium

Amadou, Amina ; Freisling, Heinz ; Jenab, Mazda ; Tsilidis, Konstantinos K. ; Trichopoulou, Antonia ; Boffetta, Paolo ; Van Guelpen, Bethany ; Mokoroa, Olatz ; Wilsgaard, Tom ; Kee, Frank ; Schottker, Ben ; Ordóñez-Mena, José M. ; Mannisto, Satu ; Söderberg, Stefan ; Vermeulen, Roel C. H. ; Quirós, J. Ramón ; Liao, Linda M. ; Sinha, Rashmi ; Kuulasmaa, Kari ; Brenner, Hermann ; Romieu, Isabelle

Background : We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. Methods : We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer [...]

Menée à partir des données de la cohorte européenne EPIC portant sur 1 609 patients atteints d'un cancer colorectal et sur 1 609 témoins, cette étude de cohorte prospective analyse l'association entre le niveau des acides gras des globules rouges mesuré avant le diagnostic et le risque de développer la maladie

Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC)

Linseisen, Jakob ; Grundmann, Nina ; Zoller, Dorothee ; Kühn, Tilman ; Jansen, Eugène H.J.M. ; Chajès, Veronique ; Fedirko, Veronika ; Weiderpass, Elisabete ; Dahm, Christina C. ; Overvad, Kim ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Rothwell, Joseph A. ; Severi, Gianluca ; Kaaks, Rudolf ; Schulze, Matthias B. ; Aleksandrova, Krasimira ; Sieri, Sabina ; Panico, Salvatore ; Tumino, Rosario ; Masala, Giovanna ; De Marco, Laura ; Bueno-de-Mesquita, Bas ; Vermeulen, Roel ; Gram, Inger T. ; Skeie, Guri ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Agudo, Antonio ; Sánchez, María-José ; Amiano, Pilar ; Wennberg, Maria ; Bodén, Stina ; Perez-Cornago, Aurora ; Aglago, Elom K. ; Gunter, Marc J. ; Jenab, Mazda ; Heath, Alicia K. ; Nieters, Alexandra

Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median [...]

Menée à partir des données de trois études incluant 2 327 patients atteints d'un cancer colorectal et 2 966 témoins, cette étude identifie des variants rares de gènes impliqués dans la réparation de l'ADN et associés au risque de développer la maladie

Rare Variants in the DNA Repair Pathway and the Risk of Colorectal Cancer

Matejcic, Marco ; Shaban, Hiba A. ; Quintana, Melanie W. ; Schumacher, Fredrick R. ; Edlund, Christopher K. ; Naghi, Leah ; Pai, Rish K. ; Haile, Robert W. ; Levine, A. Joan ; Buchanan, Daniel D. ; Jenkins, Mark A. ; Figueiredo, Jane C. ; Rennert, Gad ; Gruber, Stephen B. ; Li, Li ; Casey, Graham ; Conti, David V. ; Schmit, Stephanie L.

Background: Inherited susceptibility is an important contributor to colorectal cancer risk, and rare variants in key genes or pathways could account in part for the missing proportion of colorectal cancer heritability. Methods: We conducted an exome-wide association study including 2,327 cases and 2,966 controls of European ancestry from three large epidemiologic studies. Single variant associations were tested using logistic regression models, adjusting for appropriate study-specific [...]