Menée notamment à l'aide de données 1972-2021 d'un registre chinois des cancers, cette étude analyse les effets d'une réduction de l'exposition à l'aflatoxine alimentaire sur l'incidence du cancer du foie et l'âge au diagnostic

Profound primary prevention of liver cancer following a natural experiment in China: A 50-year perspective and public health implications

Chen, Jian-Guo ; Kensler, Thomas W. ; Zhu, Jian ; Zhu, Yuan-Rong ; Wang, Jin-Bing ; Lu, Jian-Hua ; Muñoz, Alvaro ; Groopman, John D.

Liver cancer causes upwards of 1 million cancer deaths annually and is projected to rise by at least 55% over the next 15 years. Two of the major risk factors contributing to liver cancer have been well documented by multiple epidemiologic studies and the hepatitis B virus (HBV) and aflatoxin show a synergy that increases by more than 8-fold the risk of liver cancer relative to HBV alone. Using the population-based cancer registry established by the Qidong Liver Cancer Institute in 1972 and [...]

Mené sur 8 144 fumeurs de 16 pays, cet essai randomisé identifie des facteurs épidémiologiques, économiques et réglementaires associés au sevrage tabagique

Do tobacco regulatory and economic factors influence smoking cessation outcomes? A post-hoc analysis of the multinational EAGLES randomised controlled trial

Daniel, Belinda ; Lawrence, David E ; McKenna, Benjamin S ; Saccone, Phillip ; McRae, Thomas ; Evins, A Eden ; Anthenelli, Robert M

Introduction: We previously reported global regional differences in smoking cessation outcomes, with smokers of US origin having lower quit rates than smokers from some other countries. This post-hoc analysis examined global regional differences in individual-level and country-level epidemiological, economic and tobacco regulatory factors that may affect cessation outcomes. Methods: EAGLES (Evaluating Adverse Events in a Global Smoking Cessation Study) was a randomised controlled trial that [...]