Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank", cette étude analyse l'association entre une consommation de thé et le risque d'adénocarcinome pancréatique puis identifie des facteurs médiateurs de cette association

Causal associations of tea consumption on risk of pancreatic adenocarcinoma and the mediating role of vascular endothelial growth factor D levels

Ouyang, Yonghao ; Zhou, Beini ; Chu, Lihua ; Chen, Xin ; Hao, Qiang ; Lei, Jiajia

Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2024 (9 méta-analyses et 57 articles), cette méta-analyse évalue l'association entre le niveau de cadmium, mesuré dans des échantillons biologiques, et le risque de cancer par localisation

Cadmium in biological samples and site-specific cancer risk and mortality: A systematic review of original articles and meta-analyses

Fanfani, Alice ; Papini, Sophia ; Bortolotti, Emma ; Vagnoni, Giulia ; Saieva, Calogero ; Bonaccorsi, Guglielmo ; Caini, Saverio

Background: Cadmium (Cd) is classified as a class 1 carcinogen by the IARC, yet uncertainty persists regarding the total burden of cancer (incidence and mortality) caused by exposure to it, due to the still limited evidence with regard to its aetiological role in cancer at several body sites. Objectives and methods: We searched PubMed and EMBASE for meta-analyses and original articles published by February 1st, 2024, that focused on the link between cadmium measured in biological samples [...]

A partir d'une revue systématique de la littérature publiée jusqu'au 2 janvier 2024 (46 articles), cette étude analyse l'association entre la quantité de plomb présente dans des échantillons biologiques et le risque de cancer ainsi que la mortalité

Lead (Pb) in biological samples in association with cancer risk and mortality: A systematic literature review

Vagnoni, Giulia ; Bortolotti, Emma ; Checchi, Saverio ; Saieva, Calogero ; Berti, Giovanna ; Doccioli, Chiara ; Caini, Saverio

Background and aim: Lead (Pb) is a toxic heavy metal and pervasive environmental contaminant, and a class 2 A carcinogen according to the IARC classification, yet its link with cancer at several body sites remains uncertain. Here, we aimed at summarizing the scientific evidence regarding its association with cancer risk and mortality, focusing on studies that carried out Pb measurements in biological samples. Methods: We reviewed articles published in PubMed and EMBASE until January 2nd, 2024, [...]

Menée à l'aide de données de la "UK Biobank" portant sur des échantillons sanguins collectés auprès de 200 000 hommes et 180 000 femmes ménopausées (durée médiane de suivi : 11,8 ans), cette étude analyse l'association entre les niveaux de testostérone totale, de globuline de liaison des hormones sexuelles ou de testostérone libre et le risque de cancer primitif du foie (531 cas) en fonction du sexe

Total testosterone, sex hormone-binding globulin, and free testosterone concentrations and risk of primary liver cancer: A prospective analysis of 200,000 men and 180,000 postmenopausal women

Watling, Cody Z. ; Kelly, Rebecca K. ; Watts, Eleanor L. ; Graubard, Barry I. ; Petrick, Jessica L. ; Matthews, Charles E. ; McGlynn, Katherine A.

In most countries, males have ~2–3 times higher incidence of primary liver cancer than females. Sex hormones have been hypothesized to contribute to these differences, but the evidence remains unclear. Using data from the UK Biobank, which included ~200,000 males and ~180,000 postmenopausal females who provided blood samples at recruitment, we estimated hazard ratios (HR2) and 95% confidence intervals (CI) for a doubling in hormone concentration from multivariable adjusted Cox regression for [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 1 267 témoins et 1 267 patients atteints d'un cancer colorectal, cette étude analyse, en fonction du sexe et de la localisation, l'association entre les taux sanguins de lipocaline 2 et le risque de développer la maladie

Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort

Reichmann, Robin ; Nimptsch, Katharina ; Pischon, Tobias ; Gunter, Marc J. ; Jenab, Mazda ; Eriksen, Anne Kirstine ; Tjonneland, Anne ; Janke, Jürgen ; Katzke, Verena ; Kaaks, Rudolf ; Schulze, Matthias B. ; Eichelmann, Fabian ; Masala, Giovanna ; Sieri, Sabina ; Pasanisi, Fabrizio ; Tumino, Rosario ; Giraudo, Maria Teresa ; Rothwell, Joseph ; Severi, Gianluca ; Jakszyn, Paula ; Sanchez-Perez, Maria Jose ; Amiano, Pilar ; Colorado-Yohar, Sandra M. ; Guevara, Marcela ; Van Guelpen, Bethany ; Aglago, Elom K. ; Heath, Alicia K. ; Smith-Byrne, Karl ; Weiderpass, Elisabete ; Aleksandrova, Krasimira

Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence from human research has been scant. We, therefore, explored the association of pre-diagnostic circulating LCN2 concentrations with incident colorectal cancer (CRC) in a nested case–control study within the in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. LCN2 was [...]

Menée aux Etats-Unis à l'aide de données génomiques et démographiques portant sur 2 266 témoins et 2 116 patients pédiatriques atteints d'une leucémie aiguë lymphoblastique, cette étude analyse l'effet de gènes de réparation de l'ADN sur l'association entre une exposition prénatale au tabac et le risque de développer la maladie

The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia—A Gene-Environment Interaction Study

Wang, Xinran ; Zhong, Charlie ; Ma, Xiaomei ; Metayer, Catherine ; Mancuso, Nicolas ; Gauderman, W James ; Wiemels, Joseph L.

Background: Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children. Tobacco exposure during gestation has been investigated as a potential risk factor, but its role remains undefined. Given tobacco’s toxicological profile as a DNA damaging agent, we examined the impact of DNA repair gene variability as a source of vulnerability to tobacco exposure risk for ALL. Methods: Leveraging demographic and genotype data from two large California-based ALL epidemiology [...]