Menée en population canadienne, cette étude cas-témoins évalue l'association entre le tabagisme, une consommation d'alcool, un diabète, l'obésité, le statut socio-économique et le risque de cancer colorectal

Smoking, alcohol, diabetes, obesity, socioeconomic status, and the risk of colorectal cancer in a population-based case–control study

Boyle, Terry ; Fritschi, Lin ; Tabatabaei, SeyedMehdi ; Ringwald, Kathrin ; Heyworth, JaneS

Purpose : Although previous research has identified factors that may determine willingness to participate in research, relatively few studies have attempted to quantify the impact non-participation may have on exposure–disease associations. The aims of this study were to (a) investigate the associations between smoking, alcohol, diabetes, obesity, and socioeconomic status and the risk of colorectal cancer in a case–control study (59.7 and 47.2 % response fractions among cases and controls, [...]

A partir des données de la cohorte européenne EPIC portant sur 325 006 participantes, cette étude évalue l'association entre une consommation d'acrylamide d'origine alimentaire et le risque de cancer épithélial de l'ovaire

Dietary intake of acrylamide and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Obón-Santacana, Mireia ; Peeters, Petra H. ; Freisling, Heinz ; Dossus, Laure ; Clavel-Chapelon, Françoise ; Baglietto, Laura ; Schock, Helena ; Fortner, Renée T. ; Boeing, Heiner ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Menéndez, Virginia ; Sánchez, María-José ; Larranaga, Nerea ; Huerta Castaño, José María ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth C. ; Merritt, Melissa A. ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Orfanos, Philippos ; Masala, Giovanna ; Sieri, Sabina ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-de-Mesquita, H Bas ; Onland-Moret, N. Charlotte ; Wirfalt, Elisabet ; Stocks, Tanja ; Idahl, Annika ; Lundin, Eva ; Skeie, Guri ; Gram, Inger T. ; Weiderpass, Elisabete ; Riboli, Elio ; Duell, Eric J.

Acrylamide, classified in 1994 by IARC as 'probably carcinogenic' to humans, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. The association between dietary acrylamide intake and epithelial ovarian cancer risk (EOC) has been previously studied in one case-control and three prospective cohort studies which obtained inconsistent results, and could not further examine histological subtypes other than serous EOC. The present study was carried out in the European Prospective [...]

A partir d'une revue de la littérature publiée de 2002 à 2013 (18 études), cette étude analyse l'évolution de l'incidence du cancer de la prostate, ainsi que de la mortalité spécifique, chez une population d'agriculteurs

A review of prostate cancer incidence and mortality studies of farmers and non-farmers, 2002–2013

Depczynski, Julie ; Lower, Tony

Objectives : To review the recent literature on the incidence and mortality of prostate cancer in farmers compared to non-farmers. Methods : Searches were conducted in seven electronic databases for observational studies published from 2002 to 2013. Studies were assessed against eligibility criteria and a narrative summary of findings presented. Results : Eighteen primary research articles were included in the review. Four of ten mortality studies and two of nine incidence studies reported [...]

Menée aux Etats-Unis auprès de 187 778 cas, cette étude évalue les disparités ethniques dans l'association entre une exposition aux rayonnements ultraviolets ambiants et le risque de lymphome non hodgkinien

Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: A U.S. population-based study of racial and ethnic groups

Cahoon, Elizabeth K. ; Pfeiffer, Ruth M. ; Wheeler, David C. ; Arhancet, Juan ; Lin, Shih-Wen ; Alexander, Bruce H. ; Linet, Martha S. ; Freedman, D. Michal

Associations between ultraviolet radiation (UVR) exposure and non-Hodgkin lymphoma (NHL) have been inconsistent, but few studies have examined these associations for specific subtypes or across race/ethnicities. We evaluated the relationship between ambient UVR exposure and subtype-specific NHL incidence for whites, Hispanics and blacks in the United States for years 2001–2010 (n = 187,778 cases). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles [...]

A partir des données des registres italiens des cancers portant sur 1 751 mélanomes cutanés et 15 200 cancers de la peau hors mélanome, cette étude analyse l'association entre le mois de naissance et le risque de cancers de la peau

Seasonal variation in the month of birth in patients with skin cancer

La Rosa, F. ; Liso, A. ; Bianconi, F. ; Duca, E. ; Stracci, F.

Background: Month of birth influences the risk of developing several diseases. We investigated the influence of date of birth on melanoma skin cancer (MSC) and non-melanoma skin cancer (NMSC) incidence. Methods : Enhanced cancer registry data were analysed including 1751 MSC and 15 200 NMSC. Results:People born in February to April showed significantly elevated risks of NMSC compared with those born in summertime. Conclusions:We demonstrated seasonality by date of birth for skin cancer [...]

Menée sur des lignées cellulaires de cancer du sein, cette étude met en évidence des mécanismes permettant de rendre compte des résultats de l'essai "women's Health Initiative" en matière de risques associés à des traitements hormonaux substitutifs de la ménopause

Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: An insight into the Women's Health Initiative study

Sweeney, Elizabeth ; Fan, Ping ; Jordan, V. Craig

Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women, and can comprise an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone HRT decreases the risk of breast cancer in post-menopausal women, while combined estrogen plus a progestin (medroxyprogesterone acetate, MPA) HRT increases this risk. Long-term estrogen-deprived MCF-7:5C cells were used to model the [...]

Menée sur une cohorte de 83 008 femmes ayant subi une conisation entre 1978 et 2011 (durée médiane de suivi : 14,9 ans), cette étude danoise évalue, par rapport à la population générale, l'association entre la conisation, utilisée comme marqueur d'une infection persistante par le papillomavirus humain, et le risque de cancer gastrointestinal (988 cas)

Conization as a marker of persistent cervical human papillomavirus (HPV) infection and risk of gastrointestinal cancer: a Danish 34-year nationwide cohort study

Kirkegård, Jakob ; Farkas, DoraKörmendiné ; Søgaard, Mette ; Schmidt, SigrúnAlbaJóhannesdóttir ; Ostenfeld, EvaBjerre ; Cronin-Fenton, Deirdre

Purpose : Persistent cervical infection with human papillomavirus (HPV) may be a marker of poor immune function and thus associated with an increased cancer risk. HPV infection is implicated in all cases of cervical cancer, but except for anal and esophageal cancers, the association between persistent HPV infection and gastrointestinal cancer has not been investigated. Methods : We performed a nationwide population-based cohort study of 83,008 women undergoing cervical conization between 1978 [...]

Menée en Italie auprès de 3 842 femmes présentant des anomalies cytologiques cervicales, cette étude transversale analyse l'association entre des infections multiples par le papillomavirus humain et le risque de néoplasies cervicales intraépithéliales

Multiple human papillomavirus infection with or without type 16 and risk of cervical intraepithelial neoplasia among women with cervical cytological abnormalities

Spinillo, Arsenio ; Gardella, Barbara ; Roccio, Marianna ; Alberizzi, Paola ; Cesari, Stefania ; Patrizia, Morbini ; Silini, Enrico

Purpose : To evaluate the impact of multiple human papillomavirus (HPV) infections on the risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in subjects with cervical cytological abnormalities. Methods : A cross-sectional study of 3,842 women attending a colposcopy service was carried out. Genotyping of 18 high-risk, seven low-risk, and two undefined-risk HPVs was carried out by the INNO-LiPA genotyping system. Results : The final colposcopic/pathological diagnoses were as [...]

A partir d'échantillons tumoraux prélevés sur 279 patients atteints d'un cancer de la tête et du cou, cette étude met en évidence des mécanismes par lesquels le papillomavirus humain interagit avec le génome de l'hôte pour favoriser la tumorigenèse

Characterization of HPV and host genome interactions in primary head and neck cancers

Parfenov, Michael ; Pedamallu, Chandra Sekhar ; Gehlenborg, Nils ; Freeman, Samuel S. ; Danilova, Ludmila ; Bristow, Christopher A. ; Lee, Semin ; Hadjipanayis, Angela G. ; Ivanova, Elena V. ; Wilkerson, Matthew D. ; Protopopov, Alexei ; Yang, Lixing ; Seth, Sahil ; Song, Xingzhi ; Tang, Jiabin ; Ren, Xiaojia ; Zhang, Jianhua ; Pantazi, Angeliki ; Santoso, Netty ; Xu, Andrew W. ; Mahadeshwar, Harshad ; Wheeler, David A. ; Haddad, Robert I. ; Jung, Joonil ; Ojesina, Akinyemi I. ; Issaeva, Natalia ; Yarbrough, Wendell G. ; Hayes, D. Neil ; Grandis, Jennifer R. ; El-Naggar, Adel K. ; Meyerson, Matthew ; Park, Peter J. ; Chin, Lynda ; Seidman, J. G. ; Hammerman, Peter S. ; Kucherlapati, Raju ; the Cancer Genome Atlas Network

Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with [...]

Menée au Danemark à partir des données des registres des cancers sur la période 2000-2010, cette étude analyse l'évolution de la prévalence d'une infection par le papillomavirus humain dans les tumeurs des amygdales

A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000–2010: The largest registry-based study to date

Garnaes, Emilie ; Kiss, Katalin ; Andersen, Luise ; Therkildsen, Marianne H. ; Franzmann, Maria B. ; Filtenborg-Barnkob, Bettina ; Hoegdall, Estrid ; Krenk, Lene ; Josiassen, Michael ; Lajer, Christel B. ; Specht, Lena ; Frederiksen, Kirsten ; Friis-Hansen, Lennart ; Nielsen, Finn C. ; Kjaer, Susanne K. ; Norrild, Bodil ; von Buchwald, Christian

The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000–2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin (i.e., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank [...]

Menée au Danemark auprès de 123 322 participants, cette étude de cohorte en population évalue l'association entre l'utilisation de traitements pour la fertilité chez la mère, notamment la progestérone, et le risque de cancer chez l'enfant

Maternal use of fertility drugs and risk of cancer in children—A nationwide population-based cohort study in Denmark

Hargreave, Marie ; Jensen, Allan ; Nielsen, Thor Schütt Svane ; Colov, Emilie Palmgren ; Andersen, Klaus Kaae ; Pinborg, Anja ; Kjaer, Susanne Krüger

Large population-based studies are needed to examine the effect of maternal use of fertility drugs on the risk of cancer in children, while taking into account the effect of the underlying infertility. A cohort of 123,322 children born in Denmark between 1964 and 2006 to 68,255 women who had been evaluated for infertility was established. We used a case–cohort design and calculated hazard ratios (HRs) for cancer in childhood (0–19 years) and in young adulthood (20–29 years) associated with [...]

A partir des données du registre danois des cancers portant sur 38 484 cas de carcinome basocellulaire cutané, 3 724 cas de carcinome épidermoïde cutané et autant de témoins en population, cette étude évalue l'association entre l'utilisation de statines et le risque de cancer de la peau hors mélanome, sur la période 2005-2009

Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark

Arnspang, S. ; Pottegard, A. ; Friis, S. ; Clemmensen, O. ; Andersen, K. E. ; Hallas, J. ; Gaist, D.

Background: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). Methods: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005–2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use. Results: We identified 38 484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06–1.13) for BCC and 1.01 [...]

A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 288 683 hommes et 192 514 femmes, cette étude évalue l'association entre la taille à l'âge adulte, le sexe de l'individu et le risque de cancer selon différentes localisations

Attained height, sex, and risk of cancer at different anatomic sites in the NIH-AARP Diet and Health Study

Kabat, GeoffreyC ; Kim, MimiY ; Hollenbeck, AlbertR ; Rohan, ThomasE

Purpose : To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women. Methods : The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios [...]

Menée à l'aide de modèles murins, puis à partir de données portant sur 1 771 personnes porteuses de mutations du gène TP53 associées au syndrome familial de Li-Fraumeni, cette étude propose un modèle appelé "régression génétique" pour rendre compte de l'évolution de l'âge de survenue d'un cancer d'une génération à l'autre

Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li–Fraumeni cancer predisposition syndrome

Ariffin, Hany ; Hainaut, Pierre ; Puzio-Kuter, Anna ; Choong, Soo Sin ; Chan, Adelyne Sue Li ; Tolkunov, Denis ; Rajagopal, Gunaretnam ; Kang, Wenfeng ; Lim, Leon Li Wen ; Krishnan, Shekhar ; Chen, Kok-Siong ; Achatz, Maria Isabel ; Karsa, Mawar ; Shamsani, Jannah ; Levine, Arnold J. ; Chan, Chang S.

The Li–Fraumeni syndrome (LFS) and its variant form (LFL) is a familial predisposition to multiple forms of childhood, adolescent, and adult cancers associated with germ-line mutation in the TP53 tumor suppressor gene. Individual disparities in tumor patterns are compounded by acceleration of cancer onset with successive generations. It has been suggested that this apparent anticipation pattern may result from germ-line genomic instability in TP53 mutation carriers, causing increased DNA [...]

Menée au Danemark sur la période 1993-1997 et incluant 26 944 hommes âgés de 50 à 64 ans, cette étude de cohorte prospective évalue l'association entre l'obésité, le risque de cancer de la prostate et la mortalité spécifique

Prostate cancer incidence, clinical stage and survival in relation to obesity: A prospective cohort study in Denmark

Møller, Henrik ; Roswall, Nina ; Van Hemelrijck, Mieke ; Larsen, Signe Benzon ; Cuzick, Jack ; Holmberg, Lars ; Overvad, Kim ; Tjønneland, Anne

There is no clear link between obesity and prostate cancer incidence but an association has been reported between obesity and fatal prostate cancer. We report on two prospective cohort analyses on (i) the incidence of prostate cancer in relation to obesity in a cohort of men with no previous cancer, and on (ii) the stage distribution and prostate cancer specific mortality in relation to obesity among men with prostate cancer. The “Diet, Cancer and Health” prospective cohort study was [...]

Menée aux Etats-Unis auprès de 957 patients atteints d'un cancer de la prostate et issus de 270 familles d'origine européenne affectées par le cancer de la prostate, cette étude évalue l'association entre 22 polymorphismes à simple nucléotide de gènes liés à la mortalité spécifique par cancer de la prostate et le risque d'une forme létale de cancer de la prostate

Confirmation of genetic variants associated with lethal prostate cancer in a cohort of men from hereditary prostate cancer families

Karyadi, Danielle M. ; Zhao, Shanshan ; He, Qianchuan ; McIntosh, Laura ; Wright, Jonathan L. ; Ostrander, Elaine A. ; Feng, Ziding ; Stanford, Janet L.

Germline genetic variants have been suggested as prognostic biomarkers for identifying patients at high risk for lethal prostate cancer (PCa). Validation studies have confirmed the association of several single nucleotide polymorphisms (SNPs) with fatal PCa, but whether these variants affect PCa-specific mortality (PCSM) in patients with an inherited predisposition to PCa, based on familial history, is unknown. For this study, a cohort of 957 PCa patients from 270 hereditary prostate cancer [...]

Menée sur 53 patients atteints d'une forme héréditaire de cancer colorectal appelée syndrome X, cette étude identifie des variants du gène SEMA4A prédisposant à la maladie

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X

Schulz, Eduard ; Klampfl, Petra ; Holzapfel, Stefanie ; Janecke, Andreas R. ; Ulz, Peter ; Renner, Wilfried ; Kashofer, Karl ; Nojima, Satoshi ; Leitner, Anita ; Zebisch, Armin ; Wölfler, Albert ; Hofer, Sybille ; Gerger, Armin ; Lax, Sigurd ; Beham-Schmid, Christine ; Steinke, Verena ; Heitzer, Ellen ; Geigl, Jochen B. ; Windpassinger, Christian ; Hoefler, Gerald ; Speicher, Michael R. ; Richard Boland, C. ; Kumanogoh, Atsushi ; Sill, Heinz

Familial colorectal cancer type X (FCCTX) is characterized by clinical features of hereditary non-polyposis colorectal cancer with a yet undefined genetic background. Here we identify the SEMA4A p.Val78Met germline mutation in an Austrian kindred with FCCTX, using an integrative genomics strategy. Compared with wild-type protein, SEMA4AV78M demonstrates significantly increased MAPK/Erk and PI3K/Akt signalling as well as cell cycle progression of SEMA4A-deficient HCT-116 colorectal cancer cells. [...]

Menée dans les îles Canaries (Espagne) auprès de 140 cas et 206 témoins, cette étude évalue l'association entre une exposition à des hydrocarbures aromatiques polycycliques et le risque de cancer de la vessie, selon la présence de polymorphismes des gènes liés à la glutathion S-transférase, le statut tabagique et la consommation de café

Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain)

Boada, Luis D. ; Henríquez-Hernández, Luis A. ; Navarro, Patricio ; Zumbado, Manuel ; Almeida-González, Maira ; Camacho, María ; Álvarez-León, Eva E. ; Valencia-Santana, Jorge A. ; Luzardo, Octavio P.

Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to bladder cancer. Objective: To evaluate the role of PAHs in bladder cancer, PAHs serum levels were measured in patients and controls from a case-control study. Methods:A total of 140 bladder cancer patients and 206 healthy controls were included in the study. Sixteen PAHs were analyzed from the serum of subjects by gas chromatography–mass spectrometry. Results:Serum PAHs did not appear to be related to bladder [...]