Menée à partir de données des cohortes "the Nurses’ Health Studies" et "the Health Professionals Follow-Up Study" portant sur 191 543 personnes, cette étude analyse l'association entre une consommation d'alcool au début de l'âge adulte (18-22 ans) et le risque de cancer colorectal (2 624 cas)

Alcohol intake in early adulthood and risk of colorectal cancer: three large prospective cohort studies of men and women in the United States

Hur, Jinhee ; Smith-Warner, Stephanie A. ; Rimm, Eric B. ; Willett, Walter C. ; Wu, Kana ; Cao, Yin ; Giovannucci, Edward

Heavy alcohol consumption in mid-adulthood is an established risk factor of colorectal cancer (CRC). Alcohol use in early adulthood is common, but its association with subsequent CRC risk remains largely unknown. We prospectively investigated the association of average alcohol intake in early adulthood (age 18–22) with CRC risk later in life among 191,543 participants of the Nurses’ Health Study ([NHS], 1988–2014), NHSII (1989–2015) and Health Professionals Follow-Up Study (1988–2014). Cox [...]

Menée aux Etats-Unis à partir de données portant sur 109 283 personnes infectées par le VIH (âge médian : 43 ans ; 85 % d'hommes), cette étude analyse l'évolution du risque de carcinome hépatocellulaire sur la période 1996-2015 et identifie des facteurs aggravants

Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015

Sun, Jing ; Althoff, Keri N. ; Jing, Yuezhou ; Horberg, Michael A. ; Buchacz, Kate ; Gill, M. John ; Justice, Amy C. ; Rabkin, Charles S. ; Goedert, James J. ; Sigel, Keith ; Cachay, Edward ; Park, Lesley ; Lim, Joseph K. ; Kim, H. Nina ; Lo Re, Vincent, III ; Moore, Richard ; Sterling, Timothy ; Peters, Marion G. ; Achenbach, Chad J. ; Silverberg, Michael ; Thorne, Jennifer E. ; Mayor, Angel M. ; Crane, Heidi M. ; Kitahata, Mari M. ; Klein, Marina ; Kirk, Gregory D. ; North American AIDS Cohort Collaboration on Research ; Design of IeDEA

People with HIV (PWH) are often coinfected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), leading to increased risk of developing hepatocellular carcinoma (HCC), but few cohort studies have had sufficient power to describe the trends of HCC incidence and risk among PWH in the combination antiretroviral therapy (cART) era.To determine the temporal trends of HCC incidence rates (IRs) and to compare rates by risk factors among PWH in the cART era.This cohort study used data from the [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2019 (12 études, 2 181 patients), cette méta-analyse évalue l'association entre le polymorphisme I/D du gène ACE et le risque de cancer du poumon

Associations between I/D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

Chen, Junjian ; Zhou, Min ; Sun, Mao ; Lu, Renfu

Background: We evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by performing a meta-analysis. Methods: The heterogeneity in the study was tested using the Cochran  [...]

Menée à l'aide de données de la UK Biobank portant sur 58 629 femmes ménopausées (durée médiane de suivi : 7 ans), cette étude analyse l'association entre les taux sériques d'hémoglobine glyquée, de triglycérides, de cholestérol, de protéine C-réactive, de testostérone ou de globuline de liaison des hormones stéroïdes sexuelles (SHBG) et le risque de cancer du sein (1 268 cas)

The association of prediagnostic circulating levels of cardiometabolic markers, testosterone and SHBG with risk of breast cancer among normal weight postmenopausal women in the UK Biobank

Arthur, Rhonda S. ; Dannenberg, Andrew J. ; Rohan, Thomas E.

Emerging evidence suggests that normal weight postmenopausal women with a relative excess of body fat are at increased breast cancer risk. However, little is known about the associations between obesity-related blood markers and risk of breast cancer among these individuals. In this prospective study comprising 58 629 normal weight postmenopausal women (body mass index between 18.5 kg/m2 and 24.9 kg/m2) who were enrolled in the UK Biobank cohort between 2006 and 2010, we examined the [...]