Melanoma Among Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Menée à partir de données portant sur 25 716 adultes ayant survécu à un cancer diagnostiqué durant l'enfance, cette étude évalue l'incidence des mélanomes par rapport à la population générale et identifie les facteurs de risque associés
Résumé en anglais
Purpose : Melanoma as a subsequent malignant neoplasm has been described among childhood cancer survivors; however, the risk factors and long-term survival are not well understood.
Methods : We assessed incidence, risk factors, and outcomes for melanoma among participants in the Childhood Cancer Survivor Study cohort. Cumulative incidence and standardized incidence ratios (SIRs) were calculated, and multivariable Cox models were used to determine hazard ratios (HRs) and associated 95% CI for melanoma risk factors. Radiation exposure to seven body regions and melanoma status for each of eight regions per survivor were integrated into the Cox model.
Results : Among 25,716 participants, 177 melanomas developed in 160 survivors (110 invasive, 62 in situ cutaneous, five ocular). The 40-year melanoma cumulative incidence was 1.1% (95% CI, 0.9 to 1.4) for all participants and 1.5% (95% CI, 1.0 to 2.1) among those receiving a cumulative radiation dose of
