Menée aux Etats-Unis auprès de 1 598 survivants adultes d'un cancer pédiatrique, cette étude analyse l'association entre leurs modes de vie et comportements de santé et le risque de syndrome métabolique

Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study

Smith, Webb A. ; Li, Chenghong ; Nottage, Kerri A. ; Mulrooney, Daniel A. ; Armstrong, Gregory T. ; Lanctot, Jennifer Q. ; Chemaitilly, Wassim ; Laver, Joseph H. ; Srivastava, Deo Kumar ; Robison, Leslie L. ; Hudson, Melissa M. ; Ness, Kirsten K.

BACKGROUND Childhood cancer survivors (CCS) are at an increased risk of developing metabolic syndrome (MetSyn), which may be reduced with lifestyle modifications. The purpose of this investigation was to characterize lifestyle habits and associations with MetSyn among CCS. METHODS CCS who were≥10 years from diagnosis, aged>18 years, and participating in the St. Jude Lifetime Cohort Study completed medical and laboratory tests and a food frequency questionnaire. The Third Report of the National [...]

Menée en Australie par entretiens auprès de 38 survivants d'un cancer, cette étude analyse les obstacles rencontrés dans leur retour au travail après une chimiothérapie et évalue leurs besoins en soins de support

Returning to work following curative chemotherapy: a qualitative study of return to work barriers and preferences for intervention

Knott, Vikki ; Zrim, Stephanie ; Shanahan, E. Michael ; Anastassiadis, Peter ; Lawn, Sharon ; Kichenadasse, Ganessan ; Sukumaran, Shawgi ; Karapetis, Christos ; Koczwara, Bogda

Purpose : This study aimed to explore barriers to return to work (RTW) and preferences for intervention and support for cancer patients treated with curative intent from the perspectives of cancer survivors and oncology health professionals. Methods : Participants attended a focus group (N=24) or an individual interview (N=14). A topic guide and a semi-structured recorded interview format were used to gather data, which were later transcribed and analysed for global themes and subthemes. [...]

Mené au Royaume-Uni auprès de 830 patientes atteintes d'un cancer du sein de stade précoce, cet essai multicentrique analyse la qualité de vie des patientes en fonction des traitements reçus (chimiothérapies à base de taxanes ou d'anthracyclines)

Comparison of patient reported quality of life and impact of treatment side effects experienced with a taxane-containing regimen and standard anthracycline based chemotherapy for early breast cancer: 6 year results from the UK TACT trial (CRUK/01/001)

Hall, E. ; Cameron, D. ; Waters, R. ; Barrett-Lee, P. ; Ellis, P. ; Russell, S. ; Bliss, J. M. ; Hopwood, P.

Background : The TACT trial (CRUK/01/001) compared adjuvant sequential FEC-docetaxel (FEC-D) chemotherapy with standard anthracycline-based chemotherapy of similar duration in women with early breast cancer. Results at a median of 5 years suggested no improvement in disease-free survival with FEC-D. Given differing toxicity profiles of the regimens, the impact on quality of life (QL) was explored. Methods : Patients from 44 centres completed standardised QL questionnaires before chemotherapy, [...]

Menée au Canada par questionnaires auprès de 199 survivantes d'un cancer du sein, cette étude analyse l'évolution de leur niveau d'activité physique, à 3, 6 , 9 et 12 mois après les traitements

Identification and prediction of physical activity trajectories in women treated for breast cancer

Brunet, Jennifer ; Amireault, Steve ; Chaiton, Michael ; Sabiston, Catherine M.

Purpose : In this study, we aimed to identify trajectories of physical activity (PA) in a cohort of women over a one-year period following treatment for breast cancer. We also examined factors that could predict trajectory group membership. Methods : We collected data from 199 women using questionnaires at baseline [mean = 3.46 months post-treatment], and 3, 6, 9, and 12 months thereafter. Results : Based on semi-parametric group-based modeling, there were five trajectories: consistently [...]

Menée en Italie à partir des données de tomodensitométrie de 13 565 patients atteints de cancer, cette étude rétrospective analyse l'association entre un traitement à base de taxanes et des effets secondaires de type allergique sévère liés aux injections intraveineuses de produits de contraste iodés

Taxanes as a Risk Factor for Acute Adverse Reactions to Iodinated Contrast Media in Cancer Patients

Farolfi, Alberto ; Della Luna, Corradina ; Ragazzini, Angela ; Carretta, Elisa ; Gentili, Nicola ; Casadei, Carla ; Aquilina, Michele ; Barone, Domenico ; Minguzzi, Martina ; Amadori, Dino ; Nanni, Oriana ; Gavelli, Giampaolo

Background. The impact of cytotoxic agents on the risk of acute allergy-like adverse reactions (ARs) to intravenous iodinated contrast media (ICM) injections is unknown. Methods. We retrospectively reviewed 13,565 computed tomography (CT) scans performed in a consecutive cohort of cancer patients from January 1, 2010 to December 31, 2012. Episodes of acute ICM-related ARs were reported to the pharmacovigilance officer. The following matched comparisons were made: tax code, gender, primary [...]

Menée aux Etats-Unis auprès de 1 032 patients atteints d'un cancer du poumon à petites cellules, cette étude analyse l'évolution de la survie globale sur la période 1986-2008

Temporal trends from 1986 to 2008 in overall survival of small cell lung cancer patients

Schabath, Matthew B. ; Nguyen, Anthony ; Wilson, Patrick ; Sommerer, Katelyn R. ; Thompson, Zachary J. ; Chiappori, Alberto A.

Objectives : An assessment of temporal trends in patient survival is important to determine the progress towards patient outcomes and to reveal where advancements must be made. This study assessed temporal changes spanning 22 years in demographics, clinical characteristics, and overall survival of small cell lung cancer (SCLC) patients. Materials and methods : This analysis included 1,032 SCLC patients spanning two time-periods from the H. Lee Moffitt Cancer Center and Research Institute: 1986 [...]

Menée aux Etats-Unis auprès de 43 cas et 86 témoins, cette étude de cohorte rétrospective analyse l'impact des disparités dans les traitements d'un cancer de la prostate sur la survie des patients infectés par le VIH

Are HIV-Infected Men Vulnerable to Prostate Cancer Treatment Disparities?

Murphy, Adam B. ; Bhatia, Ramona ; Martin, Iman K. ; Klein, David A. ; Hollowell, Courtney M.P. ; Nyame, Yaw ; Dielubanza, Elodi ; Achenbach, Chad ; Kittles, Rick A.

Background: HIV-infected (HIV+) men face cancer treatment disparities which impact outcome. Prostate cancer (PCa) treatment and treatment appropriateness in HIV+ men are unknown. Methods: We used electronic chart review to conduct a retrospective cohort study of 43 HIV+ cases with PCa and 86 age- and race-matched HIV-uninfected (HIV-) controls with PCa, aged 40-79, from 2001-2012. We defined treatment appropriateness using National Comprehensive Cancer Network (NCCN) guidelines and the Charlson [...]

A partir des données des registres américains des cancers portant sur 140 474 patients atteints d'un cancer de la prostate non métastatique diagnostiqué entre 1995 et 2009, cette étude analyse les effets d'un traitement anti-androgénique sur la survenue d'événements cardiovasculaires

The impact of androgen-deprivation therapy (ADT) on the risk of cardiovascular (CV) events in patients with non-metastatic prostate cancer: a population-based study

Gandaglia, Giorgio ; Sun, Maxine ; Popa, Ioana ; Schiffmann, Jonas ; Abdollah, Firas ; Trinh, Quoc-Dien ; Saad, Fred ; Graefen, Markus ; Briganti, Alberto ; Montorsi, Francesco ; Karakiewicz, Pierre I.

Objective : To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. Patients and Methods : In all, 140 474 patients diagnosed with non-metastatic prostate cancer between 1995 and 2009 within the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked [...]

Menée à Taïwan auprès de 6 937 patients atteints d'un cancer du colon et recevant un traitement chirurgical curatif, cette étude de cohorte évalue l'association entre un diabète de type 2 et la mortalité des patients

Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Asian Patients Receiving Curative Surgery for Colon Cancer

Chen, Kuo-Hsing ; Shao, Yu-Yun ; Lin, Zhong-Zhe ; Yeh, Yi-Chun ; Shau, Wen-Yi ; Kuo, Raymond Nienchen ; Chen, Ho-Min ; Lai, Chiu-Ling ; Yeh, Kun-Huei ; Cheng, Ann-Lii ; Lai, Mei-Shu

Background. We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery. Methods. From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of [...]

A partir d'une revue systématique de la littérature (29 études, 51 303 patients), cette méta-analyse évalue l'association entre le surpoids, l'obésité et la survie de patients atteints d'un cancer colorectal

Association of obesity and overweight with overall survival in colorectal cancer patients: a meta-analysis of 29 studies

Wu, Shuangjie ; Liu, Jun ; Wang, Xinhai ; Li, Mengjun ; Gan, Yu ; Tang, Yifan

Purpose : Previous studies that assessed the relationship between obesity, overweight, and survival in colorectal cancer (CRC) have provided conflicting results. Therefore, we quantitatively summarized existing evidence to estimate the association between obesity/overweight and overall survival (OS) in CRC patients and explored potentially important sources of variability. Methods : Eligible studies were identified via PubMed and EMBASE searches. The summary hazard ratio (sHR) was estimated [...]

Menée aux Etats-Unis auprès de 621 femmes atteintes d'un cancer du sein, cette étude de cohorte analyse l'association entre l'adiposité, le tour de taille et la mortalité spécifique ou la mortalité toutes causes confondues

Central adiposity after breast cancer diagnosis is related to mortality in the Health, Eating, Activity, and Lifestyle study

George, StephanieM ; Bernstein, Leslie ; Smith, AshleyW ; Neuhouser, MarianL ; Baumgartner, KathyB ; Baumgartner, RichardN ; Ballard-Barbash, Rachel

We examined whether waist circumference (WC) and waist-to-hip ratio (WHR) after breast cancer diagnosis are associated with all-cause or breast cancer-specific mortality and explored potential biological pathways mediating these relationships. Our analysis included 621 women diagnosed with local or regional breast cancer who participated in the Health, Eating, Activity, and Lifestyle study. At 30 (±4) months postdiagnosis, trained staff measured participants’ waist and hip circumferences and [...]

A partir d'une revue de la littérature, cette étude analyse l'association entre une infection par le papillomavirus humain et la survie de patients atteints d'un carcinome épidermoïde de la tête et du cou

The Current and Future Impact of Human Papillomavirus on Treatment of Squamous Cell Carcinoma of the Head and Neck

Psyrri, A. ; Rampias, T. ; Vermorken, J.B.

Background : Squamous cell carcinoma of the head and neck (SCCHN) was traditionally associated with smoking and alcohol use; however, human papillomavirus (HPV) infection has recently been implicated as a novel risk factor for oropharyngeal tumors. Furthermore, HPV-associated oropharyngeal carcinoma appears to be a distinct entity with different epidemiology, biology, and clinical outcomes. Methods : Here, we comprehensively review the existing data regarding HPV status and prognostic or [...]

A partir des données du registre irlandais des cancers portant sur 264 survivants d'un cancer de la tête et du cou, cette étude analyse les facteurs liés aux modifications de leur vie professionnelle, 1 an et 5 ans après le diagnostic

Long-term workforce participation patterns following head and neck cancer

Pearce, Alison ; Timmons, Aileen ; O’Sullivan, Eleanor ; Gallagher, Pamela ; Gooberman-Hill, Rachael ; Thomas, AudreyAlforque ; Molcho, Michal ; Butow, Phyllis ; Sharp, Linda

Purpose : This analysis describes the long-term workforce participation patterns of individuals diagnosed with head and neck cancer (HNC). Methods : Survivors of HNC (ICD10 C00-C14, C32) diagnosed at least 8 months previously were identified from the National Cancer Registry Ireland and sent a survey including questions about working arrangements before and since diagnosis. Descriptive statistics and multivariate logistic regression were used to examine the factors that influence workforce [...]

Menée en Suisse par entretiens (au moment du diagnostic et six mois plus tard) auprès de 8 patients atteints d'un mélanome malin et de leurs partenaires de vie, cette étude qualitative analyse leurs capacités de résilience

Resilience in patients and spouses faced with malignant melanoma. A qualitative longitudinal study

Engeli, L. ; Moergeli, H. ; Binder, M. ; Drabe, N. ; Meier, C. ; Buechi, S. ; Dummer, R. ; Jenewein, J.

Life-threatening diseases like malignant tumours are associated with considerable existential distress. Little is known about the factors that promote resilience within these individuals. This longitudinal qualitative partner study aimed to analyse resilience as per Antonovsky's sense of coherence. Eight patients with malignant melanoma and their partners were interviewed. They were asked about their coping strategies, attitudes towards the meaning of life and their cancer, and comprehension of [...]

Menée aux Etats-Unis auprès de 382 cas et 381 témoins, cette étude évalue les effets d'une coordination du parcours de soins sur la prescription des traitements de référence d'un cancer du sein

Can Patient Navigation Improve Receipt of Recommended Breast Cancer Care? Evidence From the National Patient Navigation Research Program

Ko, Naomi Y. ; Darnell, Julie S. ; Calhoun, Elizabeth ; Freund, Karen M. ; Wells, Kristin J. ; Shapiro, Charles L. ; Dudley, Donald J. ; Patierno, Steven R. ; Fiscella, Kevin ; Raich, Peter ; Battaglia, Tracy A.

Purpose : Poor and underserved women face barriers in receiving timely and appropriate breast cancer care. Patient navigators help individuals overcome these barriers, but little is known about whether patient navigation improves quality of care. The purpose of this study is to examine whether navigated women with breast cancer are more likely to receive recommended standard breast cancer care. Patients and Methods : Women with breast cancer who participated in the national Patient Navigation [...]