Dietary Inflammatory Index, Alternative Healthy Eating Index-2010, Mediterranean Diet Score and the risk of pancreatic cancer

Menée à partir des données de la "Melbourne Collaborative Cohort Study" portant sur 33 690 personnes (durée moyenne de suivi : 23,7 ans), cette étude analyse l'association entre la qualité et le potentiel inflammatoire de l'alimentation et le risque de cancer du pancréas (258 cas)

Résumé en anglais

Background: Previous studies of dietary patterns and pancreatic cancer risk have been inconclusive; we aimed to investigate the association of Mediterranean Diet Score (MDS), Alternative Healthy Eating Index-2010 (AHEI-2010), and Dietary Inflammatory Index (DII®) with risk of pancreatic cancer.

Methods: We used data from the Melbourne Collaborative Cohort Study including 33,690 men and women aged 40–69 years at recruitment in 1990–1994. A total of 258 incident cases of pancreatic cancer was identified over an average of 23.7 years of follow-up. Hazard ratios (HR) were estimated using Cox regression, with age as the underlying time metric, adjusting for potential confounders including sex, height, country of birth, education, socio-economic position, physical activity, energy intake, smoking status, pack-years smoking, years since quitting smoking, and alcohol intake.

Results: A healthier diet as assessed by the AHEI-2010 was associated with a lower risk of pancreatic cancer [HRQuartile4 vs Quartile1 = 0.58; 95%CI 0.40 – 0.85; p for trend 0.003]. Weaker but consistent evidence was observed for the other indexes [DII® HRQuartile4 vs Quartile1 = 1.30; 95%CI 0.82 – 2.06; p for trend 0.1], [MDS HRCategory3 vs Category1 = 0.79; 95%CI 0.49 – 1.26; p for trend 0.06].

Conclusion: Adherence to a healthier diet, as assessed by the AHEI-2010, may reduce the risk of pancreatic cancer.