Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impaired seroconversion after SARS-CoV-2 mRNA vaccines in patients with solid tumours receiving anticancer treatment

Amatu, Alessio ; Pani, Arianna ; Patelli, Giorgio ; Gagliardi, Oscar Matteo ; Loparco, Marina ; Piscazzi, Daniele ; Cassingena, Andrea ; Tosi, Federica ; Ghezzi, Silvia ; Campisi, Daniela ; Grifantini, Renata ; Abrignani, Sergio ; Siena, Salvatore ; Scaglione, Francesco ; Sartore-Bianchi, Andrea

Background: Patients with solid tumours have high COVID-19 mortality. Limited and heterogeneous data are available regarding the immunogenicity of SARS-CoV-2 mRNA vaccines in this population. Methods and Findings: This is a prospective, single-center, cohort study aiming at evaluating seroconversion in terms of anti-spike antibodies in a population of patients with solid tumours undergoing cancer therapy within 2 months before the second vaccine dose, as compared with a cohort of controls. [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of the COVID-19 pandemic on the oncologic activities (diagnosis, treatment, clinical trials enrollment) of a general hospital in a district with high prevalence of SARS-COV-2 in Italy

Ambroggi, Massimo ; Citterio, Chiara ; Vecchia, Stefano ; Riva, Alessandra ; Mordenti, Patrizia ; Cavanna, Luigi

Purpose : Little is known about the real impact of the COVID-19 outbreak on the qualitative and quantitative fall-out on the management of cancer patients. Our objective was to provide evidence of the effects of SARS-COV-2 on the management of cancer patients in the real world. Methods : In a general hospital in a district in Italy with high prevalence of COVID-19 during the first wave, we retrospectively analyzed the data of oncologic activity, namely new cancer diagnosis, types of treatment [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Third dose of anti-SARS-CoV-2 vaccine for patients with cancer: Should humoral responses be monitored? A position paper

Barrière, J. ; Carles, M. ; Audigier-Valette, C. ; Ré, D. ; Zoubir, A. ; Seitz-Polski, B. ; Gounant, V. ; Descamps, D. ; Zalcman, G.

Taking into account higher risk of severe coronavirus disease 2019 (COVID-19) or death among patients with cancer, as well as impaired immunogenicity following anti-SARS-CoV-2 vaccines, in addition to waning immunity, booster dosing appears mandatory in this patient population. This review sought to provide reasonable evidence so as to assist oncologists in their daily practice, helping them decide when an anti-SARS-Cov2 antibodies (Abs) dosage should be scheduled following a full two-dose [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Antibody Titers Before and After a Third Dose of the SARS-CoV-2 BNT162b2 Vaccine in Cancer patients

Debie, Y. ; Vandamme, T. ; Goossens, M. E. ; van Dam, P. A. ; Peeters, M.

Dear Editor, ancer patients are at increased risk for severe COVID-19 and have reduced humoral immune responses after SARS-CoV-2 infection and dual-dose BNT162b2 vaccination. Recently it was observed that a third dose of BNT162b2 is able to elicit higher SARS-CoV-2 anti-receptor-binding domain (RBD) IgG titers in solid-organ transplant patients and adults aged ≥60 years compared to two doses. Initial reports with limited sample size, also indicated that the a third BNT162b2 vaccination dose [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Assessment of Regional Variability in COVID-19 Outcomes Among Patients With Cancer in the United States

Hawley, Jessica E. ; Sun, Tianyi ; Chism, David D. ; Duma, Narjust ; Fu, Julie C. ; Gatson, Na Tosha N. ; Mishra, Sanjay ; Nguyen, Ryan H. ; Reid, Sonya A. ; Serrano, Oscar K. ; Singh, Sunny R. K. ; Venepalli, Neeta K. ; Bakouny, Ziad ; Bashir, Babar ; Bilen, Mehmet A. ; Caimi, Paolo F. ; Choueiri, Toni K. ; Dawsey, Scott J. ; Fecher, Leslie A. ; Flora, Daniel B. ; Friese, Christopher R. ; Glover, Michael J. ; Gonzalez, Cyndi J. ; Goyal, Sharad ; Halfdanarson, Thorvardur R. ; Hershman, Dawn L. ; Khan, Hina ; Labaki, Chris ; Lewis, Mark A. ; McKay, Rana R. ; Messing, Ian ; Pennell, Nathan A. ; Puc, Matthew ; Ravindranathan, Deepak ; Rhodes, Terence D. ; Rivera, Andrea V. ; Roller, John ; Schwartz, Gary K. ; Shah, Sumit A. ; Shaya, Justin A. ; Streckfuss, Mitrianna ; Thompson, Michael A. ; Wulff-Burchfield, Elizabeth M. ; Xie, Zhuoer ; Yu, Peter Paul ; Warner, Jeremy L. ; Shah, Dimpy P. ; French, Benjamin ; Hwang, Clara ; COVID-19 ; Cancer Consortium

Importance : The COVID-19 pandemic has had a distinct spatiotemporal pattern in the United States. Patients with cancer are at higher risk of severe complications from COVID-19, but it is not well known whether COVID-19 outcomes in this patient population were associated with geography. Objective : To quantify spatiotemporal variation in COVID-19 outcomes among patients with cancer. Design, Setting, and Participants : This registry-based retrospective cohort study included patients with a [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Cancer therapy with decreased SARS-CoV-2 infection rates in cancer patients

Hayashi, Takuma ; Konishi, Ikuo

The mammalian target of the rapamycin (mTOR) pathway has been demonstrated to be modulated by numerous RNA viruses. Recent evidence points toward modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Patients with cancer, who receive antineoplastic agents that suppress the mTOR/phosphoinositide 3-kinase (PI3K) signaling pathway, may have lower SARS-CoV-2 infection rates and coronavirus disease 2019 (COVID-19) severity. COVID-19 pandemic urgently warranted [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Axillary Lymphadenopathy After COVID-19 Vaccination in a Woman With Breast Cancer

Lam, Diana L. ; Flanagan, Meghan R.

A39-year-old healthy woman without family history of malignancy found a mass in her right breast at 38 weeks of pregnancy. Prior to delivery, she underwent diagnostic ultrasound of the right breast, which showed a possible mass in the location of the palpable lesion that was most consistent with a normal island of fibroglandular tissue. Follow-up mammogram and ultrasound of the right breast (without axillary evaluation) were performed 6 months later, which showed an irregular 17-mm mass with [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of the first wave of the COVID-19 pandemic on cancer registration and cancer care: a European survey

Neamtiu, Luciana ; Martos, Carmen ; Giusti, Francesco ; Negrao Carvalho, Raquel ; Randi, Giorgia ; Dimitrova, Nadya ; Flego, Manuela ; Dyba, Tadeusz ; Bettio, Manola ; Gavin, Anna ; Visser, Otto ; the ENCR Steering Committee

The COVID-19 pandemic posed a number of challenges to the oncology community, particularly the diagnosis and care of cancer patients while ensuring safety from the virus for both patients and professionals: minimisation of visits to the hospital, cancellation of the screening programmes and the difficulties in the management and operation of cancer registries (CRs) while working remotely.This paper describes the effects in the medium term of the first wave of the COVID-19 pandemic on cancer [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

COVID-19 Vaccination and Breakthrough Infections in Patients with Cancer

Schmidt, A. L. ; Labaki, C. ; Hsu, C. Y. ; Bakouny, Z. ; Balanchivadze, N. ; Berg, S. A. ; Blau, S. ; Daher, A. ; El Zarif, T. ; Friese, C. R. ; Griffiths, E. A. ; Hawley, J. E. ; Hayes-Lattin, B. ; Karivedu, V. ; Latif, T. ; Mavromatis, B. H. ; McKay, R. R. ; Nagaraj, G. ; Nguyen, R. H. ; Panagiotou, O. A. ; Portuguese, A. J. ; Puc, M. ; Dutra, M. Santos ; Schroeder, B. A. ; Thakkar, A. ; Wulff-Burchfield, E. M. ; Mishra, S. ; Farmakiotis, D. ; Shyr, Yu ; Warner, J. L. ; Choueiri, T. K.

Background : Vaccination is an important preventive health measure to protect against symptomatic and severe COVID-19. Impaired immunity secondary to an underlying malignancy or recent receipt of anti-neoplastic systemic therapies can result in less robust antibody titres following vaccination and possible risk of breakthrough infection. As clinical trials evaluating COVID-19 vaccines largely excluded patients with a history of cancer and those on active immunosuppression (including [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Short-term impact of the COVID-19 pandemic on a population-based screening program for colorectal cancer in Catalonia (Spain)

Vives, Nuria ; Binefa, Gemma ; Vidal, Carmen ; Milà, Núria ; Muñoz, Rafael ; Guardiola, Virtudes ; Rial, Olga ; Garcia, Montse

The COVID-19 pandemic caused the suspension at all levels of the Catalan FIT-based CRC screening program on March 12, 2020. Screening invitations to FIT were resumed on September 1, 2020. We aimed to assess the short-term impact of the pandemic and describe strategies implemented to minimize harm by the disruption of the FIT-based CRC screening in the Metropolitan Area of Barcelona. We analyzed participation rate, colonoscopy adherence, time intervals to colonoscopy, detection rates, and [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Gender differences in adherence to COVID-19 preventative measures and preferred sources of COVID-19 information among adolescents and young adults with cancer

Yan, Adam ; Howden, Kaitlyn ; Mahar, Alyson L. ; Glidden, Camille ; Garland, Sheila N. ; Oberoi, Sapna

Background: The COVID-19 pandemic has greatly altered the behavior of adolescents and young adults with cancer. No data exists as to the impact of gender on adherence of individuals with cancer to COVID-19 related public health guidelines and their preferred methods of receiving COVID-19 related information. Methods: We conducted a cross-sectional survey of adolescents and young adults with cancer. Data were summarized using descriptive statistics. Multiple logistic regression was used to [...]

Menée aux Etats-Unis à partir de questionnaires auprès de 380 patients atteints d'un cancer colorectal métastatique (âge médian : 59,9 ans), cette étude estime l'incidence cumulée des difficultés financières majeures et identifie les facteurs associés

S1417CD: A Prospective Multicenter Cooperative Group-Led Study of Financial Hardship in Metastatic Colorectal Cancer Patients

Shankaran, Veena ; Unger, Joseph M. ; Darke, Amy K. ; Suga, Jennifer Marie ; Wade, James L., III ; Kourlas, Peter J. ; Chandana, Sreenivasa R. ; O’Rourke, Mark A. ; Satti, Suma ; Liggett, Diane ; Hershman, Dawn L. ; Ramsey, Scott D.

Background : Financial toxicity is a growing problem in oncology, but no prior studies have prospectively measured the financial impact of cancer treatment in a diverse national cohort of newly diagnosed cancer patients. S1417CD was the first cooperative group-led multicenter prospective cohort study to evaluate financial hardship in metastatic colorectal cancer (mCRC) patients. Methods : Patients aged 18 years or older within 120 days of mCRC diagnosis completed quarterly questionnaires for 12 [...]

Menée aux Etats-Unis à partir de questionnaires auprès de 380 patients atteints d'un cancer colorectal métastatique (âge médian : 59,9 ans), cette étude estime l'incidence cumulée des difficultés financières majeures et identifie les facteurs associés

Treating the Whole Patient With Cancer: The Critical Importance of Understanding and Addressing the Trajectory of Medical Financial Hardship

Yabroff, K. Robin ; Shih, Ya-Chen Tina ; Bradley, Cathy J.

The costs of cancer treatment have grown dramatically over the past decades (1-4). Among patients with health insurance coverage, cost-sharing, including deductibles, copayments, and coinsurance, has also increased, which resulted in increases in out-of-pocket burden that outpaced general inflation (1,4). As a result, patients and their families may need to make trade-offs between paying for their cancer care and basic household needs, such as food, housing, and utilities. Patients may also [...]