Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts
Menée à partir de données de 6 cohortes européennes portant sur 302 493 personnes (durée moyenne de suivi : 18,2 ans), cette étude analyse l'association entre une exposition résidentielle au dioxyde d'azote, aux particules fines (PM2.5), au carbone noir, à l'ozone et à huit composants élémentaires des PM2.5 (cuivre, fer, potassium, nickel, soufre, silicium, vanadium et zinc) et le risque de tumeur du système nerveux central
Résumé en anglais
Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown.
Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.
Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10
