Menée en France auprès de 3 572 personnes infectées par le VIH, cette étude analyse, sur la période 2010-2017, l'incidence du cancer du poumon et des cancers liés au papillomavirus humain par rapport à la population générale

Incidence of lung and HPV-associated malignancies in HIV-infected patients

Chaussade, Hélène ; Le-Marec, Fabien ; Coureau, Gaelle ; Leleux, Olivier ; Neau, Didier ; Lazaro, Estibaliz ; Amadeo, Brice ; Duffau, Pierre ; Ferrand, Hélène ; Courtault, Carine ; Foucan, Anne-Sophie ; Wittkop, Linda ; Bonnet, Fabrice

Objective: Cancers represent one of the leading cause of mortality/morbidity in patients living with HIV (PLHIV) in industrialized countries. The objective of our study was to compare incidence of lung and HPV-related cancers among PLHIV with general population over the 2010-2017 period. Design: Prospective and multicenter cohort study. Methods: The study included patients with lung and HPV-related cancers from the ANRS CO3 Aquitaine cohort (PLHIV) and the general population-based cancer [...]

Menée à partir de données 2014-2018 du Système National des Données de Santé français portant sur 75 937 témoins et sur 23 321 patients atteints d'un cancer du pancréas (âge moyen : 69,8 ans), cette étude analyse l'association entre une utilisation d'inhibiteurs de la pompe à protons et le risque de développer la maladie

Use of Proton Pump Inhibitors and Risk of Pancreatic Cancer: A Nationwide Case-Control Study Based on the French National Health Data System (SNDS)

Lassalle, Marion ; Le Tri, Thien ; Afchain, Pauline ; Camus, Marine ; Kirchgesner, Julien ; Zureik, Mahmoud ; Dray-Spira, Rosemary

Background: Only a few studies investigated the association between proton pump inhibitors (PPIs) use and pancreatic cancer, with inconsistent results. Moreover, these studies had a number of methodological limitations. Our objective was to assess this association in a nationwide case-control study. Methods: We used the French National Health Data System (SNDS), covering 99% of the French population since 2006. Incident cases of pancreatic cancer, identified between 2014 and 2018, were matched [...]

Menée à partir de données 1999-2011 portant sur 30 418 témoins et sur 7 903 patients atteints d'un cancer colorectal, cette étude analyse l'association entre une utilisation d'antibiotiques et le risque de développer la maladie, en fonction de l'âge au moment du diagnostic (avant ou après 50 ans)

Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database

McDowell, Ronald ; Perrott, Sarah ; Murchie, Peter ; Cardwell, Christopher ; Hughes, Carmel ; Samuel, Leslie

Background: Antibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an association exists between antibiotic usage and early-onset colorectal cancer (CRC), and also evaluate this in later-onset CRC for comparison. Methods: A case-control study was conducted using primary care data from 1999–2011. Analysis were conducted separately in early-onset CRC cases (diagnosed < 50 years) and later-onset cases (diagnosed ≥ 50 [...]

Menée en Suède à partir de données 1979-2014 de registres d'histopathologie, cette étude analyse le risque de cancer gastro-oesophagien chez les patients présentant des anomalies inflammatoires et métaplasiques de l'oesophage

Esophageal abnormalities and the risk for gastroesophageal cancers—a histopathology-register-based study in Sweden

Ekheden, Isabella ; Ludvigsson, Jonas F. ; Yin, Li ; Elbe, Peter ; Ye, Weimin

Background: The poor survival of patients with gastroesophageal cancers may improve if additional esophageal precursor lesions to Barrett’s esophagus and squamous dysplasia are identified. We estimated the risk for gastroesophageal cancers among patients with various histopathological abnormalities in the esophagus, including Barrett’s esophagus, subdivided by histopathological types. Methods: Histopathology data from esophageal biopsies obtained 1979–2014 were linked with several national [...]

Menée à l'aide de données de l'Assurance maladie coréenne portant sur 6,8 millions de personnnes (durée médiane de suivi : 6,4 ans), cette étude analyse l'association entre des changements de l'indice de masse corporelle et/ou du tour de taille et le risque de carcinome hépatocellulaire (9 952 cas)

Changes in general and central fatness are associated with hepatocellular carcinoma: A Korean nationwide longitudinal study

Kim, Mi Na ; Han, Kyungdo ; Yoo, Juhwan ; Ha, Yeonjung ; Chon, Young Eun ; Lee, Ju Ho ; Hwang, Seong Gyu

We investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC) in a large, population-based cohort. We screened 7,221,479 subjects who underwent health examinations provided by the National Health Insurance Service of South Korea in 2009 and 2011. In total, 6,789,472 subjects were included in the final analysis. General fatness was defined as a body mass index (BMI) ≥25 kg/m2, and central fatness was defined as a waist circumference [...]

Menée à l'aide de données 1992-2015 des registres américains des cancers et de Medicare portant sur 1 986 735 patients âgés atteints d'un cancer (52,6 % d'hommes ; âge moyen au diagnostic : 77 ans), cette étude analyse l'association entre une maladie inflammatoire de l'intestin et le risque de développer un cancer

Associations of Inflammatory Bowel Disease and Subsequent Cancers in a Population-Based Study of Older Adults in the United States

Wang, Jeanny H ; D’Arcy, Monica ; Barnes, Edward L ; Freedman, Neal D ; Engels, Eric A ; Song, Minkyo

Cancer risk is elevated in patients with inflammatory bowel disease (IBD). A comprehensive investigation of cancer risk in older patients (≥66 years of age) is needed, as this understudied population is at high risk.We performed a case-control study using Surveillance Epidemiology and End Results-Medicare data including 1,986,735 incident cancer cases (age 66–99; diagnosed 1992–2015) and 200,000 controls matched by sex, age, race and ethnicity, and selection year. IBD was identified by [...]

Menée en Pologne sur la période 2000-2018 auprès de 813 patients atteints d'un cancer du rein, 1 418 patients atteints d'un cancer de la vessie et de 4 497 témoins (âge moyen au diagnostic : 63 ou 69 ans selon la localisation), cette étude analyse la prévalence de la mutation G84E du gène HOXB13

Germline HOXB13 mutation p.G84E do not confer an increased bladder or kidney cancer risk in polish population

Złowocka-Perłowska, Elżbieta ; Tołoczko-Grabarek, Aleksandra ; Lubinski, Jan

Introduction: The role of HOXB13 in bladder and renal tumorigenesis is unclear. Our goal was to determine the prevalence of HOXB13 p.G84E mutation in bladder and kidney cancer patients from Poland. Materials and methods: 1418 patients with bladder cancer and 813 cases with kidney cancer and 4497 controls were genotyped for HOXB13 p.G84E. Results: p.G84E mutation of HOXB13 gene was detected in three of 1418 (0.2%) bladder cancer cases and in six of 4497 controls (odds ratio [OR], 1.6; 95% CI [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2021 (27 études), cette méta-analyse évalue le risque de cancer de la prostate chez les hommes porteurs d'une mutation au niveau des gènes BRCA

BRCA1 and BRCA2 pathogenic variants and prostate cancer risk: systematic review and meta-analysis

Nyberg, Tommy ; Tischkowitz, Marc ; Antoniou, Antonis C.

Background: BRCA1 and BRCA2 pathogenic variants (PVs) are associated with prostate cancer (PCa) risk, but a wide range of relative risks (RRs) has been reported. Methods: We systematically searched PubMed, Embase, MEDLINE and Cochrane Library in June 2021 for studies that estimated PCa RRs for male BRCA1/2 carriers, with no time or language restrictions. The literature search identified 27 studies (BRCA1: n = 20, BRCA2: n = 21). Results: The heterogeneity between the published estimates was [...]