Menée en Italie, cette étude évalue l'association entre une alimentation pro-inflammatoire et le risque de cancer du larynx (460 cas et 1 088 témoins)

Inflammatory potential of diet and risk of laryngeal cancer in a case–control study from Italy

Shivappa, Nitin ; Hebert, James R. ; Rosato, Valentina ; Serraino, Diego ; La Vecchia, Carlo

Background : Besides tobacco and alcohol, diet and inflammation have been suggested to be important risk factors for laryngeal cancer. In this study, we examined the role of diet-associated inflammation, as estimated by dietary inflammatory index (DII) scores, in laryngeal cancer in a multicentre case–control study conducted between 1992 and 2000 in Italy. Methods :This study included 460 cases with incident, histologically confirmed laryngeal cancer, and 1,088 controls hospitalized for acute [...]

Menée au Japon auprès de 95 salariés d'une société d'impression offset entre 1987 et 2006, cette étude évalue l'association entre une exposition professionnelle au 1,2-dichloropropane et le risque de cholangiocarcinome (17 cas)

Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers

Kumagai, Shinji ; Sobue, Tomotaka ; Makiuchi, Takeshi ; Kubo, Shoji ; Uehara, Shinichiro ; Hayashi, Tomoshige ; Sato, Kyoko Kogawa ; Endo, Ginji

Objectives This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan. Methods : We identified 95 workers of a printing company (78 men and 17 women) who had been exposed to 1,2-DCP between 1987 and 2006, and calculated the standardised incidence ratio (SIR) of cholangiocarcinoma from 1987 to 2012. We estimated [...]

A partir de données issues d'études d'association sur le génome entier dans le myélome multiple (total de 9 866 cas et 239 188 témoins), cette méta-analyse identifie notamment 8 nouveaux loci de susceptibilité à la maladie

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

Mitchell, Jonathan S. ; Li, Ni ; Weinhold, Niels ; Försti, Asta ; Ali, Mina ; van Duin, Mark ; Thorleifsson, Gudmar ; Johnson, David C. ; Chen, Bowang ; Halvarsson, Britt-Marie ; Gudbjartsson, Daniel F. ; Kuiper, Rowan ; Stephens, Owen W. ; Bertsch, Uta ; Broderick, Peter ; Campo, Chiara ; Einsele, Hermann ; Gregory, Walter A. ; Gullberg, Urban ; Henrion, Marc ; Hillengass, Jens ; Hoffmann, Per ; Jackson, Graham H. ; Johnsson, Ellinor ; Joud, Magnus ; Kristinsson, Sigurur Y. ; Lenhoff, Stig ; Lenive, Oleg ; Mellqvist, Ulf-Henrik ; Migliorini, Gabriele ; Nahi, Hareth ; Nelander, Sven ; Nickel, Jolanta ; Nothen, Markus M. ; Rafnar, Thorunn ; Ross, Fiona M. ; da Silva Filho, Miguel Inacio ; Swaminathan, Bhairavi ; Thomsen, Hauke ; Turesson, Ingemar ; Vangsted, Annette ; Vogel, Ulla ; Waage, Anders ; Walker, Brian A. ; Wihlborg, Anna-Karin ; Broyl, Annemiek ; Davies, Faith E. ; Thorsteinsdottir, Unnur ; Langer, Christian ; Hansson, Markus ; Kaiser, Martin ; Sonneveld, Pieter ; Stefansson, Kari ; Morgan, Gareth J. ; Goldschmidt, Hartmut ; Hemminki, Kari ; Nilsson, Björn ; Houlston, Richard S.

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 [times] 10-8), 6q21 [...]

A partir de données de 39 études, cette étude évalue l'association entre l'indice de masse corporelle à l'âge adulte et le risque de cancer de l'ovaire, par sous-type histologique (14 047 cas et 23 003 témoins)

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

Dixon, Suzanne C. ; Nagle, Christina M. ; Thrift, Aaron P. ; Pharoah, Paul D. P. ; Pearce, Celeste Leigh ; Zheng, Wei ; Painter, Jodie N. ; Chenevix-Trench, AOCS Group ; Australian Cancer Study , Georgia ; Fasching, Peter A. ; Beckmann, Matthias W. ; Lambrechts, Diether ; Vergote, Ignace ; Lambrechts, Sandrina ; Van Nieuwenhuysen, Els ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Wicklund, Kristine G. ; Chang-Claude, Jenny ; Rudolph, Anja ; Moysich, Kirsten B. ; Odunsi, Kunle ; Goodman, Marc T. ; Wilkens, Lynne R. ; Thompson, Pamela J. ; Shvetsov, Yurii B. ; Dörk, Thilo ; Park-Simon, Tjoung-Won ; Hillemanns, Peter ; Bogdanova, Natalia ; Butzow, Ralf ; Nevanlinna, Heli ; Pelttari, Liisa M. ; Leminen, Arto ; Modugno, Francesmary ; Ness, Roberta B. ; Edwards, Robert P. ; Kelley, Joseph L. ; Heitz, Florian ; Karlan, Beth Y. ; Kjær, Susanne K. ; Høgdall, Estrid ; Jensen, Allan ; Goode, Ellen L. ; Fridley, Brooke L. ; Cunningham, Julie M. ; Winham, Stacey J. ; Giles, Graham G. ; Bruinsma, Fiona ; Milne, Roger L. ; Southey, Melissa C. ; Hildebrandt, Michelle A. T. ; Wu, Xifeng ; Lu, Karen H. ; Liang, Dong ; Levine, Douglas A. ; Bisogna, Maria ; Schildkraut, Joellen M. ; Berchuck, Andrew ; Cramer, Daniel W. ; Terry, Kathryn L. ; Bandera, Elisa V. ; Olson, Sara H. ; Salvesen, Helga B. ; Thomsen, Liv Cecilie ; Kopperud, Reidun K. ; Bjorge, Line ; Kiemeney, Lambertus A. ; Massuger, Leon F. A. G. ; Pejovic, Tanja ; Cook, Linda S. ; Le, Nhu D. ; Swenerton, Kenneth D. ; Brooks-Wilson, Angela ; Kelemen, Linda E. ; Lubinski, Jan ; Huzarski, Tomasz ; Gronwald, Jacek ; Menkiszak, Janusz ; Wentzensen, Nicolas ; Brinton, Louise ; Yang, Hannah ; Lissowska, Jolanta ; Høgdall, Claus K. ; Lundvall, Lene ; Song, Honglin ; Tyrer, Jonathan P. ; Campbell, Ian ; Eccles, Diana ; Paul, James ; Glasspool, Rosalind ; Siddiqui, Nadeem ; Whittemore, Alice S. ; Sieh, Weiva ; McGuire, Valerie ; Rothstein, Joseph H. ; Narod, Steven A. ; Phelan, Catherine ; Risch, Harvey A. ; McLaughlin, John R. ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Menon, Usha ; Gayther, Simon A. ; Ramus, Susan J. ; Gentry-Maharaj, Aleksandra ; Wu, Anna H. ; Pike, Malcolm C. ; Tseng, Chiu-Chen ; Kupryjanczyk, Jolanta  ; Dansonka-Mieszkowska, Agnieszka ; Budzilowska, Agnieszka ; Spiewankiewicz, Beata ; Webb, Penelope M. ; on behalf of the Ovarian Cancer Association Consortium

Background: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of association observed for serous cancers may, for instance, be due to disease-associated weight loss. Mendelian randomization (MR) uses genetic markers as proxies for risk factors to overcome limitations of observational studies. We used MR to [...]

Menée sur 692 patients atteints d'un cancer métastatique de la prostate, cette étude identifie, pour 11,8% d'entre eux, la présence de mutations constitutionnelles de gènes impliqués dans la réparation de l'ADN

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

Pritchard, Colin C. ; Mateo, Joaquin ; Walsh, Michael F. ; De Sarkar, Navonil ; Abida, Wassim ; Beltran, Himisha ; Garofalo, Andrea ; Gulati, Roman ; Carreira, Suzanne ; Eeles, Rosalind ; Elemento, Olivier ; Rubin, Mark A. ; Robinson, Dan ; Lonigro, Robert ; Hussain, Maha ; Chinnaiyan, Arul ; Vinson, Jake ; Filipenko, Julie ; Garraway, Levi ; Taplin, Mary-Ellen ; Aldubayan, Saud ; Han, G. Celine ; Beightol, Mallory ; Morrissey, Colm ; Nghiem, Belinda ; Cheng, Heather H. ; Montgomery, Bruce ; Walsh, Tom ; Casadei, Silvia ; Berger, Michael ; Zhang, Liying ; Zehir, Ahmet ; Vijai, Joseph ; Scher, Howard I. ; Sawyers, Charles ; Schultz, Nikolaus ; Kantoff, Philip W. ; Solit, David ; Robson, Mark ; Van Allen, Eliezer M. ; Offit, Kenneth ; de Bono, Johann ; Nelson, Peter S.

BACKGROUND : Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been established. METHODS : We recruited 692 men with documented metastatic prostate [...]

Cette étude passe en revue les syndromes de prédisposition génétique au cancer associés au risque de sarcome

Sarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review

Farid, Mohamad ; Ngeow, Joanne

Sarcomas are rare mesenchymal malignancies that demonstrate great clinical and biological heterogeneity. A variety of sarcomas develop in the context of well-defined heritable cancer predisposition syndromes, associations that are often overlooked, given the rarity and diversity of sarcomas, and the equivalent relative infrequency of cancer genetic syndromes. This review describes in detail selected heritable cancer predisposition syndromes that are known to be associated with sarcomas. Beyond [...]