Menée en France à partir de données portant sur 357 patients pédiatriques atteints d'un neuroblastome et sur 1 783 témoins, cette étude analyse l'association entre le tabagisme parental, la consommation d'alcool de la mère pendant la grossesse et le risque de développer la maladie chez l'enfant

Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies

Rios, Paula ; Bailey, Helen D ; Poulalhon, Claire ; Valteau-Couanet, Dominique ; Schleiermacher, Gudrun ; Bergeron, Christophe ; Petit, Arnaud ; Defachelles, Anne-Sophie ; Gambart, Marion ; Sirvent, Nicolas ; Ducassou, Stéphane ; Munzer, Caroline ; Orsi, Laurent ; Lacour, Brigitte ; Clavel, Jacqueline

Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case-control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1783 controls from general population, frequency matched by [...]

Menée en Afrique du Sud à partir de données portant sur 396 patientes atteintes d'un cancer du sein et sur 396 témoins, cette étude analyse l'association entre divers types d'aliments (fruits frais, viandes, soupes, sauces, noix, etc.) et le risque de développer la maladie

Dietary intake and breast cancer risk in black South African women: the South African Breast Cancer study

Jacobs, Inarie ; Taljaard-Krugell, Christine ; Ricci, Cristian ; Vorster, Hester ; Rinaldi, Sabina ; Cubasch, Herbert ; Laubscher, Ria ; Joffe, Maureen ; van Zyl, Tertia ; Norris, Shane A. ; Romieu, Isabelle

Incidence rates of breast cancer (BC) are increasing in South Africa. The aim of this study was to investigate the association between dietary intake and BC risk in black South African women. The study population included 396 BC cases and 396 population-based controls matched on age and residence, participating in the South African Breast Cancer study. Diet was assessed using a validated quantified FFQ from which twelve energy-adjusted food groups were formed and analysed. OR were estimated [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 824 patients atteints d'un carcinome urothélial de la vessie et sur 824 témoins, cette étude analyse l'association entre le niveau sérique de folates, d'homocystéine, de vitamines B6 et B12 mesuré avant le diagnostic, et le risque de développer la maladie

One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Vrieling, Alina ; Bueno-de-Mesquita, H. Bas ; Ros, Martine M. ; Kampman, Ellen ; Aben, Katja K. ; Büchner, Frederike L. ; Jansen, Eugène H. ; Roswall, Nina ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Cadeau, Claire ; Chang-Claude, Jenny ; Kaaks, Rudolf ; Weikert, Steffen ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Sieri, Sabina ; Palli, Domenico ; Panico, Salvatore ; Peeters, Petra H. ; Weiderpass, Elisabete ; Skeie, Guri ; Jakszyn, Paula ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Sánchez, María-José ; Ehrnström, Roy ; Malm, Johan ; Ljungberg, Börje ; Khaw, Kay-Tee ; Wareham, Nick J. ; Brennan, Paul ; Johansson, Mattias ; Riboli, Elio ; Kiemeney, Lambertus A.

Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 [...]

Menée à partir des données de deux cohortes, l'une américaine et l'autre norvégienne, portant sur un total de 220 patients atteints d'un cancer primitif du foie et sur 660 témoins, cette étude évalue l'association entre le niveau sérique, mesuré avant le diagnostic, de produits insecticides organochlorés et le risque de développer la maladie

Prediagnostic serum organochlorine insecticide concentrations and primary liver cancer: a case-control study nested within two prospective cohorts

Engel, Lawrence S. ; Zabor, Emily C. ; Satagopan, Jaya ; Widell, Anders ; Rothman, Nathaniel ; O'Brien, Thomas R. ; Zhang, Mingdong ; Van Den Eeden, Stephen K. ; Grimsrud, Tom K.

Although experimental evidence indicates that certain organochlorine insecticides are hepatocarcinogens, epidemiologic evidence for most of these chemicals is very limited. We estimated associations, using prospectively collected sera, between organochlorine insecticide concentrations and cancer registry-identified primary liver cancer in two cohorts, one from the United States and one from Norway. In nested case-control studies, we used sera collected in the 1960s-1980s from 136 cases and 408 [...]

Menée à partir des données de 20 cohortes prospectives portant sur 5 323 patients atteints d'un cancer du poumon et sur 5 323 témoins, cette étude analyse le lien entre le catabolisme de la vitamine B6 associé à une inflammation et le risque de développer la maladie

Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3)

Zuo, H ; Ueland, P M ; Midttun, Ø ; Tell, G S ; Fanidi, A ; Zheng, W ; Shu, X ; Xiang, Y ; Wu, J ; Prentice, R ; Pettinger, M ; Thomson, C A ; Giles, G G ; Hodge, A ; Cai, Q ; Blot, W J ; Johansson, M ; Hultdin, J ; Grankvist, K ; Stevens, V L ; McCullough, M L ; Weinstein, S J ; Albanes, D ; Ziegler, R G ; Freedman, N D ; Caporaso, N E ; Langhammer, A ; Hveem, K ; Næss, M ; Buring, J E ; Lee, I ; Gaziano, J M ; Severi, G ; Zhang, X ; Stampfer, M J ; Han, J ; Zeleniuch-Jacquotte, A ; Marchand, L L ; Yuan, J ; Wang, R ; Koh, W ; Gao, Y ; Ericson, U ; Visvanathan, K ; Jones, M R ; Relton, C ; Brennan, P ; Ulvik, A

Background : Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal -5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods : For this study, we included 5,323 incident lung cancer cases and 5,323 controls individually matched [...]

Menée en Corée à partir de données portant sur 142 832 participants ayant subi une endoscopie, cette étude de cohorte rétrospective analyse l'association entre l'indice de masse corporelle et le risque de métaplasie intestinale et d'atrophie gastrique (période de suivi : 444 791 personnes-années ; 2 281 cas)

Body mass index and risk of intestinal metaplasia: A cohort study

Ryu, Seungho ; Kim, Kyungeun ; Chang, Yoosoo ; Ahn, Jiin ; Yang, Hyo-Joon ; Jung, Ju Young ; Kim, Seokkyun ; Sohn, Chong Il

Background: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia (IM). Methods: This retrospective cohort study included 142,832 Korean adults free of endoscopic IM and atrophic gastritis (AG) who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident IM. Results: [...]

Menée en population chinoise à partir de données portant sur 3 097 patients atteints d'un gliome et sur 4 362 témoins, cette étude d'association sur le génome entier identifie deux nouveaux variants des gènes STK38L et RAB27A impliqués dans le développement de la maladie

Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility

Chen, Hongyan ; Chen, Gong ; Li, Gang ; Zhang, Shuo ; Chen, Haitao ; Chen, Yuanyuan ; Duggan, Dave ; Hu, Zhibin ; Chen, Juxing ; Zhao, Yingjie ; Zhao, Yao ; huang, Huiling ; Zheng, S. Lilly ; Trent, Jeffrey M. ; Yu, Long ; Jiang, Deke ; Mo, Zengnan ; Wang, Hongwei ; Mou, Yonggao ; Jiang, Tao ; Mao, Ying ; Xu, Jianfeng ; Lu, Daru

Glioma is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of glioma in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in glioma risk. To systematically investigate glioma risk–associated variants in Chinese population, we performed a multistage GWAS of glioma in the Han Chinese population, with a total of 3,097 glioma [...]