Menée aux Etats-Unis à partir de données d'enquêtes réalisées entre 2014 et 2019 auprès de 1 600 fumeurs ne souhaitant pas arrêter de fumer, cette étude analyse l'association entre une utilisation de la cigarette électronique et le sevrage tabagique

Association of e-Cigarette Use With Discontinuation of Cigarette Smoking Among Adult Smokers Who Were Initially Never Planning to Quit

Kasza, Karin A. ; Edwards, Kathryn C. ; Kimmel, Heather L. ; Anesetti-Rothermel, Andrew ; Cummings, K. Michael ; Niaura, Raymond S. ; Sharma, Akshika ; Ellis, Erin M. ; Jackson, Rebecca ; Blanco, Carlos ; Silveira, Marushka L. ; Hatsukami, Dorothy K. ; Hyland, Andrew

Cigarette smokers not planning to quit are often overlooked in population studies evaluating the risk-benefit potential of electronic nicotine delivery products (e-cigarettes).To evaluate whether e-cigarette use is associated with discontinuing cigarette smoking among smokers who were initially never planning to quit.This cohort study used US nationally representative data from the longitudinal Population Assessment of Tobacco and Health Study (waves 2-5 conducted between October 2014 and [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2021 (21 études, plus de 10 000 patients atteints d'un cancer du poumon), cette méta-analyse évalue l'effet, sur la survie, de l'arrêt du tabac au moment ou autour du diagnostic

Quitting smoking at or around diagnosis improves the overall survival of lung cancer patients: a systematic review and meta-analysis

Caini, Saverio ; Del Riccio, Marco ; Vettori, Virginia ; Scotti, Vieri ; Martinoli, Chiara ; Raimondi, Sara ; Cammarata, Giulio ; Palli, Domenico ; Banini, Marco ; Masala, Giovanna ; Gandini, Sara

Introduction: Lung cancer (LC) remains a disease with poor prognosis despite recent advances in treatments. Here, we aimed at summarizing the current scientific evidence on whether quitting smoking at or around diagnosis has a beneficial effect on the survival of LC patients. Methods: We searched MEDLINE and EMBASE for articles published until 31st October, 2021, that quantified the impact on LC patients’ survival of quitting smoking at or around diagnosis or during treatment. Study-specific [...]

Menée à partir de données des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" portant sur 159 116 participants, cette étude analyse l'association entre une utilisation d'aspirine et le risque d'adénocarcinome gastrique, selon la dose, la durée et le sexe

Association between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study

Kwon, Sohee ; Ma, Wenjie ; Drew, David A ; Klempner, Samuel J ; Leonardo, Brianna M ; Flynn, Jacqueline J. ; Cao, Yin ; Giovannucci, Edward L ; Bao, Ying ; Fuchs, Charles S ; Song, Mingyang ; Chan, Andrew T

Prospective data examining the association of aspirin use, according to dose and duration, with long-term risk of gastric adenocarcinoma in non-Asian cohorts are lacking. We evaluated the association between aspirin use and risk of gastric adenocarcinoma in two large prospective U.S. cohort studies, the Nurses' Health Study and the Health Professionals Follow-up Study. Cox proportional hazards regression models were used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence [...]

Mené en Finlande entre 2012 et 2018 sur 2 495 personnes âgées d'au moins 60 ans (43 % de femmes ; âge moyen : 68,2 ans), cet essai randomisé évalue l'effet d'une supplémentation en vitamine D3 sur le risque de maladies cardiovasculaires et de cancer

Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial

Virtanen, Jyrki K ; Nurmi, Tarja ; Aro, Antti ; Bertone-Johnson, Elizabeth R ; Hyppönen, Elina ; Kröger, Heikki ; Lamberg-Allardt, Christel ; Manson, JoAnn E ; Mursu, Jaakko ; Mäntyselkä, Pekka ; Suominen, Sakari ; Uusitupa, Matti ; Voutilainen, Ari ; Tuomainen, Tomi-Pekka ; Hantunen, Sari

Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited.To investigate the effects of vitamin D3 supplementation on CVD and cancer incidence.The study was a 5-year randomized placebo-controlled trial among 2495 male participants ≥ 60 years and post-menopausal female participants ≥ 65 years from a general Finnish population who were free of prior CVD or cancer. The [...]

Menée au Danemark auprès d'une cohorte de 52 723 patientes atteintes d'un cancer du sein et à l'aide de données de registres, cette étude analyse l'effet d'une utilisation de bêta-bloquants sur le risque de cancer du sein controlatéral (1 444 cas)

Use of beta-blockers and risk of contralateral breast cancer

Gottschau, Mathilde ; Bens, Annet ; Friis, Søren ; Cronin-Fenton, Deirdre ; Aalborg, Gitte Lerche ; Jensen, Maj-Britt ; Ejlertsen, Bent ; Kroman, Niels ; Mellemkjær, Lene

Beta-blockers have shown anti-neoplastic effects in laboratory studies but epidemiologic evidence in relation to contralateral breast cancer (CBC) is sparse. We investigated post-diagnosis beta-blocker use and risk of CBC in a cohort of 52 723 women with breast cancer by using nationwide Danish health registers and the Danish Breast Cancer Group database. We defined post-diagnosis beta-blocker use as a time-varying covariate starting one year after a second prescription was redeemed. Cox [...]

Mené en Finlande sur 3 341 jeunes filles vaccinées contre le papillomavirus humain (HPV) et sur 16 526 témoins non vaccinés (âge : 15-19 ans ; durée de suivi : jusqu'à 11 ans), cet essai randomisé évalue l'efficacité du vaccin anti-HPV contre les cancers liés au HPV (col de l'utérus, vulve, vagin, langue)

Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial

Lehtinen, Matti ; Lagheden, Camilla ; Luostarinen, Tapio ; Eriksson, Tiina ; Apter, Dan ; Bly, Anne ; Gray, Penelope ; Harjula, Katja ; Heikkilä, Kaisa ; Hokkanen, Mari ; Karttunen, Heidi ; Kuortti, Marjo ; Nieminen, Pekka ; Nummela, Mervi ; Paavonen, J ; Palmroth, Johanna ; Petäjä, Tiina ; Pukkala, Eero ; Soderlund-Strand, Anna ; Veivo, Ulla ; Dillner, Joakim

Background: Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific protection against invasive cancer. Methods: Individually and/or cluster randomised cohorts of HPV-vaccinated and non-vaccinated women were enrolled in 2002–2005. HPV vaccine cohorts comprised originally 16–17 year-old HPV 16/18-vaccinated PATRICIA [...]

Menée au Canada dans 88 écoles par enquête auprès de 13 269 adolescents, cette étude analyse l'effet, sur l'utilisation de la cigarette électronique, de programmes scolaires de prévention

More support needed: Evaluating the impact of school e-cigarette prevention and cessation programs on e-cigarette initiation among a sample of Canadian secondary school students

Williams, Gillian C. ; Cole, Adam G. ; de Groh, Margaret ; Jiang, Ying ; Leatherdale, Scott T.

Given the recent increase in e-cigarette use among adolescents, there is a need to further explore how school programs are associated with e-cigarette initiation. The objective of this quasi-experimental study was to evaluate the impact of multiple school-based e-cigarette prevention and cessation programs on e-cigarette initiation among Canadian adolescents. This study used data from Year 6 (2017/28) and Year 7 (2018/19) of the COMPASS study in British Columbia, Alberta, Ontario, and Quebec, [...]