A partir des données d'un registre britannique des cancers de l'enfant et de l'adolescent portant sur 3 247 survivants à long terme d'un cancer pédiatrique, cette étude analyse l'incidence des séquelles cardiovasculaires en fonction de l'âge au diagnostic

Cardiovascular sequelae in long-term survivors of young peoples' cancer: a linked cohort study

van Laar, M. ; Feltbower, R. G. ; Gale, C. P. ; Bowen, D. T. ; Oliver, S. E. ; Glaser, A.

Background: We aimed to define the incidence and risk of cardiovascular late effects (LEs) identified from inpatient hospital episode statistics (HES) among long-term survivors of cancer in young people by age at diagnosis (0–14 and 15–29 years). Methods: Records from the Yorkshire Specialist Register of Cancer in Children and Young People (1991–2006) were linked to inpatient HES data (1996–2011) to assess rates of cardiovascular LEs. Rates were compared with the general population in Yorkshire [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2013 (15 études), cette méta-analyse évalue les symptômes de fatigue chez les patients atteints d'une tumeur solide traitée par sorafenib, sunitinib ou pazopanib

Treatment-related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: An up-to-date review and meta-analysis of clinical trials

Santoni, Matteo ; Conti, Alessandro ; Massari, Francesco ; Arnaldi, Giorgio ; Iacovelli, Roberto ; Rizzo, Mimma ; De Giorgi, Ugo ; Trementino, Laura ; Procopio, Giuseppe ; Tortora, Giampaolo ; Cascinu, Stefano

Fatigue is the most common symptom associated with cancer and cancer treatment. We performed an up-to-date meta-analysis to determine the incidence and relative risk (RR) of fatigue in patients (pts) with cancer treated with sorafenib (SO), sunitinib (SU) and pazopanib (PZ). PubMed databases were searched for articles published till August 2013. Eligible studies were selected according to PRISMA statement. Summary incidence, RR and 95% confidence intervals were calculated using random-effects [...]

A partir des données des registres nationaux de cinq pays nordiques portant sur 32 903 survivants d'un cancer diagnostiqué avant l'âge de 20 ans, cette étude de cohorte analyse le risque de diabète dans cette population en association avec les traitements anti-cancéreux

Adult Life after Childhood Cancer in Scandinavia: Diabetes mellitus following treatment for cancer in childhood

Holmqvist, Anna Sällfors ; Olsen, Jørgen H. ; Andersen, Klaus Kaae ; Licht, Sofie de Fine ; Hjorth, Lars ; Garwicz, Stanislaw ; Moëll, Christian ; Anderson, Harald ; Wesenberg, Finn ; Tryggvadottir, Laufey ; Malila, Nea ; Boice, John D. ; Hasle, Henrik ; Winther, Jeanette Falck

An increased risk for diabetes mellitus (DM) adds significantly to the burden of late complications in childhood cancer survivors. Complications of DM may be prevented by using appropriate screening. It is, therefore, important to better characterise the reported increased risk for DM in a large population-based setting. From the national cancer registries of the five Nordic countries, a cohort of 32,903 1-year survivors of cancer diagnosed before the age of 20 between start of cancer [...]

Menée aux Etats-Unis auprès de 263 survivants d'une leucémie lymphoblastique aiguë pédiatrique (âge moyen au diagnostic : 3,9 ans ; âge au moment de l'évaluation : 7-17 ans), cette étude multicentrique analyse leur fonctionnement neurocognitif et leur qualité de vie

The contribution of neurocognitive functioning to quality of life after childhood acute lymphoblastic leukemia

Kunin-Batson, Alicia ; Kadan-Lottick, Nina ; Neglia, Joseph P.

Background : Neurocognitive late effects after childhood acute lymphoblastic leukemia (ALL) are well-documented, but their impact on quality of life (QOL) is not well understood. In this multi-site study, we examined the relative influence of neurocognitive functioning, steroid randomization (prednisone vs. dexamethasone), and demographic characteristics on QOL in first-remission survivors of childhood ALL. Methods : Participants included 263 ALL survivors (ages 7–17 years at the time of [...]

Menée en Italie auprès de 187 patientes atteintes d'un cancer du sein, cette étude analyse l'incidence, les facteurs prédictifs et le pronostic d'une scapula ailée (décollement de l'omoplate) après un curage axillaire lors d'une chirurgie mammaire

Incidence, predictive factors, and prognosis for winged scapula in breast cancer patients after axillary dissection

Nevola Teixeira, LuizFelipe ; Lohsiriwat, Visnu ; Schorr, MarioCasales ; Luini, Alberto ; Galimberti, Viviana ; Rietjens, Mario ; Garusi, Cristina ; Gandini, Sara ; Sarian, LuisOtavioZanatta ; Sandrin, Fabio ; Simoncini, MariaClaudia ; Veronesi, Paolo

Purpose : Axillary lymph node dissection is part of breast cancer surgery, and winged scapula is a possible sequela. Data regarding its incidence, predictive factors, and patient prognosis remains inconsistent. Ignorance of its diagnosis may lead to undertreatment with physical morbidity. Methods : Breast cancer patients with axillary lymph node dissection were prospectively recruited. Postoperative examinations by the physiotherapy staff were performed. Results : One hundred eighty-seven [...]

A partir des données de la cohorte "Women's Health Initiative" incluant 2 317 femmes ménopausées âgées de 50 à 79 ans et atteintes d'un cancer du sein invasif, cette étude prospective analyse l'impact de l'adhésion aux recommandations alimentaires sur leur qualité de vie et la réduction de la mortalité

Better postdiagnosis diet quality is associated with reduced risk of death among postmenopausal women with invasive breast cancer in the Women's Health Initiative

George, Stephanie M. ; Ballard-Barbash, Rachel ; Shikany, James ; Caan, Bette J. ; Freudenheim, Jo L. ; Kroenke, Candyce H. ; Vitolins, Mara Z. ; Beresford, Shirley A. A. ; Neuhouser, Marian L.

Background: Few studies have evaluated whether adherence to dietary recommendations is associated with mortality among cancer survivors. In breast cancer survivors, we examined how postdiagnosis Healthy Eating Index (HEI)-2005 scores were associated with all-cause and cause-specific mortality. Methods: Our prospective cohort study included 2317 postmenopausal women, aged 50-79 years, in the Women's Health Initiative's Dietary Modification Trial (n=1205) and Observational Study (n=1112) who were [...]

Menée au Canada auprès de 36 patients atteints de métastatases cérébrales, cette étude analyse l'effet d'une radiothérapie du cerveau entier sur leur degré de fatigue

Fatigue scores in patients with brain metastases receiving whole brain radiotherapy

Pulenzas, Natalie ; Khan, Luluel ; Tsao, May ; Zhang, Liying ; Lechner, Breanne ; Thavarajah, Nemica ; Barnes, Elizabeth ; Danjoux, Cyril ; Holden, Lori ; Lauzon, Natalie ; Sheehan, Parker ; Bedard, Gillian ; Chow, Edward

Purpose : Whole brain radiotherapy (WBRT) is a treatment strategy used commonly to relieve burdensome symptoms and improve quality of life (QOL) in patients with multiple brain metastases. The purpose of this study is to determine changes in fatigue score following WBRT as it is a common symptom experienced in this population. Methods : Fatigue and overall QOL scores were collected prospectively in patients for up to 3 months post-WBRT by several questionnaires at different times including the [...]

Menée en Australie à partir d'échantillons tumoraux prélevés sur 112 patients atteints d'un cancer anal, cette étude analyse la prévalence d'une infection par le papillomavirus humain, en fonction de l'âge du patient et du génotype

Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers

Hillman, Richard J. ; Garland, Suzanne M. ; Gunathilake, Manoji P. W. ; Stevens, Matthew ; Kumaradevan, Nirmala ; Lemech, Charlotte ; Ward, Robyn L. ; Meagher, Alan ; McHugh, Leo ; Jin, Fengyi ; Carroll, Susan ; Goldstein, David ; Grulich, Andrew E. ; Tabrizi, Sepehr N.

Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV-infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males [...]

A partir des données des registres américains des cancers portant sur 7 384 patients atteints d'un sarcome des tissus mous des extrêmités diagnostiqué entre 2004 et 2009, cette étude analyse l'impact du statut marital sur les traitements reçus et sur la survie

Effect of marital status on treatment and survival of extremity soft tissue sarcoma

Alamanda, V. K. ; Song, Y. ; Holt, G. E.

Background : Spousal support has been hypothesized as providing important psychosocial support for patients and as such has been noted to provide a survival advantage in a number of chronic diseases and cancers. However, the specific effect of marital status on survival in soft tissue sarcomas (STSs) of the extremity has not been explored in detail. Patients and methods : A total of 7384 patients were evaluated for this study using a Surveillance, Epidemiology, and End Results (SEER) registry [...]

Menée en Allemagne à partir de données portant sur 8 935 patientes atteintes d'un cancer du sein primitif, cette étude de cohorte rétrospective multicentrique analyse l'association entre une radiothérapie adjuvante conforme aux recommandations et la survie des patientes

The impact of adjuvant radiotherapy on the survival of primary breast cancer patients: a retrospective multicenter cohort study of 8935 subjects

Wöckel, A. ; Wolters, R. ; Wiegel, T. ; Novopashenny, I. ; Janni, W. ; Kreienberg, R. ; Wischnewsky, M. ; Schwentner, L. ; for the BRENDA study group

Background : Radiotherapy (RT) is proven to be an important backbone for adjuvant therapy in randomized, controlled trials, but it is unclear if these effects are provable in a daily routine cohort of breast cancer patients. This study sought to answer the following questions in a daily routine cohort of breast cancer patients:1. Does guideline-adherent RT improve primary breast cancer patient survival?2. Is breast-conserving surgery (BCS) followed by RT equal to a mastectomy (MA) with regard [...]

A partir d'échantillons tumoraux de160 patientes atteintes d'un cancer du sein triplement négatif, cette étude américaine analyse les disparités dans la survie des patientes afro-américaines et de type caucasien

Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer

Sturtz, Lori ; Melley, Jen ; Mamula, Kim ; Shriver, Craig ; Ellsworth, Rachel

BACKGROUND:Although diagnosed less often, breast cancer in African American women (AAW) displays different characteristics compared to breast cancer in Caucasian women (CW), including earlier onset, less favorable clinical outcome, and an aggressive tumor phenotype. These disparities may be attributed to differences in socioeconomic factors such as access to health care, lifestyle, including increased frequency of obesity in AAW, and tumor biology, especially the higher frequency of triple [...]

Menée dans cinq pays européens auprès de soignants de patients atteints d'un cancer (France, Allemagne, Italie, Espagne, Royaume-Uni), cette étude analyse les effets de leur pratique professionnelle sur leur santé mentale et physique

Quantifying the burden of informal caregiving for patients with cancer in Europe

Goren, Amir ; Gilloteau, Isabelle ; Lees, Michael ; daCosta DiBonaventura, Marco

Purpose : Informal caregivers for patients with cancer provide critical emotional and instrumental support, but this role can cause substantial burden. This study expands our understanding of cancer-related caregiving burden in Europe. Methods : Caregivers (n=1,713) for patients with cancer and non-caregivers (n=103,868) were identified through the 2010 and 2011 European Union National Health and Wellness Survey, administered via the Internet to adult populations in France, Germany, Italy, [...]

Menée aux Etats-Unis auprès de 248 patients atteints de cancer, cette étude analyse l'efficacité d'un outil de détection de leur détresse liée à la chirurgie plastique reconstructive et aux changements de leur image corporelle pour leur permettre d'accéder à des soins psychologiques adaptés

Body image screening for cancer patients undergoing reconstructive surgery

Fingeret, Michelle Cororve ; Nipomnick, Summer ; Guindani, Michele ; Baumann, Donald ; Hanasono, Matthew ; Crosby, Melissa

Objectives : Body image is a critical issue for cancer patients undergoing reconstructive surgery, as they can experience disfigurement and functional impairment. Distress related to appearance changes can lead to various psychosocial difficulties, and patients are often reluctant to discuss these issues with their healthcare team. Our goals were to design and evaluate a screening tool to aid providers in identifying patients who may benefit from referral for specialized psychosocial care to [...]

A partir des données du registre des cancers de l'Utah et menée par entretien auprès de 53 survivants adultes d'un cancer pédiatrique, cette étude américaine analyse leurs expériences relatives à la communication avec leur médecin généraliste et leurs connaissances en matière de programme personnalisé d'après-cancer

Childhood cancer survivors’ primary care and follow-up experiences

Kirchhoff, AnneC ; Montenegro, RobertoE ; Warner, EchoL ; Wright, Jennifer ; Fluchel, Mark ; Stroup, AntoinetteM ; Park, ElyseR ; Kinney, AnitaY

Purpose : Although most childhood cancer survivors see a primary care provider (PCP), little is known about these encounters. We explored themes related to survivors’ (1) experiences with primary care, (2) communication with their PCPs about their cancer, and (3) their knowledge and impressions about follow-up care, including their interest in a survivor care plan (SCP). Methods : From April to July 2012, we conducted in-depth, semi-structured telephone interviews with 53 adult survivors [...]

Menée dans une province canadienne, cette étude analyse le rapport coût-efficacité d'un dépistage du cancer de la prostate par mesure du PSA en prenant en compte la qualité de vie des patients

Is prostate cancer screening cost-effective? A microsimulation model of prostate-specific antigen-based screening for British Columbia, Canada

Pataky, Reka ; Gulati, Roman ; Etzioni, Ruth ; Black, Peter ; Chi, Kim N. ; Coldman, Andrew J. ; Pickles, Tom ; Tyldesley, Scott ; Peacock, Stuart

Prostate-specific antigen (PSA) screening for prostate cancer may reduce mortality, but it incurs considerable risk of over diagnosis and potential harm to quality of life. Our objective was to evaluate the cost-effectiveness of PSA screening, with and without adjustment for quality of life, for the British Columbia (BC) population. We adapted an existing natural history model using BC incidence, treatment, cost and mortality patterns. The modeled mortality benefit of screening derives from a [...]

Menée aux Etats-Unis auprès de 296 474 patients atteints d'un cancer du côlon entre 2003 et 2010 (âge moyen : 68 ans), cette étude de cohorte analyse l'association entre la distance à parcourir avant d'accéder à une structure de soins et le stade de la maladie au diagnostic

Association Between Travel Distance and Metastatic Disease at Diagnosis Among Patients With Colon Cancer

Massarweh, Nader N. ; Chiang, Yi-Ju ; Xing, Yan ; Chang, George J. ; Haynes, Alex B. ; You, Y. Nancy ; Feig, Barry W. ; Cormier, Janice N.

Purpose : Health care access and advanced cancer stage are associated with oncologic outcomes for numerous common cancers. However, the impact of patient travel distance to health care on stage at diagnosis has not been well characterized. Methods : This study used a historical cohort of patients with colon cancer in the National Cancer Data Base from 2003 through 2010. The primary outcome, stage at diagnosis, was evaluated using hierarchical regression modeling. A secondary outcome was time to [...]

Menée en Allemagne par questionnaire auprès de 350 patients atteints de cancer, cette étude analyse l'efficacité d'un protocole d'annonce et son impact sur leur état émotionnel

Breaking bad news–what patients want and what they get: evaluating the SPIKES protocol in Germany

Seifart, C. ; Hofmann, M. ; Bär, T. ; Riera Knorrenschild, J. ; Seifart, U. ; Rief, W.

Background : Evaluation of the SPIKES protocol, a recommended guideline for breaking bad news, is sparse, and information about patients' preferences for bad-news delivery in Germany is lacking. Being the first actual–theoretical comparison of a ‘breaking bad news’ guideline, the present study evaluates the recommended steps of the SPIKES protocol. Moreover, emotional consequences and quality of bad-news delivery are investigated. Patients and methods : A total of 350 cancer patients answered [...]

Cet article présente une charte visant à améliorer la prise en compte des droits des patients atteints de cancer en Europe

A Catalyst for Change: The European Cancer Patient’s Bill of Rights

Lawler, Mark ; Le Chevalier, Thierry ; Murphy, Martin J. ; Banks, Ian ; Conte, PierFranco ; De Lorenzo, Francesco ; Meunier, Françoise ; Pinedo, H.M. ; Selby, Peter ; Armand, Jean-Pierre ; Barbacid, Mariano ; Barzach, Michèle ; Bergh, Jonas ; Bode, Gerlind ; Cameron, David A. ; de Braud, Filippo ; de Gramont, Aimery ; Diehl, Volker ; Diler, Sarper ; Erdem, Sema ; Fitzpatrick, John M. ; Geissler, Jan ; Hollywood, Donal ; Højgaard, Liselotte ; Horgan, Denis ; Jassem, Jacek ; Johnson, Peter W. ; Kapitein, Peter ; Kelly, Joan ; Kloezen, Sandra ; La Vecchia, Carlo ; Löwenberg, Bob ; Oliver, Kathy ; Sullivan, Richard ; Tabernero, Josep ; Van de Velde, Cornelis J. ; Wilking, Nils ; Wilson, Roger ; Zielinski, Christoph ; zur Hausen, Harald ; Johnston, Patrick G.

Cancer and the provision of cancer care places a significant and growing burden on patients, citizens, and economies. Europe provides some of the best cancer care in the world and conducts high-quality, globally recognized cancer research. There are still significant disparities, however, in public information about cancer, accessing cancer care, delivering optimal treatment, supporting cancer survivorship, and integrating cancer research and innovation across European countries. In addition, [...]