A partir d'une revue de la littérature (11 articles), cette étude analyse la présence d'une dysgueusie après une greffe de cellules souches hématopoïétiques chez les patients atteints d'un cancer

Taste alterations after hematopoietic cell transplantation: a scoping review

Dequae, Caroline G. R. ; Raber-Durlacher, Judith E. ; Epstein, Joel B. ; de Vries, Ralph ; Laheij, Alexa M. G. A.

Purpose: This review aimed to evaluate the prevalence and characteristics of dysgeusia after hematopoietic cell transplantation (HCT). Methods: A literature search (in PubMed, Embase.com and Web of Science) for clinical studies evaluating taste before and after HCT was performed up to June 22, 2023, in collaboration with a medical information specialist. After title and abstract review (N = 807) followed by full-text review (N = 61), articles that met the inclusion criteria were summarized in a [...]

Cette étude identifie les facteurs associés au risque de colite et de diarrhée chez les patients atteints d'un cancer traité par inhibiteurs de point de contrôle immunitaire et présente des stratégies de prise en charge

Immune checkpoint inhibitor-induced diarrhea and colitis: an overview

Zoghbi, Marianne ; Burk, Kathryn J. ; Haroun, Elio ; Saade, Maria ; Carreras, Maria Teresa Cruz

Immune checkpoint inhibitors (ICIs) have emerged as an integral component of the management of various cancers and have contributed to significant improvements in overall survival. Most available ICIs target anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA4), and anti-programmed cell death 1/programmed cell death ligand 1 (anti-PD1/PDL1). Gastrointestinal immune-related adverse events remain a common complication of ICIs. The predominant manifestations include diarrhea and colitis, [...]

Menée auprès de 36 patients atteints d'un cancer du poumon à petites cellules, cette étude évalue l'effet d'une intervention de rééducation pulmonaire comportant des exercices physiques (exercices d'échauffement, de respiration, d'entraînement à la marche,...) sur leurs capacités fonctionnelles et leur qualité de vie après la chimiothérapie

The effect of pulmonary rehabilitation on quality of life and functional capacity after chemotherapy in patients with small cell lung cancer

Kocamaz, Deniz ; Dinler, Elif ; Yamak, Dilek ; Hatimoğulları, Kardelen ; Bayramlar, Kezban ; Yıldırım, Mustafa

Objective: This study aimed to investigate the effect of pulmonary rehabilitation on quality of life during the survival period in individuals with small cell lung cancer. Methods: Thirty-six patients with a diagnosis of small cell lung cancer (SCLC), who completed chemotherapy treatment and were in the survival period, were included in the study. A pulmonary rehabilitation program was applied to individuals at 40–70% of submaximal heart rate, 3 days a week for 8 weeks. The pulmonary [...]

A partir d'une revue systématique de la littérature (12 études), cette étude analyse la présence de morbidités et de séquelles, notamment un lymphoedème, à la suite des traitements anticancéreux chez des patients atteints d'un cancer de la tête et du cou

Patient-reported outcome measures and physical function following head and neck lymphedema — a systematic review

Gaitatzis, Katrina ; Thompson, Belinda ; Blake, Fiona Tisdall ; Koelmeyer, Louise

Purpose: Head and neck cancer (HNC) treatments often lead to significant morbidity, including lymphedema. This systematic review aims to comprehensively explore the prevalence and impact of head and neck lymphedema (HNL) following treatment. Methods: A systematic literature search was conducted up to September 2023. Studies evaluating HNL prevalence, associated factors, impact, patient-reported outcomes (PROMs), and physical assessments were included. Methodological quality assessment was [...]

Menée aux Etats-Unis à partir de données portant sur 1 258 patients atteints d'un cancer, cette étude analyse l'accès aux thérapies géniques et la survie globale associée, en fonction du statut socioéconomique et du lieu de vie (zone rurale ou zone urbaine)

Socioeconomic and Urban-Rural Disparities in Genome-Matched Treatment Receipt and Survival after Genomic Tumor Testing

DiBiase, Jessica F ; Scharnetzki, Elizabeth ; Edelman, Emily ; Reed, E Kate ; Helbig, Petra ; Rueter, Jens ; Miesfeldt, Susan ; Frankenfeld, Cara L ; Han, Paul K J ; Jacobs, Elizabeth A ; Anderson, Eric C ; MCGI Working Group

Purpose: Emerging cancer treatments are often most available to socially advantaged individuals. This study examines the relationship of patient educational attainment, income level, and rurality to the receipt of genome-matched treatment (GMT) and overall survival. Methods: Survey and clinical data were collected from patients with cancer (n = 1258) enrolled in the Maine Cancer Genomics Initiative. Logistic regression models examined whether receipt of GMT differed by patient education, [...]

Menée à partir de données australiennes et américaines portant sur 1 392 patients âgés ayant survécu à un cancer, cette étude analyse le risque de maladie cardiovasculaire ou d'accident vasculaire cérébral en lien avec les antécédents de cancer et les traitements anticancéreux

Cardiovascular disease and stroke following cancer and cancer treatment in older adults

Muhandiramge, Jaidyn ; Zalcberg, John R. ; Warner, Erica T. ; Polekhina, Galina ; Gibbs, Peter ; van Londen, G. J. ; Bernstein, Wendy B. ; Macrae, Finlay ; Haydon, Andrew ; Tie, Jeanne ; Millar, Jeremy L. ; Mar, Victoria J. ; Gately, Lucy ; Tonkin, Andrew ; Ford, Leslie ; Umar, Asad ; Chan, Andrew T. ; Woods, Robyn L. ; Orchard, Suzanne G.

Background: Cancer survivors can be at risk of cardiovascular disease (CVD) because of either their malignancy or its treatment. Although studies linking cancer and CVD exist, few examine risk in older adults, the impact of cancer treatment, or the effect of aspirin on reducing risk in this cohort. Methods: The authors conducted a secondary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial to investigate the impact of cancer and cancer treatment on a composite CVD end [...]

Menée au Danemark sur la période 1998-2020, cette étude de cohorte analyse l'évolution de la survie des adultes atteints d'une leucémie lymphoblastique aiguë

Temporal changes in survival among adult patients with acute lymphoblastic leukaemia diagnosed in the period 1998-2020 ; A Danish nationwide population-based cohort study

Kristensen, Daniel Tuyet ; Jåtun, Trine Louise ; Simonsen, Mikkel Runason ; Toft, Nina ; Dimitrijevic, Andreja ; Ørskov, Andreas Due ; Roug, Anne Stidsholt ; El-Galaly, Tarec Christoffer ; Severinsen, Marianne Tang

Background: Previous studies have shown continuous improved overall survival (OS) up to 2015 for young adults with acute lymphoblastic leukaemia (ALL). However, recently several important advances have been made justifying a more contemporary analysis of outcomes in adult with ALL. Methods: In this nationwide population-based cohort study, we included patients above 18 years of age diagnosed with ALL between January 1, 1998, and December 31, 2020. Patients were followed until December 31, 2022. [...]

Menée à partir de données portant sur 3 413 patients atteints d'un cancer du poumon non à petites cellules traité par inhibiteurs de points de contrôle immunitaire, cette étude rétrospective analyse l'association entre une utilisation d'antifongiques azolés et la survie globale

The association of azole antifungals with overall survival in patients with non-small cell lung cancer receiving immune checkpoint inhibitors

Sebastian, Nikhil T ; Stokes, William A ; Behera, Madhusmita ; Jiang, Renjian ; Gutman, David A ; Huang, Zhonglu ; Burns, Abigail ; Sukhatme, Vidula ; Lowe, Michael C ; Ramalingam, Suresh S ; Sukhatme, Vikas P ; Moghanaki, Drew

Background: Preclinical data suggest antifungal azole derivatives have antitumor efficacy that may modulate response to immune checkpoint inhibitors (ICIs). We aimed to evaluate the association of azole drugs with overall survival (OS) in a population of patients with non-small cell lung cancer (NSCLC) treated with ICI within the Veterans Health Administration (VHA). Methods: In this retrospective study, the VA Corporate Data Warehouse was queried for patients diagnosed with NSCLC and treated [...]

Menée à partir de données portant sur 59 patients atteints d'un cancer de stade avancé, cette étude de cohorte prospective analyse l'association entre leur perception du soutien reçu et l'intensité des soins pendant leur dernier mois de vie

Associations between perceived interpersonal support and aggressiveness of care in the last month of life among patients with advanced cancer

Hardt, Madeleine M. ; Pavao, Madison K. ; Korian, Sosi E. ; LaPlante, Charlotte D. ; Maciejewski, Paul K. ; Prigerson, Holly G.

Purpose: To determine quality of life (QoL) domains in the months leading up to death associated with the receipt of aggressive care in the last month of life among patients with advanced cancer. Methods: A multisite, prospective cohort study conducted from January 2010 to May 2015 of 59 patients with advanced cancer (distant metastases and/or progression of disease following at least first-line chemotherapy) and poor prognosis (≤ 6 months) followed through death. At baseline, a median of 4 [...]