Promises and Challenges of Dietary Intervention in Patients With Prostate Cancer: Lessons Learned From the CAPFISH-3 Trial

Mené à partir d'échantillons biopsiques prélevés sur 100 patients atteints d'un cancer de la prostate de grade 1 ou 2 et bénéficiant d'une surveillance active, cet essai de phase II évalue l'effet d'un régime alimentaire riche en oméga 3 et pauvre en oméga 6 (consommation d'huiles de poisson) sur l'index de prolifération Ki-67

Résumé en anglais

Prostate cancer remains one of the most common cancers affecting men globally, and while advances in early detection and treatment have significantly improved outcomes, there is growing interest in the role lifestyle factors, particularly diet, could play in managing the disease. Many questions concern dietary changes, an area in which publicly available claims often far exceed existing evidence, highlighting the need for rigorous examination of dietary interventions. Active surveillance in prostate cancer involves close biochemical and pathologic monitoring of low-risk disease, while avoiding potentially life-altering interventions such as prostatectomy or radiation therapy. Given the absence of concomitant therapeutic interventions and ability to obtain sequential tissue specimens, the active surveillance setting is ideal to study dietary interventions and gain mechanistic insights. Furthermore, up to one third of the patients on active surveillance make adjustments to their diet after diagnosis, highlighting the need for evidence-based guidance for patients. Therefore, we applaud the authors of the CAPFISH-3 trial in the article that accompanies this editorial for their work examining a combination of behavioral and micronutrient-based dietary interventions in a randomized setting among patients undergoing active surveillance (Fig 1).